Defining secreted factors regulating musculoskeletal stem cell biology

Degenerative diseases in the musculoskeletal tissues, such as osteoporosis and muscular dystrophy, are today widespread phenomena and many of these conditions are at present incurable. Stem cell-based regenerative medicine, however, holds great promises for restoring lost tissue. Yet, their clinical usage has so far been limited at least in part due to lack of interaction between clinicians and basic scientists.