2D-shear wave elastography: number of acquisitions can be reduced according to clinical setting

Marco Dioguardi Burgio*, Jules Grégory, Maxime Ronot, Riccardo Sartoris, Gilles Chatellier, Valérie Vilgrain, the group SSI-SWE, Jonel Trebicka (Member of author group), Maja Thiele (Member of author group), Aleksander Krag (Member of author group)

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

10 Downloads (Pure)


Background: The factors affecting intra-operator variability of two-dimensional shear wave elastography (2D-SWE) have not been clearly established. We evaluated 2D-SWE variability according to the number of measurements, clinical and laboratory features, and liver stiffness measurements (LSM). Methods: At least three LSM were performed in 452 patients who underwent LSM by 2D-SWE (supersonic shear imaging) out of an initial database of 1650 patients. The mean value of the three LSM was our best measurement method. Bland–Altman plots were used to evaluate intra-operator variability when considering only one, or the first two measurements. Variability was assessed by taking the absolute value of the difference between the first LSM and the mean of the three LSM. Logistic regression was used to assess the factors associated with the highest tertile of variability. Results: The limit of agreement was narrower with the mean of the first and second measurements than with each measurement taken separately (− 2.83 to 2.99 kPa vs. − 5.86 to 6.21 kPa and − 5.77 to 5.73 kPa for the first and second measurement, respectively). A BMI ≥ 25 kg/m2 and a first LSM by 2D-SWE ≥ 7.1 kPa increased the odds of higher variability by 3.4 and 3.9, respectively. Adding a second LSM didn’t change the variability in patients with BMI < 25 and a first LSM by 2D-SWE < 7.1 kPa. Conclusions: Intra-operator variability of LSM by 2D-SWE increases with both a high BMI and high LSM value. In patients with BMI < 25 kg/m2 and a first LSM < 7.1 kPa we recommend performing only one LSM.

Original languageEnglish
Article number145
JournalInsights into Imaging
Issue number1
Publication statusPublished - 21. Oct 2021


  • Elasticity imaging techniques
  • Observer variation
  • Ultrasonography


Dive into the research topics of '2D-shear wave elastography: number of acquisitions can be reduced according to clinical setting'. Together they form a unique fingerprint.

Cite this