γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen; Yan Luo; Miriam R. B. Porzberg; Paul B. White; Jie Jian; Giordano Proietti; Jasmin Mecinović

doi:10.1039/D1CC02589A

γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen, Yan Luo, Miriam R. B. Porzberg, Paul B. White, Jie Jian, Giordano Proietti, Jasmin Mecinović^*

^*Corresponding author for this work

Department of Physics, Chemistry and Pharmacy

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

Original language	English
Journal	Chemical Communications
Volume	57
Issue number	55
Pages (from-to)	6788-6791
ISSN	1359-7345
DOIs	https://doi.org/10.1039/D1CC02589A
Publication status	Published - 14. Jul 2021

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10.1039/D1CC02589A

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@article{2b8daa505cc54ad9a85947e85b8c8510,

title = "γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases",

abstract = "Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.",

author = "Hintzen, {Jordi C. J.} and Yan Luo and Porzberg, {Miriam R. B.} and White, {Paul B.} and Jie Jian and Giordano Proietti and Jasmin Mecinovi{\'c}",

year = "2021",

month = jul,

day = "14",

doi = "10.1039/D1CC02589A",

language = "English",

volume = "57",

pages = "6788--6791",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "55",

}

γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases. / Hintzen, Jordi C. J.; Luo, Yan; Porzberg, Miriam R. B.; White, Paul B.; Jian, Jie; Proietti, Giordano; Mecinović, Jasmin.

In: Chemical Communications, Vol. 57, No. 55, 14.07.2021, p. 6788-6791.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

AU - Hintzen, Jordi C. J.

AU - Luo, Yan

AU - Porzberg, Miriam R. B.

AU - White, Paul B.

AU - Jian, Jie

AU - Proietti, Giordano

AU - Mecinović, Jasmin

PY - 2021/7/14

Y1 - 2021/7/14

N2 - Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

AB - Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.

U2 - 10.1039/D1CC02589A

DO - 10.1039/D1CC02589A

M3 - Journal article

VL - 57

SP - 6788

EP - 6791

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 55

ER -

γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Abstract

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