γ-Difluorolysine as a 19F NMR probe for histone lysine methyltransferases and acetyltransferases

Jordi C. J. Hintzen, Yan Luo, Miriam R. B. Porzberg, Paul B. White, Jie Jian, Giordano Proietti, Jasmin Mecinović*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Histone lysine methylation and acetylation are important posttranslational modifications that regulate gene expression in humans. Due to the interplay of these two modifications, new chemical methods to study lysine posttranslational modifications are highly desired. Here, we report the use of γ-difluorolysine as a lysine mimic and 19F NMR probe for examinations of histone methylation and acetylation.
Original languageEnglish
JournalChemical Communications
Volume57
Issue number55
Pages (from-to)6788-6791
ISSN1359-7345
DOIs
Publication statusPublished - 14. Jul 2021

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