Vitamin E diffused versus conventional higly cross-linked (HXLPE) liners in total hip arthroplasty at five years

Project: Research

Project Details


Total hip replacement (THR) is one of the most common and successful procedures in joint replacement surgeries. In Denmark (DK) alone, around 9,000 patients receive a primary THA each year, revision rate is stable at 12-14%, and more than 75% of all primary THA last 20 years or more (1). Patients are often able to return to their previous profession within 1-14 weeks after surgery. The two major causes of revision are aseptic loosening and dislocation, and the two together account for more than half of the revisions in 2015 in DK. To further improve THA survival rate, it is natural to investigate options for delaying or eliminating aseptic loosening and reducing dislocation. This protocol aims to investigate the effect of material choice and head size on wear which may play a role in aseptic loosening. Moreover, clinical outcome and patient reported outcome measures (PROM), and a new method to assess wear are also investigated.

The objective of the study is to investigate liner wear, cup migration, and clinical outcome using a factorial design. Treatment groups are E-Poly versus ArComXL liners, and 36 mm versus 32 mm head size.

Layman's description

Kan e-vitamin forlænge levetiden af
den kundstige hofte?
Et prospektivt randomiseret studie om slid, kopmigration og patientrapporteret hoftefunktion og livskvalitet
Short titleE-poly
Effective start/end date01/02/201801/02/2021

Research Output

  • 1 Conference abstract for conference

Vitamin E diffused THA liners show similar head penetration after 5 years postoperatively compared to HXLPE in a randomized controlled trial

Kjærgaard, K., Ding, M., Jensen, C., Bragdon, C., Malchau, H., Andreasen, C. M., Ovesen, O., Hofbauer, C. & Overgaard, S., 15. May 2019.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review


  • 1 Conference presentations

Vitamin E diffused highly cross-linked polyethylene liners (vE-PE) show similar head penetration as conventional highly cross-linked polyethylene (XLPE) in total hip arthroplasty at five years: A randomized controlled trial

Kristian Kjærgaard (Lecturer), Ming Ding (Other), Carsten Jensen (Other), Charles Bragdon (Other), Henrik Malchau (Other), Christina M. Andreasen (Other), Ole Ovesen (Other), Søren Overgaard (Other)
24. Oct 2019

Activity: Talks and presentationsConference presentations


EFORT Free Paper Award Orthopaedics - Silver

Kristian Kjærgaard (Recipient), Ming Ding (Recipient), Carsten Jensen (Recipient), Charles Bragdon (Recipient), Henrik Malchau (Recipient), Christina Møller Andreasen (Recipient), Ole Ovesen (Recipient), Christian Hofbauer (Recipient) & Søren Overgaard (Recipient), 5. Dec 2019

Prize: Prizes, scholarships, distinctions