4-Acylamino-and 4-ureidobenzamides as melanin-concentrating hormone (MCH) receptor 1 antagonists

Jean-Marie Receveur, Emelie Bjurling, Trond Ulven, Paul Brian Little, Pia K Nørregaard, Thomas Högberg

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Synthesis, in vitro biological evaluation and structure-activity relationships of 4-acylamino-and 4-ureidobenzamides as novel hMCH1R-antagonists are disclosed. The nature of the amine side chains could be varied considerably in contrast to the central benzamide scaffold and aromatic substituents.
Original languageEnglish
JournalBioorganic & Medicinal Chemistry Letters
Volume14
Issue number20
Pages (from-to)5075-80
Number of pages5
ISSN0960-894X
DOIs
Publication statusPublished - 18. Oct 2004

Keywords

  • Animals
  • Benzamides
  • CHO Cells
  • Cricetinae
  • Cricetulus
  • Humans
  • Hypothalamic Hormones
  • Ligands
  • Melanins
  • Pituitary Hormones
  • Radioligand Assay
  • Receptors, Pituitary Hormone
  • Structure-Activity Relationship
  • Urea

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