Research output per year
Research output per year
- 33 results
Search results
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2025
Body weight control via protein kinase CK2: diet-induced obesity counteracted by pharmacological targeting
Buchwald, L. M., Pedersen, D. N., Hansen, D., Doktor, T. K., Ramesh, V., Steffensen, L. B., Blagoev, B., Litchfield, D. W., Andresen, B. S., Ravnskjær, K., Færgeman, N. J. K. & Guerra, B., Jan 2025, In: Metabolism. 162, 156060.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile4 Downloads (Pure) -
2024
Metabolic Dysfunction-Associated Steatotic Liver Disease in a Dish: Human Precision-Cut Liver Slices as a Platform for Drug Screening and Interventions
Li, M., Larsen, F. T., van den Heuvel, M. C., Gier, K., Gorter, A. R., Oosterhuis, D., Bijzet, J., de Meijer, V. E., Ravnskjaer, K., Nagelkerke, A. & Olinga, P., Mar 2024, In: Nutrients. 16, 5, 18 p., 626.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile15 Downloads (Pure) -
Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module
Bendixen, S. M., Jakobsgaard, P. R., Hansen, D., Hejn, K. H., Terkelsen, M. K., Bjerre, F. A., Thulesen, A. P., Eriksen, N. G., Hallenborg, P., Geng, Y., Dam, T. V., Larsen, F. T., Wernberg, C. W., Vijayathurai, J., Scott, E. A. H., Marcher, A. B., Detlefsen, S., Grøntved, L., Dimke, H. & Berdeaux, R. & 6 others, , Mar 2024, In: Journal of Hepatology. 80, 3, p. 467-481Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile85 Downloads (Pure) -
2023
Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness
Chandran, V. I., Wernberg, C. W., Lauridsen, M. M., Skytthe, M. K., Bendixen, S. M., Larsen, F. T., Hansen, C. D., Grønkjær, L. L., Siersbæk, M. S., Caterino, T. D., Detlefsen, S., Møller, H. J., Grøntved, L., Ravnskjaer, K., Moestrup, S. K., Thiele, M. S., Krag, A. & Graversen, J. H., Feb 2023, In: Hepatology. 77, 2, p. 558-572Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile236 Downloads (Pure) -
Stellate cell expression of SPARC-related modular calcium-binding protein 2 is associated with human non-alcoholic fatty liver disease severity
Larsen, F. T., Hansen, D., Terkelsen, M. K., Bendixen, S. M., Avolio, F., Wernberg, C. W., Lauridsen, M. M., Grønkjaer, L. L., Jacobsen, B. G., Klinggaard, E. G., Mandrup, S., Di Caterino, T., Siersbæk, M. S., Chandran, V. I., Graversen, J. H., Krag, A., Grøntved, L. & Ravnskjaer, K., Feb 2023, In: JHEP Reports. 5, 2, 100615.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile101 Downloads (Pure) -
The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
Inaba, Y., Hashiuchi, E., Watanabe, H., Kimura, K., Oshima, Y., Tsuchiya, K., Murai, S., Takahashi, C., Matsumoto, M., Kitajima, S., Yamamoto, Y., Honda, M., Asahara, S. I., Ravnskjaer, K., Horike, S. I., Kaneko, S., Kasuga, M., Nakano, H., Harada, K. & Inoue, H., Dec 2023, In: Nature Communications. 14, 1, 167.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile29 Downloads (Pure) -
Use of smoc2 as a non biomarker for developing alcoholic or non-alcoholic steatohepatitis
Graversen, N. J. H. (Inventor), Chandran, V. I. (Inventor), Larsen, F. T. (Inventor), Grøntved, L. (Inventor), Ravnskjær, K. (Inventor), Lauridsen, M. E. M. (Inventor), Wernberg, C. W. (Inventor) & Krag, A. A. (Inventor), 14. Dec 2023, IPC No. G01N33/68, Patent No. WO2023237529 (A1), Priority date 7. Jun 2022, Priority No. EP20220177513Research output: Patent
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2022
Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis
Bobowski-Gerard, M., Boulet, C., Zummo, F. P., Dubois-Chevalier, J., Gheeraert, C., Bou Saleh, M., Strub, J. M., Farce, A., Ploton, M., Guille, L., Vandel, J., Bongiovanni, A., Very, N., Woitrain, E., Deprince, A., Lalloyer, F., Bauge, E., Ferri, L., Ntandja-Wandji, L. C. & Cotte, A. K. & 18 others, , 10. Sept 2022, In: Nature Communications. 13, p. 5324 5324.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile35 Downloads (Pure) -
Plasma TREM2, a novel non-invasive biomarker for diagnosis of NASH in NAFLD patients with elevated liver stiffness
Wernberg, C. W., Chandran, V. I., Lauridsen, M., Larsen, F., Skytthe, M. K., Hansen, C. D., Siersbæk, M., Caterino, T. D., Detlefsen, S., Palarasah, Y., Ravnskjaer, K., Groentved, L., Moestrup, S. K., Thiele, M., Graversen, J. & Krag, A., Jul 2022, In: Journal of Hepatology. 77, S1, p. S434Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
Open Access -
Use of sparc-related modular calcium binding protein 2 as a non-invasive biomarker
Graversen, J. H. (Inventor), Chandran, V. I. (Inventor), Larsen, F. T. (Inventor), Grøntved, L. (Inventor), Ravnskjær, K. (Inventor), Lauridsen, M. (Inventor), Wernberg, C. (Inventor) & Krag, A. (Inventor), 2022, Patent No. EP22177513.3Research output: Patent
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2021
Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication
Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., Wolff, G., Sakurai, M., Berutti, R., Üstünel, B. E., Nawroth, P., Ravnskjaer, K., Diaz, M. B., Blagoev, B. & Herzig, S., 3. Aug 2021, In: Cell Metabolism. 33, 8, p. 1685-1700.e9Research output: Contribution to journal › Journal article › Research › peer-review
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Loss of CREB coactivator CRTC1 in SF1 cells leads to hyperphagia and obesity by high-fat diet but not normal chow diet
Matsumura, S., Ishikawa, F., Sasaki, T., Terkelsen, M. K., Ravnskjaer, K., Jinno, T., Tanaka, J., Goto, T. & Inoue, K., Sept 2021, In: Endocrinology. 162, 9, bqab076.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile46 Downloads (Pure) -
The Role of Diagnostic Biomarkers, Omics Strategies, and Single-Cell Sequencing for Nonalcoholic Fatty Liver Disease in Severely Obese Patients
Wernberg, C. W., Ravnskjaer, K., Lauridsen, M. M. & Thiele, M., 1. Mar 2021, In: Journal of Clinical Medicine. 10, 5, 15 p., 930.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile73 Downloads (Pure) -
2020
Osteoprotegerin is more than a possible serum marker in liver fibrosis: A study into its function in human and murine liver
Adhyatmika, A., Beljaars, L., Putri, K. S. S., Habibie, H., Boorsma, C. E., Reker‐smit, C., Luangmonkong, T., Guney, B., Haak, A., Mangnus, K. A., Post, E., Poelstra, K., Ravnskjaer, K., Olinga, P. & Melgert, B. N., 2020, In: Pharmaceutics. 12, 5, 21 p., 471.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile41 Downloads (Pure) -
Transcriptional dynamics of hepatic sinusoid-associated cells after liver injury
Terkelsen, M. K., Bendixen, S. M., Hansen, D., Scott, E. A. H., Moeller, A. F., Nielsen, R., Mandrup, S., Schlosser, A., Andersen, T. L., Sorensen, G. L., Krag, A., Natarajan, K. N., Detlefsen, S., Dimke, H. & Ravnskjaer, K., 20. Dec 2020, In: Hepatology. 72, 6, p. 2119-2133Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile163 Downloads (Pure) -
2019
Transcriptional regulation of Hepatic Stellate Cell activation in NASH
Marcher, A.-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. Feb 2019, In: Scientific Reports. 9, 1, 55 p., 2324.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile313 Downloads (Pure) -
2017
Identification of NASH-associated signaling networks in murine hepatic stellate cells
Ravnskjær, K., 15. Oct 2017.Research output: Contribution to conference without publisher/journal › Poster › Research
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2016
Role of the cAMP Pathway in Glucose and Lipid Metabolism
Ravnskjær, K., Madiraju, A. & Montminy, M., 1. Jan 2016, Handbook of Experimental Pharmacology. Springer, p. 29-49 21 p. (Handbook of Experimental Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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2015
Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2
Hogan, M. F., Ravnskjaer, K., Matsumura, S., Huising, M. O., Hull, R. L., Kahn, S. E. & Montminy, M., 4. Sept 2015, In: Journal of Biological Chemistry. 290, 43, p. 25997-26006Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile173 Downloads (Pure) -
2013
Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects
Ravnskjær, K., Hogan, M. F., Lackey, D., Tora, L., Dent, S. Y. R., Olefsky, J. & Montminy, M., Oct 2013, In: Journal of Clinical Investigation. 123, 10, p. 4318-4328 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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2012
Keystone Symposia on Epigenomics and Chromatin Dynamics: Keystone resort, CO, January 17-22, 2012
Ravnskjær, K., 2012, In: Epigenetics. 7, 5, p. 522-523Research output: Contribution to journal › Journal article › Research
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2011
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
Mihaylova, M. M., Vasquez, D. S., Ravnskjær, K., Denechaud, P.-D., Yu, R. T., Alvarez, J. G., Downes, M., Evans, R. M., Montminy, M. & Shaw, R. J., 2011, In: Cell. 145, 4, p. 607-621Research output: Contribution to journal › Journal article › Research › peer-review
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2010
PPAR{delta} is a fatty acid sensor, which enhances mitochondrial oxidation in insulin: secreting cells and protects against fatty acid induced dysfunction
Ravnskjaer, K., Frigerio, F., Boergesen, M., Nielsen, T., Maechler, P. & Mandrup, S., 2010, In: Journal of Lipid Research. 51, 6, p. 1370-1379Research output: Contribution to journal › Journal article › Research › peer-review
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Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity
Wang, Y., Inoue, H., Ravnskjær, K., Viste, K., Miller, N., Liu, Y., Hedrick, S., Vera, L. & Montminy, M., 16. Feb 2010, In: PNAS. 107, 7, p. 3087-3092Research output: Contribution to journal › Journal article › Research › peer-review
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2009
Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism
Frigerio, F., Brun, T., Bartley, C., Usardi, A., Bosco, D., Ravnskjær, K., Mandrup, S. & Maechler, P., 1. Jan 2009, In: Diabetologia. 53, 2, p. 331--340Research output: Contribution to journal › Journal article › Research › peer-review
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2008
Activation of PPARd and RXRa stimulates fatty acid oxidatin and insulin secretion inpancreatic beta-cells
Børgesen, M., Ravnskjær, K., Frigerio, F., Karlsen, A. E., Maechler, P. & Mandrup, S., 2008.Research output: Contribution to conference without publisher/journal › Poster › Research
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A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Liu, Y., Dentin, R., Chen, D., Hedrick, S., Ravnskjær, K., Schenk, S., Milne, J., Meyers, D. J., Cole, P., Yates, J., Olefsky, J., Guarente, L. & Montminy, M., 13. Nov 2008, In: Nature. 456, p. 269-273Research output: Contribution to journal › Journal article › Research › peer-review
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2007
Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression
Ravnskjær, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, J. R. & Montminy, M., 20. Jun 2007, In: The EMBO Journal. 26, 12, p. 2880-2889Research output: Contribution to journal › Journal article › Research › peer-review
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2006
Glucose-induced repression of PPARa gene expression in pancreatic ß-cells involves PP2A activation and AMPK inactiviation
Ravnskjær, K., Børgesen, M., Dalgaard, L. T. & Mandrup, S., 1. Apr 2006, In: Journal of Molecular Endocrinology. 36, 2, p. 289-299Research output: Contribution to journal › Journal article › Research › peer-review
Open Access -
2005
Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells.
Ravnskjaer, K., Boergesen, M., Rubi, B., Larsen, J. K., Nielsen, T., Fridriksson, J., Maechler, P. & Mandrup, S., 1. Aug 2005, In: Endocrinology. 146, 8, p. 3266-76 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PPARa potentiates whereas PPARg attenuates glucose-stimulated insulin secretion in pancreatic ß-cells
Ravnskjær, K., Børgesen, M., Rubi, B., Larsen, J. K., Nielsen, T., Fridriksson, J., Maechler, P. & Mandrup, S., 2005, In: Endocrinology. 146, p. 3266-3276Research output: Contribution to journal › Journal article › Research › peer-review
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PPARd IS A LIPID SENSOR AND A REGULATOR OF FATTY ACID OXIDATION IN PANCREATIC β-CELLS
Ravnskjær, K., Nielsen, T., Børgesen, M. & Mandrup, S., 2005.Research output: Contribution to conference without publisher/journal › Poster › Research
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2003
Pancreatic beta-cell lipotoxicity induced by overexpression of hormone-sensitive lipase.
Winzell, M. S., Svensson, H., Enerbäck, S., Ravnskjaer, K., Mandrup, S., Esser, V., Arner, P., Alves-Guerra, M.-C., Miroux, B., Sundler, F., Ahrén, B. & Holm, C., 2003, In: Diabetes. 52, 8, p. 2057-65Research output: Contribution to journal › Journal article › Research › peer-review