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Research Output 2000 2020

2020
Factor XIIa
Complement Factor H
Kringles
Surface Plasmon Resonance
2019

CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3

Block, I., Müller, C., Sdogati, D., Pedersen, H., List, M., Jaskot, A. M., Syse, S. D., Lund Hansen, P., Schmidt, S., Christiansen, H., Casella, C., Bering Olsen, S., Blomstrøm, M. M., Riedel, A., Thomassen, M., Kruse, T. A., Karlskov Hansen, S. W., Kioschis, P. & Mollenhauer, J., 6. Jun 2019, In : Oncogene. 38, 23, p. 4560-4573

Research output: Contribution to journalJournal articleResearchpeer-review

Properdin
Up-Regulation
Growth
Neoplasms
Mutation
2018
129 Downloads (Pure)

CL-L1 and CL-K1 Exhibit Widespread Tissue Distribution With High and Co-Localized Expression in Secretory Epithelia and Mucosa

Hansen, S. W. K., Aagaard, J. B., Bjerrum, K. B., Hejbøl, E. K., Nielsen, O., Schrøder, H. D., Skjoedt, K., Sørensen, A. L., Graversen, J. H. & Henriksen, M. L., 2018, In : Frontiers in Immunology. 9, 12 p., 1757.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Mucous Membrane
Epithelium
Mannose-Binding Protein-Associated Serine Proteases
Alternative Complement Pathway
Kidney

Novel Monoclonal Antibodies Against Native Human Collectin L1, Using the Heteromeric Complex CL-LK as Immunogen

Aagaard, J. B., Bjerrum, K. B., Graversen, J. H., Henriksen, M. L. & Hansen, S. W. K., Nov 2018, In : Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 37, 5, p. 207-211

Research output: Contribution to journalJournal articleResearchpeer-review

Disseminated Intravascular Coagulation
Kidney
Liver
165 Downloads (Pure)

Omics-based approach reveals complement-mediated inflammation in chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS)

Blaabjerg, M., Hemdrup, A. L., Drici, L., Ruprecht, K., Garred, P., Höftberger, R., Kristensen, B. W., Kondziella, D., Sejbaek, T., Hansen, S. W., Nielsen, H. H., Jensen, P., Meyer, M., Paul, F., Lassmann, H., Larsen, M. R. & Illes, Z., 2018, In : Frontiers in Immunology. 9, 13 p., 741.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cerebrospinal Fluid
Interleukin-8
Cerebrospinal Fluid Proteins
Vascular Cell Adhesion Molecule-1
Intercellular Adhesion Molecule-1
72 Downloads (Pure)

Surfactant Protein D Deficiency Aggravates Cigarette Smoke-Induced Lung Inflammation by Upregulation of Ceramide Synthesis

Pilecki, B., Wulf-Johansson, H., Støttrup, C., Jørgensen, P. T., Djiadeu, P., Nexøe, A. B., Schlosser, A., Hansen, S. W. K., Madsen, J., Clark, H. W., Nielsen, C. H., Vestbo, J., Palaniyar, N., Holmskov, U. & Sorensen, G. L., 2018, In : Frontiers in Immunology. 9, 12 p., 3013.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pulmonary Surfactant-Associated Protein D
Protein Deficiency
Smoke
Up-Regulation
Pulmonary Surfactant-Associated Proteins

The lectin pathway of complement activation in patients with systemic lupus erythematosus

Troldborg, A., Thiel, S., Trendelenburg, M., Friebus-Kardash, J., Nehring, J., Steffensen, R., Hansen, S. W. K., Laska, M. J., Deleuran, B., Jensenius, J. C., Voss, A. & Stengaard-Pedersen, K., 1. Aug 2018, In : Journal of Rheumatology. 45, 8, p. 1136-1144

Research output: Contribution to journalJournal articleResearchpeer-review

Mannose-Binding Protein-Associated Serine Proteases
Proteins
Classical Complement Pathway
Immunoassay
Serum
2017

A novel in vitro model for haematogenous spreading of S. aureus device biofilms demonstrating clumping dispersal as an advantageous dissemination mechanism

Grønnemose, R. B., Lindhardt Sæderup (Madsen), K., Kolmos, H. J., Hansen, S., Antoinette Asferg, C., Rasmussen, K. J., Palarasah, Y. & Andersen, T. E., Dec 2017, In : Cellular Microbiology. 19, 12, 13 p., e12785.

Research output: Contribution to journalJournal articleResearchpeer-review

Biofilms
Equipment and Supplies
Phagocytes
In Vitro Techniques
Catheters
171 Downloads (Pure)

COLEC10 is mutated in 3MC patients and regulates early craniofacial development

Munye, M. M., Diaz-Font, A., Ocaka, L., Henriksen, M. L., Lees, M., Brady, A., Jenkins, D., Morton, J., Hansen, S. W., Bacchelli, C., Beales, P. L. & Hernandez-Hernandez, V., 2017, In : PLoS Genetics. 13, 3, 15 p., e1006679.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
early development
complement
palate
lectins
gene

Collectin Liver 1 and Collectin Kidney 1 of the Lectin Complement Pathway Are Associated With Mortality After Kidney Transplantation

Smedbråten, J., Sagedal, S., Åsberg, A., Hartmann, A., Rollag, H., Mjøen, G., Fagerland, M. W., Hansen, S. W. K., Mollnes, T. E. & Thiel, S., Jan 2017, In : American Journal of Transplantation. 17, 1, p. 265-271

Research output: Contribution to journalJournal articleResearchpeer-review

Kidney Transplantation
Kidney
Liver
Immune System
Graft Survival

Endogenous natural complement inhibitor regulates cardiac development

Mortensen, S. A., Skov, L. L., Kjaer-Sorensen, K., Hansen, A. G., Hansen, S., Dagnæs-Hansen, F., Jensenius, J. C., Oxvig, C., Thiel, S. & Degn, S. E., 2017, In : Journal of Immunology. 198, 8, p. 3118-3126

Research output: Contribution to journalJournal articleResearchpeer-review

Mannose-Binding Protein-Associated Serine Proteases
Neural Crest
Western World
Perinatal Mortality
Live Birth
116 Downloads (Pure)
Open Access
File
Interstitial Lung Diseases
Collagen Type I
In Vitro Techniques
Flow Cytometry
Respiratory Function Tests

Lectin Complement Pathway Proteins in Healthy Individuals

Troldborg, A., Hansen, A., Hansen, S. W. K., Jensenius, J. C., Stengaard-Pedersen, K. & Thiel, S., Apr 2017, In : Clinical and Experimental Immunology. 188, 1, p. 138-147

Research output: Contribution to journalJournal articleResearchpeer-review

Mannose-Binding Protein-Associated Serine Proteases
Proteins
Serum
Edetic Acid
Cohort Studies
108 Downloads (Pure)

Developmental regulation of chicken surfactant protein A and its localization in lung

Zhang, W., Cuperus, T., van Dijk, A., Skjødt, K., Hansen, S. W. K., Haagsman, H. P. & Veldhuizen, E. J. A., 11. Mar 2016, In : Developmental & Comparative Immunology. 61, p. 80-87

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Pulmonary Surfactant-Associated Protein A
Chickens
Lung
Proteins
Epithelium
122 Downloads (Pure)

Limonene and its ozone-initiated reaction products attenuate allergic lung inflammation in mice

Hansen, J. S., Nørgaard, A. W., Koponen, I. K., Sørli, J. B., Paidi, M. D., Hansen, S. W. K., Clausen, P. A., Nielsen, G. D., Wolkoff, P. & Larsen, S. T., 2016, In : Journal of Immunotoxicology. 13, 6, p. 793-803

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ozone
Reaction products
Allergies
Hypersensitivity
Lung

MFAP4: a candidate biomarker for hepatic and pulmonary fibrosis?

Mölleken, C., Poschmann, G., Bonella, F., Costabel, U., Sitek, B., Stühler, K., Meyer, H. E., Schmiegel, W. H., Marcussen, N., Helmer, C. M., Nielsen, O., Hansen, S. W. K., Schlosser, A., Holmskov, U. & Sorensen, G. L., 2016, In : Sarcoidosis Vasculitis and Diffuse Lung Diseases. 33, 1, p. 41-50

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Pulmonary Fibrosis
Liver
Idiopathic Pulmonary Fibrosis
Lung
Extrinsic Allergic Alveolitis
186 Downloads (Pure)

Polarized Airway Epithelial Models for Immunological Co-Culture Studies

Papazian, D., Würtzen, P. A. & Hansen, S. W. K., 2016, In : International Archives of Allergy and Immunology. 170, 1, p. 1-21

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
Immunological Models
Coculture Techniques
Homeostasis
Respiratory Mucosa
Allergens

Surfactant protein D deficiencyaggravates cigarette smoke-inducedinflammation

Pilecki, B., Johansson, H. W., Støttrup, C., Jørgensen, P. T., Palaniyar, N., Hansen, S., Schlosser, A., Clark, H., Vestbo, J., Holmskov, U. & Sørensen, G. L., 2016, In : Scandinavian Journal of Immunology. 83, 5, p. 375 1 p., P603.

Research output: Contribution to journalConference abstract in journalResearch

The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity

Hansen, S. W. K., Ohtani, K., Roy, N. & Wakamiya, N., 2016, In : Immunobiology. 221, p. 1058–1067

Research output: Contribution to journalReviewResearchpeer-review

Placenta
Kidney
Liver
Mannose-Binding Protein-Associated Serine Proteases
Properdin

The Effect of Induced Antibodies with Respect to Neutralization, Clearance Rate and Functional Activity in a Rabbit/Infliximab Model

Henriksen, M. L., Søgaard Teisner, A., Kjeldsen, J., Kalliokoski, O., Hau, J. & Hansen, S. W. K., 2016, In : In Vivo. 30, 5, p. 557-565

Research output: Contribution to journalJournal articleResearchpeer-review

Rabbits
Antibodies
Neutralizing Antibodies
Plasma (human)
Antibodies, Monoclonal, Humanized
94 Downloads (Pure)

The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen

Lindhardt Sæderup (Madsen), K., Stødkilde, K., Graversen, J. H., Dickson, C. F., Etzerodt, A., Hansen, S. W. K., Fago, A., Gell, D., Andersen, C. B. F. & Moestrup, S. K., 2016, In : Journal of Biological Chemistry. 291, 46, p. 23989-23998

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Scavenging
Pathogens
Heme
Hemoglobins
Iron
2015

Airway responses towards allergens - from the airway epithelium to T cells

Papazian, D., Hansen, S. & Würtzen, P. A., 2015, In : Clinical and Experimental Allergy. 45, 8, p. 1268-1287

Research output: Contribution to journalReviewResearchpeer-review

Allergens
Epithelium
Th2 Cells
Environmental Exposure
Pathology

C1-inhibitor polymers activate the FXII-dependent kallikrein-kinin system: Implication for a role in hereditary angioedema

Elenius Madsen, D., Sidelmann, J. J., Biltoft, D., Gram, J. B. & Hansen, S., 2015, In : B B A - General Subjects. 1850, 6, p. 1336-1342

Research output: Contribution to journalJournal articleResearchpeer-review

Kallikrein-Kinin System
Kinins
Kallikreins
Polymers
Serine Proteinase Inhibitors

Cl-L1 and CL-K1 complement associated pattern recognition molecules in systemic lupus erythematosus

Troldborg, A., Thiel, S., Jensen, L., Laska, M. J., Hansen, S. W. K., Deleuran, B., Jensenius, J. C. & Stengaard-Pedersen, K., 2015, In : Arthritis & Rheumatology. 67, S10, 2 p., 198.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Collectin CL-LK Is a Novel Soluble Pattern Recognition Receptor for Mycobacterium tuberculosis

Troegeler, A., Lugo-Villarino, G., Hansen, S., Rasolofo, V., Henriksen, M. L., Mori, K., Ohtani, K., Duval, C., Mercier, I., Bénard, A., Nigou, J., Hudrisier, D., Wakamiya, N. & Neyrolles, O., 2015, In : PLOS ONE. 10, 7, p. e0132692

Research output: Contribution to journalJournal articleResearchpeer-review

Collectins
C-Type Lectins
Pattern Recognition Receptors
Mycobacterium tuberculosis
Pathogens

Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus

Troldborg, A., Thiel, S., Jensen, L., Hansen, S. W. K., Laska, M. J., Deleuran, B., Jensenius, J. C. & Stengaard-Pedersen, K., Nov 2015, In : Clinical and Experimental Immunology. 182, 2, p. 132-8

Research output: Contribution to journalJournal articleResearchpeer-review

Kidney
Liver
Control Groups

Direct contact between dendritic cells and bronchial epithelial cells inhibits T cell recall responses towards mite and pollen allergen extracts in vitro

Papazian, D., Wagtmann, V. R., Hansen, S. & Würtzen, P. A., 24. Feb 2015, In : Clinical and Experimental Immunology. 181, 2, p. 207-218

Research output: Contribution to journalJournal articleResearchpeer-review

Mites
Pollen
Allergens
Epithelial Cells
Homeostasis

Effect of Polarization on Airway Epithelial Conditioning of Monocyte-Derived Dendritic Cells

Papazian, D., Chhoden, T., Arge, M., Vorup-Jensen, T., Nielsen, C. H., Lund, K., Würtzen, P. A. & Hansen, S., 12. Jan 2015, In : American Journal of Respiratory Cell and Molecular Biology. 53, 3, p. 368-377

Research output: Contribution to journalJournal articleResearchpeer-review

Allergens
Polarization
Epithelial Cells
Chemokine CCL11
Epithelium

Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1)

Bayarri-Olmos, R., Hansen, S., Henriksen, M. L., Storm, L., Thiel, S., Garred, P. & Munthe-Fog, L., 2015, In : PLOS ONE. 10, 2, p. e0114883

Research output: Contribution to journalJournal articleResearchpeer-review

Collectins
Liver
kidneys
Kidney
genetic variation

Protective Effects of Surfactant Protein D (SP-D) Treatment in 1,3-β-glucan-modulated Allergic Inflammation

Fakih, D., Pilecki, B., Schlosser, A., Jepsen, C. E. S., Thomsen, L. K., Ormhøj, M., Watson, A., Madsen, J., Clark, H. W., Barfod, K. K., Hansen, S. W. K., Marcussen, N., Jounblat, R., Chamat, S., Holmskov, U. & Sorensen, G. L., 2. Oct 2015, In : American Journal of Physiology: Lung Cellular and Molecular Physiology. 309, 11, p. L1333-L1343

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Ovalbumin
Lung
Hypersensitivity
Th2 Cells
2014

Calcium-sensitive immunoaffinity chromatography: Gentle and highly specific retrieval of a scarce plasma antigen, collectin-LK (CL-LK)

Henriksen, M. L., Lindhardt Madsen, K., Skjoedt, K. & Hansen, S., 2014, In : Journal of Immunological Methods. 413, p. 25-31

Research output: Contribution to journalJournal articleResearchpeer-review

Chromatography
Proteins
Kidney
Complex Mixtures
Edetic Acid

Immunodeficiency associated with a nonsense mutation of IKBKB

Nielsen, C., Jakobsen, M. A., Larsen, M. J., Müller, A. C., Hansen, S., Lillevang, S. T., Fisker, N. & Barington, T., Nov 2014, In : Journal of Clinical Immunology. 34, 8, p. 916-21

Research output: Contribution to journalJournal articleResearchpeer-review

I-kappa B Kinase
Exome
Pneumocystis carinii
Pneumocystis Pneumonia
Nonsense Codon

Immunodeficiency caused by a non-sense mutation of IKBKB

Nielsen, C., Jakobsen, M. A., Larsen, M. J., Müller, A. C., Hansen, S., Lillevang, S. T., Fisker, N. & Barington, T., 2014.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

No effect of ablation of surfactant protein-D on acute cerebral infarction in mice

Lambertsen, K. L., Østergaard, K., Clausen, B. H., Hansen, S., Stenvang, J., Thorsen, S. B., Meldgaard, M., Kristensen, B. W., Hansen, P. B. L., Sørensen, G. L. & Finsen, B., Jul 2014, In : Journal of Neuroinflammation. 11, 13 p., 123.

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Messenger RNA
Middle Cerebral Artery
Infarction

Presence of C1-Inhibitor Polymers in a Subset of Patients Suffering from Hereditary Angioedema

Elenius Madsen, D., Hansen, S. W. K., Gram, J. B., Bygum, A., Drouet, C. & Sidelmann, J. J., 2014, In : P L o S One. 9, 11, e112051.

Research output: Contribution to journalJournal articleResearchpeer-review

Surfactant Proteins A, B, C and D in the Human Nasal Airway: Associated with Mucosal Glands and Ciliated Epithelium but Absent in Fluid-Phase Secretions and Mucus

Gaunsbaek, M. Q., Kjeldsen, A. D., Svane-Knudsen, V., Henriksen, M. L. & Hansen, S., 10. Dec 2014, In : O R L. 76, 5, p. 288-301

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Fluids and Secretions
Mucus
Nose
2013

Characterization of the interaction between collectin 11 (CL-11, CL-K1) and nucleic acids

Henriksen, M. L., Brandt, J., Iyer, S. S. C., Thielens, N. M. & Hansen, S., 2013, In : Molecular Immunology. 56, 4, p. 757-767

Research output: Contribution to journalJournal articleResearchpeer-review

Nucleic Acids
DNA
Mannose-Binding Protein-Associated Serine Proteases
Mannans
Surface Plasmon Resonance

Compositional and structural characterization of monolayers and bilayers composed of native pulmonary surfactant from wild type mice

Bernardino de la Serna, J., Hansen, S., Berzina, Z., Simonsen, A. C., Hannibal-Bach, H. K., Knudsen, J., Ejsing, C. S. & Bagatolli, L. A., Nov 2013, In : Biochimica et Biophysica Acta - Biomembranes. 1828, 11, p. 2450-2459 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactants
Monolayers
Lipids
Liquids
Phospholipids

Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate the Complement System

Henriksen, M. L., Brandt, J., Andrieu, J-P., Nielsen, C., Jensen, P. H., Holmskov, U., Jørgensen, T. J. D., Palarasah, Y., Thielens, N. M. & Hansen, S., 15. Dec 2013, In : Journal of Immunology. 191, 12, p. 6117-27 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mannose-Binding Protein-Associated Serine Proteases
Kidney
Liver
Mannans
Immune System

Lung Surfactant Protein D (SP-D) Response and Regulation During Acute and Chronic Lung Injury

Gaunsbaek, M. Q., Rasmussen, K. J., Beers, M. F., Atochina-Vasserman, E. N. & Hansen, S., 2013, In : Lung. 191, 3, p. 295-303 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Surfactant protein D and its role on inflammatory responses in the cigarette-induced COPD model

Johansson, H. W., Hansen, S., Schlosser, A., Vestbo, J., Holmskov, U. & Sørensen, G. L., 2013.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2012

An enzyme-linked immunosorbent assay (ELISA) for quantification of human collectin 11 (CL-11, CL-K1)

Selman, L., Henriksen, M. L., Brandt, J., Palarasah, Y., Waters, A., Beales, P. L., Holmskov, U., Jørgensen, T. J. D., Nielsen, C., Skjodt, K. & Hansen, S., 2012, In : Journal of Immunological Methods. 375, 1-2, p. 182-8 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Kidney
Mannose-Binding Protein-Associated Serine Proteases
Serum
Freezing
Confidence Intervals

Complement defects in patients with chronic rhinosinusitis

Gaunsbaek, M. Q., Lange, B., Kjeldsen, A. D., Svane-Knudsen, V., Skjoedt, K., Henriksen, M. L., Nielsen, C., Palarasah, Y. & Hansen, S., 2012, In : P L o S One. 7, 11, p. e47383

Research output: Contribution to journalJournal articleResearchpeer-review

complement
Defects
Nasal Polyps
Population Control
Serum

Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family

Vitashenkova, N., Moeller, J. B., Leth-Larsen, R., Schlosser, A., Lund, K. P., Tornøe, I., Vitved, L., Hansen, S., Willis, A., Kharazova, A. D., Skjødt, K., Sorensen, G. L. & Holmskov, U., 2012, In : Journal of Biological Chemistry. 287, p. 42846-42855

Research output: Contribution to journalJournal articleResearchpeer-review

Marinas
Chitin
Lectins
Carrier Proteins
Fluids

Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1)

Selman, L. & Hansen, S., 2012, In : Immunobiology. 217, 9, p. 851-63 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Liver
Mannose-Binding Protein-Associated Serine Proteases
Fucose
Mannose
Acetylglucosamine

The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection

Ali, Y. M., Lynch, N. J., Haleem, K. S., Fujita, T., Endo, Y., Hansen, S., Holmskov, U., Takahashi, K., Stahl, G. L., Dudler, T., Girija, U. V., Wallis, R., Kadioglu, A., Stover, C. M., Andrew, P. W. & Schwaeble, W. J., 2012, In : P L o S Pathogens. 8, 7, p. e1002793

Research output: Contribution to journalJournal articleResearchpeer-review

Mannose-Binding Protein-Associated Serine Proteases
Classical Complement Pathway
Alternative Complement Pathway
Theoretical Models
Enzymes
2011

Acute lung injury induces cardiovascular dysfunction: effects of IL-6 and budesonide/formoterol

Suda, K., Tsuruta, M., Eom, J., Or, C., Mui, T., Jaw, J-E., Li, Y., Bai, N., Kim, J., Man, J., Ngan, D., Lee, J., Hansen, S., Lee, S-W., Tam, S., Man, S. P., Van Eeden, S. & Sin, D. D., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 3, p. 510-516

Research output: Contribution to journalJournal articleResearchpeer-review

Budesonide
Acute Lung Injury
Interleukin-6
Acetylcholine
Myography