Mette Sørensen

M.Sc., PhD

  • J.B. Winsløws Vej 9 B, st. tv.

    5000 Odense C

    Denmark

20072019
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Research Output 2007 2019

2019
18 Downloads (Pure)

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., 2019, In : Aging Cell. 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Epigenomics
Sex Characteristics
80 Downloads (Pure)

Epigenome-wide association study of depression symptomatology in elderly monozygotic twins

Starnawska, A., Tan, Q., Sørensen, M., McGue, M., Mors, O., Børglum, A. D., Christensen, K., Nyegaard, M. & Christiansen, L., 2. Sep 2019, In : Translational Psychiatry. 9, 1, 14 p., 214.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Monozygotic Twins
Depression
DNA Methylation
Epigenomics
Flow Cytometry
67 Downloads (Pure)

Epigenome-wide association study of leukocyte telomere length

Lee, Y., Sun, D., Ori, A. P. S., Lu, A. T., Seeboth, A., Harris, S. E., Deary, I. J., Marioni, R. E., Soerensen, M., Mengel-From, J., Hjelmborg, J., Christensen, K., Wilson, J. G., Levy, D., Reiner, A. P., Chen, W., Li, S., Harris, J. R., Magnus, P., Aviv, A. & 2 others, Jugessur, A. & Horvath, S., 26. Aug 2019, In : Aging. 11, 16, p. 5876-5894

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Telomere
Epigenomics
Women's Health
DNA Methylation
Circadian Rhythm
31 Downloads (Pure)
Open Access
File
Monozygotic Twins
Cell Differentiation
HLA-C Antigens
Comb and Wattles
Nucleic Acid Regulatory Sequences
56 Downloads (Pure)

Longitudinal changes in the genetic and environmental influences on the epigenetic clocks across old age: Evidence from two twin cohorts

Jylhävä, J., Hjelmborg, J., Sørensen, M., Munoz, E., Tan, Q., Kuja-Halkola, R., Mengel-From, J., Christensen, K., Christiansen, L., Hägg, S., Pedersen, N. L. & Reynolds, C. A., Feb 2019, In : EBioMedicine. 40, p. 710-716

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epigenomics
Clocks
Research
DNA Methylation
Epidemiology
18 Downloads (Pure)

Untangling the genetics of human longevity — A challenging quest

Dato, S., Soerensen, M. & Rose, G., 1. Aug 2019, In : Genes. 10, 8, 4 p., 585.

Research output: Contribution to journalEditorialResearchpeer-review

Open Access
File
Medical Genetics
Life Expectancy
Developed Countries
2018
39 Downloads (Pure)

DNA methylation age and perceived age in elderly Danish twins

Debrabant, B., Sørensen, M., Christiansen, L., Tan, Q., McGue, M., Christensen, K. & Hjelmborg, J. V. B., 1. Jan 2018, In : Mechanisms of Ageing and Development. 169, p. 40-44

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Epigenomics
108 Downloads (Pure)

DNA Methylation and All-Cause Mortality in Middle-Aged and Elderly Danish Twins

Svane, A. M., Soerensen, M., Lund, J., Tan, Q., Jylhävä, J., Wang, Y., Pedersen, N. L., Hägg, S., Debrabant, B., Deary, I. J., Christensen, K., Christiansen, L. & Hjelmborg, J. B., 8. Feb 2018, In : Genes. 9, 2, 15 p., 78.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Twin Studies
Monozygotic Twins
Population
70 Downloads (Pure)

Epigenetic signature of preterm birth in adult twins

Tan, Q., Li, S., Frost, M., Nygaard, M., Soerensen, M., Larsen, M., Christensen, K. & Christiansen, L., 2018, In : Clinical Epigenetics. 10, 10 p., 87.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Premature Birth
Epigenomics
Health
Chromosomes, Human, Pair 5
Chromosomes, Human, Pair 3
84 Downloads (Pure)

The genetic component of human longevity: New insights from the analysis of pathway-based SNP-SNP interactions

Dato, S., Thinggaard, M. S., De Rango, F., Rose, G., Christensen, K., Christiansen, L. & Passarino, G., Jun 2018, In : Aging Cell. 17, 3, 12 p., e12755.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Medical Genetics
Single Nucleotide Polymorphism
Metabolic Networks and Pathways
Cohort Studies
Insulin
2017
67 Downloads (Pure)

Epigenome-wide association of DNA methylation in whole blood with bone mineral density

Morris, J. A., Tsai, P-C., Joehanes, R., Zheng, J., Trajanoska, K., Sørensen, M., Forgetta, V., Castillo-Fernandez, J. E., Frost, M., Spector, T. D., Christensen, K., Christiansen, L., Rivadeneira, F., Tobias, J. H., Evans, D. M., Kiel, D. P., Hsu, Y-H., Richards, J. B. & Bell, J. T., 2017, In : Journal of Bone and Mineral Research. 32, 8, p. 1644-1650

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
DNA Methylation
Bone Density
Femur Neck
Epigenomics
Cytosine

Handling blood cell composition in epigenetic studies on ageing

Tan, Q., Heijmans, B. T., Hjelmborg, J. V. B., Thinggaard, M. S., Christensen, K. & Christiansen, L., 2017, In : International Journal of Epidemiology. 46, 5, p. 1717–1718

Research output: Contribution to journalComment/debateResearchpeer-review

70 Downloads (Pure)

Limitations and risks of meta-analyses of longevity studies

Sebastiani, P., Bae, H., Gurinovich, A., Soerensen, M., Puca, A. A. & Perls, T., 2017, In : Mechanisms of Ageing and Development. 165, Part B, p. 139-146

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Meta-Analysis
Genetic Association Studies
Medical Genetics
Sample Size
Datasets
2016

Epigenetic drift in the aging genome: a ten-year follow-up in an elderly twin cohort

Tan, Q., Heijmans, B. T., Hjelmborg, J. V. B., Sørensen, M., Christensen, K. & Christiansen, L., 2016, In : International Journal of Epidemiology. 45, 4, p. 1146-1158

Research output: Contribution to journalJournal articleResearchpeer-review

Cytosine
Guanine
Epigenomics
DNA Methylation
Survival Analysis
84 Downloads (Pure)
Open Access
File
Cognition
Haplotypes
Heterozygote
Central Nervous System
Cognitive Dysfunction
Polymorphism
Nucleotides
Genes
Aging of materials
Single Nucleotide Polymorphism
2015
72 Downloads (Pure)

Association study of FOXO3A SNPs and aging phenotypes in Danish oldest-old individuals

Sørensen, M., Nygaard, M., Dato, S., Stevnsner, T., Bohr, V. A., Christensen, K. & Christiansen, L., 2015, In : Aging Cell. 14, 1, p. 60-6

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Single Nucleotide Polymorphism
Bone Fractures
Population
Wrist
Cognition
2014
Genes
Alleles
Genetic Heterogeneity
Medical Genetics
Population

Contribution of genetic polymorphisms on functional status at very old age: A gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway

Dato, S., Sørensen, M., Lagani, V., Montesanto, A., Passarino, G., Christensen, K., Tan, Q. & Christiansen, L., Apr 2014, In : Experimental Gerontology. 52, p. 23-29

Research output: Contribution to journalJournal articleResearchpeer-review

Oxidative stress
Genetic Polymorphisms
Polymorphism
Single Nucleotide Polymorphism
Genes

Gene set analysis for GWAS: Assessing the use of modified Kolmogorov-Smirnov statistics

Debrabant, B. & Soerensen, M., Oct 2014, In : Statistical Applications in Genetics and Molecular Biology. 13, 5, p. 553-66

Research output: Contribution to journalJournal articleResearchpeer-review

Kolmogorov-Smirnov Statistic
Genome-Wide Association Study
Genes
Statistics
Gene

Human longevity and variation in DNA damage response and repair: Study of the contribution of sub-processes using competitive gene-set analysis

Debrabant, B., Sørensen, M., Flachsbart, F., Dato, S., Mengel-From, J., Stevnsner, T., Bohr, V. A., Kruse, T. A., Schreiber, S., Nebel, A., Christensen, K., Tan, Q. & Christiansen, L., Sep 2014, In : European Journal of Human Genetics. 22, 9, p. 1131-6

Research output: Contribution to journalJournal articleResearchpeer-review

Recombinational DNA Repair
Single Nucleotide Polymorphism
DNA Mismatch Repair
Telomere
Population
2013

AKT1 fails to replicate as a longevity-associated gene in Danish and German nonagenarians and centenarians

Nygaard, M., Soerensen, M., Flachsbart, F., Mengel-From, J., Tan, Q., Schreiber, S., Nebel, A., Christensen, K. & Christiansen, L., 2013, In : European Journal of Human Genetics. 21, 5, p. 574-577

Research output: Contribution to journalJournal articleResearchpeer-review

Single Nucleotide Polymorphism
Medical Genetics
Population
Publications
Longitudinal Studies
Deceleration
Alleles
Cohort Effect
Genetic Models

A novel permutation test for case-only analysis identifies epistatic effects on human longevity in the FOXO gene family

Tan, Q., Sørensen, M., Kruse, T. A., Christensen, K. & Christiansen, L., 2013, In : Aging Cell. 12, 4, p. 690-694

Research output: Contribution to journalJournal articleResearchpeer-review

Single Nucleotide Polymorphism
Population
Datasets

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity

Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Suchiman, H. E. D., Jacobsen, R., McGue, M., Stevnsner, T. V., Bohr, V., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K. & Christiansen, L., 2013, In : Age (Omaha). 35, 2, p. 487-500

Research output: Contribution to journalJournal articleResearchpeer-review

Longitudinal Studies
Case-Control Studies
Interleukin-6
Single Nucleotide Polymorphism
Haplotypes

Genetisk variation og langt liv

Sørensen, M., 2013, In : Gerontologi. 29, 4, p. 30-33 201346.

Research output: Contribution to journalJournal articleResearch

Genetic variation in TERT and TERC and human leukocyte telomere length and longevity: a cross-sectional and longitudinal analysis

Soerensen, M., Thinggaard, M., Nygaard, M., Dato, S., Tan, Q., Hjelmborg, J., Andersen-Ranberg, K., Stevnsner, T. V., Bohr, V., Kimura, M., Aviv, A., Christensen, K. & Christiansen, L., Apr 2012, In : Aging Cell. 11, 2, p. 223-7 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Telomerase
Telomere
Cross-Sectional Studies
Single Nucleotide Polymorphism
Haplotypes

Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies

Soerensen, M., Dato, S., Tan, Q., Thinggaard, M., Kleindorp, R., Beekman, M., Jacobsen, R., Suchiman, H. E. D., de Craen, A. J. M., Westendorp, R. G. J., Schreiber, S., Stevnsner, T. V., Bohr, V., Slagboom, P. E., Nebel, A., Vaupel, J. W., Christensen, K., McGue, M. & Christiansen, L., May 2012, In : Experimental Gerontology. 47, 5, p. 379-87 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Insulin-Like Growth Factor I
Single Nucleotide Polymorphism
Longitudinal Studies
Repair
Cross-Sectional Studies

Pathway analysis of variation in DNA repair genes indicates involvement of repair of oxidative DNA lesions in human longevity

Sørensen, M., Debrabant, B., Mengel-From, J., Stevnsner, T. V., Bohr, V., Tan, Q. & Christiansen, L., Nov 2012.

Research output: Contribution to conference without publisher/journalPosterResearch

UCP3 polymorphisms, hand grip performance and survival at old age: Association analysis in two Danish middle aged and elderly cohorts

Dato, S., Sørensen, M., Montesanto, A., Lagani, V., Christiansen, L. & Christensen, K., 2012, In : Mechanisms of Ageing and Development. 133, 8, p. 530-537

Research output: Contribution to journalJournal articleResearchpeer-review

Single Nucleotide Polymorphism
Alleles
Genetic Polymorphisms
Haplotypes
Population

Variation in DNA Repair Pathway Genes is Associated with Human Longevity and Aging Phenotypes

Sørensen, M., Stevnsner, T. V., Bohr, V. & Christiansen, L., Nov 2012.

Research output: Contribution to conference without publisher/journalPosterResearch

2010

Replication of an Association of Variation in the FOXO3A Gene with Human Longevity Using Both Case-control and Longitudinal Data

Soerensen, M., Dato, S., Christensen, K., McGue, M., Stevnsner, T. V., Bohr, V. & Christiansen, L., Dec 2010, In : Aging Cell. 9, 6, p. 1010-7

Research output: Contribution to journalJournal articleResearchpeer-review

Single Nucleotide Polymorphism
Longitudinal Studies
Case-Control Studies
Cohort Effect
Haplotypes
2009

A potential impact of DNA repair on ageing and lifespan in the ageing model organism Podospora anserina: decrease in mitochondrial DNA repair activity during ageing

Soerensen, M., Gredilla, R., Müller-Ohldach, M., Werner, A., Bohr, V. A., Osiewacz, H. D. & Stevnsner, T., 1. Aug 2009, In : Mechanisms of Ageing and Development. 130, 8, p. 487-96 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Podospora
Mitochondrial Proteins
Free Radicals
Mammals
Lipids
Single Nucleotide Polymorphism
Reactive Oxygen Species
Alleles
Free Radicals
Proteins
2007

DNA repair activity in Podospora anserina

Sørensen, M., Diaz, R. G., Müller-Ohldach, M., Werner, A., Bohr, V., Osiewacz, H. D. & Stevnsner, T. V., 2007.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Molekylær biologisk aldringsforskning

Sørensen, M., Stevnsner, T. V. & Bohr, V., 2007, Oldetopia. Medicinsk Museion, Københavns Universitet

Research output: Chapter in Book/Report/Conference proceedingBook chapterCommunication