Shuxia Li

PhD in Health Sciences, Diploma in Clinical Medicine

20052019
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Research Output 2005 2019

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Journal article
2019
18 Downloads (Pure)

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., 2019, In : Aging Cell. 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Epigenomics
Sex Characteristics
66 Downloads (Pure)

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J. V. B., Christiansen, L., Christensen, K., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 8. Feb 2019, In : Clinical Epigenetics. 11, 8 p., 23.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Genome-Wide Association Study
Survival Analysis
Proportional Hazards Models
Epigenomics

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. Aug 2019, In : Gynecological Endocrinology. 35, 8, p. 691-694

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19

Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study

Duan, H., Zhang, D., Liang, Y., Xu, C., Wu, Y., Tian, X., Pang, Z., Tan, Q., Li, S. & Qiu, C., 1. Mar 2019, In : Ear and Hearing. 40, 2, p. 253-259

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Hearing
Population
Dizygotic Twins
Developed Countries

Longitudinal analysis of sibling correlation on blood pressure using mixed modeling

Tan, Q., Duan, H., Wang, A., Zhu, D. & Li, S., 2019, In : Annals of Epidemiology. 33, p. 49-53

Research output: Contribution to journalJournal articleResearchpeer-review

Longitudinal Studies

Network based analysis of microarray gene expression profiles in response to electroacupuncture

Mohammadnejad, A., Li, S., Duan, H. & Tan, Q., 2019, (Accepted/In press) In : Journal of Traditional and Complementary Medicine. 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Electroacupuncture
Transcriptome
Periaqueductal Gray
Gene Ontology

Weak Grip Strength and Cognition Predict Functional Limitation in Older Europeans

Wang, T., Wu, Y., Li, W., Li, S., Sun, Y., Li, S., Zhang, D. & Tan, Q., Jan 2019, In : Journal of the American Geriatrics Society. 67, 1, p. 93-99

Research output: Contribution to journalJournal articleResearchpeer-review

Cognition
Linear Models
Retirement
Health Surveys
Israel
2018
66 Downloads (Pure)

Epigenetic signature of preterm birth in adult twins

Tan, Q., Li, S., Frost, M., Nygaard, M., Soerensen, M., Larsen, M., Christensen, K. & Christiansen, L., 2018, In : Clinical Epigenetics. 10, 10 p., 87.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Premature Birth
Epigenomics
Health
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 3

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study

Xu, C., Tian, X., Sun, J., Wu, Y., Zhang, D., Pang, Z., Li, S., Petersen, I., Mengel-From, J., Christiansen, L., Christensen, K. & Tan, Q., Feb 2018, In : Geriatrics & Gerontology International. 18, 2, p. 352-359

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Cognition
cognition
HDL Cholesterol
environmental factors
104 Downloads (Pure)

Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins

Wang, W., Zhang, D., Xu, C., Wu, Y., Duan, H., Li, S. & Tan, Q., 6. Mar 2018, In : Frontiers in Endocrinology. 9, MAR, 12 p., 75.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Genome-Wide Association Study
Uric Acid
Serum
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 14
2017

A genome-wide association study of cognitive function in Chinese adult twins

Xu, C., Zhang, D., Wu, Y., Tian, X., Pang, Z., Li, S. & Tan, Q., 2017, In : Biogerontology. 18, 5, p. 811–819

Research output: Contribution to journalJournal articleResearchpeer-review

Genome-Wide Association Study
Cognition
Single Nucleotide Polymorphism
Dizygotic Twins
Metabolic Diseases
154 Downloads (Pure)

Differential DNA methylation patterns of polycystic ovarian syndrome in whole blood of Chinese women

Li, S., Zhu, D., Duan, H., Ren, A., Glintborg, D., Andersen, M., Skov, V., Thomassen, M., Kruse, T. & Tan, Q., 2017, In : Oncotarget. 8, 13, p. 20656-20666

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycystic Ovary Syndrome
DNA Methylation
Epigenomics
Prolactin
DNA
94 Downloads (Pure)

Genetic and Environmental Basis in Phenotype Correlation Between Physical Function and Cognition in Aging Chinese Twins

Xu, C., Zhang, D., Tian, X., Wu, Y., Pang, Z., Li, S. & Tan, Q., 2017, In : Twin Research and Human Genetics. 20, 1, p. 60-65

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cognition
Visual Acuity
Forced Expiratory Volume
Population Genetics
Lung
42 Downloads (Pure)

Genetic and Environmental Influences on Correlations Between Hearing and Cognitive Functions in Middle and Older Chinese Twins

Xu, C., Zhang, D., Tian, X., Duan, H., Wu, Y., Pang, Z., Li, S. & Tan, Q., 2017, In : Twin Research and Human Genetics. 20, 5, p. 374-379

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cognition
Hearing
Twin Studies
97 Downloads (Pure)

Genetic and Environmental Influences on Pulmonary Function and Muscle Strength: The Chinese Twin Study of Aging

Tian, X., Xu, C., Wu, Y., Sun, J., Duan, H., Zhang, D., Jiang, B., Pang, Z., Li, S. & Tan, Q., 2017, In : Twin Research and Human Genetics. 20, 1, p. 53-59

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Twin Studies
Forced Expiratory Volume
Lung
Individuality
69 Downloads (Pure)

Identification, replication and characterization of epigenetic remodelling in the aging genome: a cross population analysis

Li, S., Christiansen, L., Christensen, K., Kruse, T. A., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 2017, In : Scientific Reports. 7, 1, 8 p., 8183.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
CpG Islands
Population
DNA Methylation
130 Downloads (Pure)

Weighted gene co-expression network analysis of expression data of monozygotic twins identifies specific modules and hub genes related to BMI.

Wang, W., Jiang, W., Hou, L., Duan, H., Wu, Y., Xu, C., Tan, Q., Li, S. & Zhang, D., 2017, In : BMC Genomics. 18, 17 p., 872.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Monozygotic Twins
Databases
Transcriptome
Chylomicron Remnants
Chylomicrons
2016
66 Downloads (Pure)

Genetic and Environmental Regulation on Longitudinal Change of Metabolic Phenotypes in Danish and Chinese Adult Twins

Li, S., Kyvik, K. O., Pang, Z., Zhang, D., Duan, H., Tan, Q., Hjelmborg, J., Kruse, T. & Dalgård, C., Feb 2016, In : P L o S One. 11, 2, p. 1-14 e0148396.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Environmental regulations
environmental law
Triglycerides
Blood pressure
phenotype
69 Downloads (Pure)

Longitudinal Investigation into Genetics in the Conservation of Metabolic Phenotypes in Danish and Chinese Twins

Li, S., Kyvik, K. O., Duan, H., Zhang, D., Pang, Z., Hjelmborg, J., Tan, Q., Kruse, T. & Dalgård, C., 2016, In : P L o S One. 11, 9, p. 1-14 e0162805.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Blood pressure
germplasm conservation
Conservation
phenotype
Blood Glucose

The epigenomics of polycystic ovarian syndrome: from pathogenesis to clinical manifestations

Li, S., Zhu, D., Duan, H. & Tan, Q., Dec 2016, In : Gynecological Endocrinology. 32, 12, p. 942-946

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Epigenomics
Comorbidity
Ovarian Diseases
Reproductive Health
2015

Gene, environment and cognitive function: a Chinese twin ageing study

Xu, C., Sun, J., Duan, H., Ji, F., Tian, X., Zhai, Y., Wang, S., Pang, Z., Zhang, D., Zhao, Z., Li, S., Gue, M. M., Hjelmborg, J. V. B., Christensen, K. & Tan, Q., May 2015, In : Age and Ageing. 44, 3, p. 452-457

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Cognition
Linguistics
Population
Dizygotic Twins
53 Downloads (Pure)

Multivariate Modeling of Body Mass Index, Pulse Pressure, Systolic and Diastolic Blood Pressure in Chinese Twins

Wu, Y., Zhang, D., Pang, Z., Jiang, W., Wang, S., Li, S., von Bornemann Hjelmborg, J. & Tan, Q., Feb 2015, In : Twin Research and Human Genetics. 18, 1, p. 73-78

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Body Mass Index
63 Downloads (Pure)

The genetic basis for cognitive ability, memory, and depression symptomatology in middle-aged and elderly chinese twins

Xu, C., Sun, J., Ji, F., Tian, X., Duan, H., Zhai, Y., Wang, S., Pang, Z., Zhang, D., Zhao, Z., Li, S., Hjelmborg, J. V. B., Christensen, K. & Tan, Q., Feb 2015, In : Twin Research and Human Genetics. 18, 1, p. 79-85

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Depression
Cognition
Geriatrics
Population
Multivariate Analysis
2014

Probing genetic overlap in the regulation of systolic and diastolic blood pressure in Danish and Chinese twins

Li, S., Pang, Z., Zhang, D., Duan, H., von Bornemann Hjelmborg, J., Tan, Q., Kruse, T. A. & Kyvik, K. O., Oct 2014, In : Hypertension Research. 37, 10, p. 954-9

Research output: Contribution to journalJournal articleResearchpeer-review

Confidence Intervals
Publications
Research
Population
2013

Genetic investigation into ethnic disparity in polycystic ovarian syndrome

Li, S., Zhu, D., Duan, H. & Tan, Q., 2013, In : Gynecological Endocrinology. 29, 10, p. 878-882

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Population
Genetic Association Studies
DNA Sequence Analysis
Epigenomics

Heritability of eleven metabolic phenotypes in Danish and Chinese twins: A cross-population comparison

Li, S., Duan, H., Pang, Z., Zhang, D., Duan, H., von Bornemann Hjelmborg, J., Tan, Q., Kruse, T. A. & Kyvik, K. O., Sep 2013, In : Obesity. 21, 9, p. 1908-14 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2012

A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years

Wu, Y., Pang, Z., Zhang, D., Jiang, W., Wang, S., Li, S., Kruse, T. A., Christensen, K. & Tan, Q., 3. Sep 2012, In : Archives of Gerontology and Geriatrics. 54, 2, p. e213-e220

Research output: Contribution to journalJournal articleResearchpeer-review

Tooth Loss
Hearing
Cross-Sectional Studies
Sex Characteristics
Visual Acuity

Gender-specific patterns in age-related decline in general health among Danish and Chinese: A cross-national comparative study

Wu, Y., Zhang, D., Pang, Z., Oksuzyan, A., Jiang, W., Wang, S., Li, S., Kruse, T., Christensen, K. & Tan, Q., 2012, In : Geriatrics & Gerontology International. 12, 3, p. 431-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

gender
Health
health
Population
Dane

Genome-wide linkage and association scans for pulse pressure in Chinese twins

Zhang, D., Pang, Z., Li, S., Jiang, W., Wang, S., Thomassen, M., von Bornemann Hjelmborg, J., Kruse, T. A., Ohm Kyvik, K., Christensen, K., Zhu, G. & Tan, Q., 2012, In : Hypertension Research. 35, p. 1051-1057

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Genome-Wide Association Study
Dizygotic Twins
Population
China

Heritability and whole genome linkage of pulse pressure in Chinese twin pairs

Jiang, W., Zhang, D., Pang, Z., Li, S., Duan, H., Wang, S. & Tan, Q., 2012, In : Twin Research and Human Genetics. 15, 6, p. 759-766

Research output: Contribution to journalJournal articleResearchpeer-review

Lod Score
Population
Chromosomes, Human, Pair 18
Dizygotic Twins
Chromosomes, Human, Pair 12

High-Resolution Genome-Wide Linkage Mapping Identifies Susceptibility Loci for BMI in the Chinese Population

Zhang, D. F., Pang, Z., Li, S., Thomassen, M., Wang, S., Jiang, W., Hjelmborg, J. V. B., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., Apr 2012, In : Obesity. 20, 4, p. 830-3 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Lod Score
Population
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 14

Twin-based DNA methylation analysis takes the center stage of studies of human complex diseases

Zhang, D., Li, S., Tan, Q. & Pang, Z., 2012, In : Journal of Genetics and Genomics. 39, 11, p. 581-6 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

DNA Methylation
Epigenomics
Twin Studies
Environmental Exposure
2011

Genetic and environmental dissections of sub-phenotypes of metabolic syndrome in the chinese population: a twin-based heritability study

Duan, H., Pang, Z., Zhang, D., Li, S., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., 2011, In : Obesity Facts. 4, 2, p. 99-104 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Population
structural model
LDL Cholesterol
municipality
Lipids
2010

Multivariate modelling of endophenotypes associated with the metabolic syndrome in Chinese twins

Pang, Z., Zhang, D., Li, S., Duan, H., Hjelmborg, J., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., 29. Sep 2010, In : Diabetologia. 53, 12, p. 2554-2561

Research output: Contribution to journalJournal articleResearchpeer-review

Endophenotypes
Lipids
Fasting
Multivariate Analysis

Power assessment for genetic association study of human longevity using offspring of long-lived subjects

Tan, Q., Zhao, J. H., Li, S., Kruse, T. A. & Christensen, K., Jul 2010, In : European Journal of Epidemiology. 25, 7, p. 501-6 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Association Studies
Sample Size
Proportional Hazards Models
Computer Simulation
Single Nucleotide Polymorphism
2008

Differential and correlation analyses of microarray gene expression data in the CEPH Utah families

Tan, Q., Zhao, J., Li, S., Christiansen, L., Kruse, T. & Christensen, K., 1. Aug 2008, In : Genomics. 92, 2, p. 94-100 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

X Chromosome Inactivation
Age Groups
Medicine
2007

Retrospective analysis of main and interaction effects in genetic association studies of human complex traits

Tan, Q., Christiansen, L., Brasch-Andersen, C., Zhao, J. H., Li, S., Kruse, T. A. & Christensen, K., 2007, In : BMC Genetics. 8, p. 70

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Association Studies
Logistic Models
Alleles
Environmental Exposure
Sample Size
2006

Genetic Association Analysis of Human Longevity in Cohort Studies of Elderly Subjects: An Example of the PON1 Gene in the Danish 1905 Birth Cohort

Tan, Q., Christiansen, L., Bathum, L., Li, S., Kruse, T. & Christensen, K., 2006, In : Genetics. 172, 3, p. 1821-1828

Research output: Contribution to journalJournal articleResearchpeer-review

Cohort Studies
Haplotypes
Aryldialkylphosphatase
Selection Bias
Computer Simulation
2005

Haplotype association analysis of human disease traits using genotype data of unrelated individuals

Tan, Q., Christiansen, L., Christensen, K., Bathum, L., Li, S., Zhao, JH. & Kruse, T. A., 2005, In : Genetics Research. 86, 03, p. 223 - 231

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotypes
Logistic Models
Chromosome Mapping
Linkage Disequilibrium
Medical Genetics