TY - JOUR
T1 - [18F]FDG PET/CT for identifying the causes of fever of unknown origin (FUO)
AU - Singh, Shashi B
AU - Shrestha, Niki
AU - Bhandari, Sadikshya
AU - Shrestha, Suprita
AU - Shrestha, Bijay
AU - Shrestha, Neharika
AU - Rijal, Swarnima
AU - Singh, Rajshree
AU - Hess, Soren
AU - Werner, Thomas J
AU - Alavi, Abass
AU - Revheim, Mona-Elisabeth
N1 - AJNMMI Copyright © 2024.
PY - 2024
Y1 - 2024
N2 - Fever of unknown origin (FUO) continues to be a challenging diagnosis in clinical medicine. It has more than 200 known causes, including infections, autoimmune diseases, neoplasia, and other miscellaneous disorders. Despite the development of a wide range of diagnostic tools, a specific diagnostic algorithm for FUO is not yet available. However, [18F]FDG PET/CT, which yields information on cellular metabolism, in addition to details of organ anatomy, has been shown to be successful in the FUO investigation. This study highlights the uses of [18F]FDG PET/CT in diagnosing various causes of FUO. [18F]FDG PET/CT has been increasingly used to detect septic infections, sterile inflammatory processes, and malignancies, occupying a significant portion of the known causes of FUO. It has led to a more definitive identification of the etiology of FUO and accurate clinical management. However, more in-depth studies are crucial to understanding if [18F]FDG PET/CT can be used in the work-up of FUO.
AB - Fever of unknown origin (FUO) continues to be a challenging diagnosis in clinical medicine. It has more than 200 known causes, including infections, autoimmune diseases, neoplasia, and other miscellaneous disorders. Despite the development of a wide range of diagnostic tools, a specific diagnostic algorithm for FUO is not yet available. However, [18F]FDG PET/CT, which yields information on cellular metabolism, in addition to details of organ anatomy, has been shown to be successful in the FUO investigation. This study highlights the uses of [18F]FDG PET/CT in diagnosing various causes of FUO. [18F]FDG PET/CT has been increasingly used to detect septic infections, sterile inflammatory processes, and malignancies, occupying a significant portion of the known causes of FUO. It has led to a more definitive identification of the etiology of FUO and accurate clinical management. However, more in-depth studies are crucial to understanding if [18F]FDG PET/CT can be used in the work-up of FUO.
U2 - 10.62347/OQQC6007
DO - 10.62347/OQQC6007
M3 - Journal article
C2 - 38737639
SN - 2160-8407
VL - 14
SP - 87
EP - 96
JO - American Journal of Nuclear Medicine and Molecular Imaging
JF - American Journal of Nuclear Medicine and Molecular Imaging
IS - 2
ER -