20022020

Research output per year

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Research Output

2020

Is the Total Amount as Important as Localization and Type of Collagen in Liver Fibrosis Attributable to Steatohepatitis?

Karsdal, M. A., Detlefsen, S., Daniels, S. J., Nielsen, M. J., Krag, A. & Schuppan, D., Jan 2020, In : Hepatology (Baltimore, Md.). 71, 1, p. 346-351

Research output: Contribution to journalReviewResearchpeer-review

2019

ADAPT: An algorithm incorporating PRO-C3 accurately identifies patients with NAFLD and advanced fibrosis

Daniels, S. J., Leeming, D. J., Eslam, M., Hashem, A. M., Nielsen, M. J., Krag, A., Karsdal, M. A., Grove, J. I., Guha, I. N., Kawaguchi, T., Torimura, T., McLeod, D., Akiba, J., Kaye, P., de Boer, B., Aithal, G. P., Adams, L. A. & George, J., Mar 2019, In : Hepatology (Baltimore, Md.). 69, 3, p. 1075-1086

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
171 Downloads (Pure)

Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis

Lehmann, J., Praktiknjo, M., Nielsen, M. J., Schierwagen, R., Meyer, C., Thomas, D., Violi, F., Strassburg, C. P., Bendtsen, F., Møller, S., Krag, A., Karsdal, M. A., Leeming, D. J. & Trebicka, J., May 2019, In : Liver International. 39, 5, p. 885-893

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
79 Downloads (Pure)

Different biomarkers reflecting different aspects of fibrogenesis holds a potential to improve diagnostics of alcohol liver disease: serological deconstruction of fibrosis, ballooning and inflammation.

Villesen, I., Gudmann, N., Thiele, M., Nielsen, M. J., Leeming, D. J., Karsdal, M. & Krag, A., Oct 2019, In : Hepatology. 70, Suppl. 1, p. 824A 1357.

Research output: Contribution to journalConference abstract in journalResearch

Extracellular matrix remodeling with focus on biochemical markers in liver fibrosis: Limitations and possibilities

Nielsen, M. J., Karsdal, M. A., Krag, A. & Leeming, D. J., 2019, The Human Gut-Liver-Axis in Health and Disease. Krag, A. & Hansen, T. (eds.). Springer Publishing Company, p. 265-286

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

High levels of basement membrane remodelling (C4M) and low activity of wound healing (FPA) reflect fibrosis in alcoholic liver disease

Gudmann, N., Thiele, M., Nielsen, M. J., Madsen, B. S., Detlefsen, S., Moeller, L. S., Kjaergaard, M., Leeming, D., Karsdal, M. & Krag, A., Apr 2019, In : Journal of Hepatology. 70, 1 Suppl.1, p. E817

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Serum markers of interstitial matrix formation (PRO-C3) and basement membrane remodeling (PRO-C4 and C4M) predict recurrence of fibrosis and survival in post-liver transplanted patients: Poster presentations

Nielsen, M. J., Villesen, I., Gudmann, N., Leeming, D., Krag, A., Karsdal, M., Surabattula, R., Zimmermann, T. & Schuppan, D., Apr 2019, In : Journal of Hepatology. 70, 1, Supplement, p. E199-E200 THU-088.

Research output: Contribution to journalConference abstract in journalResearch

Serum markers of type III and IV procollagen processing predict recurrence of fibrosis in liver transplanted patients

Nielsen, M. J., Villesen, I. F., Gudmann, N. S., Leeming, D. J., Krag, A., Karsdal, M. A., Zimmermann, T. & Schuppan, D., 16. Oct 2019, In : Scientific Reports. 9, 9 p., 14857.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
68 Downloads (Pure)

The Pro-Peptide Of Type Vi Collagen (Endotrophin) Is Equipotent To Tgf-B In Inducing Fibrosis: Identification Of A Self-Perpetuating Vicious Cycle Driving Fibrosis Mediated By Collagen Signals

Karsdal, M., Reese-Petersen, A., Nielsen, M. J., Krag, A., Thiele, M., Gudmann, N. & Genovese, F., Oct 2019, In : Hepatology. 70, Suppl. 1, p. 84A-85A 128.

Research output: Contribution to journalConference abstract in journalResearch

2018

Acute decompensation boosts hepatic collagen type III deposition and deteriorates experimental and human cirrhosis

Praktiknjo, M., Lehmann, J., Nielsen, M. J., Schierwagen, R., Uschner, F. E., Meyer, C., Thomas, D., Strassburg, C. P., Bendtsen, F., Møller, S., Krag, A., Karsdal, M. A., Leeming, D. J. & Trebicka, J., 2018, In : Hepatology communications. 2, 2, p. 211-222

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
194 Downloads (Pure)

PRO-C3: a new and more precise collagen marker for liver fibrosis in patients with chronic hepatitis C

Hansen, J. F., Juul Nielsen, M., Nyström, K., Leeming, D. J., Lagging, M., Norkrans, G., Brehm Christensen, P. & Karsdal, M., Jan 2018, In : Scandinavian Journal of Gastroenterology. 53, 1, p. 83-87

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Fibrogenesis assessed by serological type III collagen formation identifies patients with progressive liver fibrosis and responders to a potential antifibrotic therapy

Karsdal, M. A., Henriksen, K., Nielsen, M. J., Byrjalsen, I., Leeming, D. J., Gardner, S., Goodman, Z., Patel, K., Krag, A., Christiansen, C. & Schuppan, D., 2016, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 311, 6, p. G1009-G1017

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
235 Downloads (Pure)
2015
Open Access

Fibrosis is not just fibrosis: Extracellular matrix turnover is markedly different in two types of viral hepatitis, suggesting different fibrotic representations

Nielsen, M. J., Karsdal, M. A., Kazankov, K., Krag, A., Leeming, D. J., George, J., Grønbæk, H. & Schuppan, D., 2015, In : Hepatology. 62, Suppl. 1, p. 270A 1 p., 119.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Markers of Collagen Remodeling Detect Clinically Significant Fibrosis in Chronic Hepatitis C Patients

Nielsen, M. J., Kazankov, K., Leeming, D. J., Karsdal, M. A., Krag, A., Barrera, F., McLeod, D., George, J. & Grønbæk, H., 2015, In : PLOS ONE. 10, 9, 12 p., e0137302.

Research output: Contribution to journalJournal articleResearchpeer-review

Novel insights into the function and dynamics of extracellular matrix in liver fibrosis

Karsdal, M. A., Manon-Jensen, T., Genovese, F., Kristensen, J. H., Nielsen, M. J., Sand, J. M. B., Hansen, N-U. B., Bay-Jensen, A-C., Bager, C. L., Krag, A., Blanchard, A., Krarup, H., Leeming, D. J. & Schuppan, D., 15. May 2015, In : American Journal of Physiology: Gastrointestinal and Liver Physiology. 308, 10, p. G807-G830

Research output: Contribution to journalReviewResearchpeer-review

Plasma Pro-C3 (N-terminal type III collagen propeptide) predicts fibrosis progression in patients with chronic hepatitis C

Nielsen, M. J., Veidal, S. S., Karsdal, M. A., Orsnes-Leeming, D. J., Vainer, B., Gardner, S. D., Hamatake, R., Goodman, Z. D., Schuppan, D. & Patel, K., Feb 2015, In : Liver International. 35, 2, p. 429-437

Research output: Contribution to journalJournal articleResearchpeer-review

Pro-C5, a marker of true type V collagen formation and fibrillation, correlates with portal hypertension in patients with alcoholic cirrhosis

Leeming, D. J., Veidal, S. S., Karsdal, M. A., Nielsen, M. J., Trebicka, J., Busk, T., Bendtsen, F., Krag, A. & Møller, S., 1. Feb 2015, In : Scandinavian Journal of Gastroenterology. Supplement. 50, 5, p. 584-592

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Combined antiretroviral therapy attenuates hepatic extracellular matrix remodeling in HIV patients assessed by novel protein fingerprint markers

Leeming, D. J., Anadol, E., Schierwagen, R., Karsdal, M. A., Byrjalsen, I., Nielsen, M. J., Schwarzer-Zander, C., Boesecke, C., Bendtsen, F., Møller, S., Strassburg, C. P., Spengler, U., Krag, A., Rockstroh, J. & Trebicka, J. K., 2014, In : AIDS. 28, 14, p. 2081-90

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Serum markers of the extracellular matrix remodeling reflect antifibrotic therapy in bile-duct ligated rats

Schierwagen, R., Leeming, D. J., Klein, S., Granzow, M., Nielsen, M. J., Sauerbruch, T., Krag, A., Karsdal, M. A. & Trebicka, J., 2013, In : Frontiers in Physiology. 4, July, p. 195

Research output: Contribution to journalJournal articleResearchpeer-review

The protein fingerprint technology reflects liver fundtion and detects clinically significant portal hypertension in patients with alcoholic liver cirrhosis

Nielsen, M. J., Leeming, D. J., Krag, A., Karsdal, M. A., Trebicka, J., Byrjalsen, I., Bendtsen, F. & Møller, S., 2013.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

2002

Spontaneous interleukin-5 production in cutaneous T-cell lymphoma lines is mediated by constitutively activated Stat3

Nielsen, M., Nissen, M. H., Gerwien, J., Zocca, M-B., Rasmussen, H. M., Nakajima, K., Röpke, C., Geisler, C., Kaltoft, K. & Ødum, N., 1. Feb 2002, In : Blood. 99, 3, p. 973-7 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review