Poul Nielsen

Ph.D.

  • Campusvej 55

    5230 Odense M

    Denmark

1994 …2021
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Research Output 1994 2019

2019

A double-headed nucleotide with two cytosines: DNA with condensed information and improved duplex stability

Beck, K., Reslow-Jacobsen, C., Hornum, M., Henriksen, C. & Nielsen, P., 1. Mar 2019, In : Bioorganic and Medicinal Chemistry Letters. 29, 5, p. 740-743

Research output: Contribution to journalJournal articleResearchpeer-review

Cytosine
Nucleotides
Oligonucleotides
Monomers
DNA

Base-Pairing Properties of Double-Headed Nucleotides

Hornum, M., Stendevad, J., Sharma, P. K., Kumar, P., Nielsen, R. B., Petersen, M. & Nielsen, P., 28. May 2019, In : Chemistry: A European Journal. 25, 30, p. 7387-7395

Research output: Contribution to journalJournal articleResearchpeer-review

Base Pairing
Hypoxanthine
DNA
Guanine
Adenine
2017
165 Downloads (Pure)

Condensing the information in DNA with double-headed nucleotides

Hornum, M., Sharma, P. K., Reslow-Jacobsen, C., Kumar, P., Petersen, M. & Nielsen, P., 2017, In : Chemical Communications. 53, 70, p. 9717-9720 4 p.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
File
Nucleotides
DNA
Phosphates
124 Downloads (Pure)

Nucleobase-modified antisense oligonucleotides containing 5-(phenyltriazol)-2′-deoxyuridine nucleotides induce exon-skipping: In vitro

Le, B. T., Hornum, M., Sharma, P. K., Nielsen, P. & Veedu, R. N., 2017, In : RSC Advances. 7, 86, p. 54542-54545

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Deoxyuridine
Antisense Oligonucleotides
Oligonucleotides
Nucleotides
Exons

Synthesis, hybridization and fluorescence properties of a 2'-C-pyrene-triazole modified arabino-uridine nucleotide

Kumar, P., Sharma, P. K. & Nielsen, P., 2017, In : Bioorganic & Medicinal Chemistry. 25, 7, p. 2084–2090

Research output: Contribution to journalJournal articleResearchpeer-review

Uracil Nucleotides
Triazoles
Monomers
Fluorescence
Oligonucleotides
2016

Double-Headed Nucleotides: Building Blocks for New Nucleic Acid Architectures

Sharma, P. K., Kumar, P. & Nielsen, P., 2016, In : Australian Journal of Chemistry. 69, 10, p. 1094-1101

Research output: Contribution to journalJournal articleResearchpeer-review

122 Downloads (Pure)

Synthesis of new C-5-triazolyl-functionalized thymidine analogs and their ability to engage in aromatic stacking in DNA:DNA and DNA:RNA duplexes

Hornum, M., Djukina, A., Sassnau, A-K. & Nielsen, P., 2016, In : Organic & Biomolecular Chemistry. 19, p. 4436-4447

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Three new double headed nucleotides with additional nucleobases connected to C-5 of pyrimidines: synthesis, duplex and triplex studies

Kumar, P., Sharma, P. K., Hansen, J., Jedinak, L., Reslow-Jacobsen, C., Hornum, M. & Nielsen, P., 2016, In : Bioorganic & Medicinal Chemistry. 24, 4, p. 742-749

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Allele Selective Inhibition of Mutant Huntingtin With 2-Thio- and C5-Triazoylphenyl- Deoxythymidine Modified Antisense Oligonucleotides

Østergaard, M. E., Kumar, P., Nichols, J., Watt, A., Sharma, P. K., Nielsen, P. & Seth, P. P., 2015, In : Nucleic Acid Therapeutics. 25, 5, p. 266-274

Research output: Contribution to journalJournal articleResearchpeer-review

102 Downloads (Pure)

Double-headed nucleotides introducing thymine nucleobases in the major groove of nucleic acid duplexes

Jensen, M. D., Andersen, N. K., Kumar, P., Nielsen, P. & Sharma, P. K., 2015, In : Organic & Biomolecular Chemistry. 13, p. 7040-7049

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

Increasing the stability of DNA: RNA duplexes by introducing stacking phenyl-substituted pyrazole, furan and triazole moieties in the major groove

Hornum, M., Kumar, P., Podsiadly, P. & Nielsen, P., 2015, In : Journal of Organic Chemistry. 80, 19, p. 9592-9602

Research output: Contribution to journalJournal articleResearchpeer-review

2014
Click Chemistry
Adenine
Derivatives
Escherichia coli
Growth

Double-coding nucleic acids; Introduction of a nucleobase sequence in the major groove of the DNA duplex using double-headed nucleotides

Kumar, P., Sorinas, A. F., Nielsen, L. J., Slot, M., Skytte, K., Nielsen, A. S., Jensen, M. D., Sharma, P. K., Vester, B., Petersen, M. & Nielsen, P., 2014, In : Journal of Organic Chemistry. 79, p. 8020-8030 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Double-headed nucleotides with arabino-configuration; synthesis and hybridization properties

Kumar, P., Sharma, P. K. & Nielsen, P., 2014, In : Journal of Organic Chemistry. 79, p. 11534-11540 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

High affinity RNA targeting by oligonucleotides displaying aromatic stacking and amino groups in the major groove. Comparison of triazoles and phenylsubstituents

Kumar, P., Hornum, M., Nielsen, L. J., Enderlin, G., Andersen, N. K., Len, C., Hervé, G., Sartori, G. & Nielsen, P., 2014, In : Journal of Organic Chemistry. 79, 7, p. 2854-2863 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of a bicyclic double-headed nucleoside

Kumar, S., Steffansen, S. I., Albæk, N. & Nielsen, P., 2014, In : Tetrahedron. 70, 3, p. 583-589

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Double-headed nucleotides in DNA-zipper structures; base-base interactions and UV-induced cross-coupling in the minor groove

Stahl Madsen, C., Nielsen, L. J., Pedersen, N. S., Lauritsen, A. & Nielsen, P., 2013, In : R S C Advances. 3, p. 10696-10706

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of 2´-O-(thymin-1-yl)methyluridine and its incorporation into secondary nucleic acid structures.

Kumar, P., Stahl Madsen, C. & Nielsen, P., 2013, In : Bioorganic & Medicinal Chemistry Letters. 23, p. 6847-6850

Research output: Contribution to journalJournal articleResearchpeer-review

The extension of a DNA double helix by an additional Watson-Crick base pair on the same backbone

Kumar, P., Sharma, P. K., Madsen, C. S., Petersen, M. & Nielsen, P., 2013, In : ChemBioChem. 14, 9, p. 1072-1074

Research output: Contribution to journalJournal articleResearchpeer-review

Base Pairing
Nucleotides
DNA
2012

A Click Chemistry Approach to Pleuromutilin Derivatives, Part 2: Conjugates with Acyclic Nucleosides and Their Ribosomal Binding and Antibacterial Activity

Dreier, I., Kumar, S., Søndergaard, H., Rasmussen, M. L., Hansen, L. H., List, N. H., Kongsted, J., Vester, B. & Nielsen, P., 2012, In : Journal of Medicinal Chemistry. 55, 5, p. 2067-2077

Research output: Contribution to journalJournal articleResearchpeer-review

Additional Base Pair Formation in DNA Duplexes by a Double-Headed Nucleotide

Stahl Madsen, C., Witzke, S., Kumar, P., Negi, K., Sharma, P. K., Petersen, M. & Nielsen, P., 2012, In : Chemistry: A European Journal. 18, p. 7434-7442 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sulfonamide bearing oligonucleotides: Simple synthesis and efficient RNA recognition

Kumar, P., Chandak, N., Nielsen, P. & Sharma, P. K., 2012, In : Bioorganic & Medicinal Chemistry. 20, 12, p. 3843-3849 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Three pyrene modified nucleotides; synthesis and effects in secondary nucleic acid structures

Kumar, P., Shaikh, K. I., Jørgensen, A. S., Kumar, S. & Nielsen, P., 2012, In : Journal of Organic Chemistry. 77, p. 9562−9573 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Duplex and Triplex Formation of Mixed Pyrimidine Oligonucleotides with Stacking of Phenyl-triazole Moieties in the Major Groove

Andersen, N. K., Døssing, H., Jensen, F., Vester, B. & Nielsen, P., 5. Aug 2011, In : Journal of Organic Chemistry. 76, 15, p. 6177-87 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Triazoles
Uridine
Oligonucleotides
Cytidine
Complementary RNA

High-affinity DNA-targeting using Readily Accessible Mimics of N2’-Functionalized 2’-Amino-α-L-LNA

Karmakar, S., Anderson, B. A., Rathje, R. L., Andersen, S., Jensen, T. B., Nielsen, P. & Hrdlicka, P. J., 2011, In : Journal of Organic Chemistry. 76, p. 7119-7131 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Introduction of Additional Nucleobases into the Double Helix

Nielsen, P., Stahl Madsen, C., Jørgensen, A. S., Witzke, S., Shaikh, K. I., Kumar, P., Sharma, P. K. & Petersen, M., 2011, In : Collection Symposium Series. 12, p. 189-193 4 p.

Research output: Contribution to journalJournal articleResearch

The synthesis of double-headed nucleosides by the CuAAC reaction and their effect in secondary nucleic acid structures

Jørgensen, A. S., Shaikh, K. I., Enderlin, G., Ivarsen, E., Kumar, S. & Nielsen, P., 2011, In : Organic & Biomolecular Chemistry. 9, p. 1381 - 1388 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Efficient RNA-targeting by the introduction of aromatic stacking in the duplex major groove via 5-(1-phenyl-1,2,3-triazol-4-yl)-2′-deoxyuridines.

Andersen, N. K., Chandak, N., Brulikova, L., Kumar, P., Jensen, M. D., Jensen, F., Sharma, P. K. & Nielsen, P., 2010, In : Bioorganic & Medicinal Chemistry. 18, p. 4702-4710 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis and molecular modelling of double-functionalized nucleosides with aromatic moieties in the 5´(S)-position and minor groove interactions in DNA zipper structures

Shaikh, K. I., Madsen, C. S., Nielsen, L. J., Jørgensen, A. S., Nielsen, H., Petersen, M. & Nielsen, P., 2010, In : Chemistry: A European Journal. 16, p. 12904-12919 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Parallel RNA-strand recognition by 2'-amino-β-LNA

Kumar, T. S., Østergaard, M. E., Sharma, P. K., Nielsen, P., Wengel, J. & Hrdlicka, P. J., 2009, In : Bioorganic & Medicinal Chemistry Letters. 19, 9, p. 2396-2399 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Thymine
RNA
Complementary RNA
Nucleosides
Monomers

Synthesis of bicyclic 2´-deoxynucleosides with α-L-ribo- and β-D-xylo-configurations and restricted S- and N-type conformations

Shaikh, K. I., Kumar, S., Lundhus, L., Bond, A., Sharma, P. K. & Nielsen, P., 2009, In : Journal of Organic Chemistry. 74, 4, p. 1557-1566 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of Functionalized Carbocyclic Locked Nucleic Acid Analogues by Ring-Closing Diene and Enyne Metathesis and their Influence on Nucleic Acid Stability and Structure

Kumar, S., Haslund Hansen, M., Albæk, N., Inglev Steffansen, S., Petersen, M. & Nielsen, P., 2009, In : Journal of Organic Chemistry. 74, 17, p. 6756-6769 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2008

A click chemistry approach to Pleuromutilin conjugates with nucleosides or acyclic nucleoside derivatives and their binding to the bacterial ribosome

Lolk, L., Pøhlsgaard, J., Jepsen, A. S., Hansen, L. H., Nielsen, H., Steffansen, S. I., Sparving, L., NIelsen, A. B., Vester, B. & Nielsen, P., 5. Aug 2008, In : Journal of Medicinal Chemistry. 51, p. 4957-4967 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

A click chemistry approach towards nucleic acid major groove functionalization

Andersen, N. K., Spacilova, L., Jensen, M. D., Kocalka, P., Jensen, F. & Nielsen, P., 8. Sep 2008, In : Nucleic Acids Symposium Series. 52, p. 149-150 2 p.

Research output: Contribution to journalJournal articleResearch

Chemically modified oligonucleotides with efficient RNase H response

Vester, B., Boel, A. M., Lobedanz, S., Babu, B. R., Raunkjaer, M., Lindegaard, D., Raunak, Hrdlicka, P. J., Højland, T., Sharma, P. K., Kumar, S., Nielsen, P. & Wengel, J., 1. Apr 2008, In : Bioorganic & Medicinal Chemistry Letters. 18, 7, p. 2296-2300 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Ribonuclease H
Oligonucleotides
RNA
Complementary RNA
DNA

Locked Nucleic Acids; Properties, Applications and Perspectives

Nielsen, P. & Wengel, J., 2008, Modified Nucleosides in Biochemistry, Biotechnology and Medicine. Herdewijn, P. (ed.). Wiley-VCH, p. 133-152 20 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Nucleic acid duplexes with zippers of additional nucleobases and aromatics in minor or major groove

Nielsen, P., Shaikh, K. I., Nielsen, L. J., Andersen, N. K., Spacilova, L., Nielsen, H., Kocalka, P. & Christensen, M. S., 2008, In : Nucleic Acids Symposium Series. 52, p. 5-6 2 p.

Research output: Contribution to journalJournal articleResearch

Nucleic acid secondary structures containing the double-headed nucleoside 5′(S)-C-(2-(thymine-1-yl)ethyl)­thymidine.

Andersen, C., Sharma, P. K., Christensen, M. S., Steffansen, S. I., Madsen, C. M. & Nielsen, P., 2008, In : Organic & Biomolecular Chemistry. 6, p. 3983-3988 6 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Palladium-Catalyzed Three-Component Approach to Promazine with Formation of One Carbon-Sulfur and Two Carbon-Nitrogen Bonds

Dahl, T., Tornøe, C. W., Bang-Andersen, B., Nielsen, P. & Jørgensen, M., 2008, In : Angewandte Chemie - International Edition. 47, 9, p. 1726-1728 3 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of 3´- and 6´-functionalised Locked Nucleic Acid (LNA) analogues

Sharma, P. K., Enderlin, G., Kumar, S. & Nielsen, P., 8. Sep 2008, In : Nucleic Acids Symposium Series. 52, p. 135-136 2 p.

Research output: Contribution to journalJournal articleResearch

Synthesis of 6´-branched Locked Nucleic Acid by a radical TEMPO-scavanged stereoselective mercurycyclization

Enderlin, G. & Nielsen, P., 2. Aug 2008, In : Journal of Organic Chemistry. 73, p. 6891-6894 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of double-headed nucleosides with the additional nucleobase in the 5´-C-position

Andersen, C., Sharma, P. K., Pedersen, N. S., Christensen, M. S. & Nielsen, P., 2008, In : Nucleic Acids Symposium Series. 52, p. 275-276 2 p.

Research output: Contribution to journalJournal articleResearch

Synthesis of the 3′-C-hydroxymethyl-branched locked nucleic acid thymidine monomer

Kumar, S., Sharma, P. K., Stein, P. C. & Nielsen, P., 2008, In : European Journal of Organic Chemistry. 2008, 34, p. 5715-5722 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Ether
Thymidine
Monomers
Glucose
3-hydroxybutanal

Synthetic nucleic acid secondary structures containing the four stereoisomers of 1,4-bis(thymine-1-yl)butane-2,3-diol

Christensen, M. S., Bond, A. & Nielsen, P., 2008, In : Organic & Biomolecular Chemistry. 6, p. 81-91 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2007

(1R,4R,7R,8R,9R)-8-Benzyloxy-7-benzyloxymethyl-2,5,10-trioxatricyclo[5.2.1.04,8]decan-9-ol

Sharma, P. K., Nielsen, P. & Bond, A., 2007, In : Acta Crystallographica. Section E: Structure Reports Online. E63, p. o4537

Research output: Contribution to journalJournal articleResearchpeer-review

Collision-induced dissociation of cytidine and its derivatives

Jensen, S. S., Ariza, X., Nielsen, P., Vilarrasa, J. & Kirpekar, F., 1. Jan 2007, In : Journal of Mass Spectrometry. 42, 1, p. 49-57 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

LNA (locked nucleic acid) and analogs as triplex-forming oligonucleotides

Højland, T., Kumar, S., Babu, B. R., Umemoto, T., Albaek, N., Sharma, P. K., Nielsen, P. & Wengel, J., 2007, In : Organic & Biomolecular Chemistry. 5, 15, p. 2375-9 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Oligonucleotides
Monomers
Conformations
Nucleotides
locked nucleic acid

Selective reduction of mono- and disubstituted olefins by NaBH4 and catalytic RuCl3

Sharma, P. K., Kumar, S., Kumar, P. & Nielsen, P., 2007, In : Tetrahedron Letters. 48, p. 8704-8708 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis and modelling of DNA junction and minor groove zipper motifs incorporating the double-headed nucleoside 5'(S)-C-(thymine-1-ylmethyl)-thymidine

Christensen, M. S., Madsen, C. M. & Nielsen, P., 2007, In : Organic & Biomolecular Chemistry. 5, p. 1586-1594 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Synthesis of  5-(1,2,3-triazol-4-yl)-2'-deoxy­uridines by a click chemistry approach;  stacking of triazoles in the major groove gives increased nucleic acid duplex stability

Kocalka, P., Andersen, N. K., Jensen, F. & Nielsen, P., 2007, In : ChemBioChem. 8, p. 2106-2116 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review