Maria Timofeeva

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Maria Timofeeva

PhD

 https://orcid.org/0000-0002-2503-4253

Personal profile

Research interests

I am a cancer researcher with a specific interest in cancer prevention and prediction. My work  focuses on cancer aetiology, through studying effects of environmental and genetics factors on 
cancer risk and progression. I use range of approaches in my work, from observational  epidemiological studies of risk factors, including case-control, population-based cohort studies,  twin studies, to meta-analysis and umbrella reviews, and multi-omics data analysis to study associations between environmental exposures, genetics, and intermediate phenotypes (biomarkers). The overarching aim of my work is to improve cancer prediction by understanding risk factors of cancer, improving cancer screening, and thus improving survival 
of cancer patient and cancer outcomes. My work is characterized by collaborative and international nature as reflected in my publication list.

Research areas

  • Understanding genetics of cancer risk through multi-omic analysis.
  • Interdisciplinary Project on Adherance to Colorectal Cancer Screening. A short description of the project can be found here.
  • Meta-analysis and systematic literature review of factors associated with false-positive and false-negative FOBT results. The details of the study protocol and methods are published in PROSPERO (ID: CRD42022315767).
  • COlorectal Cancer screening Among RElatives (CoCARE): a twin-family study in Denmark.

Education/Academic qualification

Epidemiology, Dr.sc.hum, Investigations into the role of Glutathione-S-transferase (GST) and Cytochrome-P450-monooxygenase (CYP) polymorphisms as risk factors for early onset lung cancer, Heidelberg University

2005 → 2009

Award Date: 19. Feb 2009

External positions

Honorary Fellow, The University of Edinburgh

7. Dec 2019 → …

Statistical Geneticist , The University of Edinburgh

2013 → 2019

Postdoctoral Fellow, International Agency for Research on Cancer

2009 → 2013

Research areas

  • Cancer
  • genetic and environmental risk factors
  • molecular epidemiology
  • Bioinformatics
  • Genome Analysis
  • Genetics
  • RNA
  • DNA
  • Prevention and Screening

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Collaborations and top research areas from the last five years

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  • 58 Journal article
  • 1 Conference abstract in journal
  • 1 Other contribution

  • Circulating 25-hydroxyvitamin D and survival outcomes of colorectal cancer: evidence from population-based prospective cohorts and Mendelian randomisation

    Zhang, X., He, Y., Li, X., Shraim, R., Xu, W., Wang, L., Farrington, S. M., Campbell, H., Timofeeva, M., Zgaga, L., Vaughan-Shaw, P., Theodoratou, E. & Dunlop, M. G., May 2024, In: British Journal of Cancer. 130, 9, p. 1585-1591

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access

  • Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes

    Asian-UK-US Collaboration on Colorectal Cancer, 26. Apr 2024, In: Nature Communications. 15, 1, p. 3557

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access

  • Impact of ambient air pollution on colorectal cancer risk and survival: insights from a prospective cohort and epigenetic Mendelian randomization study

    Jiang, F., Zhao, J., Sun, J., Chen, W., Zhao, Y., Zhou, S., Yuan, S., Timofeeva, M., Law, P. J., Larsson, S. C., Chen, D., Houlston, R. S., Dunlop, M. G., Theodoratou, E. & Li, X., May 2024, In: EBioMedicine. 103, 12 p., 105126.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File
    11 Downloads (Pure)

  • Combining Asian and European genome-wide association studies of colorectal cancer improves risk prediction across racial and ethnic populations

    Thomas, M., Su, Y. R., Rosenthal, E. A., Sakoda, L. C., Schmit, S. L., Timofeeva, M. N., Chen, Z., Fernandez-Rozadilla, C., Law, P. J., Murphy, N., Carreras-Torres, R., Diez-Obrero, V., van Duijnhoven, F. J. B., Jiang, S., Shin, A., Wolk, A., Phipps, A. I., Burnett-Hartman, A., Gsur, A. & Chan, A. T. & 108 others, Zauber, A. G., Wu, A. H., Lindblom, A., Um, C. Y., Tangen, C. M., Gignoux, C., Newton, C., Haiman, C. A., Qu, C., Bishop, D. T., Buchanan, D. D., Crosslin, D. R., Conti, D. V., Kim, D. H., Hauser, E., Siegel, E., Schumacher, F. R., Rennert, G., Giles, G. G., Hampel, H., Brenner, H., Oze, I., Oh, J. H., Lee, J. K., Schneider, J. L., Chang-Claude, J., Kim, J., Huyghe, J. R., Zheng, J., Hampe, J., Greenson, J., Hopper, J. L., Palmer, J. R., Visvanathan, K., Matsuo, K., Matsuda, K., Jung, K. J., Li, L., Le Marchand, L., Vodickova, L., Bujanda, L., Gunter, M. J., Matejcic, M., Jenkins, M. A., Slattery, M. L., D’Amato, M., Wang, M., Hoffmeister, M., Woods, M. O., Kim, M., Song, M., Iwasaki, M., Du, M., Udaltsova, N., Sawada, N., Vodicka, P., Campbell, P. T., Newcomb, P. A., Cai, Q., Pearlman, R., Pai, R. K., Schoen, R. E., Steinfelder, R. S., Haile, R. W., Vandenputtelaar, R., Prentice, R. L., Küry, S., Castellví-Bel, S., Tsugane, S., Berndt, S. I., Lee, S. C., Brezina, S., Weinstein, S. J., Chanock, S. J., Jee, S. H., Kweon, S. S., Vadaparampil, S., Harrison, T. A., Yamaji, T., Keku, T. O., Vymetalkova, V., Arndt, V., Jia, W. H., Shu, X. O., Lin, Y., Ahn, Y. O., Stadler, Z. K., Van Guelpen, B., Ulrich, C. M., Platz, E. A., Potter, J. D., Li, C. I., Meester, R., Moreno, V., Figueiredo, J. C., Casey, G., Lansdorp Vogelaar, I., Dunlop, M. G., Gruber, S. B., Hayes, R. B., Pharoah, P. D. P., Houlston, R. S., Jarvik, G. P., Tomlinson, I. P., Zheng, W., Corley, D. A., Peters, U. & Hsu, L., 2. Oct 2023, In: Nature Communications. 14, 13 p., 6147.

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
    File
    22 Downloads (Pure)

  • Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

    Fernandez-Rozadilla, C., Timofeeva, M., Chen, Z., Law, P., Thomas, M., Schmit, S., Díez-Obrero, V., Hsu, L., Fernandez-Tajes, J., Palles, C., Sherwood, K., Briggs, S., Svinti, V., Donnelly, K., Farrington, S., Blackmur, J., Vaughan-Shaw, P., Shu, X. O., Long, J. & Cai, Q. & 190 others, Guo, X., Lu, Y., Broderick, P., Studd, J., Huyghe, J., Harrison, T., Conti, D., Dampier, C., Devall, M., Schumacher, F., Melas, M., Rennert, G., Obón-Santacana, M., Martín-Sánchez, V., Moratalla-Navarro, F., Oh, J. H., Kim, J., Jee, S. H., Jung, K. J., Kweon, S. S., Shin, M. H., Shin, A., Ahn, Y. O., Kim, D. H., Oze, I., Wen, W., Matsuo, K., Matsuda, K., Tanikawa, C., Ren, Z., Gao, Y. T., Jia, W. H., Hopper, J., Jenkins, M., Win, A. K., Pai, R., Figueiredo, J., Haile, R., Gallinger, S., Woods, M., Newcomb, P., Duggan, D., Cheadle, J., Kaplan, R., Maughan, T., Kerr, R., Kerr, D., Kirac, I., Böhm, J., Mecklin, L. P., Jousilahti, P., Knekt, P., Aaltonen, L., Rissanen, H., Pukkala, E., Eriksson, J., Cajuso, T., Hänninen, U., Kondelin, J., Palin, K., Tanskanen, T., Renkonen-Sinisalo, L., Zanke, B., Männistö, S., Albanes, D., Weinstein, S., Ruiz-Narvaez, E., Palmer, J., Buchanan, D., Platz, E., Visvanathan, K., Ulrich, C., Siegel, E., Brezina, S., Gsur, A., Campbell, P., Chang-Claude, J., Hoffmeister, M., Brenner, H., Slattery, M., Potter, J., Tsilidis, K., Schulze, M., Gunter, M., Murphy, N., Castells, A., Castellví-Bel, S., Moreira, L., Arndt, V., Shcherbina, A., Stern, M., Pardamean, B., Bishop, T., Giles, G., Southey, M., Idos, G., McDonnell, K., Abu-Ful, Z., Greenson, J., Shulman, K., Lejbkowicz, F., Offit, K., Su, Y. R., Steinfelder, R., Keku, T., van Guelpen, B., Hudson, T., Hampel, H., Pearlman, R., Berndt, S., Hayes, R., Martinez, M. E., Thomas, S., Corley, D., Pharoah, P., Larsson, S., Yen, Y., Lenz, H. J., White, E., Li, L., Doheny, K., Pugh, E., Shelford, T., Chan, A., Cruz-Correa, M., Lindblom, A., Hunter, D., Joshi, A., Schafmayer, C., Scacheri, P., Kundaje, A., Nickerson, D., Schoen, R., Hampe, J., Stadler, Z., Vodicka, P., Vodickova, L., Vymetalkova, V., Papadopoulos, N., Edlund, C., Gauderman, W., Thomas, D., Shibata, D., Toland, A., Markowitz, S., Kim, A., Chanock, S., van Duijnhoven, F., Feskens, E., Sakoda, L., Gago-Dominguez, M., Wolk, A., Naccarati, A., Pardini, B., FitzGerald, L., Lee, S. C., Ogino, S., Bien, S., Kooperberg, C., Li, C., Lin, Y., Prentice, R., Qu, C., Bézieau, S., Tangen, C., Mardis, E., Yamaji, T., Sawada, N., Iwasaki, M., Haiman, C., Le Marchand, L., Wu, A., Qu, C., McNeil, C., Coetzee, G., Hayward, C., Deary, I., Harris, S., Theodoratou, E., Reid, S., Walker, M., Ooi, L. Y., Moreno, V., Casey, G., Gruber, S., Tomlinson, I., Zheng, W., Dunlop, M., Houlston, R. & Peters, U., Jan 2023, In: Nature Genetics. 55, p. 89-99

    Research output: Contribution to journal › Journal article › Research › peer-review

    Open Access
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    100 Downloads (Pure)
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  • 10 Peer review of manuscripts
  • 1 Conference organisation or participation
  • 1 Editor of research journal
  • 1 Membership of review committee
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