Personal profile
Research Interests
Jesper Nylandsted is Professor at Cancer and Inflammation Research Unit, Department of Molecular Medicine, University of Southern Denmark, and Group Leader at the Danish Cancer Society Research Center in Copenhagen:
https://www.cancer.dk/research/dcrc-research/membrane-integrity/
Dr. Nylandsted ([email protected]) leads the Membrane Integrity Group and has extensive expertise within molecular mechanisms of membrane repair and cell death signaling. His research focuses on cell repair mechanisms in cancer and other human disorders, and novel approaches to target cancer cells by compromising membrane integrity. His work is characterized by interdisciplinary research within molecular and cellular cancer biology, theoretical/experimental physics with a core expertise in live-cell imaging techniques. Fundamental mechanisms of cell membrane repair and homeostasis are deciphered by integrating physics-based analysis of both simple and complex in vitro model systems, with the molecular interactions and cellular phenomena that drive membrane repair in vivo.
The group studies repair mechanisms across a wide range of cancers, which are of clinical significance to develop novel strategies to target cancer cells broadly for future therapy.
The goal is to develop novel approaches that can be directly translated into clinically relevant concepts, methodologies and tools.
Fingerprint
- 1 Similar Researchers
Collaborations and top research areas from the last five years
-
Cellular wound healing: A two-step mechanism of plasma membrane repair by annexins and calpains
Elmi, S. & Nylandsted, J., 7. Jul 2025, In: The Journal of cell biology. 224, 7, 3 p., e202505027.Research output: Contribution to journal › Editorial › peer-review
-
Revisiting the role of Annexins in membrane trafficking
Grewal, T., Gerke, V., Nylandsted, J., Rentero, C. & Enrich, C., Dec 2025, In: Cellular and Molecular Life Sciences. 82, 1, 26 p., 230.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile24 Downloads (Pure) -
Viscoelastic differences between isolated and live MCF7 cancer cell nuclei resolved with AFM microrheology
Juel Pørtner, E., Mularski, A., William Jarrett, T., Lauritzen Sønder, S., Nylandsted, J. & Simonsen, A. C., 18. Jun 2025, In: Journal of the Royal Society Interface. 22, 227, 13 p., 20240885.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile23 Downloads (Pure) -
Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics
Gerke, V., Gavins, F. N. E., Geisow, M., Grewal, T., Jaiswal, J. K., Nylandsted, J. & Rescher, U., Dec 2024, In: Nature Communications. 15, 1, 15 p., 1574.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile41 Downloads (Pure) -
Modulation of Annexin-Induced Membrane Curvature by Cholesterol and the Anionic Lipid Headgroup during Plasma Membrane Repair
Hakami Zanjani, A. A., Ebstrup, M. L., Nylandsted, J. & Khandelia, H., 2024, In: Journal of Physical Chemistry B. 128, 36, p. 8701–8711Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile27 Downloads (Pure)
Press/Media
-
Novo Nordisk Fonden uddeler 75 mio. kr. til forskning i bæredygtighed og sundhed
21/08/2025
1 Media contribution
Press/Media: Press / Media