Majken Siersbæk

Cand.scient Biomedicine

  • Campusvej 55

    5230 Odense M

    Denmark

20082019
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Research Output 2008 2019

2019
103 Downloads (Pure)

Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12. Mar 2019, In : Journal for immunotherapy of cancer. 7, 1, 15 p., 68.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Cell Proliferation
Gene Expression Profiling
Autocrine Communication
CD4-CD8 Ratio
2018
105 Downloads (Pure)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. Dec 2018, In : PLOS Biology. 16, 12, p. 1-32 e2006249.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Glucocorticoid Receptors
Gene expression
Liver
insulin
Genes

Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver

Siersbæk, M., Kalvisa, A., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 11. Sep 2018.

Research output: Contribution to conference without publisher/journalPosterResearch

2017
194 Downloads (Pure)

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. Jan 2017, In : Scientific Reports. 7, 13 p., 40220.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
High Fat Diet
Liver
Fasting
Insulin
Transcriptome

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J., Liao, X. H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., Latteyer, S., Engels, K., Strucksberg, K. H., Kleinbongard, P., Zwanziger, D., Rozman, J., Gailus-Durner, V., Fuchs, H., De Angelis, M. H., Klein-Hitpass, L. & 8 others, Köhrle, J., Armstrong, D. L., Grøntved, L., Bassett, J. H. D., Williams, G. R., Refetoff, S., Führer, D. & Moeller, L. C., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11323-E11332

Research output: Contribution to journalJournal articleResearchpeer-review

Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Mutation
Nucleic Acid Regulatory Sequences
DNA
126 Downloads (Pure)

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26. Dec 2017, In : Cell Reports. 21, 13, p. 3662-3671

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Macrophages
Tumors
Collagen
Neoplasms
Degradation
2016

HIGH FAT DIET-INDUCED CHANGES OF MOUSE HEPATIC TRANSCRIPTION AND ENHANCER ACTIVITY ARE REVERSED BY SUBSEQUENT WEIGHT LOSS.

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 25. Aug 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

117 Downloads (Pure)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. Jul 2016, In : Cell Death & Disease. 7, 6, p. e2289

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Adipocytes
Adipogenesis
Ligases
Ubiquitin
Neoplasms
2015
282 Downloads (Pure)

Browning of human adipocytes requires KLF11 and reprogramming of PPARgamma superenhancers

Loft, A., Forss, I., Siersbæk, M. S., Schmidt, S. F., Larsen, A-S. B., Madsen, J. G. S., Pisani, D. F., Nielsen, R., Aagaard, M. M., Mathison, A., Neville, M. J., Urrutia, R., Karpe, F., Amri, E-Z. & Mandrup, S., 2015, In : Genes & Development. 29, 1, p. 7-22

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
rosiglitazone
PPAR gamma
Adipocytes
White Adipocytes
Rodentia

Pharmacological Inhibition of Protein Kinase G1 Enhances Bone Formation by Human Skeletal Stem Cells Through Activation of RhoA-Akt Signaling.

Jafari, A., Siersbæk, M., Chen, L., Qanie, D. W. M., Zaher, W., Abdallah, B. & Kassem, M., 2015, In : Stem Cells. 33, 7, p. 2219–2231

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Osteogenesis
Mesenchymal Stromal Cells
Osteoblasts
Adipogenesis
2012

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

Siersbæk, M., Loft, A., Jørgensen, M. M. A., Nielsen, R., Schmidt, S. F., Petrovic, N., Nedergaard, J. & Mandrup, S., 2012, In : Molecular and Cellular Biology. 32, 17, p. 3452-63 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Brown Adipocytes
Groin
Adipocytes
White Adipocytes
Chromatin Immunoprecipitation

Genome-wide profiling of peroxisome proliferator-activated receptor γ in primary epididymal, inguinal, and brown adipocytes reveals depot-selective binding correlated with gene expression

Loft, A., Siersbæk, M., Jørgensen, M. M. A., Nielsen, R., Schmidt, S. F., Petrovic, N., Nedergaard, J. & Mandrup, S., 27. Aug 2012.

Research output: Contribution to conference without publisher/journalPosterResearch

PPARs: fatty acid sensors controlling metabolism

Poulsen, L. L. C., Siersbæk, M. & Mandrup, S., 2012, In : Seminars in Cell and Developmental Biology. 23, 6, p. 631-9 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Fatty Acids
Lipid Metabolism
Cytoplasmic and Nuclear Receptors
Growth
2011

Transcriptional regulators and epigenetic modulators involved in differentiation of brite adipocytes

Loft, A., Siersbæk, M., Jørgensen, M. M. A. & Mandrup, S., 12. Oct 2011.

Research output: Contribution to conference without publisher/journalPosterResearch

2010

A novel intronic peroxisome proliferator-activated receptor gamma enhancer in the uncoupling protein (UCP) 3 gene as a regulator of both UCP2 and -3 expression in adipocytes

Bugge, A., Siersbæk, M., Madsen, M. S., Göndör, A., Rougier, C. & Mandrup, S., 4. Jun 2010, In : Journal of Biological Chemistry. 285, 23, p. 17310-7 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
Adipocytes
Genes
Introns
Peroxisome Proliferator-Activated Receptors
2008

Identification of putative PPAR response elements in and around the murine UCP3 gene

Siersbæk, M., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

Adipocytes
Skeletal Muscle
Messenger RNA
Fatty Acids
3T3-L1 Cells