Cryoneurolysis for the management of chronic pain in knee osteoarthritis

Project: Research

Project Details


Pain is the principal symptom in knee osteoarthritis (OA). Current treatment options have only moderate effects and often patients experience persistent pain or side-effects. Novel advances in the field of cryoneurolysis applies low temperatures to disrupt nerve signaling at the painful area, providing pain relief. The primary objective of the current project is to determine the effectiveness of cryoneurolysis in its ability to decrease pain in patients with knee OA. 90 individuals with knee OA in the knee will be randomly allocated in either a cryoneurolysis intervention group (CRYO) or a sham group (SHAM). Both groups will be assessed at baseline, post intervention and at 3, 6, 12 and 24 months after completion of an exercise program (GLA:D). The primary outcome is The VAS knee pain intensity score, measured post cryoneurolysis treatment. Secondary outcome measures include functional performance, PRO-data (KOOS and EQ5D), use of analgesics, and adverse effects.
Effective start/end date01/12/201831/12/2021


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