Activities per year
The proposed Center for Adipocyte Signaling (ADIPOSIGN) is based on an outstanding team of scientists with highly complementary competences but with a common interest in understanding the role and mechanisms of adipocyte signal transduction in obesity disease etiology. By combining experimental and computational systems approaches (WP1), we will obtain unprecedented insights into how mouse adipocytes receive and respond to signals at the level of the genome and the cell membrane depending on depot, gender and genetic makeup. Based on unique human cohorts, adipose tissue samples and human genetic data we will characterize the signaling states of obese human adipocytes, and we will infer the impact of human genetic variation on obesity etiology (WP2). Through detailed molecular studies in advanced ex vivo and in vivo model systems (WP3), we will decipher how these signaling functions respond to obesity.
Our long-term ambition is that insights obtained in ADIPOSIGN will form the basis not only for future drug discovery, and possible treatment strategies, but also for new predictive and preventive strategies for obesity. The experimental and computational approaches developed in ADIPOSIGN can be applied to uncover the mechanism of other complex human disease beyond obesity.
|Effective start/end date||01/01/2019 → 31/12/2024|
Susanne Mandrup (Organizer), Marianne Holmer (Panel member), Jakob Møller-Jensen (Panel member), Jan-Wilhelm Kornfeld (Panel member), Zachary Gerhart-Hines (Panel member), M. Madan Babu (Panel member), Matthias Blüher (Panel member), Ruth J F Loos (Panel member), Martin Klingenspor (Panel member) & Christian Wolfrum (Panel member)27. May 2019
Activity: Attending an event › Organisation or participation in workshops, courses or seminars