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Research Output 1998 2019

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Journal article
2008

Power for genetic association study of human longevity using the case-control design

Tan, Q., Zhao, J. H., Zhang, D., Kruse, T. A. & Christensen, K., 15. Oct 2008, In : American Journal of Epidemiology. 168, 8, p. 890-896 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Association Studies
Alleles
Sample Size
2007

Arrayed primer extension in the "array of arrays" format: a rational approach for microarray-based SNP genotyping

Klitø, N. G. F., Tan, Q., Nyegaard, M., Brusgaard, K., Thomassen, M., Skouboe, C., Dahlgaard, J. & Kruse, T. A., 1. Jan 2007, In : Genetic Testing. 11, 2, p. 160-6 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Linkage Disequilibrium
HapMap Project
Chromosome Mapping
Databases
Population

Comparison of gene sets for expression profiling: prediction of metastasis from low-malignant breast cancer

Thomassen, M., Tan, Q., Eiriksdottir, F., Bak, M., Cold, S. & Kruse, T. A., 15. Sep 2007, In : Clinical Cancer Research. 13, 18 Pt 1, p. 5355-5360 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene Expression Profiling
Neoplasms

dlk1/FA1 regulates the function of human bone marrow mesenchymal stem cells by modulating gene expression of pro-inflammatory cytokines and immune response-related factors

Abdallah, B. M., Boissy, P., Tan, Q., Dahlgaard, J., Traustadottir, G. A., Kupisiewicz, K., Laborda, J., Delaisse, J-M. & Kassem, M., 9. Mar 2007, In : Journal of Biological Chemistry. 282, 10, p. 7339-7351 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Mesenchymal Stromal Cells
Gene expression
Bone
Cytokines

Feature selection for predicting tumor metastasis in microarray experiments using paired design

Tan, Q., Thomassen, M. & Kruse, T., 2007, In : Cancer Informatics. 3, p. 213-218

Research output: Contribution to journalJournal articleResearchpeer-review

Gene expression in epithelial ovarian cancer: A study of intra-tumor heterogeneity

Jochumsen, K. M., Tan, Q., Hølund, B., Kruse, T. & Mogensen, O., 1. Sep 2007, In : International Journal of Gynecological Cancer. 17, 5, p. 979-985 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mining gene networks with application to GAW15 problem 1

Zhao, J. H., Luan, J., Baksh, F. & Tan, Q., 2007, In : B M C Proceedings. 1, Suppl. 1, p. 52

Research output: Contribution to journalJournal articleResearchpeer-review

Prediction of metastasis from low-malignant breast cancer by gene expression profiling

Thomassen, M., Tan, Q., Eiriksdottir, F., Bak, M., Cold, S. & Kruse, T. A., 1. Mar 2007, In : International Journal of Cancer. 120, 5, p. 1070-1075 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene Expression Profiling
Neoplasms
Guidelines

Reduced expression of nuclear-encoded genes involved in mitochondrial oxidative metabolism in skeletal muscle of insulin-resistant women with polycystic ovary syndrome

Skov, V., Glintborg, D., Knudsen, S., Kruse, T. A., Jensen, T., Tan, Q., Brusgaard, K., Beck-Nielsen, H. & Højlund, K., 1. Sep 2007, In : Diabetes. 56, 9, p. 2349-2355 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Skeletal Muscle
Insulin
Oxidative Phosphorylation
Insulin Resistance

Retrospective analysis of main and interaction effects in genetic association studies of human complex traits

Tan, Q., Christiansen, L., Brasch-Andersen, C., Zhao, J. H., Li, S., Kruse, T. A. & Christensen, K., 2007, In : BMC Genetics. 8, p. 70

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Association Studies
Logistic Models
Alleles
Environmental Exposure
Sample Size

RNA quality and gene expression analysis of ovarian tumor tissue undergoing repeated thaw-freezing

Jochumsen, K. M., Tan, Q., Dahlgaard, J., Kruse, T. A. & Mogensen, O., 1. Feb 2007, In : Experimental and Molecular Pathology. 82, 1, p. 95-102 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene expression
Freezing
Tumors
RNA
Tissue
2006

A genome-wide linkage search for bipolar disorder susceptibility loci in a large and complex pedigree from the eastern part of Cuba

Marcheco-Teruel, B., Flint, T. J., Wikman, F. P., Torralbas, M., Gonzalez, L., Blanco, L., Tan, Q., Ewald, H., Ørntoft, T., Kruse, T., Børglum, A. D. & Mors, O., 2006, In : American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics. 141B, 8, p. 833-843

Research output: Contribution to journalJournal articleResearchpeer-review

Candidate gene polymorphisms in the serotonergic pathway: influence on depression symptomatology in an elderly population

Christiansen, L., Tan, Q., Iachina, M., Bathum, L., Kruse, T., McGue, M. & Christensen, K., 2006, In : Biological Psychiatry. 61, 2, p. 223-239

Research output: Contribution to journalJournal articleResearchpeer-review

Depression
Population
Vesicular Monoamine Transport Proteins
Haplotypes

Design and analysis in genetic studies of human ageing and longevity

Tan, Q., Kruse, T. & Christensen, K., 2006, In : Ageing Research Reviews. 5, 4, p. 371-387

Research output: Contribution to journalJournal articleResearchpeer-review

Medical Genetics
Genotyping Techniques
Aging of materials
Human Genome Project
Sampling Studies

Genetic Association Analysis of Human Longevity in Cohort Studies of Elderly Subjects: An Example of the PON1 Gene in the Danish 1905 Birth Cohort

Tan, Q., Christiansen, L., Bathum, L., Li, S., Kruse, T. & Christensen, K., 2006, In : Genetics. 172, 3, p. 1821-1828

Research output: Contribution to journalJournal articleResearchpeer-review

Cohort Studies
Haplotypes
Aryldialkylphosphatase
Selection Bias
Computer Simulation

Genetic dissection of complex traits in silico: Approaches, problems and solutions

Zhao, J. H. & Tan, Q., 2006, In : Current Bioinformatics. 1, 3, p. 359-369

Research output: Contribution to journalJournal articleResearchpeer-review

Heat-Shock Protein 70 Genes and Human Longevity. A View from Denmark

Singh, R., Kølvraa, S., Bross, P., Christensen, K., Gregersen, N., Tan, Q., Birk Jensen, U., Eiberg, H. & Rattan, S. I. A., 2006, In : Annals of the New York Academy of Sciences. 1067, 1, p. 301-308

Research output: Contribution to journalJournal articleResearchpeer-review

HSP70 Heat-Shock Proteins
Denmark
Polymorphism
Blood
Nucleotides

Integrated analysis of genetic data with R

Zhao, J. H. & Tan, Q., 2006, In : Human Genomics. 2, 4, p. 258-265

Research output: Contribution to journalJournal articleResearchpeer-review

Reduced heat shock response in human mononuclear cells during aging and its association with polymorphisms in HSP70 genes

Singh, R., Kølvraa, S., Bross, P., Jensen, U. B., Gregersen, N., Tan, Q., Knudsen, C. & Rattan, S. I. S., 2006, In : Cell Stress & Chaperones. 11, 3, p. 208-215 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Heat-Shock Response
Cell Aging
Polymorphism
Genes
Aging of materials

Significant linkage to chromosome 12q24.32-q24.33 and identification of SFRS8 as a possible asthma susceptibility gene

Andersen, C. B., Tan, Q., Børglum, A. D., Haagerup, A., Larsen, T. R., Vestbo, J. & Kruse, T., 2006, In : Thorax. 61, 10, p. 874-879

Research output: Contribution to journalJournal articleResearchpeer-review

Spotting and validation of a genome wide oligonucleotide chip with duplicate measurement of each gene

Thomassen, M., Skov, V., Eiriksdottir, F., Tan, Q., Jochumsen, K. M., Fritzner, N. G., Brusgaard, K., Dahlgaard, J. & Kruse, T., 2006, In : Biochemical and Biophysical Research Communications. 344, p. 1111-1120

Research output: Contribution to journalJournal articleResearchpeer-review

2005

A non-parametric approach for identifying differentially expressed genes in factorial microarray experiments

Tan, Q., Dahlgaard, J., Kassem, M., Vach, W. & Kruse, T., 2005, In : Genome Biology. 6, 4, p. 5

Research output: Contribution to journalJournal articleResearchpeer-review

Estimating haplotype relative risks on human survival in population-based association studies

Tan, Q., Christiansen, L., Bathum, L., Zhao, J. H., Yashin, A. I., Vaupel, J. W., Christensen, K. & Kruse, T., 2005, In : Human Heredity. 59, 2, p. 88-97

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotypes
Population
Linkage Disequilibrium
Chromosome Mapping
Statistical Models

Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins.

Tan, Q., Christensen, K., Christiansen, L., Frederiksen, H. B., Bathum, L., Dahlgaard, J. & Kruse, T., 2005, In : Human Genetics. 117, 2-3, p. 262-274

Research output: Contribution to journalJournal articleResearchpeer-review

Monozygotic Twins
Dizygotic Twins
Gene Ontology
Population Genetics

Haplotype association analysis of human disease traits using genotype data of unrelated individuals

Tan, Q., Christiansen, L., Christensen, K., Bathum, L., Li, S., Zhao, JH. & Kruse, T. A., 2005, In : Genetics Research. 86, 03, p. 223 - 231

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotypes
Logistic Models
Chromosome Mapping
Linkage Disequilibrium
Medical Genetics
Haplotypes
Longitudinal Studies
Single Nucleotide Polymorphism
Proteins
Population
2004

Apolipoprotein E genotype frequency patterns in aged Danes as revealed by logistic regression models

Tan, Q., Christiansen, L., Christensen, K., Kruse, T. & Bathum, L., 2004, In : European Journal of Epidemiology. 19, 7, p. 651-656

Research output: Contribution to journalJournal articleResearchpeer-review

Logistic Models
Alleles
Dominant Genes
Research Design
Age Groups

Assessing genetic association with human survival at multi-allelic loci

Tan, Q., De Benedictis, G., Yashin, I. A., Bathum, L., Christiansen, L., Dahlgaard, J., Frizner, N., Vach, W., Vaupel, J. W., Christensen, K. & Kruse, T., 2004, In : Biogerontology. 5, 2, p. 89-97

Research output: Contribution to journalJournal articleResearchpeer-review

Alleles
Genetic Selection
Survival Analysis
Renin
Research

Atopic dermatitis: a total genome-scan for susceptibility genes

Haagerup, A., Bjerke, T., Schiøtz, P. O., Dahl, R., Binderup, H. G., Tan, Q. & Kruse, T. A., 2004, In : Acta Dermato-Venereologica. 84, 5, p. 346-352

Research output: Contribution to journalJournal articleResearchpeer-review

Atopic Dermatitis
Hypersensitivity
Genetic Research
Incidence

Correspondance analysis of microarray time-course data in case control design

Tan, Q., Brusgaard, K., Kruse, T., Oakley, E., Hemmings, B., Beck-Nielsen, H., Hansen, L. & Gaster, M., 2004, In : Journal of Biomedical Informatics. 37, p. 358-365

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotype effects on human survival: logistic regression models applied to unphased genotype data

Tan, Q., Christiansen, L., Bathum, L., Zhao, J. H., Vach, W., Vaupel, J. W., Christensen, K. & Kruse, T., 2004, In : Annals of Human Genetics. 69, Pt 2, p. 168-175

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotypes
Logistic Models
Linkage Disequilibrium
Chromosome Mapping
Medical Genetics

Multidisciplinary Approaches in Genetic Studies on Human Aging and Longevity

Tan, Q., Yashin, A. I., Christensen, K., Jeune, B., De Benedictis, G., Kruse, T. & Vaupel, J. W., 2004, In : Current Genomics. 5, 5, p. 409-416

Research output: Contribution to journalJournal articleResearchpeer-review

Population Genetics
Research

Possible gene dosage effect of glutathione-S-transferases on atopic asthma: Using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers

Andersen, C. B., Christiansen, L., Tan, Q., Haagerup, A., Vestbo, J. & Kruse, T., 1. Sep 2004, In : Human Mutation. 24, 3, p. 208-214

Research output: Contribution to journalJournal articleResearchpeer-review

Real-Time Polymerase Chain Reaction
Enzymes

Power of non-parametric linkage analysis in mapping genes contributing to human longevity in long-lived sib-pairs

Tan, Q., Zhao, J. H., Iachine, I., Hjelmborg, J., Vach, W., Vaupel, J. W., Christensen, K. & Kruse, T. A., 1. Apr 2004, In : Genetic Epidemiology. 26, 3, p. 245-253 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Sample Size
Dominant Genes
Statistical Models
Alleles
2003

Logistic regression models for polymorphic and antagonistic pleiotropic gene action on human aging and longevity

Tan, Q., Bathum, L., Christiansen, L., De Benedictis, G., Dahlgaard, J., Frizner, N., Vach, W., Vaupel, J. W., Yashin, A. I., Christensen, K. & Kruse, T. A., 1. Nov 2003, In : Annals of Human Genetics. 67, Pt 6, p. 598-607 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Logistic Models
Alleles

Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly

Rose, G., Dato, S., Altomare, K., Bellizzi, D., Garasto, S., Greco, V., Passarino, G., Feraco, E., Mari, V., Barbi, C., BonaFe, M., Franceschi, C., Tan, Q., Boiko, S., Yashin, AI. & Benedictis, G., Oct 2003, In : Experimental Gerontology. 38, 10, p. 1065-70 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2002
Case-Control Studies

A centenarian-only approach for assessing gene-gene interaction in human longevity

Tan, Q., De Benedictis, G., Ukraintseva, S. V., Franceschi, C., Vaupel, J. W. & Yashin, A. I., 2002, In : European Journal of Human Genetics. 10(2), p. 119-24

Research output: Contribution to journalJournal articleResearchpeer-review

Haplotypes
Mitochondrial Genes
Alleles
Population

DNA-chips revolutionerer lægevidenskaben

Dahlgaard, J., Fritzner, N. G., Tan, Q. & Kruse, T., 2002, In : Aktuel Naturvidenskab. 1, p. 19-21

Research output: Contribution to journalJournal articleResearchpeer-review

The influences on human longevity by HUMTHO1.STR polymorphism (Tyrosine Hydroxylase gene): A relative risk approach

Tan, Q., Bellizzi, D., Rose, G., Garasto, S., Franceschi, C., Kruse, T., Vaupel, J. W., De Benedictis, G. & Yashin, A. I., 2002, In : Mechanisms of Ageing and Development. 123, 10, p. 1403-10

Research output: Contribution to journalJournal articleResearchpeer-review

Tyrosine 3-Monooxygenase
Alleles
2001

A logistic regression model for measuring gene-longevity associations

Tan, Q., Yashin, A. I., De Benedictis, G., Cintolesi, F., Rose, G., Bonafe, M., Francheschi, C., Vach, W. & Vaupel, J. W., 2001, In : Clinical Genetics. 60, p. 463-469

Research output: Contribution to journalJournal articleResearchpeer-review

Logistic Models
Research

Measuring the genetic influence on human life span: gene-environment interaction and sex-specific genetic effects

Tan, Q., De Benedictis, G., Yashin, A., Bonafe, M., DeLuca, M., Valensin, S., Vaupel, J. W. & Franceschi, F., 2001, In : Biogerontology. 2, p. 141 - 153 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene-Environment Interaction

Recent advances in human gene-longevity association studies

De Benedictis, G., Tan, Q., Jeune, B., Christensen, K., Ukraintseva, S. V., Bonafè, M., Franceschi, C., Vaupel, J. W. & Yashin, A. I., 15. Jul 2001, In : Mechanisms of Ageing and Development. 122, 9, p. 909-920 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Epidemiology
Research Personnel

Replication studies in longevity: Puzzling findings in Danish centenarians at the 3'APOB-VNTR locus

Varcasia, O., Garasto, S., Rizza, T., Andersen-Ranberg, K., Jeune, B., Bathum, L., Andreev, K., Tan, Q., Yashin, A. I., Bonafè, M., Franceschi, C. & De Benedictis, G., 1. Jul 2001, In : Annals of Human Genetics. 65, Pt 4, p. 371-376 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Minisatellite Repeats
Alleles
Population Genetics
Denmark
Italy

Variations of cardiovascular disease associated genes exhibit sex-dependent influence on human longevity

Tan, Q., Yashin, A. I., Bladbjerg, E. M., Maat, M. D., Andersen-Ranberg, K., Jeune, B., Christensen, K. & Vaupel, J. W., Aug 2001, In : Experimental Gerontology. 36, 8, p. 1303-1315

Research output: Contribution to journalJournal articleResearchpeer-review

Factor VII
Angiotensinogen
Genes
Alleles
Chemical vapor deposition
2000

Genes and Longevity: Lessons from Studies of Centenarians

Yashin, AI., De Benedictis, G., Vaupel, JW., Tan, Q., Andereev, KF., Iachine, IA., Bonafe, M., Valensin, S., De Luca, M., Carotenuto, L. & Franceschi, C., 2000, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 55, 7, p. B319 - 328 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Markers
Alleles
Age Groups
Research
Population
1999

Genes, Demography, and Life Span: The Contribution of Demographic Data in Genetic Studies on Aging and Longevity

Yashin, AI., De Benedictis, G., Vaupel, JW., Tan, Q., Andreev, KF., Iachine, IA., Monafe, M., DeLuca, M., Valensin, S., Carotenuto, L. & Franceschi, C., 1999, In : American Journal of Human Genetics. 65, 4, p. 1178-1193 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Markers
Age Groups
Population
1998

Combining genetic and demographic information in population studies of aging and longevity

Yashin, AI., Vaupel, JW., Andereev, AF., Tan, Q., Iachine, IA., Carotenuto, L., De Benedictis, G., Bonafe, M., Valensin, S. & Franceschi, C., 1998, In : Journal of Epidemiology and Biostatistics. 3, 3, p. 289-294 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review