A bacterial biofilm is a community of cells held together by an extracellular matrix. Bacterial biofilms pose a serious problem in human health as they protect the cells making them highly resistant to antibiotics and extremely difficult to eradicate. Therefore, understanding the mechanisms involved in the formation of biofilms is important for developing effective means of controlling their formation and targeting the cells with antibiotics. Biofilms affect many parts of our everyday life especially in the clinical and the medical fields. We have exciting preliminary data showing new aspects in biofilm development. Combining national and international expertise, we will employ state-of-the-art microfluidics techniques in a novel approach to study biofilm development and maturation. The specific aim of this proposal is to dissect the mechanisms of bacterial colonization on surfaces and the virulence traits associated herewith. We will uncover hitherto unknown regulatory pathways of biofilm development and reveal new aspects of host-pathogen interactions. These findings will provide new ‘points of attack’ in the combat against pathogenic bacteria. Given the economic and health importance of biofilms, the full understanding of biofilm development and the regulatory systems involved is likely to have significant and immediate practical implications.
|Effective start/end date||01/06/2014 → 24/07/2016|