2018 Update of the EULAR recommendations for the management of Behçet's syndrome

Gulen Hatemi*, Robin Christensen, Dongsik Bang, Bahram Bodaghi, Aykut Ferhat Celik, Farida Fortune, Julien Gaudric, Ahmet Gul, Ina Kötter, Pietro Leccese, Alfred Mahr, Robert Moots, Yesim Ozguler, Jutta Richter, David Saadoun, Carlo Salvarani, Francesco Scuderi, Petros P. Sfikakis, Aksel Siva, Miles Stanford & 5 others Ilknur Tugal-Tutkun, Richard West, Sebahattin Yurdakul, Ignazio Olivieri, Hasan Yazici

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
Volume77
Issue number6
Pages (from-to)808-818
ISSN0003-4967
DOIs
Publication statusPublished - Jun 2018

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Rheumatic Diseases
Gastroenterology
Advisory Committees
Dermatology
Health
Ophthalmology
Research
Neurology
Oral Medicine
Surgery
Medicine
Oral Health
Rheumatology
Internal Medicine
Joints
Physicians

Keywords

  • anti-TNF
  • behcet's disease
  • treatment

Cite this

Hatemi, Gulen ; Christensen, Robin ; Bang, Dongsik ; Bodaghi, Bahram ; Celik, Aykut Ferhat ; Fortune, Farida ; Gaudric, Julien ; Gul, Ahmet ; Kötter, Ina ; Leccese, Pietro ; Mahr, Alfred ; Moots, Robert ; Ozguler, Yesim ; Richter, Jutta ; Saadoun, David ; Salvarani, Carlo ; Scuderi, Francesco ; Sfikakis, Petros P. ; Siva, Aksel ; Stanford, Miles ; Tugal-Tutkun, Ilknur ; West, Richard ; Yurdakul, Sebahattin ; Olivieri, Ignazio ; Yazici, Hasan. / 2018 Update of the EULAR recommendations for the management of Behçet's syndrome. In: Annals of the Rheumatic Diseases. 2018 ; Vol. 77, No. 6. pp. 808-818.
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title = "2018 Update of the EULAR recommendations for the management of Beh{\cc}et's syndrome",
abstract = "Several new treatment modalities with different mechanisms of action have been studied in patients with Beh{\cc}et's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.",
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author = "Gulen Hatemi and Robin Christensen and Dongsik Bang and Bahram Bodaghi and Celik, {Aykut Ferhat} and Farida Fortune and Julien Gaudric and Ahmet Gul and Ina K{\"o}tter and Pietro Leccese and Alfred Mahr and Robert Moots and Yesim Ozguler and Jutta Richter and David Saadoun and Carlo Salvarani and Francesco Scuderi and Sfikakis, {Petros P.} and Aksel Siva and Miles Stanford and Ilknur Tugal-Tutkun and Richard West and Sebahattin Yurdakul and Ignazio Olivieri and Hasan Yazici",
note = "{\circledC} Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.",
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Hatemi, G, Christensen, R, Bang, D, Bodaghi, B, Celik, AF, Fortune, F, Gaudric, J, Gul, A, Kötter, I, Leccese, P, Mahr, A, Moots, R, Ozguler, Y, Richter, J, Saadoun, D, Salvarani, C, Scuderi, F, Sfikakis, PP, Siva, A, Stanford, M, Tugal-Tutkun, I, West, R, Yurdakul, S, Olivieri, I & Yazici, H 2018, '2018 Update of the EULAR recommendations for the management of Behçet's syndrome', Annals of the Rheumatic Diseases, vol. 77, no. 6, pp. 808-818. https://doi.org/10.1136/annrheumdis-2018-213225

2018 Update of the EULAR recommendations for the management of Behçet's syndrome. / Hatemi, Gulen; Christensen, Robin; Bang, Dongsik; Bodaghi, Bahram; Celik, Aykut Ferhat; Fortune, Farida; Gaudric, Julien; Gul, Ahmet; Kötter, Ina; Leccese, Pietro; Mahr, Alfred; Moots, Robert; Ozguler, Yesim; Richter, Jutta; Saadoun, David; Salvarani, Carlo; Scuderi, Francesco; Sfikakis, Petros P.; Siva, Aksel; Stanford, Miles; Tugal-Tutkun, Ilknur; West, Richard; Yurdakul, Sebahattin; Olivieri, Ignazio; Yazici, Hasan.

In: Annals of the Rheumatic Diseases, Vol. 77, No. 6, 06.2018, p. 808-818.

Research output: Contribution to journalJournal articleResearchpeer-review

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T1 - 2018 Update of the EULAR recommendations for the management of Behçet's syndrome

AU - Hatemi, Gulen

AU - Christensen, Robin

AU - Bang, Dongsik

AU - Bodaghi, Bahram

AU - Celik, Aykut Ferhat

AU - Fortune, Farida

AU - Gaudric, Julien

AU - Gul, Ahmet

AU - Kötter, Ina

AU - Leccese, Pietro

AU - Mahr, Alfred

AU - Moots, Robert

AU - Ozguler, Yesim

AU - Richter, Jutta

AU - Saadoun, David

AU - Salvarani, Carlo

AU - Scuderi, Francesco

AU - Sfikakis, Petros P.

AU - Siva, Aksel

AU - Stanford, Miles

AU - Tugal-Tutkun, Ilknur

AU - West, Richard

AU - Yurdakul, Sebahattin

AU - Olivieri, Ignazio

AU - Yazici, Hasan

N1 - © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

PY - 2018/6

Y1 - 2018/6

N2 - Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.

AB - Several new treatment modalities with different mechanisms of action have been studied in patients with Behçet's syndrome (BS). The aim of the current effort was to update the recommendations in the light of these new data under the auspices of the European League Against Rheumatism (EULAR) Standing Committee for Clinical Affairs. A task force was formed that included BS experts from different specialties including internal medicine, rheumatology, ophthalmology, dermatology, neurology, gastroenterology, oral health medicine and vascular surgery, along with a methodologist, a health professional, two patients and two fellows in charge of the systematic literature search. Research questions were determined using a Delphi approach. EULAR standardised operating procedures was used as the framework. Results of the systematic literature review were presented to the task force during a meeting. The former recommendations were modified or new recommendations were formed after thorough discussions followed by voting. The recommendations on the medical management of mucocutaneous, joint, eye, vascular, neurological and gastrointestinal involvement of BS were modified; five overarching principles and a new recommendation about the surgical management of vascular involvement were added. These updated, evidence-based recommendations are intended to help physicians caring for patients with BS. They also attempt to highlight the shortcomings of the available clinical research with the aim of proposing an agenda for further research priorities.

KW - anti-TNF

KW - behcet's disease

KW - treatment

U2 - 10.1136/annrheumdis-2018-213225

DO - 10.1136/annrheumdis-2018-213225

M3 - Journal article

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JF - Annals of the Rheumatic Diseases

SN - 0003-4967

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