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Research Output 1998 2019

2019
23 Downloads (Pure)

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., 2019, In : Aging Cell. 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Epigenomics
Sex Characteristics

DNA methylome profiling in identical twin pairs discordant for body mass index

Li, W., Zhang, D., Wang, W., Wu, Y., Mohammadnejad, A., Lund, J., Baumbach, J., Christiansen, L. & Tan, Q., 31. May 2019, In : International Journal of Obesity. 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Monozygotic Twins
Body Mass Index
DNA Methylation
Epigenomics
Adiposity
70 Downloads (Pure)

DNA methylome profiling of all-cause mortality in comparison with age-associated methylation patterns

Lund, J., Li, S., Baumbach, J., Svane, A. M., Hjelmborg, J. V. B., Christiansen, L., Christensen, K., Redmond, P., Marioni, R. E., Deary, I. J. & Tan, Q., 8. Feb 2019, In : Clinical Epigenetics. 11, 8 p., 23.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Genome-Wide Association Study
Survival Analysis
Proportional Hazards Models
Epigenomics
10 Downloads (Pure)

Enriched power of disease-concordant twin-case-only design in detecting interactions in genome-wide association studies

Li, W., Baumbach, J., Mohammadnejad, A., Brasch-Andersen, C., Vandin, F., Korbel, J. O. & Tan, Q., 1. Apr 2019, In : European Journal of Human Genetics. 27, 4, p. 631-636

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Dizygotic Twins
Genome-Wide Association Study
Sample Size
Siblings
Monozygotic Twins

Epigenetic association analysis of clinical sub-phenotypes in patients with polycystic ovary syndrome (PCOS)

Jacobsen, V. M., Li, S., Wang, A., Zhu, D., Liu, M., Thomassen, M., Kruse, T. A. & Tan, Q., 3. Aug 2019, In : Gynecological Endocrinology. 35, 8, p. 691-694

Research output: Contribution to journalJournal articleResearchpeer-review

Polycystic Ovary Syndrome
Epigenomics
DNA Methylation
HLA-G Antigens
Chromosomes, Human, Pair 19
85 Downloads (Pure)

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

Starnawska, A., Tan, Q., Sørensen, M., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2. Sep 2019, In : Translational Psychiatry. 9, 1, 14 p., 214.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Monozygotic Twins
Depression
DNA Methylation
Epigenomics
Flow Cytometry
31 Downloads (Pure)
Open Access
File
Monozygotic Twins
Cell Differentiation
HLA-C Antigens
Comb and Wattles
Nucleic Acid Regulatory Sequences

Genomisk medicin og kunstig intelligens

Translated title of the contribution: Genomic medicine and artificial intelligenceKruse, T. A., Larsen, M. J., Tan, Q., Andersen, L. & Thomassen, M., 1. Apr 2019, In : Ugeskrift for Laeger. 181, 7A, V02190085.

Research output: Contribution to journalJournal articleResearchpeer-review

Medicine
Datasets
Clinical Decision-Making

Global expression profiling of cognitive level and decline in middle-aged monozygotic twins

Nygaard, M., Larsen, M. J., Thomassen, M., McGue, M., Christensen, K., Tan, Q. & Christiansen, L., Dec 2019, In : Neurobiology of Aging. 84, p. 141-147

Research output: Contribution to journalJournal articleResearchpeer-review

Monozygotic Twins
Immune System Diseases
Transcriptome
Individuality
Cognition

Global microRNA profiling of metastatic conjunctival melanoma

Mikkelsen, L. H., Andersen, M., Andreasen, S., Larsen, A-C., Tan, Q., Toft, P. B., Wadt, K. & Heegaard, S., Oct 2019, In : Melanoma Research. 29, 5, p. 465-473

Research output: Contribution to journalJournal articleResearchpeer-review

MicroRNAs
Melanoma
Down-Regulation
Neoplasms
Referral and Consultation

Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study

Duan, H., Zhang, D., Liang, Y., Xu, C., Wu, Y., Tian, X., Pang, Z., Tan, Q., Li, S. & Qiu, C., 1. Mar 2019, In : Ear and Hearing. 40, 2, p. 253-259

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Hearing
Population
Dizygotic Twins
Developed Countries

Impact of obesity and physical inactivity on the long-term change in grip strength among middle-aged and older European adults

Wang, T., Feng, W., Li, S., Tan, Q., Zhang, D. & Wu, Y., 1. Jul 2019, In : Journal of Epidemiology & Community Health. 73, 7, p. 619-624

Research output: Contribution to journalJournal articleResearchpeer-review

Exercise
Retirement
Health Surveys
Surveys and Questionnaires

Longitudinal analysis of sibling correlation on blood pressure using mixed modeling

Tan, Q., Duan, H., Wang, A., Zhu, D. & Li, S., 2019, In : Annals of Epidemiology. 33, p. 49-53

Research output: Contribution to journalJournal articleResearchpeer-review

Longitudinal Studies
60 Downloads (Pure)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

Jylhävä, J., Hjelmborg, J., Sørensen, M., Munoz, E., Tan, Q., Kuja-Halkola, R., Mengel-From, J., Christensen, K., Christiansen, L., Hägg, S., Pedersen, N. L. & Reynolds, C. A., Feb 2019, In : EBioMedicine. 40, p. 710-716

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
Clocks
Research
DNA Methylation
Epidemiology

Network based analysis of microarray gene expression profiles in response to electroacupuncture

Mohammadnejad, A., Li, S., Duan, H. & Tan, Q., 2019, (Accepted/In press) In : Journal of Traditional and Complementary Medicine. 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Electroacupuncture
Transcriptome
Periaqueductal Gray
Gene Ontology
49 Downloads (Pure)

Sex and age specific reduction in stress resistance and mitochondrial DNA copy number in Drosophila melanogaster

Kristensen, T. N., Loeschcke, V., Tan, Q., Pertoldi, C. & Mengel-From, J., 23. Aug 2019, In : Scientific Reports. 9, 7 p., 12305.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
stress tolerance
Drosophila melanogaster
mitochondrial DNA
gender
age structure

The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins

The CODATwins Project, 13. Jul 2019, In : Twin Research and Human Genetics.

Research output: Contribution to journalJournal articleResearchpeer-review

Smoking
Term Birth
Education
Dizygotic Twins
Weights and Measures

The epigenome of twins as a perfect laboratory for studying behavioural traits

Tan, Q., 2019, In : Neuroscience & Biobehavioral Reviews. 107, p. 192-195

Research output: Contribution to journalReviewResearchpeer-review

epigenetics
human behavior
epidemiology
experimental design
environmental impact

Weak Grip Strength and Cognition Predict Functional Limitation in Older Europeans

Wang, T., Wu, Y., Li, W., Li, S., Sun, Y., Li, S., Zhang, D. & Tan, Q., Jan 2019, In : Journal of the American Geriatrics Society. 67, 1, p. 93-99

Research output: Contribution to journalJournal articleResearchpeer-review

Cognition
Linear Models
Retirement
Health Surveys
Israel
Twin Studies
2018
36 Downloads (Pure)

A Case-only Genome-Wide Association Study on Gene-Sex Interaction in Allergic Rhinitis

Mohammadnejad, A., Brasch-Andersen, C., Li, W., Haagerup, A., Baumbach, J. & Tan, Q., Sep 2018, In : Annals of Allergy, Asthma, & Immunology. 121, 3, p. 366-367.e2

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File

Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles

Andreasen, S., Tan, Q., Agander, T. K., Steiner, P., Bjørndal, K., Høgdall, E., Larsen, S. R., Erentaite, D., Olsen, C. H., Ulhøi, B. P., von Holstein, S. L., Wessel, I., Heegaard, S. & Homøe, P., Aug 2018, In : Modern Pathology. 31, 8, p. 1211–1225

Research output: Contribution to journalJournal articleResearchpeer-review

Lacrimal Apparatus
Adenoid Cystic Carcinoma
MicroRNAs
Neoplasms
Glandular and Epithelial Neoplasms

Age-dependent patterns of X chromosome DNA methylation in the elderly.

Li, S. & Tan, Q., 2018. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

DNA Methylation
X Chromosome Inactivation
Age Factors
Scotland
Epigenomics
59 Downloads (Pure)

Association of current and former smoking with body mass index: A study of smoking discordant twin pairs from 21 twin cohorts

Piirtola, M., Jelenkovic, A., Latvala, A., Sund, R., Honda, C., Inui, F., Watanabe, M., Tomizawa, R., Iwatani, Y., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Tarnoki, A. D., Tarnoki, D. L., Martin, N. G., Montgomery, G. W., Medland, S. E., Rasmussen, F., Tynelius, P., Tan, Q. & 30 others, Zhang, D., Pang, Z., Rebato, E., Stazi, M. A., Fagnani, C., Brescianini, S., Busjahn, A., Harris, J. R., Brandt, I., Nilsen, T. S., Cutler, T. L., Hopper, J. L., Corley, R. P., Huibregtse, B. M., Sung, J., Kim, J., Lee, J., Lee, S., Gatz, M., Butler, D. A., Franz, C. E., Kremen, W. S., Lyons, M. J., Magnusson, P. K. E., Pedersen, N. L., Dahl Aslan, A. K., Öncel, S. Y., Aliev, F., Derom, C. A. & Vlietinck, R. F., 2018, In : PLOS ONE. 13, 7, 17 p., e0200140.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
body mass index
Body Mass Index
Smoking
confidence interval
Confidence Intervals
109 Downloads (Pure)

Association of miR-548c-5p, miR-7-5p, miR-210-3p, miR-128-3p with recurrence in systemically untreated breast cancer

Block, I., Burton, M., Sørensen, K. P., Andersen, L., Larsen, M. J., Bak, M., Cold, S., Thomassen, M., Tan, Q. & Kruse, T. A., 6. Feb 2018, In : OncoTarget. 9, 10, p. 9030-9042

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Association study between gene expression and body mass index for middle aged Danish twins using weighted correlation network analysis

Li, W., Baumbach, J., Christiansen, L. & Tan, Q., Oct 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Body Mass Index
Monozygotic Twins
Twin Studies
Genome-Wide Association Study
Environmental Exposure

Circulating, Cell-Free Micro-RNA Profiles Reflect Discordant Development of Dementia in Monozygotic Twins

Mengel-From, J., Rønne, M. E., Carlsen, A. L., Skogstrand, K., Larsen, L. A., Tan, Q., Christiansen, L., Christensen, K. & Heegaard, N. H. H., 1. Jan 2018, In : Journal of Alzheimer's disease : JAD. 63, 2, p. 591-601

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Monozygotic Twins
MicroRNAs
Immunoassay
Lipoproteins
Longitudinal Studies

Circulating microRNAs disclose biology of normal cognitive function in healthy elderly people – a discovery twin study

Mengel-From, J., Feddersen, S., Halekoh, U., Heegaard, N. H. H., McGue, M., Christensen, K., Tan, Q. & Christiansen, L., Sep 2018, In : European Journal of Human Genetics. 26, 9, p. 1378–1387

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Twin Studies
MicroRNAs
Cognition
Neurobiology
Monozygotic Twins
72 Downloads (Pure)

Differential effect of surgical manipulation on gene expression in normal breast tissue and breast tumor tissue

Pedersen, I. S., Thomassen, M., Tan, Q., Kruse, T. A., Thorlacius-Ussing, O., Garne, J. P. & Krarup, H. B., 16. Nov 2018, In : Molecular Medicine. 24, 8 p., 57.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Gene Expression Profiling
Transcriptome
Freezing

DiMmer: Discovery of Differentially Methylated Regions in Epigenome-Wide Association Study (EWAS) Data

Frisch, T., Møller Gøttcke, J., Röttger, R., Tan, Q. & Baumbach, J., 2018, Data Mining for Systems Biology: Methods and Protocols. Mamitsuka, H. (ed.). Humana Press, p. 51-62 (Methods in Molecular Biology, Vol. 1807).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Programming Languages
DNA Methylation
Random Allocation
42 Downloads (Pure)

DNA methylation age and perceived age in elderly Danish twins

Debrabant, B., Sørensen, M., Christiansen, L., Tan, Q., McGue, M., Christensen, K. & Hjelmborg, J. V. B., 1. Jan 2018, In : Mechanisms of Ageing and Development. 169, p. 40-44

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Epigenomics
109 Downloads (Pure)

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins

Svane, A. M., Soerensen, M., Lund, J., Tan, Q., Jylhävä, J., Wang, Y., Pedersen, N. L., Hägg, S., Debrabant, B., Deary, I. J., Christensen, K., Christiansen, L. & Hjelmborg, J. B., 8. Feb 2018, In : Genes. 9, 2, 15 p., 78.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Twin Studies
Monozygotic Twins
Population

DNA methylation linked to all-cause mortality in older people: An epigenome-wide association study.

Lund, J., Baumbach, J. & Tan, Q., Mar 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

DNA Methylation
G-Protein-Coupled Receptors
Proportional Hazards Models
Epigenomics
Skeleton
74 Downloads (Pure)

Epigenetic signature of preterm birth in adult twins

Tan, Q., Li, S., Frost, M., Nygaard, M., Soerensen, M., Larsen, M., Christensen, K. & Christiansen, L., 2018, In : Clinical Epigenetics. 10, 10 p., 87.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Premature Birth
Epigenomics
Health
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 3

Epigenetic signature of preterm birth in adult twins.

Tan, Q. & Li, S., 2018. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Premature Birth
Epigenomics
Health
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 3

Gene methylation co-regulation network analysis of all-cause mortaltiy in ageing individuals

Lund, J., Baumbach, J. & Tan, Q., 16. Oct 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Proportional Hazards Models
DNA Methylation
Epigenomics
Population

Genetic and environmental influences on cardiovascular risk factors and cognitive function: A Chinese twin aging study

Xu, C., Tian, X., Sun, J., Wu, Y., Zhang, D., Pang, Z., Li, S., Petersen, I., Mengel-From, J., Christiansen, L., Christensen, K. & Tan, Q., Feb 2018, In : Geriatrics & Gerontology International. 18, 2, p. 352-359

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
Cognition
cognition
HDL Cholesterol
environmental factors
108 Downloads (Pure)

Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland

Andreasen, S., Agander, T. K., Bjørndal, K., Erentaite, D., Heegaard, S., Larsen, S. R., Melchior, L. C., Tan, Q., Ulhøi, B. P., Wessel, I. & Homøe, P., 13. Apr 2018, In : Oncotarget. 9, 28, p. 19675-19687

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Adenoid Cystic Carcinoma
MicroRNAs
Mutation
Neoplasms
84 Downloads (Pure)

Genetics of Obesity Traits: A Bivariate Genome-Wide Association Analysis

Wu, Y., Duan, H., Tian, X., Xu, C., Wang, W., Jiang, W., Pang, Z., Zhang, D. & Tan, Q., 16. May 2018, In : Frontiers in Genetics. 9, MAY, 9 p., 179.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Genome-Wide Association Study
Dizygotic Twins
Body Mass Index
Twin Studies
Quantitative Trait Loci
104 Downloads (Pure)

Heritability and Genome-Wide Association Analyses of Serum Uric Acid in Middle and Old-Aged Chinese Twins

Wang, W., Zhang, D., Xu, C., Wu, Y., Duan, H., Li, S. & Tan, Q., 6. Mar 2018, In : Frontiers in Endocrinology. 9, MAR, 12 p., 75.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Genome-Wide Association Study
Uric Acid
Serum
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 14

MicroRNA dysregulation in adenoid cystic carcinoma of the salivary gland in relation to prognosis and gene fusion status: a cohort study

Andreasen, S., Tan, Q., Agander, T. K., Thomas V. O., H., Steiner, P., Bjørndal, K., Høgdall, E., Larsen, S. R., Erentaite, D., Olsen, C. H., Ulhøi, B. P., Heegaard, S., Wessel, I. & Homøe, P., Sep 2018, In : Virchows Archiv. 473, 3, p. 329-340

Research output: Contribution to journalJournal articleResearchpeer-review

Adenoid Cystic Carcinoma
MicroRNAs
Cohort Studies
Neoplasms
Survival Analysis

Network analysis of DNA methylation of visceral adipose tissue comparing obese individuals with and without type 2 diabetes

Mohammadnejad, A., Li, W., Lund, J., Baumbach, J. & Tan, Q., 25. Sep 2018.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Online interactive microbial classification and geospatial distributional analysis using BioAtlas

Lund, J., Tan, Q. & Baumbach, J., 2018, Data Mining for Systems Biology: Methods and Protocols. Mamitsuka, H. (ed.). New York: Humana Press, Vol. 1807. p. 21-35 (Methods in Molecular Biology, Vol. 1807).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Databases
rRNA Genes
16S Ribosomal RNA
Metagenomics
Datasets

On the power of epigenome-wide association studies using a disease-discordant twin design

Li, W., Christiansen, L., Hjelmborg, J. V. B., Baumbach, J. & Tan, Q., 1. Dec 2018, In : Bioinformatics. 34, 23, p. 4073–4078

Research output: Contribution to journalJournal articleResearchpeer-review

Diseases in Twins
Monozygotic Twins
DNA Methylation
Computational Biology
Epigenomics
109 Downloads (Pure)

Sex Differences in Genetic Associations With Longevity

Zeng, Y., Nie, C., Min, J., Chen, H., Liu, X., Ye, R., Chen, Z., Bai, C., Xie, E., Yin, Z., Lv, Y., Lu, J., Li, J., Ni, T., Bolund, L., Land, K. C., Yashin, A. I., O'Rand, A. M., Sun, L., Yang, Z. & 22 others, Tao, W., Gurinovich, A., Franceschi, C., Xie, J., Gu, J., Hou, Y., Liu, X., Xu, X., Robine, J-M., Deelen, J., Sebastiani, P., Slagboom, E., Perls, T. T., Hauser, E. R., Gottschalk, W., Tan, Q., Christensen, K., Shi, X., Lutz, M., Tian, X-L., Yang, H. & Vaupel, J. W., Aug 2018, In : JAMA Network Open. 1, 4, 15 p., 1670.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Sex Characteristics
Genome-Wide Association Study
Delivery of Health Care
Tryptophan
Case-Control Studies

Surfactant protein-D, a potential mediator of inflammation in axial spondyloarthritis

Munk, H. L., Fakih, D., Christiansen, L., Tan, Q., Christensen, A. F., Ejstrup, L., Loft, A. G., Junker, K., Kyvik, K. O., Jounblat, R., Holmskov, U., Sorensen, G. L. & Junker, P., 1. Oct 2018, In : Rheumatology (Oxford, England). 57, 10, p. 1861–1865

Research output: Contribution to journalJournal articleResearchpeer-review

Pulmonary Surfactant-Associated Protein D
Molecular Weight
Serum
Single Nucleotide Polymorphism
Smoking

Weighted gene co-expression network analysis of microarray mRNA expression profiling in response to electroacupuncture

Mohammadnejad, A., Li, S., Duan, H., Lund, J., Li, W., Baumbach, J. & Tan, Q., Dec 2018, Proceedings of the 2018 IEEE International Conference on Bioinformatics and Biomedicine. Schmidt, H., Griol, D., Wang, H., Baumbach, J., Zheng, H., Callejas, Z., Hu, X., Dickerson, J. & Zhang, L. (eds.). IEEE, p. 1876-1883 8621258

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

Electroacupuncture
Messenger RNA
Periaqueductal Gray
Gene Ontology
2017

A case-only genome-wide association study for assessing gene-sex interaction in Allergic rhinitis

Mohammadnejad, A., Brasch-Andersen, C., Haagerup, A., Vestbo, J., Baumbach, J. & Tan, Q., Aug 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Genome-Wide Association Study
Single Nucleotide Polymorphism
Chromosomes, Human, Pair 12
Posters
Chromosomes, Human, Pair 5

A genome-wide association study of cognitive function in Chinese adult twins

Xu, C., Zhang, D., Wu, Y., Tian, X., Pang, Z., Li, S. & Tan, Q., 2017, In : Biogerontology. 18, 5, p. 811–819

Research output: Contribution to journalJournal articleResearchpeer-review

Genome-Wide Association Study
Cognition
Single Nucleotide Polymorphism
Dizygotic Twins
Metabolic Diseases