Photo of Kim Ravnskjær

Kim Ravnskjær

PhD in Biomedicine

  • Campusvej 55

    5230 Odense M

    Denmark

20032023
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Personal profile

Research areas

FUNCTIONAL GENOMICS AND METABOLIC SIGNALING IN THE LIVER

Metabolic disease is one of the biggest health problems in modern society and a tremendous burden on healthcare systems worldwide. Obesity, high blood pressure, heart disease, insulin resistance, and diabetes are aspects of a systemic state of metabolic dysfunction referred to as the metabolic syndrome.

The metabolic syndrome is commonly linked to a sedentary lifestyle with excess calorie intake but it is well documented that also genetic traits contribute. Hallmarks at the cellular level include chronic, systemic inflammation and a profound metabolic inflexibility.

We are interested in the hepatic manifestations of the metabolic syndrome: Hepatic insulin resistance, steatosis, fibrosis, and cirrhosis. Insufficiently treated liver cirrhosis may result in liver failure or progress into hepatocellular carcinoma.

Through in vivo studies of cell-signaling pathways, transcriptional networks, and physiology we pursue a deeper understanding of disease mechanisms. This knowledge will help us identify and explore novel molecular targets for therapeutic intervention.

Areas of particular interest to us:

- Cross talk between hepatic cell types in the pathogenesis of hepatic fibrosis.
- Mechanisms controlling hepatic stellate cell trans-differentiation in the fibrotic liver.
- Nutritional and hormonal signaling in metabolic disease.

Our core techniques include:

- Transgenic animals and animal models of metabolic disease
- In vivo gene manipulation by adeno-associated virus
- Isolation and culture of primary hepatic cell populations
- Cre-TRAP Ribosomal profiling
- RNA-seq and RT-qPCR
- ChIP-qPCR and ChIP-seq
- Confocal fluorescence microscopy
- Protein analyses by western blotting, immunofluorescence, and mass spectrometry*
- Bioinformatic data analysis*

(* collaborative projects possible)

We are currently looking for highly motivated and committed students at the bachelor-, ITEK-, and master-level.


For inquiries about our research and student projects please contact me at ravnskjaer@bmb.sdu.dk or swing by my office at BMB on Campusvej.

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Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 2003 2019

207 Downloads (Pure)

Transcriptional regulation of Hepatic Stellate Cell activation in NASH

Marcher, A-B., Bendixen, S. M., Terkelsen, M. K., Hohmann, S. S., Hansen, M. H., Larsen, B. D., Mandrup, S., Dimke, H., Detlefsen, S. & Ravnskjaer, K., 20. Feb 2019, In : Scientific Reports. 9, 1, 55 p., 2324.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Hepatic Stellate Cells
Fatty Liver
Liver
Liver Diseases
Extracellular Matrix Proteins

Role of the cAMP Pathway in Glucose and Lipid Metabolism

Ravnskjær, K., Madiraju, A. & Montminy, M., 1. Jan 2016, Handbook of Experimental Pharmacology. Springer, p. 29-49 21 p. (Handbook of Experimental Pharmacology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Lipid Metabolism
Glycogenolysis
Metabolic Networks and Pathways
Glucagon
Homeostasis
118 Downloads (Pure)

Hepatic Insulin Resistance Following Chronic Activation of the CREB Coactivator CRTC2

Hogan, M. F., Ravnskjaer, K., Matsumura, S., Huising, M. O., Hull, R. L., Kahn, S. E. & Montminy, M., 4. Sep 2015, In : Journal of Biological Chemistry. 290, 43, p. 25997-26006

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Phosphorylation
Insulin Resistance
Chemical activation
Gene expression
Insulin

Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects

Ravnskjær, K., Hogan, M. F., Lackey, D., Tora, L., Dent, S. Y. R., Olefsky, J. & Montminy, M., Oct 2013, In : Journal of Clinical Investigation. 123, 10, p. 4318-28 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cyclic AMP Response Element-Binding Protein
Gluconeogenesis
Glucagon
Epigenomics
Fasting

Keystone Symposia on Epigenomics and Chromatin Dynamics: Keystone resort, CO, January 17-22, 2012

Ravnskjær, K., 2012, In : Epigenetics. 7, 5, p. 522-523

Research output: Contribution to journalJournal articleResearch

Epigenomics

Activities 2015 2019

  • 3 Talks and presentations in private or public companies
  • 2 Organisation or participation in workshops, courses or seminars
  • 1 Conference organisation or participation
  • 1 Peer review of manuscripts

ATLAS Symposium 2019 - Tissue Plasticity of Obesity

Susanne Mandrup (Organizer), Lars Grøntved (Chairman), Kim Ravnskjær (Chairman), Blagoy Blagoev (Chairman), Jesper Grud Skat Madsen (Chairman), Aleksander Krag (Chairman), Søren Kragh Moestrup (Chairman), Jonas Heilskov Graversen (Chairman)
30. Jun 20191. Jul 2019

Activity: Attending an eventOrganisation or participation in workshops, courses or seminars

Hepatic deconstruction - listening in on the cellular symphony of disease

Kim Ravnskjær (Lecturer)
30. Nov 2016

Activity: Talks and presentationsTalks and presentations in private or public companies

Hepatic deconstruction: Behind the scenes of hepatic fibrosis

Kim Ravnskjær (Lecturer)
29. Jun 2016

Activity: Talks and presentationsTalks and presentations in private or public companies

2nd International Symposium on Mesenchymal Stem Cell Differentiation

Kim Ravnskjær (Organizer)
27. Jun 2016

Activity: Attending an eventConference organisation or participation

First year projects - Poster session

Kim Ravnskjær (Organizer)
10. Jun 2016

Activity: Attending an eventOrganisation or participation in workshops, courses or seminars