• Campusvej 55

    5230 Odense M

    Denmark

20132019
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Personal profile

Research areas

  • Surface and Colloid Science
  • Single (micro- nano-) Particle Science and Engineering;
  • Biological materials science;;
  • 2-phase microsystems:
    • proteins, (enzymes, antibodies); lipids; emulsions; surfactants; micelles; micro and nano crystals; micro and nano glasses;
  • Drug delivery:
    • micro- and nano-carrier engineering; liposomal drug delivery to tumors;Temperature-triggered drug release; polymer microspheres; drug formulation; endogenous theranostics.

Research information

The Center for Single Particle Science and Engineering focuses on lipid bilayer membranes and other two-phase micro and nano systems. Of significant importance in the past five years has been the invention, fabrication, and testing, both in vitro and in vivo, (including Human Clinical trials, now in Phase III for Liver Cancer and Phase I/II for Chest Wall Recurrence of breast cancer), of a new low-temperature sensitive liposome (LTSL). This new anti-cancer drug-delivery and drug-releasing system is designed to release its drug, doxorubicin, within seconds upon being heated from a waxy state at body temperatures and below, to its main acyl chain melting transition at around 41C to 42C. This work has been carried out in close collaboration with researchers and clinicians in the DUMC Hyperthermia Program (Dewhirst PI) as well as by independent RO1 funding awarded to Professor Needham. New research with liposomes includes diagnostic applications using MRI contrast and the formulation of other drugs like cis-platin and other biological modifiers of cancer cell resistance to therapy. In other systems we are focusing on diffusion-solubility, crystallization and solidification of polymers, lipids, proteins, inorganic crystals and drugs from 2 phase Microsystems, including formulating protein nanobeads in degradable PLGA polymer microspheres. Particular applications of these materials and materials processing concepts have been expanded into 3 Small Business Research Initiation Grants from NSF and NIH that aim to develop and commercialize the dehydration technology for enzymes peptides, and antibodies. We are also interested in new formulations of more hydrophobic drugs as Bio-inspired pure-drug nano particles for metastatic tumor targeting. Here, collaborations are being established with researchers in BMB. Other collaborations include: developing an invention of a new bilayer model system (Droplet INterface Bilayers -DIBs) for studying and using single protein channel activity with collaborators at Oxford Univ., UK, and Oxford NanoPore Technologies; liposomes for fighting infectious disease, with Molecular Express, in LA.Specialist Experimental Techniques in the Laboratory:Micropipet manipulation of single and pairs of microparticles, optical/video-digital microscopy

Education/Academic qualification

Physical Chemistry, PhD, University of Nottingham

1. Sep 197731. Aug 1980

External positions

Honorary Professor, University of Nottingham

1. Sep 201431. Aug 2019

Professor, Duke University

1. Jan 1887 → …

Research areas

  • Drug delivery from nanoparticles
  • Pharmaceuticals
  • Physical chemistry

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  • 2 Similar Profiles
Emulsification Engineering & Materials Science
Surface tension Engineering & Materials Science
Dissolution Engineering & Materials Science
Water Chemical Compounds
Dehydration Medicine & Life Sciences
Surface-Active Agents Chemical Compounds
Oils Medicine & Life Sciences
Lipids Medicine & Life Sciences

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Research Output 2013 2019

89 Downloads (Pure)
Open Access
File
Microbubbles
Oils
Lung
Capillary Action
Margarine
32 Downloads (Pure)

Oleogelating properties of ethylcellulose in oil-in-water emulsions: The impact of emulsification methods studied by 13C MAS NMR, surface tension and micropipette manipulation studies

Munk, M. B., Utoft, A., Larsen, F. H., Needham, D. & Risbo, J., Apr 2019, In : Food Hydrocolloids. 89, p. 700-706

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Emulsification
surface tension
emulsifying
Emulsions
emulsions

På grænsen mellem materialer

Translated title of the contribution: Material's boarderMadsen, A. U., Kinoshita, K. & Needham, D., Sep 2019, In : Aktuel Naturvidenskab. 4, p. 18-22

Research output: Contribution to journalJournal articleCommunication

Particle formation from miscible binary and ternary liquid microdroplets in an immiscible environment

Madsen, A. U., Kinoshita, K., Walke, P. & Needham, D., Sep 2019, p. 303. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearch

Open Access

Uptake of New Lipid-Coated Nanoparticles Containing Falcarindiol by Human Mesenchymal Stem Cells

Ollé, E. P., Walke, P., Notabi, M., El-Houri, R., Andersen, M. Ø., Needham, D. & Arnspang, E. C., 10. Feb 2019, In : Journal of Visualized Experiments. 144

Research output: Contribution to journalJournal articleResearchpeer-review

Stem cells
Mesenchymal Stromal Cells
Lipids
Nanoparticles
Cholesterol

Projects 2013 2019

Teaching & Supervision