Lars Grøntved

2024

Dissecting tumor microenvironment heterogeneity in syngeneic mouse models: insights on cancer-associated fibroblast phenotypes shaped by infiltrating T cells

Carretta, M., Thorseth, M.-L., Schina, A., Agardy, D. A., Johansen, A. Z., Baker, K. J., Khan, S., Rømer, A. M. A., Fjæstad, K. Y., Linder, H., Kuczek, D. E., Donia, M., Grøntved, L. & Madsen, D. H., 8. Jan 2024, In: Frontiers in Immunology. 14, p. 1320614 16 p.

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Single cell-resolved study of advanced murine MASH reveals a homeostatic pericyte signaling module

Bendixen, S. M., Jakobsgaard, P. R., Hansen, D., Hejn, K. H., Terkelsen, M. K., Bjerre, F. A., Thulesen, A. P., Eriksen, N. G., Hallenborg, P., Geng, Y., Dam, T. V., Larsen, F. T., Wernberg, C. W., Vijayathurai, J., Scott, E. A. H., Marcher, A. B., Detlefsen, S., Grøntved, L., Dimke, H. & Berdeaux, R. & 6 others, de Aguiar Vallim, T. Q., Olinga, P., Lauridsen, M. M., Krag, A., Blagoev, B. & Ravnskjaer, K., Mar 2024, In: Journal of Hepatology. 80, 3, p. 467-481

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2023

Acute deletion of the glucocorticoid receptor in hepatocytes disrupts postprandial lipid metabolism in male mice

Correia, C. M., Præstholm, S. M., Havelund, J. F., Pedersen, F. B., Siersbæk, M. S., Ebbesen, M. F., Gerhart-Hines, Z., Heeren, J., Brewer, J., Larsen, S., Blagoev, B., Færgeman, N. J. & Grøntved, L., Oct 2023, In: Endocrinology. 164, 10, 17 p., bqad128.

Research output: Contribution to journal › Journal article › Research › peer-review

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Chandran, V. I., Wernberg, C. W., Lauridsen, M. M., Skytthe, M. K., Bendixen, S. M., Larsen, F. T., Hansen, C. D., Grønkjær, L. L., Siersbæk, M. S., Caterino, T. D., Detlefsen, S., Møller, H. J., Grøntved, L., Ravnskjaer, K., Moestrup, S. K., Thiele, M. S., Krag, A. & Graversen, J. H., Feb 2023, In: Hepatology. 77, 2, p. 558-572

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Protocol for bulk and single-nuclei chromatin accessibility quantification in mouse liver tissue

Korenfeld, N., Toft, N. I., Dam, T. V., Charni-Natan, M., Grøntved, L. & Goldstein, I., 15. Sept 2023, In: STAR Protocols. 4, 3, 102462.

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Stellate cell expression of SPARC-related modular calcium-binding protein 2 is associated with human non-alcoholic fatty liver disease severity

Larsen, F. T., Hansen, D., Terkelsen, M. K., Bendixen, S. M., Avolio, F., Wernberg, C. W., Lauridsen, M. M., Grønkjaer, L. L., Jacobsen, B. G., Klinggaard, E. G., Mandrup, S., Di Caterino, T., Siersbæk, M. S., Chandran, V. I., Graversen, J. H., Krag, A., Grøntved, L. & Ravnskjaer, K., Feb 2023, In: JHEP Reports. 5, 2, 100615.

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Use of smoc2 as a non biomarker for developing alcoholic or non-alcoholic steatohepatitis

Graversen, N. J. H. (Inventor), Chandran, V. I. (Inventor), Larsen, F. T. (Inventor), Grøntved, L. (Inventor), Ravnskjær, K. (Inventor), Lauridsen, M. E. M. (Inventor), Wernberg, C. W. (Inventor) & Krag, A. A. (Inventor), 14. Dec 2023, IPC No. G01N33/68, Patent No. WO2023237529 (A1), Priority date 7. Jun 2022, Priority No. EP20220177513

Research output: Patent

2022

Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells

Weis-Banke, S. E., Lisle, T. L., Perez-Penco, M., Schina, A., Hübbe, M. L., Siersbæk, M., Holmström, M. O., Jørgensen, M. A., Marie Svane, I., Met, Ö., Ødum, N., Madsen, D. H., Donia, M., Grøntved, L. & Andersen, M. H., Oct 2022, In: Journal for immunotherapy of cancer. 10, 10, e005326.

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Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

Fjæstad, K. Y., Rømer, A. M. A., Goitea, V., Johansen, A. Z., Thorseth, M. L., Carretta, M., Engelholm, L. H., Grøntved, L., Junker, N. & Madsen, D. H., Feb 2022, In: Oncogene. 41, 9, p. 1364-1375

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Cell-Type Resolved Insights into the Cis-Regulatory Genome of NAFLD

Dam, T. V., Toft, N. I. & Grøntved, L., 1. Mar 2022, In: Cells. 11, 5, 870.

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Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice

Skoda, J., Dohnalova, K., Chalupsky, K., Stahl, A., Templin, M., Maixnerova, J., Micuda, S., Grøntved, L., Braeuning, A. & Pavek, P., Mar 2022, In: Biochemical Pharmacology. 197, 11 p., 114905.

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Plasma TREM2, a novel non-invasive biomarker for diagnosis of NASH in NAFLD patients with elevated liver stiffness

Wernberg, C. W., Chandran, V. I., Lauridsen, M., Larsen, F., Skytthe, M. K., Hansen, C. D., Siersbæk, M., Caterino, T. D., Detlefsen, S., Palarasah, Y., Ravnskjaer, K., Groentved, L., Moestrup, S. K., Thiele, M., Graversen, J. & Krag, A., Jul 2022, In: Journal of Hepatology. 77, S1, p. S434

Research output: Contribution to journal › Conference abstract in journal › Research › peer-review

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TGFβ-derived immune modulatory vaccine: targeting the immunosuppressive and fibrotic tumor microenvironment in a murine model of pancreatic cancer

Perez-Penco, M., Weis-Banke, S. E., Schina, A., Siersbæk, M., Hübbe, M. L., Jørgensen, M. A., Lecoq, I., Lara De La Torre, L., Bendtsen, S. K., Martinenaite, E., Holmström, M. O., Madsen, D. H., Donia, M., Ødum, N., Grøntved, L. & Andersen, M. H., 6. Dec 2022, In: Journal for immunotherapy of cancer. 10, 12, e005491.

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Use of sparc-related modular calcium binding protein 2 as a non-invasive biomarker

Graversen, J. H. (Inventor), Chandran, V. I. (Inventor), Larsen, F. T. (Inventor), Grøntved, L. (Inventor), Ravnskjær, K. (Inventor), Lauridsen, M. (Inventor), Wernberg, C. (Inventor) & Krag, A. (Inventor), 2022, Patent No. EP22177513.3

Research output: Patent

2021

Impaired glucocorticoid receptor expression in liver disrupts feeding-induced gene expression, glucose uptake, and glycogen storage

Præstholm, S. M., Correia, C. M., Goitea, V. E., Siersbæk, M. S., Jørgensen, M., Havelund, J. F., Pedersen, T. Å., Færgeman, N. J. & Grøntved, L., 2. Nov 2021, In: Cell Reports. 37, 5, 109938.

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Propranolol reduces sarcoma growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment

Fjæstad, K. Y., Rømer, A. M. A., Goitea, V., Johansen, A. Z., Thorseth, M.-L., Carretta, M., Engelholm, L. H., Grøntved, L., Junker, N. & Madsen, D. H., 12. Mar 2021, 37 p. bioRxiv.

Research output: Other contribution › Research

2020

C57BL/6J substrain differences in response to high-fat diet intervention

Siersbæk, M. S., Ditzel, N., Hejbøl, E. K., Præstholm, S. M., Markussen, L. K., Avolio, F., Li, L., Lehtonen, L., Hansen, A. K., Schrøder, H. D., Krych, L., Mandrup, S., Langhorn, L., Bollen, P. & Grøntved, L., 1. Dec 2020, In: Scientific Reports. 10, 15 p., 14052.

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Collagen Density Modulates the Immunosuppressive Functions of Macrophages

Larsen, A. M. H., Kuczek, D. E., Kalvisa, A., Siersbæk, M. S., Thorseth, M. L., Johansen, A. Z., Carretta, M., Grøntved, L., Vang, O. & Madsen, D. H., 1. Sept 2020, In: Journal of immunology (Baltimore, Md. : 1950). 205, 5, p. 1461-1472

Research output: Contribution to journal › Journal article › Research › peer-review

Multifaceted Control of GR Signaling and Its Impact on Hepatic Transcriptional Networks and Metabolism

Præstholm, S. M., Correia, C. M. & Grøntved, L., 8. Oct 2020, In: Frontiers in Endocrinology. 11, 17 p., 572981.

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Multiple mechanisms regulate H3 acetylation of enhancers in response to thyroid hormone

Præstholm, S. M., Siersbæk, M. S., Nielsen, R., Zhu, X., Hollenberg, A. N., Cheng, S.-Y. & Grøntved, L., 2020, In: PLOS Genetics. 16, 5, 26 p., e1008770.

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Remote ischemic conditioning in active ulcerative colitis: An explorative randomized clinical trial

Godskesen, L. E., Lassen, T. R., Jespersen, N. R., Siersbæk, M., Yan, Y., Nielsen, M. M., Tjønnfjord, S. K., Grøntved, L., Madsen, G., Kjems, J., Bøtker, H. E., Schmidt, M. R., Krag, A. & Kjeldsen, J., 12. Jun 2020, In: Scientific Reports. 10, 15 p., 9537.

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2019

Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M.-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12. Mar 2019, In: Journal for ImmunoTherapy of Cancer. 7, 1, 15 p., 68.

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Editorial: Regulating Liver Transcriptional Networks by Endocrine, Extracellular, and Intrinsic Cues

Grøntved, L. & Goldstein, I., 13. Dec 2019, In: Frontiers in Endocrinology. 10, 3 p., 878.

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Meta-analysis of Chromatin Programming by Steroid Receptors

Paakinaho, V., Swinstead, E. E., Presman, D. M., Grøntved, L. & Hager, G. L., 24. Sept 2019, In: Cell Reports. 28, 13, p. 3523-3534 15 p.

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2018

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. Dec 2018, In: PLOS Biology. 16, 12, p. 1-32 e2006249.

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Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver

Siersbæk, M., Kalvisa, A., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 11. Sept 2018.

Research output: Contribution to conference without publisher/journal › Poster › Research

2017

Genome-wide identification of basic helix-loop-helix and NF-1 motifs underlying GR binding sites in male rat hippocampus

Pooley, J. R., Flynn, B. P., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R. L., Hager, G. L., Lightman, S. L. & Conway-Campbell, B. L., 2017, In: Endocrinology. 158, 5, p. 1486-1501

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High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. Jan 2017, In: Scientific Reports. 7, 13 p., 40220.

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Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J., Liao, X. H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., Latteyer, S., Engels, K., Strucksberg, K. H., Kleinbongard, P., Zwanziger, D., Rozman, J., Gailus-Durner, V., Fuchs, H., De Angelis, M. H. & Klein-Hitpass, L. & 8 others, Köhrle, J., Armstrong, D. L., Grøntved, L., Bassett, J. H. D., Williams, G. R., Refetoff, S., Führer, D. & Moeller, L. C., 2017, In: PNAS. 114, 52, p. E11323-E11332

Research output: Contribution to journal › Journal article › Research › peer-review

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26. Dec 2017, In: Cell Reports. 21, 13, p. 3662-3671

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2016

HIGH FAT DIET-INDUCED CHANGES OF MOUSE HEPATIC TRANSCRIPTION AND ENHANCER ACTIVITY ARE REVERSED BY SUBSEQUENT WEIGHT LOSS.

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 25. Aug 2016.

Research output: Contribution to conference without publisher/journal › Poster › Research

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. Jul 2016, In: Cell Death & Disease. 7, 6, p. e2289

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Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions

Swinstead, E. E., Miranda, T. B., Paakinaho, V., Baek, S., Goldstein, I., Hawkins, M., Karpova, T. S., Ball, D., Mazza, D., Lavis, L. D., Grimm, J. B., Morisaki, T., Grøntved, L., Presman, D. M. & Hager, G. L., 21. Apr 2016, In: Cell. 165, 3, p. 593-605

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2015

Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP

Muratcioglu, S., Presman, D. M., Pooley, J. R., Grøntved, L., Hager, G. L., Nussinov, R., Keskin, O. & Gursoy, A., 15. Sept 2015, In: Biophysical Journal. 109, 6, p. 1227-1239 13 p.

Research output: Contribution to journal › Journal article › Research › peer-review

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

Grøntved, L., Waterfall, J. J., Kim, D. W., Baek, S., Sung, M.-H., Zhao, L., Park, J. W., Nielsen, R., Walker, R. L., Zhu, Y. J., Meltzer, P. S., Hager, G. L. & Cheng, S.-Y., 2015, In: Nature Communications. 6, 7048.

Research output: Contribution to journal › Journal article › Research › peer-review

2014

Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor

Presman, D. M., Ogara, M. F., Stortz, M., Alvarez, L. D., Pooley, J. R., Schiltz, R. L., Grøntved, L., Johnson, T. A., Mittelstadt, P. R., Ashwell, J. D., Ganesan, S., Burton, G., Levi, V., Hager, G. L. & Pecci, A., Mar 2014, In: PLOS Biology. 12, 3, p. e1001813

Research output: Contribution to journal › Journal article › Research › peer-review

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2013

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

Grøntved, L., John, S., Baek, S., Liu, Y., Buckley, J. R., Vinson, C., Aguilera, G. & Hager, G. L., 2013, In: The EMBO Journal. 32, 11, p. 1568-1583

Research output: Contribution to journal › Journal article › Research › peer-review

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci

Mousavi, K., Zare, H., Dell'orso, S., Grøntved, L., Gutierrez-Cruz, G., Derfoul, A., Hager, G. L. & Sartorelli, V., 2013, In: Molecular Cell. 51, 5, p. 606-617

Research output: Contribution to journal › Journal article › Research › peer-review

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation

Kieffer-Kwon, K.-R., Tang, Z., Mathe, E., Qian, J., Sung, M.-H., Li, G., Resch, W., Baek, S., Pruett, N., Grøntved, L., Vian, L., Nelson, S., Zare, H., Hakim, O., Reyon, D., Yamane, A., Nakahashi, H., Kovalchuk, A. L., Zou, J. & Joung, J. K. & 6 others, Sartorelli, V., Wei, C.-L., Ruan, X., Hager, G. L., Ruan, Y. & Casellas, R., 19. Dec 2013, In: Cell. 155, 7, p. 1507-1520

Research output: Contribution to journal › Journal article › Research › peer-review

Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level

Miranda, T. B., Voss, T. C., Sung, M.-H., Baek, S., John, S., Hawkins, M., Grøntved, L., Schiltz, R. L. & Hager, G. L., 15. Aug 2013, In: Cancer Research. 73, 16, p. 5130-5139

Research output: Contribution to journal › Journal article › Research › peer-review

2012

Impact of chromatin structure on PR signaling: transition from local to global analysis

Grøntved, L. & Hager, G. L., 2012, In: Molecular and Cellular Endocrinology. 357, 1-2, p. 30-36

Research output: Contribution to journal › Journal article › Research › peer-review

Rapid genome-scale mapping of chromatin accessibility in tissue

Grøntved, L., Bandle, R., John, S., Baek, S., Chung, H.-J., Liu, Y., Aguilera, G., Oberholtzer, C., Hager, G. L. & Levens, D., 2012, In: Epigenetics & Chromatin. 5, 10, 12 p.

Research output: Contribution to journal › Journal article › Research › peer-review

The Transcription Factor Encyclopedia

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y., Dickman, C. T., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E.W.-F., Kist, R., Wilson, M. S. & Marco-Ferreres, R. & 94 others, Brosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperriere, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., Del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P.-S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., Lebrun, D. P., Biswal, S., Harvey, C. J., Debruyne, J. P., Hogenesch, J. B., Hevner, R. F., Heligon, C., Luo, X. M., Blank, M. C., Millen, K. J., Sharlin, D. S., Forrest, D., Dahlman-Wright, K., Zhao, C., Mishima, Y., Sinha, S., Chakrabarti, R., Portales-Casamar, E., Sladek, F. M., Bradley, P. H. & Wasserman, W. W., 2012, In: Genome Biology. 13, 3, p. R24

Research output: Contribution to journal › Journal article › Research › peer-review

2010

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis

Grøntved, L., Madsen, M. S., Boergesen, M., Roeder, R. G. & Mandrup, S., 1. May 2010, In: Molecular and Cellular Biology. 30, 9, p. 2155-69 15 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2009

MED14 tethers the Mediator to the N-terminal domain of PPARg and is required for full transcriptional activity and adipogenesis

Grøntved, L., 2009.

Research output: Contribution to conference without publisher/journal › Poster › Research

The PPAR{gamma}2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment

Bugge, A. S., Grøntved, L., Aagaard, M. M., Borup, R. & Mandrup, S., 1. Jun 2009, In: Molecular Endocrinology. 23, 6, p. 794-808 14 p.

Research output: Contribution to journal › Journal article › Research › peer-review

2008

Lars Grøntved

Research output

Search results