20102019
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Research Output 2010 2019

2019
40 Downloads (Pure)

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In : Cell Death & Disease. 10, 11, 12 p., 841.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Epirubicin
Proteins
Cell Aging
Nevus
85 Downloads (Pure)

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

Ehmsen, S., Pedersen, M. H., Wang, G., Terp, M. G., Arslanagic, A., Hood, B. L., Conrads, T. P., Leth-Larsen, R. & Ditzel, H. J., 25. Jun 2019, In : Cell Reports. 27, 13, p. 3927-3938.e6

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Biosynthesis
Stem cells
Cholesterol
Tumors
Hydroxymethylglutaryl-CoA Reductase Inhibitors
63 Downloads (Pure)

Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

Traynor, S., Møllegaard, N. E., Jørgensen, M. G., Brückmann, N. H., Pedersen, C. B., Terp, M. G., Johansen, S., Dejardin, J., Ditzel, H. J. & Gjerstorff, M. F., 26. Jul 2019, In : Nucleic acids research. 47, 13, p. 6668-6684

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Chromosomes, Human, Pair 1
Proteins
Satellite DNA
DNA Methylation
Epigenomics
116 Downloads (Pure)

Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

Hubackova, S., Davidova, E., Rohlenova, K., Stursa, J., Werner, L., Andera, L., Dong, L. F., Terp, M. G., Hodny, Z., Ditzel, H. J., Rohlena, J. & Neuzil, J., 1. Feb 2019, In : Cell Death and Differentiation. 26, 2, p. 276–290

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cell Aging
Cell Cycle Checkpoints
Neoplasms
Down-Regulation
Pathology
2018
116 Downloads (Pure)

Human cancer evolution in the context of a human immune system in mice

Gammelgaard, O. L., Terp, M. G., Preiss, B. & Ditzel, H. J., Oct 2018, In : Molecular Oncology. 12, 10, p. 1797-1810

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Immune System
Neoplasms
Tumor-Infiltrating Lymphocytes
Ligands
Cell Line
150 Downloads (Pure)

KDM4B-regulated unfolded protein response as a therapeutic vulnerability in PTEN-deficient breast cancer

Wang, W., Oguz, G., Lee, P. L., Bao, Y., Wang, P., Terp, M. G., Ditzel, H. J. & Yu, Q., 5. Nov 2018, In : The Journal of Experimental Medicine. 215, 11, p. 2833-2849

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Histone Demethylases
Apoptosis

Proteomic comparison of clinical breast cancer samples, corresponding patient derived xenografts (PDX) and mammospheres reveal increased cholesterol biosynthesis as a key feature of cancer stem cells

Ehmsen, S., Pedersen, M. H., Arslanagic, A., Terp, M. G., Leth-Larsen, R., Ditzel, H., Hood, B. L. & Conrads, T. P., 4. May 2018.

Research output: Contribution to conference without publisher/journalPosterCommunication

2017

Elucidation of altered pathways in tumor-initiating cells of triple-negative breast cancer: A useful cell model system for drug screening

Christensen, A. G., Ehmsen, S., Terp, M. G., Batra, R., Alcaraz, N., Baumbach, J., Noer, J. B., Moreira, J. M. A., Leth-Larsen, R., Larsen, M. R. & Ditzel, H. J., Aug 2017, In : Stem Cells. 35, 8, p. 1898–1912

Research output: Contribution to journalJournal articleResearchpeer-review

Neoplasms
Apoptosis
Apoptosis Regulatory Proteins
Interleukin-2
Organism Cloning
2016
132 Downloads (Pure)

Development of a specific affinity-matured exosite inhibitor to MT1-MMP that efficiently inhibits tumor cell invasion in vitro and metastasis in vivo

Botkjaer, K. A., Kwok, H. F., Terp, M. G., Karatt-Vellatt, A., Santamaria, S., McCafferty, J., Andreasen, P. A., Itoh, Y., Ditzel, H. J. & Murphy, G., 2016, In : Oncotarget. 7, 13, p. 16773-16792

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Matrix Metalloproteinase 14
Catalytic Domain
Neoplasms
Membrane-Associated Matrix Metalloproteinases
Random Allocation

Dual epitope targeting of CD73 exhibits potent anti-cancer activity

Gammelgaard, O. L., Terp, M. G., Parren, P. W. H. I., Leth-Larsen, R. & Ditzel, H., 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

139 Downloads (Pure)

The role of GAGE cancer/testis antigen in metastasis: the jury is still out

Gjerstorff, M. F., Terp, M. G., Hansen, M. B. & Ditzel, H. J., 2016, In : BMC Cancer. 16, p. 7

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Proteins
Clone Cells
Lung
Down-Regulation
2015
135 Downloads (Pure)

Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability

Greve, K. B. V., Lindgreen, J., Terp, M. G., Pedersen, C. B., Schmidt, S., Mollenhauer, J., Kristensen, S. B., Andersen, R. S., Relster, M. M., Ditzel, H. & Gjerstorff, M., Feb 2015, In : Molecular Oncology. 9, 2, p. 437-449 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Melanoma
Double-Stranded DNA Breaks
Growth
Galactosidases
G1 Phase Cell Cycle Checkpoints
175 Downloads (Pure)

miR-155, identified as anti-metastatic by global miRNA profiling of a metastasis model, inhibits cancer cell extravasation and colonization in vivo and causes significant signaling alterations

Gravgaard, K. H., Terp, M. G., Lund, R. R., Søkilde, R., Elias, D., Bak, M., Litman, T., Beck, H. C., Lyng, M. B. & Ditzel, H. J., 2015, In : OncoTarget. 6, 30, p. 29224–29239

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
MicroRNAs
Neoplasms
Tumor Burden
Lung
Proteins
683 Downloads (Pure)

NADH-Cytochrome b5 Reductase 3 Promotes Colonization and Metastasis Formation and Is a Prognostic Marker of Disease-Free and Overall Survival in Estrogen Receptor-Negative Breast Cancer

Lund, R. R., Leth-Larsen, R., Caterino, T. D., Terp, M. G., Nissen, J., Lænkholm, A-V., Jensen, O. N. & Ditzel, H. J., Nov 2015, In : Molecular and Cellular Proteomics. 14, 11, p. 2988-99

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Cytochrome-B(5) Reductase
Cytochromes b5
Cytochrome Reductases
Estrogen Receptors
Disease-Free Survival
191 Downloads (Pure)

Selection of LNA-containing DNA aptamers against recombinant human CD73

Elle, I. C., Karlsen, K. K., Terp, M. G., Larsen, N., Nielsen, R., Derbyshire, N., Mandrup, S., Ditzel, H. J. & Wengel, J., 21. Apr 2015, In : Molecular BioSystems. 11, 5, p. 1260-1270

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Nucleotide Aptamers
Surface Plasmon Resonance
Computational Biology
Libraries
Cluster Analysis
2014

Application of proteomics in the study of rodent models of cancer

Terp, M. G. & Ditzel, H. J., 8. Mar 2014, In : Proteomics - Clinical Applications. 8, 9-10, p. 640–652

Research output: Contribution to journalJournal articleResearchpeer-review

Tumors
Rodentia
Biomarkers
Neoplasms
Proteins
2013

Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells

Terp, M. G., Olesen, K. A., Christensen, E. A., Lund, R. R., Lagerholm, B. C., Ditzel, H. J. & Leth-Larsen, R., 2013, In : Journal of Immunology. 191, 8, p. 4165-4173

Research output: Contribution to journalJournal articleResearchpeer-review

Cluster Analysis
Circulating Neoplastic Cells
Neoplasms
5'-Nucleotidase
Growth

Set-up of Mouse Models for Nanodrug Testing

Hansen, P. L., Riedel, A., Schmidt, S., Terp, M. G., Trojnar, J. H., Schifter, S., Olsen, B. B., Thisgaard, H., Ditzel, H., Høilund-Carlsen, P. F. & Mollenhauer, J., 2013.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

2012

Functional heterogeneity within the CD44 high human breast cancer stem cell-like compartment reveals a gene signature predictive of distant metastasis

Leth-Larsen, R., Terp, M. G., Christensen, A. G. L., Elias, D., Kühlwein, T., Jensen, O. N., Petersen, O. W. & Ditzel, H., 2012, In : Molecular Medicine. 18, p. 1109-1121 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Clone Cells
Lipoprotein Receptors
Cell Line
Mucin-1
Pharmaceutical Preparations

Identification of markers associated with highly aggressive metastatic phenotypes using quantitative comparative proteomics

Terp, M. G., Lund, R. R., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 2012, In : Cancer Genomics & Proteomics. 9, 5, p. 265-273

Research output: Contribution to journalJournal articleResearchpeer-review

Tumors
Cells
Neoplasms
Proteins
Proteomics

Identification of Markers Associated with Highly Aggressive Metastatic Phenotypes Using Quantitative Comparative Proteomics

Terp, M. G., Lund, R. R., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 29. Nov 2012.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Quantitative proteomics of primary tumors with varying metastatic capabilities using stable isotope-labeled proteins of multiple histogenic origins

Lund, R. R., Terp, M. G., Laenkholm, A-V., Jensen, O. N., Leth-Larsen, R. & Ditzel, H. J., 2012, In : Proteomics. 12, 13, p. 2139-2148

Research output: Contribution to journalJournal articleResearchpeer-review

Isotopes
Tumors
Neoplasms
Proteins
Proteome
2011

Antibodies targeting human CD73 inhibit breast tumor growth

Terp, M. G., Fredberg, L., Lund, R. R., Skjødt, K., Ditzel, H. & Leth-Larsen, R., 9. Mar 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Construction of new cancer cell models for nanodrug discovery and testing

Hansen, P. L., Olsen, S. B., Terp, M. G., Schmidt, S., Riedel, A., Müller, C., Block, I., Christiansen, H., Ditzel, H. & Mollenhauer, J., 23. May 2011.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Heterogeneity within the cancer stem cell population as defined by CD44+/CD24low/- in breast cancer

Leth-Larsen, R., Terp, M. G., Christensen, A. G. L., Elias, D., Kühlwein, T., Jensen, O. N., Petersen, O. W. & Ditzel, H., 6. Mar 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

Quantitative Proteome Analysis of Cancer Tissues using SILAC-labeled Proteins of Multiple Histogenic Origins

Lund, R. R., Terp, M. G., Jensen, O. N., Leth-Larsen, R. & Ditzel, H., 20. Jun 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

The cancer-germline antigen SSX2 causes cell cycle arrest and DNA damage in cancer cells

Greve, K. B. V., Lindgreen, J., Terp, M. G., Schmidt, S., Mollenhauer, J., Ditzel, H. & Gjerstorff, M., Oct 2011. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearch

2010

CD44 Variant Isoforms in Triple-Negative Breast Cancer

Leth-Larsen, R., Christensen, A. G. L., Terp, M. G., Hansen, H. V., Petersen, O. W. & Ditzel, H., 2010.

Research output: Contribution to conference without publisher/journalPosterResearch

Protein Profiling of Primary Tumors with Different Abilities to Establish Lung Metastases

Lund, R. R., Terp, M. G., Leth-Larsen, R., Jensen, O. N. & Ditzel, H., 2010.

Research output: Contribution to conference without publisher/journalPosterResearch