Uddannelses og Forskningsministeriet- Styrelsen for Forskning og Uddannelse - EUopSTART - Metabolism-net_11-2019_EUopSTART

Project: Research Councils

Project Details

Description

Providing tools and new knowledge about disease-specific cellular and structural
changes affecting NR function and on NR-dependent regulation of gene expression programs associated with metabolic disease like obesity and type-2-diabetes along with in depth scientific understanding will be the overriding scientific impact of METABOLISM-NET.

METABOLISM-NET will produce new knowledge on e.g. the role of NR and
NRcoregulatory function in the epigenetic regulation of metabolism and linked
inflammatory processes in physiological and various pathological contexts.

METABOLISM-NET will increase the likelihood of ESRs finding innovative solutions and contribute to a knowledge based economy and society, by a cross disciplinary approach, with a strong involvement of the non-academic partners collaborating with excellent scientific research environments. METABOLISM-NET will impact society directly through the training of 15 highly qualified, multidisciplinary and innovative ESR´s employable in the academic and non-academic sector and thereby drive the development of novel approaches in obesity and type 3 diabetes treatment. METABOLISM-NET will increase the international, interdisciplinary and intersectoral mobility of researchers in Europe through secondments.

METABOLISM-NET will further impact society by providing new knowledge available for the wider scientific and public audience, which will boost and secure the future research in Nuclear Receptor, provide knowledge for future political decisions and raise public awareness. This will be achieved by publishing policy reports and position papers both in close collaboration with EU and national authorities.

METABOLISM-NET will actively utilize outreach activities in order to disseminate
relevant results to the public at large, including involvement of interest
organizations and publications in the local press. Dissemination and exploitation of the results of METABOLISM-NET will be guaranteed by publications, patents, symposia and workshops, both during the project duration and after completion of the grant agreement.

Layman's description

The main scientific objective of METABOLISM-NET is to study the role of nuclear
receptor signaling pathways in the regulation of metabolic homeostasis in
physiological and pathological settings. Focus will be on the understanding of
disease-specific cellular and structural changes affecting NR function and on
NRdependent regulation of gene expression programs associated with metabolic
disease, e.g. obesity and type-2-diabetes (T2D). We propose a multifaceted
approach organized under 3 major overlapping activities with the following.

Specific Aims:

1. Studies on the role of NR and NR-coregulator function in the epigenetic
regulation of metabolism and linked inflammatory processes in physiological and various pathological contexts.

2. Studies on the mechanism of NR and NR-coregulator mediated regulation of gene networks implicated in obesity, type 2 diabetes and fatty liver disease.

3. Studies on the role of NRs in the control of metabolism flexibility capacity and
the regulation of circadian rhythm.

The above broad thematic areas offer a rich interface for scientific training, with
opportunities for students to become exposed to fields as diverse as medical
therapeutics, epigenetics, network biology, genomics, metabolism, proteomics, and endocrinology.
StatusFinished
Effective start/end date30/09/201914/01/2020