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Research Output 1998 2019

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Journal article
2013

A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family

Tan, Q., Sørensen, M., Kruse, T. A., Christensen, K. & Christiansen, L., 2013, In : Aging Cell. 12, 4, p. 690-694

Research output: Contribution to journalJournal articleResearchpeer-review

Single Nucleotide Polymorphism
Population
Datasets

Association of serum uric acid level with muscle strength and cognitive function among Chinese aged 50-74 years

Wu, Y., Zhang, D., Pang, Z., Jiang, W., Wang, S. & Tan, Q., 2013, In : Geriatrics & Gerontology International. 13, 3, p. 672-677

Research output: Contribution to journalJournal articleResearchpeer-review

Uric Acid
Cognition
regression
comorbidity
Caucasian

Circulating surfactant protein D is associated to mortality in elderly women: A twin study

Johansson, H. W., Thinggaard, M., Tan, Q., Johansson, S. L., Schlosser, A., Christensen, K., Holmskov, U. & Sorensen, G. L., 2013, In : Immunobiology. 218, 5, p. 712-717

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Twin Studies
Confidence Intervals
Lung
Survival Analysis

Classifications within Molecular Subtypes Enables Identification of BRCA1/BRCA2 Mutation Carriers by RNA Tumor Profiling

Larsen, M. J., Kruse, T. A., Tan, Q., Lænkholm, A-V., Bak, M., Lykkesfeldt, A. E., Sørensen, K. P., Hansen, T. V. O., Ejlertsen, B., Gerdes, A-M. & Thomassen, M., 2013, In : P L o S One. 8, 5, p. e64268

Research output: Contribution to journalJournal articleResearchpeer-review

Tumors
RNA
mutation
Mutation
neoplasms
Cognition
Alleles
Mental Health

Epigenetic Epidemiology of Complex Diseases Using Twins

Tan, Q., Jan 2013, In : Medical Epigenetics. 1, p. 46-51

Research output: Contribution to journalJournal articleResearchpeer-review

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Suchiman, H. E. D., Jacobsen, R., McGue, M., Stevnsner, T. V., Bohr, V., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K. & Christiansen, L., 2013, In : Age (Omaha). 35, 2, p. 487-500

Research output: Contribution to journalJournal articleResearchpeer-review

Longitudinal Studies
Case-Control Studies
Interleukin-6
Single Nucleotide Polymorphism
Haplotypes

Gene expression signatures that predict outcome of tamoxifen-treated estrogen receptor-positive, high-risk, primary breast cancer patients: A DBCG study

Lyng, M. B., Lænkholm, A-V., Tan, Q., Vach, W., Gravgaard, K. H., Knoop, A. & Ditzel, H. J., 2013, In : P L o S One. 8, 1, p. e54078

Research output: Contribution to journalJournal articleResearchpeer-review

tamoxifen
Tamoxifen
Transcriptome
Gene expression
Estrogen Receptors

Genetic Alterations within the DENND1A Gene in Patients with Polycystic Ovary Syndrome (PCOS)

Eriksen, M. B., Nielsen, M. F. B., Brusgaard, K., Tan, Q., Andersen, M. S., Glintborg, D. & Gaster, M., 2013, In : PLOS ONE. 8, 9, p. e77186

Research output: Contribution to journalJournal articleResearchpeer-review

polycystic ovary syndrome
Polycystic Ovary Syndrome
Polymorphism
Nucleotides
Genes

Genetic investigation into ethnic disparity in polycystic ovarian syndrome

Li, S., Zhu, D., Duan, H. & Tan, Q., 2013, In : Gynecological Endocrinology. 29, 10, p. 878-882

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Population
Genetic Association Studies
DNA Sequence Analysis
Epigenomics

Genome-wide linkage analysis for human longevity: Genetics of Healthy Aging Study

Beekman, M., Blanché, H., Perola, M., Hervonen, A., Bezrukov, V., Sikora, E., Flachsbart, F., Christiansen, L., De Craen, A. J. M., Kirkwood, T. B. L., Rea, I. M., Poulain, M., Robine, J-M., Valensin, S., Stazi, M. A., Passarino, G., Deiana, L., Gonos, E. S., Paternoster, L., Sørensen, T. & 21 others, Tan, Q., Helmer, Q., van den Akker, E. B., Deelen, J., Martella, F., Cordell, H. J., Ayers, K. L., Vaupel, J. W., Törnwall, O., Johnson, T. E., Schreiber, S., Lathrop, M., Skytthe, A., Westendorp, R. G. J., Christensen, K., Gampe, J., Nebel, A., Houwing-Duistermaat, J. J., Slagboom, P. E., Franceschi, C. & GEHA consortium, 2013, In : Aging Cell. 12, 2, p. 184-93

Research output: Contribution to journalJournal articleResearchpeer-review

Medical Genetics
Alleles
Genome-Wide Association Study
Meta-Analysis
Siblings

Heritability of eleven metabolic phenotypes in Danish and Chinese twins: A cross-population comparison

Li, S., Duan, H., Pang, Z., Zhang, D., Duan, H., von Bornemann Hjelmborg, J., Tan, Q., Kruse, T. A. & Kyvik, K. O., Sep 2013, In : Obesity. 21, 9, p. 1908-14 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Interactions between Social/ behavioral factors and ADRB2 genotypes may be associated with health at advanced ages in China

Zeng, Y., Cheng, L. G., Zhao, L., Tan, Q. H., Feng, Q. S., Chen, H. S., Shen, K., Li, J. X., Zhang, F. Y., Cao, H. Q., Gregory, S. G., Yang, Z., Gu, J., Tao, W., Tian, X. L. & Hauser, E. R., 2013, In : B M C Geriatrics. 13, 13 p., 91.

Research output: Contribution to journalJournal articleResearchpeer-review

China
Alleles
Cognition
Health
Leisure Activities
Long Noncoding RNA
Antisense RNA
Neoplasms
Liver Neoplasms
Survival Analysis

The Danish Twin Registry: Linking surveys, national registers, and biological information

Skytthe, A., Christiansen, L., Kyvik, K. O., Bødker, F. L., Hvidberg, L., Petersen, I., Nielsen, M. M. F., Bingley, P., Hjelmborg, J., Tan, Q., Holm, N. V., Vaupel, J. W., McGue, M. & Christensen, K., Feb 2013, In : Twin Research and Human Genetics. 16, 1, p. 104-11 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Registries
Research
Denmark
Surveys and Questionnaires
Health

The Qingdao Twin Registry: A status update

Duan, H., Ning, F., Zhang, D., Wang, S., Zhang, D., Tan, Q., Tian, X. & Pang, Z., 2013, In : Twin Research and Human Genetics. 16, 1, p. 79-85

Research output: Contribution to journalJournal articleResearchpeer-review

Registries
Genome-Wide Association Study
Health Behavior
Denmark
Finland

Twins for epigenetic studies of human aging and development

Tan, Q., Christiansen, L., Thomassen, M., Kruse, T. A. & Christensen, K., 2013, In : Ageing Research Reviews. 12, 1, p. 182-187

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Epigenomics
Genes
Aging of materials
DNA sequences
2012

A cross-sectional analysis of age and sex patterns in grip strength, tooth loss, near vision and hearing levels in Chinese aged 50-74 years

Wu, Y., Pang, Z., Zhang, D., Jiang, W., Wang, S., Li, S., Kruse, T. A., Christensen, K. & Tan, Q., 3. Sep 2012, In : Archives of Gerontology and Geriatrics. 54, 2, p. e213-e220

Research output: Contribution to journalJournal articleResearchpeer-review

Tooth Loss
Hearing
Cross-Sectional Studies
Sex Characteristics
Visual Acuity
Hirsutism
Polycystic Ovary Syndrome
Single Nucleotide Polymorphism
Referral and Consultation
Endocrine System Diseases

Gender-specific patterns in age-related decline in general health among Danish and Chinese: A cross-national comparative study

Wu, Y., Zhang, D., Pang, Z., Oksuzyan, A., Jiang, W., Wang, S., Li, S., Kruse, T., Christensen, K. & Tan, Q., 2012, In : Geriatrics & Gerontology International. 12, 3, p. 431-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

gender
Health
health
Population
Dane

Gene expression profiles for predicting metastasis in breast cancer: A cross-study comparison of classification methods

Burton, M., Thomassen, M., Tan, Q. & Kruse, T. A., 2012, In : Scientific World Journal. 2012, p. 380495 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis

Soerensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., Andersen-Ranberg, K., Stevnsner, T. V., Bohr, V., Kimura, M., Aviv, A., Christensen, K. & Christiansen, L., Apr 2012, In : Aging Cell. 11, 2, p. 223-7 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Telomerase
Telomere
Cross-Sectional Studies
Single Nucleotide Polymorphism
Haplotypes

Genome-wide linkage and association scans for pulse pressure in Chinese twins

Zhang, D., Pang, Z., Li, S., Jiang, W., Wang, S., Thomassen, M., von Bornemann Hjelmborg, J., Kruse, T. A., Ohm Kyvik, K., Christensen, K., Zhu, G. & Tan, Q., 2012, In : Hypertension Research. 35, p. 1051-1057

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Genome-Wide Association Study
Dizygotic Twins
Population
China

Heritability and whole genome linkage of pulse pressure in Chinese twin pairs

Jiang, W., Zhang, D., Pang, Z., Li, S., Duan, H., Wang, S. & Tan, Q., 2012, In : Twin Research and Human Genetics. 15, 6, p. 759-766

Research output: Contribution to journalJournal articleResearchpeer-review

Lod Score
Population
Chromosomes, Human, Pair 18
Dizygotic Twins
Chromosomes, Human, Pair 12

High-Resolution Genome-Wide Linkage Mapping Identifies Susceptibility Loci for BMI in the Chinese Population

Zhang, D. F., Pang, Z., Li, S., Thomassen, M., Wang, S., Jiang, W., Hjelmborg, J. V. B., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., Apr 2012, In : Obesity. 20, 4, p. 830-3 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Lod Score
Population
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 14

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Jacobsen, R., Suchiman, H. E. D., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Stevnsner, T. V., Bohr, V., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K., McGue, M. & Christiansen, L., May 2012, In : Experimental Gerontology. 47, 5, p. 379-87 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Insulin-Like Growth Factor I
Single Nucleotide Polymorphism
Longitudinal Studies
Repair
Cross-Sectional Studies

Prediction of breast cancer metastasis by gene expression profiles: A comparison of metagenes and single genes

Burton, M., Thomassen, M., Tan, Q. & Kruse, T. A., 2012, In : Cancer Informatics. 11, p. 193-217 25 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Twin-based DNA methylation analysis takes the center stage of studies of human complex diseases

Zhang, D., Li, S., Tan, Q. & Pang, Z., 2012, In : Journal of Genetics and Genomics. 39, 11, p. 581-6 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

DNA Methylation
Epigenomics
Twin Studies
Environmental Exposure
2011

A growth curve model with fractional polynomials for analysing incomplete time-course data in microarray gene expression studies

Tan, Q., Thomassen, M., Hjelmborg, J. V. B., Clemmensen, A., Andersen, K. E., Petersen, T. K., McGue, M., Christensen, K. & Kruse, T. A., 27. Sep 2011, In : Advances in Bioinformatics. 2011, Article ID 261514, 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microarrays
Gene expression
Genes
Polynomials
Growth

Genetic and environmental dissections of sub-phenotypes of metabolic syndrome in the chinese population: a twin-based heritability study

Duan, H., Pang, Z., Zhang, D., Li, S., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., 2011, In : Obesity Facts. 4, 2, p. 99-104 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Population
structural model
LDL Cholesterol
municipality
Lipids

Investigation of archived formalin-fixed paraffin-embedded pancreatic tissue with whole-genome gene expression microarray

Michelsen, N. V., Brusgaard, K., Tan, Q., Thomassen, M., Hussain, K. & Christensen, H. T., Dec 2011, In : Pathology. 2011, 275102, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

[Heritability analysis on serum lipids of adult twins in Qingdao City]: Article in Chinese

Translated title of the contribution: [Heritability analysis on serum lipids of adult twins in Qingdao City]Lan, J., Pang, Z., Wang, S., Zhang, H., Duan, H., Zhang, D., Tan, Q. & Zhang, D., 1. May 2010, In : Weisheng Yanjiu. 39, 3, p. 291-4 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

LDL Cholesterol
HDL Cholesterol
Lipids
Serum
Fasting

Anti-Inflammatory Heat Shock Protein 70 Genes are Positively Associated with Human Survival

Singh, R., Kølvraa, S., Bross, P. G., Christensen, K., Bathum, L., Gregersen, N., Tan, Q. & Rattan, S., 2010, In : Current Pharmaceutical Design. 16, 7, p. 796-801 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

HSP70 Heat-Shock Proteins
Haplotypes
Heat-Shock Response
Survival Analysis
Single Nucleotide Polymorphism

Dissecting complex phenotypes using the genomics of twins

Tan, Q., Ohm Kyvik, K., Kruse, T. A. & Christensen, K., Aug 2010, In : Functional & Integrative Genomics. 10, 3, p. 321-7 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Genetic Markers
Computational Biology
Epigenomics
Research Design

Effects of FOXO Genotypes on Longevity: A Biodemographic Analysis

Zeng, Y., Cheng, L., Chen, H., Cao, H., Hauser, E. R., Liu, Y., Xiao, Z., Tan, Q., Tian, X-L. & Vaupel, J. W., Dec 2010, In : Journals of Gerontology. Series A: Biological Sciences & Medical Sciences. 65, 12, p. 1285-99

Research output: Contribution to journalJournal articleResearchpeer-review

Genome-Wide Expression Analysis of Human In Vivo Irritated Epidermis: Differential Profiles Induced by Sodium Lauryl Sulfate and Nonanoic Acid

Clemmensen, A., Andersen, K. E., Clemmensen, O., Tan, Q., Petersen, T. K., Kruse, T. A. & Thomassen, M., Sep 2010, In : Journal of Investigative Dermatology. 130, 9, p. 2201-10 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Irritant Dermatitis
Irritants
Contact Dermatitis
Epidermis
Sodium Dodecyl Sulfate

Heritability of serum uric acid in adult twins

Duan, H-P., Pang, Z-C., Zhang, D-F., Wang, S-J., Zhai, Y-M., Zhang, D. & Tan, Q., 1. Apr 2010, In : Chinese Journal of Epidemiology. 31, 4, p. 384-8 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Multivariate modelling of endophenotypes associated with the metabolic syndrome in Chinese twins

Pang, Z., Zhang, D., Li, S., Duan, H., Hjelmborg, J., Kruse, T. A., Kyvik, K. O., Christensen, K. & Tan, Q., 29. Sep 2010, In : Diabetologia. 53, 12, p. 2554-2561

Research output: Contribution to journalJournal articleResearchpeer-review

Endophenotypes
Lipids
Fasting
Multivariate Analysis

Power assessment for genetic association study of human longevity using offspring of long-lived subjects

Tan, Q., Zhao, J. H., Li, S., Kruse, T. A. & Christensen, K., Jul 2010, In : European Journal of Epidemiology. 25, 7, p. 501-6 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Genetic Association Studies
Sample Size
Proportional Hazards Models
Computer Simulation
Single Nucleotide Polymorphism
2009

A combinatory approach for selecting prognostic genes in microarray studies of tumour survivals

Tan, Q., Thomassen, M., Jochumsen, K. M., Mogensen, O., Christensen, K. & Kruse, T. A., 2009, In : Advances in Bioinformatics. 2009, p. 480-486 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Microarrays
Tumors
Genes
Gene expression
Feature extraction
Depression
Chromosomes, Human, Pair 12
Longitudinal Studies
Reference Values

Extraction of high-quality epidermal RNA after ammonium thiocyanate-induced dermo-epidermal separation of 4 mm human skin biopsies

Clemmensen, A., Thomassen, M., Clemmensen, O., Tan, Q., Kruse, T. A., Petersen, T. K., Andersen, F. & Andersen, K. E., 23. Jul 2009, In : Experimental Dermatology. 18, 11, p. 979-984

Research output: Contribution to journalJournal articleResearchpeer-review

RNA
Skin
Cystatin M
Dermis
Epidermis

Gene expression meta-analysis identifies chromosomal regions and candidate genes involved in breast cancer metastasis

Thomassen, M., Tan, Q. & Kruse, T., 1. Jan 2009, In : Breast Cancer Research and Treatment. 113, 2, p. 239-249 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Gene expression meta-analysis identifies chromosomal regions involved in ovarian cancer survival

Thomassen, M., Jochumsen, K. M., Mogensen, O., Tan, Q. & Kruse, T. A., 1. Aug 2009, In : Genes, Chromosomes & Cancer. 48, 8, p. 711-24 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Ovarian Neoplasms
Meta-Analysis
Mutation
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 7

Gene Expression Profiles as Prognostic Marker in Women with Ovarian Cancer

Jochumsen, K. M., Tan, Q., Høgdall, EV., Høgdall, C., Kjær, SK., Blaakær, O., Kruse, T. & Mogensen, O., 1. Oct 2009, In : International Journal of Gynecological Cancer. 19, 7, p. 1205-1213

Research output: Contribution to journalJournal articleResearchpeer-review

Transcriptome
Ovarian Neoplasms
Survivors
Gynecology
Obstetrics
2008

Combined experimental and statistical strategy for mass spectrometry based serum protein profiling for diagnosis of breast cancer: a case-control study

Callesen, A. K., Vach, W., Jørgensen, P. E., Cold, S., Tan, Q., Depont Christensen, R., Mogensen, O., Kruse, T., Madsen, J. S. & Jensen, O. N., 1. Apr 2008, In : Journal of Proteome Research. 7, 4, p. 1419-1426 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Mass spectrometry
Case-Control Studies
Blood Proteins
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Serum

Differential and correlation analyses of microarray gene expression data in the CEPH Utah families

Tan, Q., Zhao, J., Li, S., Christiansen, L., Kruse, T. & Christensen, K., 1. Aug 2008, In : Genomics. 92, 2, p. 94-100 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

X Chromosome Inactivation
Age Groups
Medicine

Gene expression meta-analysis identifies metastatic pathways and transcription factors in breast cancer

Thomassen, M., Tan, Q. & Kruse, T., 30. Dec 2008, In : BMC Cancer. 8, 1, p. 394

Research output: Contribution to journalJournal articleResearchpeer-review

Meta-Analysis
Neoplasms
Proteasome Endopeptidase Complex
Metabolic Networks and Pathways
Epidermal Growth Factor

Pioglitazone enhances mitochondrial biogenesis and ribosomal protein biosynthesis in skeletal muscle in polycystic ovary syndrome

Skov, V., Glintborg, D., Knudsen, S., Tan, Q., Jensen, T., Kruse, T., Beck-Nielsen, H. & Højlund, K., 18. Jun 2008, In : PLoS ONE. 3, 6, p. e2466

Research output: Contribution to journalJournal articleResearchpeer-review

pioglitazone
polycystic ovary syndrome
Ribosomal Proteins
Polycystic Ovary Syndrome
Mitochondrial Proteins