γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen; Yan Luo; Miriam R. B. Porzberg; Paul B. White; Jie Jian; Giordano Proietti; Jasmin Mecinović

doi:10.1039/D1CC02589A

γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen, Yan Luo, Miriam R. B. Porzberg, Paul B. White, Jie Jian, Giordano Proietti, Jasmin Mecinović^*

^*Corresponding author for this work

Department of Physics, Chemistry and Pharmacy

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

Original language	English
Journal	Chemical Communications
Volume	57
Issue number	55
Pages (from-to)	6788-6791
ISSN	1359-7345
DOIs	https://doi.org/10.1039/D1CC02589A
Publication status	Published - 14. Jul 2021

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10.1039/D1CC02589A

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1 Ph.D. thesis

Chemical Basis of Arginine Citrullination and Methylation in Epigenetics
Porzberg, M., 14. Sept 2022, Syddansk Universitet. Det Naturvidenskabelige Fakultet. 196 p.
Research output: Thesis › Ph.D. thesis

Cite this

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title = "γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases",

abstract = "Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.",

author = "Hintzen, {Jordi C. J.} and Yan Luo and Porzberg, {Miriam R. B.} and White, {Paul B.} and Jie Jian and Giordano Proietti and Jasmin Mecinovi{\'c}",

year = "2021",

month = jul,

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doi = "10.1039/D1CC02589A",

language = "English",

volume = "57",

pages = "6788--6791",

journal = "Chemical Communications",

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TY - JOUR

T1 - γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

AU - Hintzen, Jordi C. J.

AU - Luo, Yan

AU - Porzberg, Miriam R. B.

AU - White, Paul B.

AU - Jian, Jie

AU - Proietti, Giordano

AU - Mecinović, Jasmin

PY - 2021/7/14

Y1 - 2021/7/14

N2 - Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

AB - Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

U2 - 10.1039/D1CC02589A

DO - 10.1039/D1CC02589A

M3 - Journal article

SN - 1359-7345

VL - 57

SP - 6788

EP - 6791

JO - Chemical Communications

JF - Chemical Communications

IS - 55

ER -

γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Abstract

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Related research output

Chemical Basis of Arginine Citrullination and Methylation in Epigenetics

Cite this