Rikke Leth-Larsen

Search results

• 2024

  Lack of integration of research in clinical practice: A qualitative study of clinical academics’ challenges in the workplace environment

  Jensen, J., Jensen, C., Pedersen , M. R., Leth-Larsen, R., Christensen, M. & Høgsgaard, D., 2. Oct 2024.

  Research output: Contribution to conference without publisher/journal › Conference abstract for conference › Research › peer-review

• Lack of Integration of Research into Clinical Practice: A Qualitative Study of Clinical Academics’ Challenges in the Workplace Environment

  Jensen, J. F., Jensen, C. F., Pedersen, M. R. V., Leth-Larsen, R., Christensen, M. & Høgsgaard, D., 18. Jul 2024

  Research output: Other contribution › Research › peer-review
• 2023

  Forskere om lægers overgang til praksis: Implementér erfaringer fra Esbjerg i hele landet

  Münster, A.-M. B., Knudsen, T., Korsholm, M. & Leth-Larsen, R., 26. Oct 2023, In: Altinget.

  Research output: Contribution to journal › Contribution to newspaper - Feature article

• Gode erfaringer med borgerinvolvering i forskning

  Overgaard, A. K., Kaarsted, T., Leth-Larsen, R., Kyvik, K., Skøtt, O. & Espersen, K., 16. Oct 2023, In: Ugeskrift for Læger. 185, 20

  Research output: Contribution to journal › Comment/debate › Communication

• Synlighed omkring karriereveje for sundhedsvidenskabelige professioner: Ressourceoverblik og anbefalinger til afdelinger og miljøer for sundhedsvidenskabelige professioner i Region Syddanmark, Region Sjælland & Syddansk Universitet

  Pedersen , M. R., Knudsen, T., Hølge-Hazelton, B. & Leth-Larsen, R., 28. Apr 2023, 26 p.

  Research output: Book/report › Report › Commissioned

  Open Access

  File
  46 Downloads (Pure)
• 2021

  MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

  Løkkegaard, S., Elias, D., Alves, C. L., Bennetzen, M. V., Lænkholm, A. V., Bak, M., Gjerstorff, M. F., Johansen, L. E., Vever, H., Bjerre, C., Kirkegaard, T., Nordenskjöld, B., Fornander, T., Stål, O., Lindström, L. S., Esserman, L. J., Lykkesfeldt, A. E., Andersen, J. S., Leth-Larsen, R. & Ditzel, H. J., Jan 2021, In: npj Breast Cancer. 7, 15 p., 2.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Breast Cancer 100%
  • Upregulation 100%
  • Tamoxifen 100%
  • Predictive Marker 100%
  • Minichromosome Maintenance Protein 3 100%
  47 Downloads (Pure)
• 2019

  CYPOR is a novel and independent prognostic biomarker of recurrence-free survival in triple-negative breast cancer patients

  Pedersen, M. H., Hood, B. L., Ehmsen, S., Beck, H. C., Conrads, T. P., Bak, M., Ditzel, H. J. & Leth-Larsen, R., 1. Feb 2019, In: International Journal of Cancer. 144, 3, p. 631-640

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Recurrence Free Survival 100%
  • Mass Spectrometry 20%
  • Overall Survival 20%
  • Protein Expression 20%
  • Proteomics 20%
  134 Downloads (Pure)

• Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

  Ehmsen, S., Pedersen, M. H., Wang, G., Terp, M. G., Arslanagic, A., Hood, B. L., Conrads, T. P., Leth-Larsen, R. & Ditzel, H. J., 25. Jun 2019, In: Cell Reports. 27, 13, p. 3927-3938.e6

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Breast Cancer 100%
  • Cancer Stem Cell 100%
  • Cholesterol Synthesis 100%
  • Malignant Neoplasm 80%
  • Neoplasm 80%
  160 Downloads (Pure)
• 2018

  Proteomic comparison of clinical breast cancer samples, corresponding patient derived xenografts (PDX) and mammospheres reveal increased cholesterol biosynthesis as a key feature of cancer stem cells

  Ehmsen, S., Pedersen, M. H., Arslanagic, A., Terp, M. G., Leth-Larsen, R., Ditzel, H., Hood, B. L. & Conrads, T. P., 4. May 2018.

  Research output: Contribution to conference without publisher/journal › Poster › Communication

• Research integrity among PhD students within clinical research at the University of Southern Denmark

  Bredahl, L., Kyvik, K. O., Leth-Larsen, R. & Eriksen, M. B., 1. Apr 2018, In: Danish Medical Journal. 65, 4, 5 p., A5469.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Denmark 100%
  • Clinical Research 100%
  • Doctor of Philosophy 100%
  • Scientific Misconduct 75%
  • Swedish 50%
  165 Downloads (Pure)
• 2017

  Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors

  Pedersen, M. H., Hood, B. L., Beck, H. C., Conrads, T. P., Ditzel, H. & Leth-Larsen, R., 16. Mar 2017, In: OncoImmunology. 6, 5, 14 p., e1305531.

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  • Neoplasm 100%
  • Downregulation 100%
  • Antigen Presentation 100%
  • Triple Negative Breast Cancer 100%
  • Proteomics 75%

• Elucidation of altered pathways in tumor-initiating cells of triple-negative breast cancer: A useful cell model system for drug screening

  Christensen, A. G., Ehmsen, S., Terp, M. G., Batra, R., Alcaraz, N., Baumbach, J., Noer, J. B., Moreira, J. M. A., Leth-Larsen, R., Larsen, M. R. & Ditzel, H. J., Aug 2017, In: Stem Cells. 35, 8, p. 1898–1912

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cancer Stem Cell 100%
  • Drug Screening 100%
  • Cancer Cell 44%
  • Catenin 22%
  • Stem Cell 11%
• 2016

  Dual epitope targeting of CD73 exhibits potent anti-cancer activity

  Gammelgaard, O. L., Terp, M. G., Parren, P. W. H. I., Leth-Larsen, R. & Ditzel, H., 2016.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• S100A14 increases tumorigenesis in triple-negative breast cancer

  Ehmsen, S., Nørgaard, K., Ditzel, H. & Leth-Larsen, R., 9. Jul 2016.

  Research output: Contribution to conference without publisher/journal › Poster › Research

  Open Access
• 2015

  NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

  Lund, R. R., Leth-Larsen, R., Caterino, T. D., Terp, M. G., Nissen, J., Lænkholm, A.-V., Jensen, O. N. & Ditzel, H. J., Nov 2015, In: Molecular and Cellular Proteomics. 14, 11, p. 2988-2999

  Research output: Contribution to journal › Journal article › Research › peer-review

  Open Access

  File

  • Overall Survival 100%
  • Estrogen Receptor 100%
  • Disease Free Survival 100%
  • Cytochrome B5 Reductase 100%
  • Cancer Cell 57%
  748 Downloads (Pure)

• Quantitative proteomics of formalin-fixed paraffin-embedded, primary triple-negative breast cancer tissues of patients who experienced distant metastasis or no recurrence

  Pedersen, M. H., Hood, B. L., Conrads, T. P., Ditzel, H. & Leth-Larsen, R., 2015.

  Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

• S100A14 is a novel independent prognostic biomarker in the triple-negative breast cancer subtype

  Ehmsen, S., Hansen, L. T., Bak, M., Brasch-Andersen, C., Ditzel, H. J. & Leth-Larsen, R., 1. Nov 2015, In: International Journal of Cancer. 137, 9, p. 2093-2103 11 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Disease Free Survival 100%
  • Prognostic Biomarker 100%
  • Biological Marker 100%
  • Triple Negative Breast Cancer 100%
  • Axillary Lymph Node 66%

• Targeting VEGF with LNA-stabilized G-rich oligonucleotide for efficient breast cancer inhibition

  Edwards, S. L., Poongavanam, V., R Kanwar, J., Roy, K., M. Hillman, K., Prasad, N., Leth-Larsen, R., Petersen, M., Marusic, M., Plavec, J., Wengel, J. & Veedu, R. N., 7. May 2015, In: Chemical Communications. 51, 46, p. 9499-9502

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Oligonucleotide 100%
  • Locked Nucleic Acid 100%
  • Vascular Endothelial Growth Factor 100%
  • Cancer Cell 50%
  • Cell Proliferation 25%
• 2014

  Elucidation of epithelial-mesenchymal transition-related pathways in a triple-negative breast cancer cell line model by multi-omics interactome analysis

  Pauling, J. K., Christensen, A. G., Batra, R., Alcaraz, N., Barbosa, E., Larsen, M. R., Beck, H. C., Leth-Larsen, R., Azevedo, V., Ditzel, H. J. & Baumbach, J., 15. Aug 2014, In: Integrative Biology. 6, 11, p. 1058-1068

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cancer Cell 100%
  • Mesenchymal-Epithelial Transition 100%
  • Interactome 100%
  • Protein Expression 50%
  • Gene Expression 50%
• 2013

  Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells

  Terp, M. G., Olesen, K. A., Christensen, E. A., Lund, R. R., Lagerholm, B. C., Ditzel, H. J. & Leth-Larsen, R., 15. Oct 2013, In: Journal of Immunology. 191, 8, p. 4165-4173

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Surface Property 100%
  • Monoclonal Antibody 100%
  • Cancer Cell 100%
  • Internalization 100%
  • Breast Cancer 100%

• S100A14: A Novel Prognostic Biomarker of Triple-Negative Breast Cancer Subtype

  Ehmsen, S., Bak, M., Ditzel, H. & Leth-Larsen, R., 25. Jun 2013.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2012

  Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis

  Leth-Larsen, R., Terp, M. G., Christensen, A. G. L., Elias, D., Kühlwein, T., Jensen, O. N., Petersen, O. W. & Ditzel, H., 2012, In: Molecular Medicine. 18, p. 1109-1121 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Breast Cancer 100%
  • Distant Metastasis 100%
  • Cancer Stem Cell 100%
  • Gene Signature 100%
  • CD44 100%

• Heterogeneity within the Cancer Stem Cell Population of the Triple-Negative Breast Cancer Subtype

  Ehmsen, S., Christensen, A. G. L., Ditzel, H. & Leth-Larsen, R., 7. Jul 2012.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Identification and characterization of a chitin-binding protein purified from coelomic fluid of the lugworm Arenicola marina defining a novel protein sequence family

  Vitashenkova, N., Moeller, J. B., Leth-Larsen, R., Schlosser, A., Lund, K. P., Tornøe, I., Vitved, L., Hansen, S., Willis, A., Kharazova, A. D., Skjødt, K., Sorensen, G. L. & Holmskov, U., 2012, In: Journal of Biological Chemistry. 287, p. 42846-42855

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Protein Binding 100%
  • Amino Acid Sequence 100%
  • Liquid 100%
  • Chitin Binding 100%
  • Arenicola Marina 100%

• Identification of markers associated with highly aggressive metastatic phenotypes using quantitative comparative proteomics

  Terp, M. G., Lund, R. R., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 2012, In: Cancer Genomics & Proteomics. 9, 5, p. 265-273

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Proteomics 100%
  • Cancer Cell 100%

• Identification of Markers Associated with Highly Aggressive Metastatic Phenotypes Using Quantitative Comparative Proteomics

  Terp, M. G., Lund, R. R., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 29. Nov 2012.

  Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

• Kinomic and phospho-proteomic analysis of breast cancer stem-like cells

  Leth-Larsen, R., Christensen, A. G. L., Ehmsen, S., Møller, M., Palmisano, G., Larsen, M. R. & Ditzel, H., 5. Dec 2012.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Quantitative proteomics of primary tumors with varying metastatic capabilities using stable isotope-labeled proteins of multiple histogenic origins

  Lund, R. R., Terp, M. G., Laenkholm, A.-V., Jensen, O. N., Leth-Larsen, R. & Ditzel, H. J., 2012, In: Proteomics. 12, 13, p. 2139-2148

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mouse 100%
  • Cell Line 100%
  • Lymph Node 100%
  • Cancer Cell Line 100%
  • Elongation Factor Tu 100%
• 2011

  Antibodies targeting human CD73 inhibit breast tumor growth

  Terp, M. G., Fredberg, L., Lund, R. R., Skjødt, K., Ditzel, H. & Leth-Larsen, R., 9. Mar 2011.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Heterogeneity within the cancer stem cell population as defined by CD44⁺/CD24^low/- in breast cancer

  Leth-Larsen, R., Terp, M. G., Christensen, A. G. L., Elias, D., Kühlwein, T., Jensen, O. N., Petersen, O. W. & Ditzel, H., 6. Mar 2011.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Quantitative Proteome Analysis of Cancer Tissues using SILAC-labeled Proteins of Multiple Histogenic Origins

  Lund, R. R., Terp, M. G., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 20. Jun 2011.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• The phosphoproteome of breast cancer stem cells as determined by mass spectrometry

  Christensen, A. G. L., Palmisano, G., Leth-Larsen, R., Larsen, M. R. & Ditzel, H., 7. Mar 2011.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2010

  CD44 Variant Isoforms in Triple-Negative Breast Cancer

  Leth-Larsen, R., Christensen, A. G. L., Terp, M. G., Hansen, H. V., Petersen, O. W. & Ditzel, H., 2010.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Oncosialobiology: the sialylation and metastasis linker

  Leth-Larsen, R., Larsen, M. R. & Palmisano, G., 19. Sept 2010.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Plasma membrane proteomics and its application in clinical cancer biomarker discovery

  Leth-Larsen, R., Lund, R. & Ditzel, H. J., 1. Jul 2010, In: Molecular and Cellular Proteomics. 9, 7, p. 1369-82 14 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Membrane 100%
  • Proteomics 100%
  • Tumor Marker 100%
  • Biomarker Discovery 100%
  • Cancer Cell 60%

• Protein Profiling of Primary Tumors with Different Abilities to Establish Lung Metastases

  Lund, R. R., Terp, M. G., Leth-Larsen, R., Jensen, O. N. & Ditzel, H., 2010.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Selective enrichment of sialic acid-containing glycopeptides using titanium dioxide chromatography with analysis by HILIC and mass spectrometry

  Palmisano, G., Lendal, S. E., Engholm-Keller, K., Leth-Larsen, R., Parker, B. L. & Larsen, M. R., 1. Dec 2010, In: Nature Protocols. 5, 12, p. 1974-82 9 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mass Spectrometry 100%
  • Glycopeptide 100%
  • Sialic Acid 100%
  • Hydrophilic Interaction Chromatography 100%
  • Glycosylation 14%

• Sialylation and metastasis: a biological interplay

  Palmisano, G., Leth-Larsen, R. & Larsen, M. R., 2010.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2009

  Efficient Isolation and Quantitative Proteomic Analysis of Cancer Cell Plasma Membrane Proteins for Identification of Metastasis-Associated Cell Surface Markers

  Lund, R., Leth-Larsen, R., Jensen, O. N. & Ditzel, H. J., 27. Apr 2009, In: Journal of Proteome Research. 8, 6, p. 3078–3090 13 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Cell Membrane 100%
  • Quantitative Proteomics 100%
  • Transmembrane Protein 100%
  • Cancer Cell 100%
  • Cell Surface Marker 100%

• Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry

  Leth-Larsen, R., Lund, R., Hansen, H. V., Laenkholm, A.-V., Tarin, D., Jensen, O. N. & Ditzel, H., 24. Mar 2009, In: Molecular and Cellular Proteomics. 8, 6, p. 1436-1449

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Mass Spectrometry 100%
  • Cell Membrane 100%
  • Transmembrane Protein 100%
  • Cancer Cell 100%
  • Tandem Mass Spectrometry 50%

• Multimeric and trimeric subunit SP-D are interconvertible structures with distinct ligand interaction

  Sørensen, G. L., Hoegh, S. V., Leth-Larsen, R., Thomsen, T. H., Floridon, C., Smith, K., Kejling, K., Tornoe, I., Crouch, E. C. & Holmskov, U., 2009, In: Molecular Immunology. 46, 15, p. 3060-3069

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Surfactant Protein D 100%
  • Disulfide 16%
  • N-Terminus 16%
  • Cross-Link 16%
  • Affinity Chromatography 16%
• 2008

  Cell Culture PET (CC-PET): an in-vitro model for evaluation of 18F-FDG and 18F-FCH uptake in prostate cancer celles

  Bouchelouche, K., Ögren, M., Braad, P.-E., Madsen, K. L., Lippert, S., Leth-Larsen, R., Marcussen, N. & Oehr, P., 2008.

  Research output: Contribution to conference without publisher/journal › Poster › Research
• 2007

  Efficient separation of plasma membrane proteins allowing identification of increased numbers of cancer cell surface markers associated with breast cancer metastasis by comparative quantitative proteomics

  Lund, R., Leth-Larsen, R., Jensen, O. N. & Ditzel, H., 2007.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Identification of plasma membrane proteins on breast cancer cells associated with metastasis using comparative proteomic analysis

  Leth-Larsen, R., Lund, R., Hansen, H. V., Lænkholm, A. V., Tarin, D., Jensen, O. N. & Ditzel, H., 2007.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Monitoring phenotypical changes of breast cancer cells, sorted in accordance to their CD44 and CD24 marker expression

  Mink, N. R., Leth-Larsen, R. & Ditzel, H., 2007.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• The SARS coronavirus spike glycoprotein is selectively recognized by lung surfactant protein D and activates macrophages

  Leth-Larsen, R., Zhong, F., Chow, V. T. K., Holmskov, U. & Lu, J., 1. Jan 2007, In: Immunobiology. 212, 3, p. 201-11 10 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Pulmonary Surfactant 100%
  • Glycoprotein 100%
  • Macrophage 100%
  • Surfactant Protein D 100%
  • SARS Coronavirus 100%
• 2006

  New molecular targets of metastatic breast cancer cells: Identified by comparative proteomic analysis

  Leth-Larsen, R., Lund, R., Lænkholm, A. V., Jensen, O. N. & Ditzel, H., 2006.

  Research output: Contribution to conference without publisher/journal › Poster › Research

• Surfactant Protein D of the Innate Immune Defence is Inversely Associated with Human Obesity and SP-D Deficiency Infers Increased Body Weight in Mice

  Sørensen, G. L., Hjelmborg, J. V. B., Leth-Larsen, R., Schmidt, V. A., Fenger, M., Poulain, F., Hawgood, S., Sørensen, T. I., Kyvik, K. O. & Holmskov, U., 2006, In: Scandinavian Journal of Immunology. 64, 6, p. 633-638 5 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Surfactant Protein D 100%
  • Mouse 100%
  • Immunity 100%
  • Body Weight 100%
  • Body Mass 50%
• 2005

  A Common Polymorphism in the SFTPD Gene Influences Assembly, Function, and Concentration of Surfactant Protein D.

  Leth-Larsen, R., Garred, P., Jensenius, H., Meschi, J., Hartshorn, K., Madsen, J., Tornoe, I., Madsen, H. O., Sørensen, G., Crouch, E. & Holmskov, U., 2005, In: Journal of Immunology. 174, 3, p. 1532-1538 7 p.

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Surfactant Protein D 100%
  • Genotyping 23%
  • Blood Level 7%
  • N-Terminus 7%
  • Immunoreactivity 7%

• Respiratory innate immune proteins differentially modulate the neutrophil respiratory burst response to influenza A virus

  White, M. R., Crouch, E., Vesona, J., Tacken, P. J., Batenburg, J. J., Leth-Larsen, R., Holmskov, U. & Hartshorn, K. L., 2005, In: American Journal of Physiology-Lung Cellular and Molecular Physiology. 289, 4, p. L606-L616

  Research output: Contribution to journal › Journal article › Research › peer-review

  • Surfactant Protein D 100%
  • Influenzavirus A 100%
  • Neutrophil 100%
  • Respiratory Burst 100%
  • Neutrophil Granulocyte 25%