The liver is a central responder to feeding and acts to take up and redistribute nutrients to maintain homeostasis. This requires an enormous transcriptional plasticity regulated by a number of transcription factors. Unlike terminal differentiation during development, hepatic transcriptional networks regulated by feeding are completely reversible, emphasizing a highly dynamic process. How regulation of this network is coordinated at a genome-wide level is not well understood, and this PhD project aims to use a functional genomics approach to characterize dynamic genome organization in response to feeding and identify central mechanisms regulating dynamic gene transcription.
|Effective start/end date||15/09/2014 → 14/09/2016|