MICROBiome-based biomarkers to PREDICT decompensation of liver cirrhosis and treatment response

Project: Research

Project Details


22 European institutions join forces in MICROB-PREDICT to improve the prevention and treatment of chronic liver disease (cirrhosis). We aim to identify microbiome-based biomarkers and mechanisms that predict in advance when the body can no longer compensate for the dysfunctional liver (decompensated cirrhosis), when such decompensated cirrhosis will progress to acute-on-chronic liver failure (ACLF), and a patient’s individual treatment response. Based on such biomarkers, we strive to develop novel diagnostic tools for earlier and better patient stratification and to establish personalised and effective treatment strategies.
Effective start/end date01/01/201931/03/2025


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  • Two-dimensional shear wave elastography predicts survival in advanced chronic liver disease

    Trebicka, J., Gu, W., de Ledinghen, V., Aubé, C., Krag, A., Praktiknjo, M., Castera, L., Dumortier, J., Bauer, D. J. M., Friedrich-Rust, M., Pol, S., Grgurevic, I., Zheng, R., Francque, S., Gottfriedovà, H., Mustapic, S., Sporea, I., Berzigotti, A., Uschner, F. E., Simbrunner, B., & 29 othersRonot, M., Cassinotto, C., Kjaergaard, M., Andrade, F., Schulz, M., Semmler, G., Drinkovic, I. T., Chang, J., Brol, M. J., Rautou, P. E., Vanwolleghem, T., Strassburg, C. P., Boursier, J., Ferstl, P. G., Rasmussen, D. N., Reiberger, T., Vilgrain, V., Guibal, A., Guillaud, O., Zeuzem, S., Vassord, C., Lu, X., Vonghia, L., Senkerikova, R., Popescu, A., Margini, C., Wang, W., Thiele, M. & Jansen, C., Feb 2022, In: GUT. 71, 2, p. 402-414

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    7 Downloads (Pure)
  • 2D shear wave liver elastography by aixplorer to detect portal hypertension in cirrhosis: an individual patient data meta‐analysis

    Thiele, M., Hugger, M. B., Kim, Y., Rautou, PE., Elkrief, L., Jansen, C., Verlinden, W., Allegretti, G., Israelsen, M., Stefanescu, H., Piscaglia, F., García‐Pagán, J. C., Franque, S., Berzigotti, A., Castera, L., Jeong, W. K., Trebicka, J. & Krag, A., 1. Jun 2020, In: Liver International. 40, 6, p. 1435-1446

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    41 Downloads (Pure)