Majken Siersbæk

Cand.scient Biomedicine

  • Campusvej 55

    5230 Odense M

    Denmark

20082019
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Research Output 2008 2019

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Journal article
2019
105 Downloads (Pure)

Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12. Mar 2019, In : Journal for immunotherapy of cancer. 7, 1, 15 p., 68.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Cell Proliferation
Gene Expression Profiling
Autocrine Communication
CD4-CD8 Ratio
2018
107 Downloads (Pure)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. Dec 2018, In : PLOS Biology. 16, 12, p. 1-32 e2006249.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Glucocorticoid Receptors
Gene expression
Liver
insulin
Genes
2017
198 Downloads (Pure)

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. Jan 2017, In : Scientific Reports. 7, 13 p., 40220.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
High Fat Diet
Liver
Fasting
Insulin
Transcriptome

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J., Liao, X. H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., Latteyer, S., Engels, K., Strucksberg, K. H., Kleinbongard, P., Zwanziger, D., Rozman, J., Gailus-Durner, V., Fuchs, H., De Angelis, M. H., Klein-Hitpass, L. & 8 others, Köhrle, J., Armstrong, D. L., Grøntved, L., Bassett, J. H. D., Williams, G. R., Refetoff, S., Führer, D. & Moeller, L. C., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11323-E11332

Research output: Contribution to journalJournal articleResearchpeer-review

Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Mutation
Nucleic Acid Regulatory Sequences
DNA
130 Downloads (Pure)

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26. Dec 2017, In : Cell Reports. 21, 13, p. 3662-3671

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Macrophages
Tumors
Collagen
Neoplasms
Degradation
2016
118 Downloads (Pure)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. Jul 2016, In : Cell Death & Disease. 7, 6, p. e2289

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Adipocytes
Adipogenesis
Ligases
Ubiquitin
Neoplasms
2015
286 Downloads (Pure)

Browning of human adipocytes requires KLF11 and reprogramming of PPARgamma superenhancers

Loft, A., Forss, I., Siersbæk, M. S., Schmidt, S. F., Larsen, A-S. B., Madsen, J. G. S., Pisani, D. F., Nielsen, R., Aagaard, M. M., Mathison, A., Neville, M. J., Urrutia, R., Karpe, F., Amri, E-Z. & Mandrup, S., 2015, In : Genes & Development. 29, 1, p. 7-22

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
rosiglitazone
PPAR gamma
Adipocytes
White Adipocytes
Rodentia

Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.

Jafari, A., Siersbæk, M., Chen, L., Qanie, D. W. M., Zaher, W., Abdallah, B. & Kassem, M., 2015, In : Stem Cells. 33, 7, p. 2219–2231

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Osteogenesis
Mesenchymal Stromal Cells
Osteoblasts
Adipogenesis
2012

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

Siersbæk, M., Loft, A., Jørgensen, M. M. A., Nielsen, R., Schmidt, S. F., Petrovic, N., Nedergaard, J. & Mandrup, S., 2012, In : Molecular and Cellular Biology. 32, 17, p. 3452-63 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Brown Adipocytes
Groin
Adipocytes
White Adipocytes
Chromatin Immunoprecipitation

PPARs: fatty acid sensors controlling metabolism

Poulsen, L. L. C., Siersbæk, M. & Mandrup, S., 2012, In : Seminars in Cell and Developmental Biology. 23, 6, p. 631-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Fatty Acids
Lipid Metabolism
Cytoplasmic and Nuclear Receptors
Growth
2010

A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes

Bugge, A., Siersbæk, M., Madsen, M. S., Göndör, A., Rougier, C. & Mandrup, S., 4. Jun 2010, In : Journal of Biological Chemistry. 285, 23, p. 17310-7 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
Adipocytes
Genes
Introns
Peroxisome Proliferator-Activated Receptors