Personal profile

Research areas

Design, analysis, and reporting of diagnostic and prognostic trials in molecular imaging

---- Nonparametric norm curve estimation -----

** Nonparametric percentile curve estimation for a nonnegative marker with excessive zeros. MethodsX. 2022; 9: 101757. https://doi.org/10.1016/j.mex.2022.101757

** Prevalence and extent of coronary artery calcification in the middle-aged and elderly population. Eur J Prev Cardiol. 2021; 28(18): 2048-2055. https://doi.org/10.1093/eurjpc/zwab111 (Authors’ Accepted Manuscript: https://findresearcher.sdu.dk/ws/portalfiles/portal/183884929/EJPC_D_21_00065_R1.pdf)

----- Sequential and adaptive trial designs in diagnostic research -----

** Sample size recalculation based on the prevalence in a randomized test-treatment study. BMC Med Res Methodol. 2022; 22(1): 205. https://doi.org/10.1186/s12874-022-01678-7

** Randomized test-treatment studies with an outlook on adaptive designs. BMC Med Res Methodol. 2021; 21(1): 110. https://doi.org/10.1186/s12874-021-01293-y

** The potential for seamless designs in diagnostic research. J Clin Epidemiol. 2021; 129: 51-59. https://doi.org/10.1016/j.jclinepi.2020.09.019

** Adaptive trial designs in diagnostic accuracy research. Stat Med. 2020; 39(5): 591-601. https://doi.org/10.1002/sim.8430

----- Agreement -----          

** Modeling Bland–Altman Limits of Agreement with Fractional Polynomials – An Example with the Agatston Score for Coronary Calcification. Axioms. 2023; 12(9): 884. https://doi.org/10.3390/axioms12090884

** Bland-Altman Limits of Agreement from a Bayesian and frequentist perspective. Stats. 2021; 4(4): 1080-1090. https://doi.org/10.3390/stats4040062

** Nonparametric Limits of Agreement in method comparison studies: a simulation study on extreme quantile estimation. Int J Environ Res Public Health. 2020; 17(22): 8330.  https://doi.org/10.3390/ijerph17228330

** Reporting standards for a Bland-Altman agreement analysis: a review of methodological reviews. Diagnostics. 2020; 10(5): 334. https://doi.org/10.3390/diagnostics10050334

Curriculum

Current position

Biostatistician, Department of Nuclear Medicine, Odense University Hospital & Professor in Clinical Biostatistics in Diagnostic Research, Dept. of Clinical Research, University of Southern Denmark

Former positions

2011-18 Associate Professor (20%), Dept. of Business and Economics, SDU

2006 Senior Statistician, Early Clinical Development, Novartis Pharma AG, Basel

2002-06 Biometrician, Clinical Statistics Europe, Schering AG, Berlin

2001/02 Junior Specialist, Information Resources GfK GmbH, Nürnberg

Former positive assessments for professorships

2019 Associate Professor in Statistics, Dept. of Mathematics and Computer Science, SDU

2013 Associate Professor in Econometrics/Economics, Dept. of Business and Economics, SDU

2011 Associate Professor in Statistics and Economics, Dept. of Business and Economics, SDU

2009 Associate Professor in Biostatistics, Dept. of Regional Health Research, SDU

Higher education & academic degrees

2010 Lecturer Training Programme, University of Southern Denmark

2001 PhD, Department of Statistics and Econometrics, Faculty of Economics, University of Hamburg

1998 MSc in Mathematics and Economics, University of Hamburg

Membership of scientific societies

International Biometric Society (IBS)

International Society for Clinical Biostatistics (ISCB)

German Statistical Society (DStatG)

Danish Society for Theoretical Statistics (DSTS)

Co-supervision of ongoing PhD projects: 4

Main / co-supervision of completed PhD projects: 1 / 22

Main supervision of completed master theses: 10

Odense, 03 April 2024

Odense, 04 January 2024

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