Richard Sprenger

2024

Dietary intake of a MFGM/EV-rich concentrate promotes accretion of very long odd-chain sphingolipids and increases lipid metabolic turnover at the whole-body level

Sprenger, R. R., Bilgin, M., Ostenfeld, M. S., Bjørnshave, A., Rasmussen, J. T. & Ejsing, C. S., Aug 2024, In: Food Research International. 190, 15 p., 114601.

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Lipidomic Characterization of Whey Concentrates Rich in Milk Fat Globule Membranes and Extracellular Vesicles

Sprenger, R. R., Ostenfeld, M. S., Bjørnshave, A., Rasmussen, J. T. & Ejsing, C. S., 2024, In: Biomolecules. 14, 1, 13 p., 55.

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Lipotype acquisition during neural development is not recapitulated in stem cell-derived neurons

Gopalan, A. B., van Uden, L., Sprenger, R. R., Fernandez-Novel Marx, N., Bogetofte, H., Neveu, P. A., Meyer, M., Noh, K.-M., Diz-Muñoz, A. & Ejsing, C. S., 28. Feb 2024, In: Life Science Alliance. 7, 5, 13 p., e202402622.

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2022

Brain lipidomics and neurodevelopmental outcomes in intrauterine growth restricted piglets fed dairy or vegetable fat diets

Henriksen, N. L., Asmussen, K. S., Pan, X., Jiang, P. P., Mori, Y., Christiansen, L. I., Sprenger, R. R., Ejsing, C. S., Pankratova, S. & Thymann, T., 28. Feb 2022, In: Scientific Reports. 12, 10 p., 3303.

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Cholestasis alters brain lipid and bile acid composition and compromises motor function in neonatal piglets

Henriksen, N. L., Hansen, S. H., Lycas, M. D., Pan, X., Eriksen, T., Johansen, L. S., Sprenger, R. R., Ejsing, C. S., Burrin, D. G., Skovgaard, K., Christensen, V. B., Thymann, T. & Pankratova, S., Jul 2022, In: Physiological Reports. 10, 13, e15368.

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DDA-imaging with structural identification of lipid molecules on an Orbitrap Velos Pro mass spectrometer

Khalil, S. M., Sprenger, R. R., Hermansson, M. & Ejsing, C. S., Sept 2022, In: Journal of Mass Spectrometry. 57, 9, e4882.

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Molecular species selectivity of lipid transport creates a mitochondrial sink for di-unsaturated phospholipids

Renne, M. F., Bao, X., Hokken, M. W. J., Bierhuizen, A. S., Hermansson, M., Sprenger, R. R., Ewing, T. A., Ma, X., Cox, R. C., Brouwers, J. F., De Smet, C. H., Ejsing, C. S. & de Kroon, A. I. P. M., 17. Jan 2022, In: The EMBO Journal. 41, 2, 16 p., e106837.

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Silencing of ceramide synthase 2 in hepatocytes modulates plasma ceramide biomarkers predictive of cardiovascular death

Schmidt, S., Gallego, S. F., Zelnik, I. D., Kovalchuk, S., Albæk, N., Sprenger, R. R., Øverup, C., Pewzner-Jung, Y., Futerman, A. H., Lindholm, M. W., Jensen, O. N. & Ejsing, C. S., 6. Apr 2022, In: Molecular Therapy. 30, 4, p. 1661-1674

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2021

Dairy-derived emulsifiers in infant formula show marginal effects on the plasma lipid profile and brain structure in preterm piglets relative to soy lecithin

Henriksen, N. L., Aasmul-Olsen, K., Venkatasubramanian, R., Nygaard, M. K. E., Sprenger, R. R., Heckmann, A. B., Ostenfeld, M. S., Ejsing, C. S., Eskildsen, S. F., Müllertz, A., Sangild, P. T., Bering, S. B. & Thymann, T., 2021, In: Nutrients. 13, 3, 17 p., 718.

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Lipid molecular timeline profiling reveals diurnal crosstalk between the liver and circulation

Sprenger, R. R., Hermansson, M., Neess, D., Becciolini, L. S., Sørensen, S. B., Fagerberg, R., Ecker, J., Liebisch, G., Jensen, O. N., Vance, D. E., Færgeman, N. J., Klemm, R. W. & Ejsing, C. S., 2. Feb 2021, In: Cell Reports. 34, 5, 23 p., 108710.

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2020

Phosphoproteomic Analysis across the Yeast Life Cycle Reveals Control of Fatty Acyl Chain Length by Phosphorylation of the Fatty Acid Synthase Complex

Martínez-Montañés, F., Casanovas, A., Sprenger, R. R., Topolska, M., Marshall, D. L., Moreno-Torres, M., Poad, B. L. J., Blanksby, S. J., Hermansson, M., Jensen, O. N. & Ejsing, C. S., 11. Aug 2020, In: Cell Reports. 32, 6, 108024.

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2019

Angiotensin-(1-7) oral treatment after experimental myocardial infarction leads to downregulation of CXCR4

Gómez-Mendoza, D. P., Marques, F. D., Melo-Braga, M. N., Sprenger, R. R., Sinisterra, R. D., Kjeldsen, F., Santos, R. A. & Verano-Braga, T., 30. Sept 2019, In: Journal of Proteomics. 208, 11 p., 103486.

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Increasing jojoba-like wax ester production in Saccharomyces cerevisiae by enhancing very long-chain, monounsaturated fatty acid synthesis

Wenning, L., Ejsing, C. S., David, F., Sprenger, R. R., Nielsen, J. & Siewers, V., 11. Mar 2019, In: Microbial Cell Factories. 18, 1, 49.

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2018

Discovery of a Potent Thiazolidine Free Fatty Acid Receptor 2 Agonist with Favorable Pharmacokinetic Properties

Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Rexen Ulven, E., Milligan, G. & Ulven, T., 8. Nov 2018, In: Journal of Medicinal Chemistry. 61, 21, p. 9534-9550

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Organic matter processing by microbial communities throughout the Atlantic water column as revealed by metaproteomics

Bergauer, K., Fernandez-Guerra, A., Garcia, J. A. L., Sprenger, R. R., Stepanauskas, R., Pachiadaki, M. G., Jensen, O. N. & Herndl, G. J., 16. Jan 2018, In: PNAS. 115, 3, p. E400-E408

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2017

Multi-omics Analyses of Starvation Responses Reveal a Central Role for Lipoprotein Metabolism in Acute Starvation Survival in C. elegans

Harvald, E. B., Sprenger, R. R., Dall, K. B., Ejsing, C. S., Nielsen, R., Mandrup, S., Murillo, A. B., Larance, M., Gartner, A., Lamond, A. I. & Færgeman, N. J., 2017, In: Cell Systems. 5, 1, p. 38-52.e4

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Quantitative lipidomics reveals age-dependent perturbations of whole-body lipid metabolism in ACBP deficient mice

Gallego, S. F., Sprenger, R. R., Neess, D., Pauling, J. K., Færgeman, N. J. & Ejsing, C. S., Feb 2017, In: BBA Molecular and Cell Biology of Lipids. 1862, 2, p. 145-155

Research output: Contribution to journal › Journal article › Research › peer-review

2015

Quantitative analysis of proteome and lipidome dynamics reveals functional regulation of global lipid metabolism

Casanovas, A., Sprenger, R. R., Tarasov, K., Ruckerbauer, D. E., Hannibal-Bach, H. K., Zanghellini, J., Jensen, O. N. & Ejsing, C. S., 19. Mar 2015, In: Chemistry & Biology. 22, 3, p. 412-425 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2014

Microbial stratification in low pH oxic and suboxic macroscopic growths along an acid mine drainage: Microbial stratification in low pH (sub)oxic AMD

Méndez-García, C., Mesa, V., Sprenger, R. R., Richter, M., Diez, M. S., Solano, J., Bargiela, R., Golyshina, O. V., Manteca, A., Ramos, J. L., Gallego, J. R., Llorente, I., Martins Dos Santos, V. A., Jensen, O. N., Peláez, A. I., Sánchez, J. & Ferrer, M., Jun 2014, In: The ISME Journal. 8, p. 1259-1274 16 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Selective renal vasoconstriction, exaggerated natriuresis and excretion rates of exosomic proteins in essential hypertension

Damkjaer, M., Jensen, P. H., Schwämmle, V., Sprenger, R. R., Jacobsen, I. A., Jensen, O. N. & Bie, P., Sept 2014, In: Acta Physiologica. 212, 1, p. 106-118 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2013

Application of complementary ions to identify co-isolated peptides in complex samples

Kjeldsen, F., Hansen, T. A., Verano-Braga, T., Sprenger, R. R. & Kryuchkov, F., 12. Jun 2013.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Characterization of barley chloroplast proteins by quantitative proteomics using optimized 2D-LC coupled to an LTQ-Orbitrap Velos tandem mass spectrometer

Petersen, J., Sprenger, R. R., Rogowska-Wrzesinska, A., Pedas, P., Krogholm, K., Husted, S., Jensen, P. E., Kofod Schjoerring, J. & Jensen, O. N., 10. Jun 2013.

Research output: Contribution to conference without publisher/journal › Poster › Research

Characterization of chloroplast phosphoproteins controlling manganese use efficiency using quantitative proteomics

Petersen, J., Sprenger, R. R., Rogowska-Wrzesinska, A., Pedas, P., Krogholm, K. S., Powikrowska, M., Husted, S., Jensen, P. E., Schjørring, J. K. & Jensen, O. N., 15. Apr 2013.

Research output: Contribution to conference without publisher/journal › Poster › Research

Characterization of chloroplast proteins controlling manganese use efficiency by quantitative proteomics using 2D-LC-MS/MS

Petersen, J., Sprenger, R. R., Rogowska-Wrzesinska, A., Pedas, P., Naumann-Busch, B., Husted, S., Jensen, P. E., K. Schjoerring, J. & Jensen, O. N., 31. Jan 2013.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Deconvolution of mixture spectra and increased throughput of Peptide identification by utilization of intensified complementary ions formed in tandem mass spectrometry

Kryuchkov, F., Verano-Braga, T., Hansen, T. A., Sprenger, R. R. & Kjeldsen, F., 3. Jun 2013, In: Journal of Proteome Research. 12, 7, p. 3362–3371

Research output: Contribution to journal › Journal article › Research › peer-review

Precision mapping of coexisting modifications in histone H3 tails from embryonic stem cells by ETD-MS/MS

Jung, H. R., Sidoli, S., Haldbo, S., Sprenger, R. R., Schwämmle, V., Pasini, D., Helin, K. & Jensen, O. N., 2013, In: Analytical Chemistry. 85, 17, p. 8232–8239

Research output: Contribution to journal › Journal article › Research › peer-review

Proteomics identifies molecular networks affected by tetradecylthioacetic acid and fish oil supplemented diets

Wrzesinski, K., León, I. R., Kulej, K., Sprenger, R. R., Bjørdal , B., Christiansen, B., Berge, R. K., Jensen, O. N. & Rogowska-Wrzesinska, A., 2013, In: Journal of Proteomics. 84, p. 61-77

Research output: Contribution to journal › Journal article › Research › peer-review

Quantitative assessment of in-solution digestion efficiency identifies optimal protocols for unbiased protein analysis: Quantitative assessment of protein digestion protocols

Leon, I. R., Schwämmle, V., Jensen, O. N. & Sprenger, R. R., 2013, In: Molecular and Cellular Proteomics. 12, 10, p. 2992-3005

Research output: Contribution to journal › Journal article › Research › peer-review

2012

Diet-induced perturbation of the rat liver mitochondrial acetylome studied by quantitative (iTRAQ) LC-MS/MS

León, I. R., Schwämmle, V., Williamson, J., Palmisano, G., Bak, S., Sprenger, R. R., Rogowska-Wrzesinska, A. & Jensen, O. N., May 2012. 1 p.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

Label-free absolute quantification of proteomes: evaluation and comparison of bioinformatics platforms and strategies

Sprenger, R. R., Casanovas, A., Sidoli, S., Schwämmle, V., Ejsing, C. S. & Jensen, O. N., 2012.

Research output: Contribution to conference without publisher/journal › Poster › Research

Mass Spectrometry Instrumentation in Proteomics

Sprenger, R. R. & Roepstorff, P., 2012, Encyclopedia of Life Sciences. Wiley, 10 p.

Research output: Chapter in Book/Report/Conference proceeding › Encyclopedia chapter › Research › peer-review

2011

Absolute Quantitative Protein Profiling of Colon Tumors and Adjacent, Morphologically Normal Epithelial Tissue by Label-Free Mass Spectrometry

Lund, R. R., Sprenger, R. R., Hansen, T. P., Jensen, O. N. & Ditzel, H., 20. Jun 2011.

Research output: Contribution to conference without publisher/journal › Poster › Research

Automated setup for characterization of intact histone tails in Suz12-/- stem cells

Sidoli, S., Schwämmle, V., Hansen, T. A., Sprenger, R. R. & Jensen, O. N., 27. Nov 2011.

Research output: Contribution to conference without publisher/journal › Poster › Research

Determination of the binding sites for oxaliplatin on insulin using mass spectrometry-based approaches

Møller, C., Sprenger, R. R., Stürup, S. & Højrup, P., 19. Jul 2011, In: Analytical and Bioanalytical Chemistry. 401, 5, p. 1623-1633 11 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Innovative hybrid setup for detection of histone tail modifications and their interplay using nanoLC and high resolution MS/MS

Sidoli, S., Haldbo, S. N., Sprenger, R. R. & Jensen, O. N., 12. Jan 2011.

Research output: Contribution to conference without publisher/journal › Poster › Research

2010

Assessment of protein digestion protocols by combining standard (LTQ-Orbitrap-MS) and unbiased (QToF-MSE) tandem mass spectrometry

León, I. R., Sprenger, R. R., Sidoli, S., Young, C. & Jensen, O. N., 2010.

Research output: Contribution to conference without publisher/journal › Poster › Research

Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome

Agar, C., van Os, G. M. A., Mörgelin, M., Sprenger, R., Marquart, J. A., Urbanus, R. T., Derksen, R. H. W. M., Meijers, J. C. M. & de Groot, P. G., 26. Aug 2010, In: Blood. 116, 8, p. 1336-43 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Proteome-wide alterations in Escherichia coli translation rates upon anaerobiosis

Kramer, G., Sprenger, R., Nessen, M. A., Roseboom, W., Speijer, D., de Jong, L., de Mattos, M. J. T., Back, J. & de Koster, C. G., 1. Nov 2010, In: Molecular and Cellular Proteomics. 9, 11, p. 2508-16 9 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Proteomics and the dynamic plasma membrane: Quo Vadis?

Sprenger, R. R. & Jensen, O. N., 1. Nov 2010, In: Proteomics. 10, 22, p. 3997-4011 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2009

Common G102S polymorphism in chitotriosidase differentially affects activity towards 4-methylumbelliferyl substrates

Bussink, A. P., Verhoek, M., Vreede, J., Ghauharali-van der Vlugt, K., Donker-Koopman, W. E., Sprenger, R. R., Hollak, C. E., Aerts, J. M. F. G. & Boot, R. G., 1. Oct 2009, In: The FEBS Journal. 276, 19, p. 5678-88 10 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Gaucher disease: a model disorder for biomarker discovery

Boot, R. G., van Breemen, M. J., Wegdam, W., Sprenger, R. R., de Jong, S., Speijer, D., Hollak, C. E. M., van Dussen, L., Hoefsloot, H. C. J., Smilde, A. K., de Koster, C. G., Vissers, J. P. C. & Aerts, J. M. F. G., 1. Aug 2009, In: Expert Review of Proteomics. 6, 4, p. 411-9 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Identification and quantitation of newly synthesized proteins in Escherichia coli by enrichment of azidohomoalanine-labeled peptides with diagonal chromatography

Kramer, G., Sprenger, R. R., Back, J., Dekker, H. L., Nessen, M. A., van Maarseveen, J. H., de Koning, L. J., Hellingwerf, K. J., de Jong, L. & de Koster, C. G., 1. Jul 2009, In: Molecular and Cellular Proteomics. 8, 7, p. 1599-611 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

MRM quantification of chitotriosidase in human plasma: Application Note

Sprenger, R. R., Doneanu, C., Langridge, J., Vissers, H. & Aerts, H., 2009

Research output: Other contribution › Net publication - Internet publication › Research

Mucin 6 in seminal plasma binds DC-SIGN and potently blocks dendritic cell mediated transfer of HIV-1 to CD4(+) T-lymphocytes

Stax, M. J., van Montfort, T., Sprenger, R. R., Melchers, M., Sanders, R. W., van Leeuwen, E., Repping, S., Pollakis, G., Speijer, D. & Paxton, W. A., 1. Sept 2009, In: Virology. 391, 2, p. 203-11 8 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Toward understanding the effect of bioactive marine food components on the human health

León, I. R., Wrzesinski, K., Rogowska-Wrzesinska, A., Kulej, K., Sprenger, R., Ytterberg, J., Berge, R. K., Burri, L. & Jensen, O. N., 2009.

Research output: Contribution to conference without publisher/journal › Poster › Research

2008

Biomarkers for lysosomal storage disorders: identification and application as exemplified by chitotriosidase in Gaucher disease

Aerts, J. M., van Breemen, M. J., Bussink, A. P., Ghauharali, K., Sprenger, R., Boot, R. G., Groener, J. E., Hollak, C. E., Maas, M., Smit, S., Hoefsloot, H. C., Smilde, A. K., Vissers, J. P., de Jong, S., Speijer, D. & de Koster, C. G., 1. Apr 2008, In: Acta Paediatrica. 97, s457, p. 7-14 7 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Potential artefacts in proteome analysis of plasma of Gaucher patients due to protease abnormalities

van Breemen, M. J., Aerts, J. M. F. G., Sprenger, R. R. & Speijer, D., 1. Oct 2008, In: Clinica Chimica Acta. 396, 1-2, p. 26-32 6 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2007

Richard Sprenger

Research output

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