1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

Morten Jørgensen; Benny Bang-Andersen; Nicholas Moore; André Faldt; Arne Mørk; Heidi Lopez De Diego; René Holm; Tine Bryan Stensbøl; Lone Munch Ringgard; Michael J Mealy; Michael Harold Rock; Jørgen Brodersen

1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

Morten Jørgensen (Inventor), Benny Bang-Andersen (Inventor), Nicholas Moore (Inventor), André Faldt (Inventor), Arne Mørk (Inventor), Heidi Lopez De Diego (Inventor), René Holm (Inventor), Tine Bryan Stensbøl (Inventor), Lone Munch Ringgard (Inventor), Michael J Mealy (Inventor), Michael Harold Rock (Inventor), Jørgen Brodersen (Inventor)

Research output: Patent

Abstract

1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

Original language	English
IPC	C07D 295/ 096 A I
Patent number	US2016083359
Country/Territory	Denmark
Priority date	23/11/2015
Priority number	US201514948775
Publication status	Published - 24. Mar 2016
Externally published	Yes

Cite this

Jørgensen, M., Bang-Andersen, B., Moore, N., Faldt, A., Mørk, A., De Diego, H. L., Holm, R., Stensbøl, T. B., Ringgard, L. M., Mealy, M. J., Rock, M. H., & Brodersen, J. (2016). 1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment. (Patent No. US2016083359).

Jørgensen, Morten (Inventor) ; Bang-Andersen, Benny (Inventor) ; Moore, Nicholas (Inventor) ; Faldt, André (Inventor) ; Mørk, Arne (Inventor) ; De Diego, Heidi Lopez (Inventor) ; Holm, René (Inventor) ; Stensbøl, Tine Bryan (Inventor) ; Ringgard, Lone Munch (Inventor) ; Mealy, Michael J (Inventor) ; Rock, Michael Harold (Inventor) ; Brodersen, Jørgen (Inventor). / 1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment. Patent No.: US2016083359. Mar 24, 2016.

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title = "1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment",

abstract = "1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.",

author = "Morten J{\o}rgensen and Benny Bang-Andersen and Nicholas Moore and Andr{\'e} Faldt and Arne M{\o}rk and {De Diego}, {Heidi Lopez} and Ren{\'e} Holm and Stensb{\o}l, {Tine Bryan} and Ringgard, {Lone Munch} and Mealy, {Michael J} and Rock, {Michael Harold} and J{\o}rgen Brodersen",

year = "2016",

month = mar,

day = "24",

language = "English",

type = "Patent",

note = "US2016083359; C07D 295/ 096 A I",

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1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment. / Jørgensen, Morten (Inventor); Bang-Andersen, Benny (Inventor); Moore, Nicholas (Inventor); Faldt, André (Inventor); Mørk, Arne (Inventor); De Diego, Heidi Lopez (Inventor); Holm, René (Inventor); Stensbøl, Tine Bryan (Inventor); Ringgard, Lone Munch (Inventor); Mealy, Michael J (Inventor); Rock, Michael Harold (Inventor); Brodersen, Jørgen (Inventor).

Patent No.: US2016083359. Mar 24, 2016.

Research output: Patent

TY - PAT

T1 - 1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

AU - Jørgensen, Morten

AU - Bang-Andersen, Benny

AU - Moore, Nicholas

AU - Faldt, André

AU - Mørk, Arne

AU - De Diego, Heidi Lopez

AU - Holm, René

AU - Stensbøl, Tine Bryan

AU - Ringgard, Lone Munch

AU - Mealy, Michael J

AU - Rock, Michael Harold

AU - Brodersen, Jørgen

PY - 2016/3/24

Y1 - 2016/3/24

N2 - 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

AB - 1-[2-(2,4-dimethylphenylsulphanyl)phenyl]piperazine exhibits potent activity on SERT, 5-HT3 and 5-HT1A and may as such be useful for the treatment of cognitive impairment, especially in depressed patients.

M3 - Patent

M1 - US2016083359

ER -

1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl]piperazine as a compound with combined serotonin reuptake, 5-HT3 and 5-HT1A activity for the treatment of cognitive impairment

Abstract

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