Homeostatic regulation of body temperature is fundamental to mammalian physiology and is controlled by acute and chronic responses of local, endocrine and neuronal regulators. Although the skin is the largest sensory organ of the human body, and plays a fundamental role in regulating body temperature, it is surprising that adaptive alterations in skin functions and morphology by far have been associated to physiological responses to temperature variations in the environment including cold. Recent work from our laboratory shows that mice with an impaired epidermal barrier are not capable of maintaining normal body temperature, have increased heat dissipation and energy expenditure, and are resistant to diet-induced obesity and inflammation in the liver. We therefore hypothesize that a compromised epidermal barrier results in elevated energy expenditure and heat evaporation, which have systemic-wide effects on metabolism in numerous tissues. We therefore aim to unravel the physiological and cellular responses to a compromised epidermal barrier at a molecular level.
|Effective start/end date||01/01/2018 → 31/12/2019|