10 years of research: from ignoring Modic Changes to considerations regarding treatment and prevention of low-grade disc infections

Claus Manniche, Alan Jordan

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Abstract

After many years of essentially ignoring or considering Modic changes (MC) as seen on MRI scans as incidental findings, a new era began with the publication of Kjær et al. 10 years ago, who were the first research group in the world to demonstrate a clear correlation between MC and the 1-year prevalence of low back pain [1]. This important discovery ‘upset’ the prevailing consensus among back specialists that loe back pain was predominantly a biopsychosocial phenomenon with an emphasis on the psychosocial dimension [2]. Since Kjær et al.'s publication, the biological dimension of back pain has become a hot topic among back pain researchers throughout the world. Currently, new publications dealing with Modic-related topics are published almost weekly in scientific journals.

We will introduce the reader to the concept of MC and present the current status of our knowledge from the very latest scientific literature including the presence of Propionibacterium acnes inside the disc. Many of the bricks involved in this puzzle are beginning to form a biologically sound ‘picture’.
Original languageEnglish
Article numberFSO117
JournalFuture Science O A
Volume2
Issue number2
ISSN2056-5623
DOIs
Publication statusPublished - 2016

Keywords

  • Low back pain
  • modic changes
  • disc egeneration
  • pain
  • Modic changes
  • disc infection
  • low back pain

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