Morten Frier Gjerstorff

2025

Stochastic demethylation and redundant epigenetic suppressive mechanisms generate highly heterogeneous responses to pharmacological DNA methyltransferase inhibition

Jakobsen, M. K., Traynor, S., Nielsen, A. Y., Dahl, C., Staehr, M., Jakobsen, S. T., Madsen, M. S., Siersbaek, R., Terp, M. G., Jensen, J. B., Pedersen, C. B., Shrestha, A., Brewer, J. R., Duijf, P. H. G., Gammelgaard, O. L., Ditzel, H. J., Kirkin, A. F., Guldberg, P. & Gjerstorff, M. F., 23. Jan 2025, In: Journal of Experimental & Clinical Cancer Research. 44, 1, 15 p., 21.

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2024

Adoptive cell transfer therapy with ex vivo primed peripheral lymphocytes in combination with anti-PDL1 therapy effectively inhibits triple-negative breast cancer growth and metastasis

Gammelgaard, O. L., Terp, M. G., Kirkin, A. F., Johansen, S., Traynor, S., Vever, H., Guldberg, P., Kodahl, A. R., Gjerstorff, M. F. & Ditzel, H. J., 6. Jan 2024, In: Molecular Cancer. 23, 16 p., 6.

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Aldersrelaterede forskelle i kræftbiologi hos ældre

Translated title of the contribution: Age-related differences in cancer biology in older patientsGammelgaard, O. L., Guldberg, P., Gjerstorff, M. F. & Ditzel, H. J., 22. Jan 2024, In: Ugeskrift for Læger. 186, 2, p. 135-138 V07230474.

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AMBRA1 levels predict resistance to MAPK inhibitors in melanoma

Leo, L. D., Pagliuca, C., Kishk, A., Rizza, S., Tsiavou, C., Pecorari, C., Dahl, C., Pacheco, M. P., Tholstrup, R., Brewer, J. R., Berico, P., Hernando, E., Cecconi, F., Ballotti, R., Bertolotto, C., Filomeni, G., Gjerstorff, M. F., Sauter, T., Lovat, P. & Guldberg, P. & 1 others, De Zio, D., 1. Jun 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 25, e2400566121.

Research output: Contribution to journal › Journal article › Research › peer-review

Correction to: HMGA2 Supports Cancer Hallmarks in Triple-Negative Breast Cancer (Cancers, (2021), 13, 20, (5197), 10.3390/cancers13205197)

Mansoori, B., Terp, M. G., Mohammadi, A., Pedersen, C. B., Ditzel, H. J., Baradaran, B. & Gjerstorff, M. F., 11. Oct 2024, In: Cancers. 16, 20, 3444.

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Single-cell sequencing unveils extensive intratumoral heterogeneity of cancer/testis antigen expression in melanoma and lung cancer

Traynor, S., Jakobsen, M. K., Green, T. M., Komic, H., Palarasah, Y., Pedersen, C. B., Ditzel, H. J., Thoren, F. B., Guldberg, P. & Gjerstorff, M. F., 17. Jun 2024, In: Journal for ImmunoTherapy of Cancer. 12, 6, 9 p., e008759.

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2023

Crosstalk between interferon and interleukin-1 antiviral signaling in cancer cells: implications for immune evasion and therapeutic resistance

Gjerstorff, M. F., 8. Jun 2023, In: Frontiers in Immunology. 14, 4 p., 1219870.

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DNA methyltransferase inhibition promotes recruitment of myeloid-derived suppressor cells to the tumor microenvironment through induction of tumor cell-intrinsic interleukin-1

Traynor, S., Terp, M. G., Nielsen, A. Y., Guldberg, P., Jakobsen, M., Pedersen, P. G., Gammelgaard, O. L., Pedersen, C. B., Pedersen, M. T., Rattenborg, S., Ditzel, H. J. & Gjerstorff, M. F., 1. Jan 2023, In: Cancer Letters. 552, 9 p., 215982.

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Epigenetic targeting of myeloid-derived suppressor cells: time to move into infectious diseases?

Gjerstorff, M. F., 23. Aug 2023, In: Frontiers in Immunology. 14, 4 p., 1247715.

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Therapeutic cancer vaccination against mutant calreticulin in myeloproliferative neoplasms induces expansion of specific T cells in the periphery but specific T cells fail to enrich in the bone marrow

Holmström, M. O., Andersen, M., Traynor, S., Ahmad, S. M., Lisle, T. L., Handlos Grauslund, J., Skov, V., Kjær, L., Ottesen, J. T., Gjerstorff, M. F., Hasselbalch, H. C. & Andersen, M. H., 17. Aug 2023, In: Frontiers in Immunology. 14, 14 p., 1240678.

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2022

PDX Models: A Versatile Tool for Studying the Role of Myeloid-Derived Suppressor Cells in Breast Cancer

Gjerstorff, M. F., Traynor, S., Gammelgaard, O. L., Johansen, S., Pedersen, C. B., Ditzel, H. J. & Terp, M. G., Dec 2022, In: Cancers. 14, 24, 16 p., 6153.

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SSX2 promotes the formation of a novel type of intranuclear lamin bodies

Traynor, S., Jakobsen, N. D., Ebbesen, M. F., Bennedsen, S. N., Johansen, S., Ebstrup, M. L., Pedersen, C. B., Ditzel, H. J., Brewer, J. R. & Gjerstorff, M. F., Jan 2022, In: The International Journal of Biochemistry & Cell Biology. 142, 8 p., 106121.

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SSX addiction in melanoma propagates tumor growth and metastasis

Traynor, S., Ebstrup, M. L., Gammelgaard, O. L., Mansoori, B., Terp, M. G., Rein, C. R. H., Rattenborg, S., Pedersen, C. B., Ditzel, H. J. & Gjerstorff, M. F., 7. Oct 2022, In: Frontiers in Oncology. 12, 11 p., 998000.

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Targeting two distinct epitopes on human CD73 with a bispecific antibody improves anticancer activity

Gammelgaard, O. L., Terp, M. G., Renn, C., Labrijn, A. F., Hamaker, O., Nielsen, A. Y., Vever, H., Hansen, S. W., Gjerstorff, M. F., Müller, C. E., Parren, P. W. & Ditzel, H. J., 12. Sept 2022, In: Journal for ImmunoTherapy of Cancer. 10, 9, 32 p., e004554.

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The ROC skin model: A robust skin equivalent for permeation and live cell imaging studies

Jakobsen, N. D., Kaiser, K., Ebbesen, M. F., Lauritsen, L., Gjerstorff, M. F., Kuntsche, J. & Brewer, J. R., 1. Nov 2022, In: European Journal of Pharmaceutical Sciences. 178, 106282.

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ZBED1 Regulates Genes Important for Multiple Biological Processes of the Placenta

Johansen, S., Traynor, S., Ebstrup, M. L., Terp, M. G., Pedersen, C. B., Ditzel, H. J. & Gjerstorff, M. F., Jan 2022, In: Genes. 13, 1, 14 p., 133.

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2021

Hmga2 as a critical regulator in cancer development

Mansoori, B., Mohammadi, A., Ditzel, H. J., Duijf, P. H. G., Khaze, V., Gjerstorff, M. F. & Baradaran, B., Feb 2021, In: Genes. 12, 2, 23 p., 269.

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Hmga2 supports cancer hallmarks in triple-negative breast cancer

Mansoori, B., Terp, M. G., Mohammadi, A., Pedersen, C. B., Ditzel, H. J., Baradaran, B. & Gjerstorff, M. F., 1. Oct 2021, In: Cancers. 13, 20, 17 p., 5197.

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MCM3 upregulation confers endocrine resistance in breast cancer and is a predictive marker of diminished tamoxifen benefit

Løkkegaard, S., Elias, D., Alves, C. L., Bennetzen, M. V., Lænkholm, A. V., Bak, M., Gjerstorff, M. F., Johansen, L. E., Vever, H., Bjerre, C., Kirkegaard, T., Nordenskjöld, B., Fornander, T., Stål, O., Lindström, L. S., Esserman, L. J., Lykkesfeldt, A. E., Andersen, J. S., Leth-Larsen, R. & Ditzel, H. J., Jan 2021, In: npj Breast Cancer. 7, 15 p., 2.

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MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy

Mansoori, B., Duijf, P. H. G., Mohammadi, A., Safarzadeh, E., Ditzel, H. J., Gjerstorff, M. F., Cho, W. C. S. & Baradaran, B., 1. Jul 2021, In: Life Sciences. 276, 119431.

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Sustained compensatory p38 MAPK signaling following treatment with MAPK inhibitors induces the immunosuppressive protein CD73 in cancer: combined targeting could improve outcomes

Terp, M. G., Gammelgaard, O. L., Vever, H., Gjerstorff, M. F. & Ditzel, H. J., Dec 2021, In: Molecular Oncology. 15, 12, p. 3299-3316

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The Cancer/Testis Antigen Gene VCX2 Is Rarely Expressed in Malignancies but Can Be Epigenetically Activated Using DNA Methyltransferase and Histone Deacetylase Inhibitors

Jakobsen, M. K., Traynor, S., Stæhr, M., Duijf, P. G., Nielsen, A. Y., Terp, M. G., Pedersen, C. B., Guldberg, P., Ditzel, H. J. & Gjerstorff, M. F., 9. Feb 2021, In: Frontiers in Oncology. 10, 12 p., 584024.

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2020

Augmenting engineered T-cell strategies in solid cancers through epigenetic priming

Nielsen, A. Y., Ormhøj, M., Traynor, S. & Gjerstorff, M. F., Nov 2020, In: Cancer Immunology, Immunotherapy. 69, 11, p. 2169-2178

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Cancer/testis antigens in the development and treatment of cancer

Gjerstorff, M. F., 2020, Syddansk Universitet. Det Sundhedsvidenskabelige Fakultet. 226 p.

Research output: Thesis › Doctoral Thesis

CAR T-Cell Cancer Therapy Targeting Surface Cancer/Testis Antigens

Jakobsen, M. K. & Gjerstorff, M. F., 2. Sept 2020, In: Frontiers in Immunology. 11, 7 p., 1568.

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Correction: VersicanV1 promotes proliferation and metastasis of hepatocellular carcinoma through the activation of EGFR–PI3K–AKT pathway (Oncogene, (2018), 37, 41, (5585-5586), 10.1038/s41388-018-0495-6)

Elias, D., Vever, H., Lænkholm, A. V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., Mar 2020, In: Oncogene. 39, 10, p. 2229-2230

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Corrigendum to "MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis" [Free Radic. Biol. Med. 139 (2019) 1-15]

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H., Mohammadi, A., Gjerstorff, M. & Baradaran, B., Jan 2020, In: Free Radical Biology and Medicine. 146, p. 402

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Interaction between Polycomb and SSX Proteins in Pericentromeric Heterochromatin Function and Its Implication in Cancer

Johansen, S. & Gjerstorff, M. F., 16. Jan 2020, In: Cells. 9, 1

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miR-330 suppresses EMT and induces apoptosis by downregulating HMGA2 in human colorectal cancer

Mansoori, B., Mohammadi, A., Naghizadeh, S., Gjerstorff, M., Shanehbandi, D., Shirjang, S., Najafi, S., Holmskov, U., Khaze, V., Duijf, P. H. G. & Baradaran, B., Feb 2020, In: Journal of Cellular Physiology. 235, 2, p. 920-931

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Novel Insights Into Epigenetic Reprogramming and Destabilization of Pericentromeric Heterochromatin in Cancer

Gjerstorff, M. F., 5. Nov 2020, In: Frontiers in Oncology. 10, 8 p., 594163.

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Overexpression of HMGA2 in breast cancer promotes cell proliferation, migration, invasion and stemness

Mansoori, B., Duijf, P. H. G., Mohammadi, A., Najafi, S., Roshani, E., Shanehbandi, D., Hajiasgharzadeh, K., Shirjang, S., Ditzel, H. J., Kazemi, T., Mokhtarzadeh, A., Gjerstorff, M. F. & Baradaran, B., 3. Mar 2020, In: Expert Opinion on Therapeutic Targets. 24, 3, p. 255-265

Research output: Contribution to journal › Journal article › Research › peer-review

2019

A functional genetic screen identifies the Mediator complex as essential for SSX2-induced senescence

Brückmann, N. H., Bennedsen, S. N., Duijf, P. H. G., Terp, M. G., Thomassen, M., Larsen, M., Pedersen, C. B., Kruse, T., Alcaraz, N., Ditzel, H. J. & Gjerstorff, M. F., 6. Nov 2019, In: Cell Death & Disease. 10, 11, 12 p., 841.

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Chimeric Antigen Receptor T Cells Targeting CD79b Show Efficacy in Lymphoma with or without Cotargeting CD19

Ormhøj, M., Scarfò, I., Cabral, M. L., Bailey, S. R., Lorrey, S. J., Bouffard, A. A., Castano, A. P., Larson, R. C., Riley, L. S., Schmidts, A., Choi, B. D., Andersen, R. S., Cédile, O., Nyvold, C. G., Haaber, J., Gjerstorff, M. F., Ditzel, H. J., Weinstock, D. M., Barington, T. & Frigault, M. J. & 1 others, Maus, M. V., 1. Dec 2019, In: Clinical Cancer Research. 25, 23, p. 7046-7057

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HMGA2 and Bach-1 cooperate to promote breast cancer cell malignancy

Mansoori, B., Mohammadi, A., Asadzadeh, Z., Shirjang, S., Minouei, M., Abedi Gaballu, F., Shajari, N., Kazemi, T., Gjerstrorff, M. F., Duijf, P. H. G. & Baradaran, B., Oct 2019, In: Journal of Cellular Physiology. 234, 10, p. 17714-17726

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Identification of miRNAs correlating with stage and progression of colorectal cancer

Asadi, M., Talesh, S. T., Gjerstorff, M. F., Shanehbandi, D., Baradaran, B., Hashemzadeh, S. & Zafari, V., 1. Nov 2019, In: Colorectal Cancer. 8, 2, 10 p., CRC06.

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MicroRNAs in cancer cell death pathways: Apoptosis and necroptosis

Shirjang, S., Mansoori, B., Asghari, S., Duijf, P. H. G., Mohammadi, A., Gjerstorff, M. & Baradaran, B., 1. Aug 2019, In: Free Radical Biology and Medicine. 139, p. 1-15

Research output: Contribution to journal › Journal article › Research › peer-review

miR-142-3p as tumor suppressor miRNA in the regulation of tumorigenicity, invasion and migration of human breast cancer by targeting Bach-1 expression

Mansoori, B., Mohammadi, A., Ghasabi, M., Shirjang, S., Dehghan, R., Montazeri, V., Holmskov, U., Kazemi, T., Duijf, P., Gjerstorff, M. & Baradaran, B., Jun 2019, In: Journal of Cellular Physiology. 234, 6, p. 9816-9825

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miR-142-3p is a tumor suppressor that inhibits estrogen receptor expression in ER-positive breast cancer

Mansoori, B., Mohammadi, A., Gjerstorff, M. F., Shirjang, S., Asadzadeh, Z., Khaze, V., Holmskov, U., Kazemi, T., Duijf, P. H. G. & Baradaran, B., 1. Sept 2019, In: Journal of Cellular Physiology. 234, 9, p. 16043-16053

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Photodynamic therapy for cancer: Role of natural products

Mansoori, B., Mohammadi, A., Amin Doustvandi, M., Mohammadnejad, F., Kamari, F., Gjerstorff, M. F., Baradaran, B. & Hamblin, M. R., Jun 2019, In: Photodiagnosis and Photodynamic Therapy. 26, p. 395-404

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Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins

Traynor, S., Møllegaard, N. E., Jørgensen, M. G., Brückmann, N. H., Pedersen, C. B., Terp, M. G., Johansen, S., Dejardin, J., Ditzel, H. J. & Gjerstorff, M. F., 26. Jul 2019, In: Nucleic Acids Research. 47, 13, p. 6668-6684

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Targeting CD79b with chimeric antigen receptors shows potent pre-clinical efficacy in mantle cell lymphoma

Ormhøj, M., Scarfò, I., Andersen, R. S., Cédile, O., Bailey, S. R., Lorrey, S., Bouffard, A. A., Castano, A. P., Nyvold, C. G., Christensen, J. H., Gjerstorff, M., Ditzel, H., Weinstock, D. M., Barington, T. & Maus, M. V., 14. Feb 2019.

Research output: Contribution to conference without publisher/journal › Poster › Research › peer-review

2018

Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells

Kirkin, A. F., Dzhandzhugazyan, K. N., Guldberg, P., Fang, J. J., Andersen, R. S., Dahl, C., Mortensen, J., Lundby, T., Wagner, A., Law, I., Broholm, H., Madsen, L., Lundell-Ek, C., Gjerstorff, M. F., Ditzel, H. J., Jensen, M. R. & Fischer, W., 6. Mar 2018, In: Nature Communications. 9, 12 p., 785.

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Correction to: Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy (Oncogene, (2015), 34, 15, (1919-1927), 10.1038/onc.2014.138)

Elias, D., Vever, H., Lænkholm, A. V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., Oct 2018, In: Oncogene. 37, 41, p. 5585–5586

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Epigenetic reprogramming of pericentromeric satellite DNA in premalignant and malignant lesions

Brückmann, N. H., Pedersen, C. B., Ditzel, H. J. & Gjerstorff, M. F., Mar 2018, In: Molecular Cancer Research. 16, 3, p. 417-427

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Human DREF/ZBED1 is a nuclear protein widely expressed in multiple cell types derived from all three primary germ layers

Hansen, S. V., Traynor, S., Ditzel, H. J. & Gjerstorff, M. F., 1. Oct 2018, In: PLOS ONE. 13, 10, 13 p., e0205461.

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2016

Ectopic Expression of Testis Germ Cell Proteins in Cancer and Its Potential Role in Genomic Instability

Nielsen, A. Y. & Gjerstorff, M., 6. Jun 2016, In: International Journal of Molecular Sciences. 17, 6, 15 p., 890.

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The role of GAGE cancer/testis antigen in metastasis: the jury is still out

Gjerstorff, M. F., Terp, M. G., Hansen, M. B. & Ditzel, H. J., 8. Jan 2016, In: BMC Cancer. 16, 4 p., 7.

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2015

Ectopic expression of cancer/testis antigen SSX2 induces DNA damage and promotes genomic instability

Greve, K. B. V., Lindgreen, J., Terp, M. G., Pedersen, C. B., Schmidt, S., Mollenhauer, J., Kristensen, S. B., Andersen, R. S., Relster, M. M., Ditzel, H. & Gjerstorff, M., Feb 2015, In: Molecular Oncology. 9, 2, p. 437-449 13 p.

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Gene expression profiling identifies FYN as an important molecule in tamoxifen resistance and a predictor of early recurrence in patients treated with endocrine therapy

Elias, D., (Hansen) Vever, H., Lænkholm, A.-V., Gjerstorff, M. F., Yde, C. W., Lykkesfeldt, A. E. & Ditzel, H. J., 9. Apr 2015, In: Oncogene. 34, p. 1919–1927

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Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer

Maheswaran, E., Pedersen, C. B., Ditzel, H. J. & Gjerstorff, M. F., 2015, In: PLOS ONE. 10, 8, 10 p., e0134967.

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Morten Frier Gjerstorff

Research output

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