Rikke Leth-Larsen

Search results

• 2021

  MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

  Løkkegaard, S., Elias, D., Alves, C. L., Bennetzen, M. V., Lænkholm, A. V., Bak, M., Gjerstorff, M. F., Johansen, L. E., Vever, H., Bjerre, C., Kirkegaard, T., Nordenskjöld, B., Fornander, T., Stål, O., Lindström, L. S., Esserman, L. J., Lykkesfeldt, A. E., Andersen, J. S., Leth-Larsen, R. & Ditzel, H. J., Jan 2021, In: npj Breast Cancer. 7, 15 p., 2.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Minichromosome Maintenance Proteins
  • Tamoxifen
  • Up-Regulation
  • Breast Neoplasms
  • Cell Cycle
  41 Downloads (Pure)
• 2019

  CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients

  Pedersen, M. H., Hood, B. L., Ehmsen, S., Beck, H. C., Conrads, T. P., Bak, M., Ditzel, H. J. & Leth-Larsen, R., 1. Feb 2019, In: International Journal of Cancer. 144, 3, p. 631-640

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Triple Negative Breast Neoplasms
  • Biomarkers
  • Recurrence
  • Survival
  • Breast Neoplasms
  171 Downloads (Pure)

• Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

  Ehmsen, S., Pedersen, M. H., Wang, G., Terp, M. G., Arslanagic, A., Hood, B. L., Conrads, T. P., Leth-Larsen, R. & Ditzel, H. J., 25. Jun 2019, In: Cell Reports. 27, 13, p. 3927-3938.e6

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Biosynthesis
  • Stem cells
  • Neoplastic Stem Cells
  • Cholesterol
  • Breast Neoplasms
  161 Downloads (Pure)
• 2018

  Research integrity among PhD students within clinical research at the University of Southern Denmark

  Bredahl, L., Kyvik, K. O., Leth-Larsen, R. & Eriksen, M. B., 1. Apr 2018, In: Danish Medical Journal. 65, 4, 5 p., A5469.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Students
  • Pressure
  • Authorship
  • Publications
  • Research Personnel
  105 Downloads (Pure)
• 2017

  Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors

  Pedersen, M. H., Hood, B. L., Beck, H. C., Conrads, T. P., Ditzel, H. & Leth-Larsen, R., 16. Mar 2017, In: OncoImmunology. 6, 5, 14 p., e1305531.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Triple Negative Breast Neoplasms
  • Antigen Presentation
  • Recurrence
  • Proteins
  • Neoplasms

• Elucidation of altered pathways in tumor-initiating cells of triple-negative breast cancer: A useful cell model system for drug screening

  Christensen, A. G., Ehmsen, S., Terp, M. G., Batra, R., Alcaraz, N., Baumbach, J., Noer, J. B., Moreira, J. M. A., Leth-Larsen, R., Larsen, M. R. & Ditzel, H. J., Aug 2017, In: Stem Cells. 35, 8, p. 1898–1912

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Triple Negative Breast Neoplasms
  • Preclinical Drug Evaluations
  • Neoplastic Stem Cells
  • Neoplasms
  • Catenins
• 2015

  NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

  Lund, R. R., Leth-Larsen, R., Caterino, T. D., Terp, M. G., Nissen, J., Lænkholm, A-V., Jensen, O. N. & Ditzel, H. J., Nov 2015, In: Molecular and Cellular Proteomics. 14, 11, p. 2988-2999

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Cytochrome-B(5) Reductase
  • Cytochromes b5
  • Cytochrome Reductases
  • Cells
  • Disease-Free Survival
  783 Downloads (Pure)

• S100A14 is a novel independent prognostic biomarker in the triple-negative breast cancer subtype

  Ehmsen, S., Hansen, L. T., Bak, M., Brasch-Andersen, C., Ditzel, H. J. & Leth-Larsen, R., 1. Nov 2015, In: International Journal of Cancer. 137, 9, p. 2093-2103 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Triple Negative Breast Neoplasms
  • Biomarkers
  • Disease-Free Survival
  • Lymph Nodes
  • Calcium-Binding Proteins

• Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

  Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. May 2015, In: Chemical Communications. 51, 46, p. 9499-9502

  Research output: Contribution to journal › Journal article › Research › peer-review

  • locked nucleic acid
  • Nucleic acids
  • Oligonucleotides
  • Vascular Endothelial Growth Factor A
  • Cell proliferation
• 2014

  Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis

  Pauling, J. K., Christensen, A. G., Batra, R., Alcaraz, N., Barbosa, E., Larsen, M. R., Beck, H. C., Leth-Larsen, R., Azevedo, V., Ditzel, H. J. & Baumbach, J., 15. Aug 2014, In: Integrative Biology. 6, 11, p. 1058-1068

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Triple Negative Breast Neoplasms
  • Epithelial-Mesenchymal Transition
  • Cells
  • Phosphorylation
  • Cell Line
• 2013

  Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells

  Terp, M. G., Olesen, K. A., Christensen, E. A., Lund, R. R., Lagerholm, B. C., Ditzel, H. J. & Leth-Larsen, R., 15. Oct 2013, In: Journal of Immunology. 191, 8, p. 4165-4173

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cluster Analysis
  • Monoclonal Antibodies
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Circulating Neoplastic Cells
• 2012

  Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis

  Leth-Larsen, R., Terp, M. G., Christensen, A. G. L., Elias, D., Kühlwein, T., Jensen, O. N., Petersen, O. W. & Ditzel, H., 2012, In: Molecular Medicine. 18, p. 1109-1121 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Neoplastic Stem Cells
  • Breast Neoplasms
  • Neoplasm Metastasis
  • Triple Negative Breast Neoplasms
  • Genes

• Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family

  Vitashenkova, N., Moeller, J. B., Leth-Larsen, R., Schlosser, A., Lund, K. P., Tornøe, I., Vitved, L., Hansen, S., Willis, A., Kharazova, A. D., Skjødt, K., Sorensen, G. L. & Holmskov, U., 2012, In: Journal of Biological Chemistry. 287, p. 42846-42855

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Marinas
  • Chitin
  • Lectins
  • Carrier Proteins
  • Fluids

• Identification of markers associated with highly aggressive metastatic phenotypes using quantitative comparative proteomics

  Terp, M. G., Lund, R. R., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 2012, In: Cancer Genomics & Proteomics. 9, 5, p. 265-273

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics
  • Tumors
  • Cells
  • Phenotype
  • Neoplasm Metastasis

• Quantitative proteomics of primary tumors with varying metastatic capabilities using stable isotope-labeled proteins of multiple histogenic origins

  Lund, R. R., Terp, M. G., Laenkholm, A-V., Jensen, O. N., Leth-Larsen, R. & Ditzel, H. J., 2012, In: Proteomics. 12, 13, p. 2139-2148

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics
  • Isotopes
  • Tumors
  • Proteins
  • Neoplasms
• 2010

  Plasma membrane proteomics and its application in clinical cancer biomarker discovery

  Leth-Larsen, R., Lund, R. & Ditzel, H. J., 1. Jul 2010, In: Molecular and Cellular Proteomics. 9, 7, p. 1369-82 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell membranes
  • Proteomics
  • Tumor Biomarkers
  • Cells
  • Cell Membrane

• Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry

  Palmisano, G., Lendal, S. E., Engholm-Keller, K., Leth-Larsen, R., Parker, B. L. & Larsen, M. R., 1. Dec 2010, In: Nature Protocols (Print). 5, 12, p. 1974-82 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • titanium dioxide
  • Glycopeptides
  • N-Acetylneuraminic Acid
  • Hydrophobic and Hydrophilic Interactions
  • Liquid Chromatography
• 2009

  Efficient Isolation and Quantitative Proteomic Analysis of Cancer Cell Plasma Membrane Proteins for Identification of Metastasis-Associated Cell Surface Markers

  Lund, R., Leth-Larsen, R., Jensen, O. N. & Ditzel, H. J., 27. Apr 2009, In: Journal of Proteome Research. 8, 6, p. 3078–3090 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell membranes
  • Proteomics
  • Blood Proteins
  • Membrane Proteins
  • Cell Membrane

• Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry

  Leth-Larsen, R., Lund, R., Hansen, H. V., Laenkholm, A-V., Tarin, D., Jensen, O. N. & Ditzel, H., 24. Mar 2009, In: Molecular and Cellular Proteomics. 8, 6, p. 1436-1449

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell membranes
  • Mass spectrometry
  • Cells
  • Mass Spectrometry
  • Blood Proteins

• Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction

  Sørensen, G. L., Hoegh, S. V., Leth-Larsen, R., Thomsen, T. H., Floridon, C., Smith, K., Kejling, K., Tornoe, I., Crouch, E. C. & Holmskov, U., 2009, In: Molecular Immunology. 46, 15, p. 3060-3069

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Ligands
  • Protein Subunits
  • Amniotic Fluid
  • Disulfides
• 2007

  The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages

  Leth-Larsen, R., Zhong, F., Chow, V. T. K., Holmskov, U. & Lu, J., 1. Jan 2007, In: Immunobiology. 212, 3, p. 201-11 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Coronavirus Spike Glycoproteins
  • Pulmonary Surfactant-Associated Proteins
  • SARS Virus
  • Pulmonary Surfactant-Associated Protein D
  • Macrophages
• 2006

  Surfactant Protein D of the Innate Immune Defence is Inversely Associated with Human Obesity and SP-D Deficiency Infers Increased Body Weight in Mice

  Sørensen, G. L., Hjelmborg, J. V. B., Leth-Larsen, R., Schmidt, V. A., Fenger, M., Poulain, F., Hawgood, S., Sørensen, T. I., Kyvik, K. O. & Holmskov, U., 2006, In: Scandinavian Journal of Immunology. 64, 6, p. 633-638 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Protein Deficiency
  • Body Weight
  • Blood Proteins
  • Waist Circumference
• 2005

  A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D.

  Leth-Larsen, R., Garred, P., Jensenius, H., Meschi, J., Hartshorn, K., Madsen, J., Tornoe, I., Madsen, H. O., Sørensen, G., Crouch, E. & Holmskov, U., 2005, In: Journal of Immunology. 174, 3, p. 1532-1538 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Genes
  • Genotype
  • Serum
  • Pulmonary Surfactant-Associated Proteins

• Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus

  White, M. R., Crouch, E., Vesona, J., Tacken, P. J., Batenburg, J. J., Leth-Larsen, R., Holmskov, U. & Hartshorn, K. L., 2005, In: American Journal of Physiology: Lung Cellular and Molecular Physiology. 289, 4, p. L606-L616

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Influenza A virus
  • Neutrophils
  • Oxidants
  • Proteins

• Surfactant protein D binds to human immunodeficiency virus (HIV) envelope protein gp120 and inhibits HIV replication

  Meschi, J., Crouch, E. C., Skolnik, P., Yahya, K., Holmskov, U., Leth-Larsen, R., Tornoe, I., Tecle, T., White, M. R. & Hartshorn, K. L., 2005, In: Journal of General Virology. 86, Pt 11, p. 3097-3107 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Human Immunodeficiency Virus env Gene Products
  • Pulmonary Surfactant-Associated Protein D
  • Mannose-Binding Lectin
  • HIV
  • Carrier Proteins
• 2004

  Surfactant protein D in the female genital tract

  Leth-Larsen, R., Floridon, C., Nielsen, O. & Holmskov, U., 2004, In: Molecular Human Reproduction. 10, 3, p. 149-154 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Female Genitalia
  • Placenta
  • Fallopian Tubes
  • Alveolar Epithelial Cells

• The effects of GH and hormone replacement therapy on serum concentrations of mannan-binding lectin, surfactant protein D and vitamin D binding protein in Turner syndrome

  Gravholt, C. H., Leth-Larsen, R., Lauridsen, A. L., Thiel, S., Hansen, T. K., Holmskov, U., Naeraa, R. W. & Christiansen, J. S., 2004, In: European Journal of Endocrinology. 150, 3, p. 355-362 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Vitamin D-Binding Protein
  • Pulmonary Surfactant-Associated Protein D
  • Mannose-Binding Lectin
  • Hormone Replacement Therapy
  • Growth Hormone
• 2003

  Surfactant protein D (SP-D) serum levels in patients with community-acquired pneumonia

  Leth-Larsen, R., Nordenbaek, C., Tornoe, I., Moeller, V., Schlosser, A., Koch, C., Teisner, B., Junker, P. & Holmskov, U., 2003, In: Clinical Immunology. 108, 1, p. 29-37 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Pneumonia
  • Serum
  • Blood Proteins
  • Healthy Volunteers
• 2001

  Human salivary agglutinin binds to lung surfactant protein-D and is identical with scavenger receptor protein gp-340

  Ligtenberg, T. J., Bikker, F. J., Groenink, J., Tornoe, I., Leth-Larsen, R., Veerman, E. C., Nieuw Amerongen, A. V. & Holmskov, U., 1. Oct 2001, In: The Biochemical journal. 359, Pt 1, p. 243-8 6 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • glycoprotein 340
  • Pulmonary Surfactant-Associated Proteins
  • Pulmonary Surfactant-Associated Protein D
  • Agglutinins
  • Scavenger Receptors
• 2000

  Human salivary agglutinin binds to lung surfactant protein D and is identical to gp-340

  Ligtenberg, T. J. M., Bikker, F., Groenink, J., Veerman, E., Tornoe, I., Leth-Larsen, R., Amerongen, A. V. N. & Holmskov, U., 2000, In: Biochemical Journal. 359, p. 243-248

  Research output: Contribution to journal › Journal article › Research

• Structural characterisation of human proteinosis surfactant protein A

  Berg, T., Leth-Larsen, R., Holmskov, U. & Højrup, P., 2000, In: BBA General Subjects. 1543, 1, p. 159-173

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein A
  • Disulfides
  • Proline
  • Glycosylation
  • Hydroxyproline
• 1999

  Structural characterization of human and bovine surfactant protein D (SP-D)

  Leth-Larsen, R., Holmskov, U. & Højrup, P., 1999, In: Biochemical Journal. 343 , Pt 3, p. 645-652

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant-Associated Protein D
  • Cattle
  • Lysine
  • Molecular mass
  • Maltose
• 1998

  The third serine proteinase with chymotrypsin specificity isolated from Atlantic cod (Gadus morhua) is a type-II elastase

  Asgeirsson, B., Leth-Larsen, R., Thórólfsson, M., Nedertoft, M. M. & Højrup, P., 1. Aug 1998, In: European Journal of Biochemistry. 255, 3, p. 638-646

  Research output: Contribution to journal › Journal article › Research › peer-review

  • pancreatic elastase II
  • Gadus morhua
  • Chymotrypsin
  • Pancreatic Elastase
  • Serine Proteases
• 1996

  Structure of chymotrypsin variant B from Atlantic cod, Gadus morhua

  Leth-Larsen, R., Asgeirsson, B., Thórólfsson, M., Nørregaard-Madsen, M. & Højrup, P., 13. Sep 1996, In: BBA General Subjects. 1297, 1, p. 49-56 8 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Gadus morhua
  • Chymotrypsin
  • Autolysis
  • Cattle
  • Amino Acids