1979 …2019
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Personal profile

Curriculum

Academic qualifications
1974: B.Sc., McGill University, Montreal, Canada
1977:M.Sc., McGill University, Montreal, Canada
1981:PhD, University of Ottawa, Canada

Postdoctoral training: University College London 1981-1984 (NA Mitchison); Walter and Eliza Hall Institute, Melbourne 1984-1987 (JFAP Miller).

Relevant Professional Positions and Employment
1987 - Appointed to faculty, McGill University, Montreal
2001 - 2006 Professor, McGill University
2004 - Professor, Univ. of Southern Denmark (SDU), Odense, Denmark.
2006 - Adjunct Professor, McGill University
2010 - Head of Research, Neurobiology Dept, Inst of Molecular Medicine, SDU

Research Funding
Danish Agency for Research and Innovation, Scleroseforeningen, Lundbeckfonden, NovoNordiskfonden, Carlsbergfondet.

Lab members: Reza Khorooshi, Nasrin Asgari, Agnieszka Wlodarczyk, Joanna Marczynska, Ruthe Storgaard Dieu, Marlene Mørch, Mads Olesen, Anouk Benmamar-Badel, Sofie Forsberg Sørensen, Dina Arengoth, Pia Nyborg Nielsen


PUBLICATIONS: 169 total, 118 peer-reviewed.

Research areas
Neuroimmunology, central nervous system inflammation and glial response, with reference to Mutliple sclerosis (see Owens group here)

Positions
We do not have funded PhD or postdoc positions but we always welcome bright and interested candidates who will apply for funds to join one of our projects

Selected activities
•Head of Research, Neurobiology Dept, Inst of Molecular Medicine, SDU - 2010
•President, Scandinavian Society for Immunology – 2015 - present
•Editorial Board for: J Neuropathol Exp Neurol - 2005-2017; Glia - 2010-present; Scan J Immunol - 2016-present

Selected recent papers (from 169 total)

•Wlodarczyk A, Benmamar-Badel A, Cédile O, Jensen KN, Kramer I, Elsborg NB, and Owens T. 2018. CSF1R stimulation promotes increased neuroprotection by CD11c+ microglia in EAE. Frontiers Cell. Neurosci. 12: doi: 10.3389/fncel.2018.00523.

•Mørch, M, Forsberg Sørensen, S, Khorooshi, R, Asgari, N, Owens, T. 2018. Selective localization of IgG from cerebrospinal fluid to brain parenchyma. J Neuroinflammation 15:110. doi:10.1186/s12974-018-1159-8

•Wlodarczyk A, Holtman IR, Krueger M, Yogev N, Bruttger J, Khorooshi, R, Benmamar-Badel, A, de Boer-Bergsma JJ, Martin,NA, Karram K, Kramer, I, Boddeke EWGM, Waisman A, Eggen BJL and Owens T. (2017). A novel microglial subset plays a key role in myelinogenesis in developing brain. EMBO J. doi: 10.15252/embj.201696056

•Berg, CT, Khorooshi, R, Asgari, N. and Owens, T. (2017). Influence of Type I IFN signaling on anti-MOG antibody-mediated demyelination. J. Neuroinflammation 14:127

•Wlodarczyk, A, Cédile, O, Jensen, KN, Jasson, A, Mony, JT, Khorooshi, R, and Owens, T. 2015. Pathologic and protective roles for microglial subsets and bone marrow- and blood-derived myeloid cells in central nervous system inflammation. Frontiers in Immunology 6:463 doi: 10.3389/fimmu.2015.00463
•Asgari N, Berg CT, Mørch MT, Khorooshi R, and Owens T. 2015. Cerebrospinal Fluid Aquaporin-4-IgG induces blood brain barrier breakdown. Ann Clin Trans Neurol, 2: 857-863 DOI: 101002/acn3221:n/a-n/a
•Khorooshi, R., Mørch, M, Berg, CT, Holm, TH, Dieu, RT, Dræby, D, Issazadeh-Navikas, S, Weiss, S, Lienenklaus, S and Owens, T. 2015. Induction of endogenous Type I interferon within the central nervous system plays a protective role in experimental autoimmune encephalomyelitis. Acta Neuropathologica, 130:107-118.
•Cédile, O, Løbner, M, Toft-Hansen, H, Frank, I, Wlodarczyk, A, Irla, M, & Owens, T. 2014 Thymic CCL2 influences induction of T-cell tolerance. J Autoimmun 55:73-85.
•Mony, JT, Khorooshi R, & Owens, T. 2014. Chemokine receptor expression by inflammatory T cells in EAE. Front. Cell. Neurosci. 8:187. doi: 10.3389/fncel.2014.00187.
•Wlodarczyk, A., Løbner, M., Cédile, O., and Owens, T. 2014. Comparison of microglia and infiltrating CD11c+ cells as antigen presenting cells for T cell proliferation and cytokine response. J Neuroinflammation 11:57-65.
•Khorooshi R, Wlodarczyk A, Asgari N, Owens T. 2013. Neuromyelitis optica-like pathology is dependent on type I interferon response. Exp Neurol, 247:744-747.
•Owens, T., Khorooshi, R., Wlodarczyk, A. and Asgari, N. (2013), Interferons in the central nervous system: A few instruments play many tunes. Glia. doi: 10.1002/glia.22608
•Khorooshi, R., Wlodarczyk, A., Asgari, N., Owens, T., 2013. Neuromyelitis optica-like pathology is dependent on type I interferon response. Exp Neurol. doi: 10.1016/j.expneurol.2013.02.005.
•Asgari, N., R. Khorooshi, S. Lillevang, and T. Owens. 2013. Complement-dependent pathogenicity of brain-specific antibodies in cerebrospinal fluid. J. Neuroimmunol. 254:76-82. Epub 2012/10/04.
•Maiorino, C., R Khorooshi, F Ruffini, M Løbner, A Bergami, L Garzetti, G Martino, T Owens, and R Furlan. 2012. Lentiviral-mediated administration of IL-25 in the CNS induces alternative activation of microglia. Gene Therapy Epub 2012/08/03.
•Holm, TH., D, Draeby, and T. Owens. 2012. Microglia are required for astroglial Toll-like receptor 4 response, and for optimal Toll-like receptor 2 and 3 response. Glia 60:630-638
•Finsen, B. and Owens, T. 2011. Innate immune responses in central nervous system inflammation. FEBS Letts 585:3806-3812.
•Khorooshi, R., and T. Owens. 2010. Injury-induced type I interferon signaling regulates inflammatory responses in the CNS. J Immunol. 185:1258-1264
•Khorooshi, R., Babcock, A.A., and Owens, T. 2008. NFkappaB-driven STAT2 and CCL2 expression in astrocytes in response to brain injury. J. Immunol. 181: 7284-7291
•Babcock AA, Wirenfeldt M, Holm, T, Nielsen, HH, Dissing-Olesen, L, Toft-Hansen H, Millward JM, Landmann R, Rivest S, Finsen B, and Owens T. 2006. Toll-like receptor 2 signaling in response to brain injury: an innate bridge to neuroinflammation. J Neurosci 26:12826-12837.

 

Research information

 

We study inflammation in the central nervous system, using animal models to dissect cellular and molecular interactions that underlie pathogenesis of diseases such as Multiple sclerosis (MS) and Neuromyelitis optica (NMO). MS is considered to be primarily a T-cell-mediated autoimmune inflammatory disease, with associated neurodegeneration, whereas NMO is considered to be an antibody-mediated inflammatory disease with demyelination. Both diseases show activation of microglia, and astrocytes are the main target of antibody in NMO. The interactions of these cells with T cells macrophages and antibodies are the major focus of our research.

For more information see www.sdu.dk/immed/nb-ow

Also follow this link to COPING-AD, a collaborative project

http://www.sdu.dk/en/Om_SDU/Institutter_centre/IMM_Molekylaer_Medicin/Forskning/Forskningsenheder/Neurobiologisk/COPING+AD

 

Fingerprint Dive into the research topics where Trevor Owens is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 33 Similar Profiles
Autoimmune Experimental Encephalomyelitis Medicine & Life Sciences
Central Nervous System Medicine & Life Sciences
Microglia Medicine & Life Sciences
Demyelinating Diseases Medicine & Life Sciences
Macrophages Medicine & Life Sciences
Neuroglia Medicine & Life Sciences
Interferon-gamma Medicine & Life Sciences
Neuromyelitis Optica Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1979 2019

Angiotensin AT2-receptor induced interleukin-10 attenuates neuromyelitis optica spectrum disorder-like pathology

Khorooshi, R. M. H., Tofte-Hansen, E. U., Tygesen, C., Montañana Rosell, R., Limburg, H. L., Marczynska, J., Asgari, N., Steckelings, M. & Owens, T., 2019, In : Multiple Sclerosis Journal.

Research output: Contribution to journalJournal articleResearchpeer-review

Angiotensin Type 2 Receptor
Neuromyelitis Optica
Interleukin-10
Pathology
Central Nervous System Diseases
67 Downloads (Pure)

CSF1R Stimulation Promotes Increased Neuroprotection by CD11c+ Microglia in EAE

Wlodarczyk, A., Benmamar-Badel, A., Cédile, O., Nolling Jensen, K., Kramer, I., Elsborg, N. B. & Owens, T., 10. Jan 2019, In : Frontiers in Cellular Neuroscience. 12, 10 p., 523.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Colony-Stimulating Factor Receptors
Macrophage Colony-Stimulating Factor
Microglia
Ligands
Complement Receptors
107 Downloads (Pure)

Experimental demyelination and axonal loss are reduced in MicroRNA-146a deficient mice

Martin, N. A., Molnar, V., Szilagyi, G. T., Elkjaer, M. L., Nawrocki, A., Okarmus, J., Wlodarczyk, A., Thygesen, E. K., Palkovits, M., Gallyas, F., Larsen, M. R., Lassmann, H., Benedikz, E., Owens, T., Svenningsen, A. F. & Illes, Z., 2018, In : Frontiers in Immunology. 9, 14 p., 490.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Demyelinating Diseases
Oligodendroglia
Corpus Callosum
Cuprizone
MicroRNAs
89 Downloads (Pure)

Selective localization of IgG from cerebrospinal fluid to brain parenchyma

Mørch, M. T., Forsberg Sørensen, S., Khorooshi, R. M. H., Asgari, N. & Owens, T., 17. Apr 2018, In : Journal of Neuroinflammation. 15, 8 p., 110.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cerebrospinal Fluid
Neuromyelitis Optica
Pathology
Needles
Cisterna Magna
142 Downloads (Pure)

A novel microglial subset plays a key role in myelinogenesis in developing brain

Wlodarczyk, A., Holtman, I., Krueger, M., Yogev, N., Bruttger, J., Khorooshi, R. M. H., Benmamar-Badel, A., de Boer Bergsma, J., Martin, N. A., Karram, K., Kramer, I., Boddeke, E. W. G. M., Waisman, A., Eggen, B. J. L. & Owens, T., 2017, In : E M B O Journal. 36, 22, p. 3292-3308

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Microglia
Brain
Immunotoxins
Macrophages
Neurology

Activities 2001 2019

Microglia and myeloid cells as regulators of neuroinflammation

Trevor Owens (Guest lecturer)
22. Oct 2019

Activity: Talks and presentationsConference presentations

PhD defense Jay Roodselaar Somerville College University of Oxford (Event)

Trevor Owens (Member)
8. Oct 2019

Activity: MembershipMembership of review committee

European School of Neuroimmunology

Trevor Owens (Guest lecturer)
16. Jul 201919. Jul 2019

Activity: Talks and presentationsGuest lectures, external teaching and course activities at other universities

XIV European Meeting Glial cells in Health and Disease

Trevor Owens (Participant)
10. Jul 201913. Jul 2019

Activity: Attending an eventConference organisation or participation

PhD defense (Event)

Trevor Owens (Member)
26. Apr 2019

Activity: MembershipMembership of review committee