• Campusvej 55

    5230 Odense M

    Denmark

20022023
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Research Output 2002 2019

  • 24 Journal article
  • 8 Poster
  • 2 Conference abstract for conference
  • 1 Ph.D. thesis
2019
89 Downloads (Pure)

Collagen density regulates the activity of tumor-infiltrating T cells

Kuczek, D. E., Larsen, A. M. H., Thorseth, M-L., Carretta, M., Kalvisa, A., Siersbæk, M. S., Simões, A. M. C., Roslind, A., Engelholm, L. H., Noessner, E., Donia, M., Svane, I. M., Straten, P. T., Grøntved, L. & Madsen, D. H., 12. Mar 2019, In : Journal for immunotherapy of cancer. 7, 1, 15 p., 68.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Neoplasms
Cell Proliferation
Gene Expression Profiling
Autocrine Communication
CD4-CD8 Ratio
27 Downloads (Pure)

Meta-analysis of Chromatin Programming by Steroid Receptors

Paakinaho, V., Swinstead, E. E., Presman, D. M., Grøntved, L. & Hager, G. L., 24. Sep 2019, In : Cell Reports. 28, 13, p. 3523-3534 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Steroid Receptors
Chromatin
Meta-Analysis
Transcription Factors
Forkhead Transcription Factors
2018
92 Downloads (Pure)

Insulin signaling and reduced glucocorticoid receptor activity attenuate postprandial gene expression in liver

Kalvisa, A., Siersbæk, M. S., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 10. Dec 2018, In : PLOS Biology. 16, 12, p. 1-32 e2006249.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Glucocorticoid Receptors
Gene expression
Liver
insulin
Genes

Insulin signaling in combination with reduced glucocorticoid activity attenuate post-prandial gene expression in liver

Siersbæk, M., Kalvisa, A., Præstholm, S. M., Christensen, L. J. L., Nielsen, R., Stohr, O., Vettorazzi, S., Tuckermann, J., White, M., Mandrup, S. & Grøntved, L., 11. Sep 2018.

Research output: Contribution to conference without publisher/journalPosterResearch

2017
141 Downloads (Pure)

Genome-wide identification of basic helix-loop-helix and NF-1 motifs underlying GR binding sites in male rat hippocampus

Pooley, J. R., Flynn, B. P., Grøntved, L., Baek, S., Guertin, M. J., Kershaw, Y. M., Birnie, M. T., Pellatt, A., Rivers, C. A., Schiltz, R. L., Hager, G. L., Lightman, S. L. & Conway-Campbell, B. L., 2017, In : Endocrinology. 158, 5, p. 1486-1501

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Glucocorticoid Receptors
Glucocorticoids
Chromatin Immunoprecipitation
Sequence Analysis
Organizations
185 Downloads (Pure)

High fat diet-induced changes of mouse hepatic transcription and enhancer activity can be reversed by subsequent weight loss

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 10. Jan 2017, In : Scientific Reports. 7, 13 p., 40220.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
High Fat Diet
Liver
Fasting
Insulin
Transcriptome

Noncanonical thyroid hormone signaling mediates cardiometabolic effects in vivo

Hönes, G. S., Rakov, H., Logan, J., Liao, X. H., Werbenko, E., Pollard, A. S., Præstholm, S. M., Siersbæk, M. S., Rijntjes, E., Gassen, J., Latteyer, S., Engels, K., Strucksberg, K. H., Kleinbongard, P., Zwanziger, D., Rozman, J., Gailus-Durner, V., Fuchs, H., De Angelis, M. H., Klein-Hitpass, L. & 8 others, Köhrle, J., Armstrong, D. L., Grøntved, L., Bassett, J. H. D., Williams, G. R., Refetoff, S., Führer, D. & Moeller, L. C., 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 52, p. E11323-E11332

Research output: Contribution to journalJournal articleResearchpeer-review

Thyroid Hormone Resistance Syndrome
Thyroid Hormone Receptors
Mutation
Nucleic Acid Regulatory Sequences
DNA
117 Downloads (Pure)

Tumor-Associated Macrophages Derived from Circulating Inflammatory Monocytes Degrade Collagen through Cellular Uptake

Madsen, D. H., Jürgensen, H. J., Siersbæk, M. S., Kuczek, D. E., Grey Cloud, L., Liu, S., Behrendt, N., Grøntved, L., Weigert, R. & Bugge, T. H., 26. Dec 2017, In : Cell Reports. 21, 13, p. 3662-3671

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Macrophages
Tumors
Collagen
Neoplasms
Degradation
2016

HIGH FAT DIET-INDUCED CHANGES OF MOUSE HEPATIC TRANSCRIPTION AND ENHANCER ACTIVITY ARE REVERSED BY SUBSEQUENT WEIGHT LOSS.

Siersbæk, M., Varticovski, L., Yang, S., Baek, S., Nielsen, R., Mandrup, S., Hager, G., H. Chung, J. & Grøntved, L., 25. Aug 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

106 Downloads (Pure)

MDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3

Hallenborg, P., Siersbæk, M., Barrio-Hernandez, I., Nielsen, R., Kristiansen, K., Mandrup, S., Grøntved, L. & Blagoev, B., 1. Jul 2016, In : Cell Death & Disease. 7, 6, p. e2289

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Adipocytes
Adipogenesis
Ligases
Ubiquitin
Neoplasms

Steroid receptors reprogram FoxA1 occupancy through dynamic chromatin transitions

Swinstead, E. E., Miranda, T. B., Paakinaho, V., Baek, S., Goldstein, I., Hawkins, M., Karpova, T. S., Ball, D., Mazza, D., Lavis, L. D., Grimm, J. B., Morisaki, T., Grøntved, L., Presman, D. M. & Hager, G. L., 21. Apr 2016, In : Cell. 165, 3, p. 593-605

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Steroid Receptors
Estrogen Receptors
Chromatin
Glucocorticoid Receptors
Forkhead Transcription Factors
2015

Structural Modeling of GR Interactions with the SWI/SNF Chromatin Remodeling Complex and C/EBP

Muratcioglu, S., Presman, D. M., Pooley, J. R., Grøntved, L., Hager, G. L., Nussinov, R., Keskin, O. & Gursoy, A., 15. Sep 2015, In : Biophysical Journal. 109, 6, p. 1227-39 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromatin Assembly and Disassembly
Glucocorticoid Receptors
Mutation
Proteins
Leucine

Transcriptional activation by the thyroid hormone receptor through ligand-dependent receptor recruitment and chromatin remodelling

Grøntved, L., Waterfall, J. J., Kim, D. W., Baek, S., Sung, M-H., Zhao, L., Park, J. W., Nielsen, R., Walker, R. L., Zhu, Y. J., Meltzer, P. S., Hager, G. L. & Cheng, S-Y., 2015, In : Nature Communications. 6, 7048.

Research output: Contribution to journalJournal articleResearchpeer-review

Thyroid Hormone Receptors
chromatin
Chromatin Assembly and Disassembly
hormones
Transcriptional Activation
2014

Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor

Presman, D. M., Ogara, M. F., Stortz, M., Alvarez, L. D., Pooley, J. R., Schiltz, R. L., Grøntved, L., Johnson, T. A., Mittelstadt, P. R., Ashwell, J. D., Ganesan, S., Burton, G., Levi, V., Hager, G. L. & Pecci, A., Mar 2014, In : P L o S Biology. 12, 3, p. e1001813

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
dimerization
Dimerization
Glucocorticoid Receptors
image analysis
Imaging techniques
2013

C/EBP maintains chromatin accessibility in liver and facilitates glucocorticoid receptor recruitment to steroid response elements

Grøntved, L., John, S., Baek, S., Liu, Y., Buckley, J. R., Vinson, C., Aguilera, G. & Hager, G. L., 2013, In : E M B O Journal. 32, 11, p. 1568-83

Research output: Contribution to journalJournal articleResearchpeer-review

Glucocorticoid Receptors
Response Elements
Liver
Chromatin
Steroids

eRNAs promote transcription by establishing chromatin accessibility at defined genomic loci

Mousavi, K., Zare, H., Dell'orso, S., Grøntved, L., Gutierrez-Cruz, G., Derfoul, A., Hager, G. L. & Sartorelli, V., 2013, In : Molecular Cell. 51, 5, p. 606-17

Research output: Contribution to journalJournal articleResearchpeer-review

Nucleic Acid Regulatory Sequences
RNA
Myogenin
Chromatin Assembly and Disassembly
Muscle Development

Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation

Kieffer-Kwon, K-R., Tang, Z., Mathe, E., Qian, J., Sung, M-H., Li, G., Resch, W., Baek, S., Pruett, N., Grøntved, L., Vian, L., Nelson, S., Zare, H., Hakim, O., Reyon, D., Yamane, A., Nakahashi, H., Kovalchuk, A. L., Zou, J., Joung, J. K. & 6 others, Sartorelli, V., Wei, C-L., Ruan, X., Hager, G. L., Ruan, Y. & Casellas, R., 2013, In : Cell. 155, 7, p. 1507-20

Research output: Contribution to journalJournal articleResearchpeer-review

Genes
Cells
myc Genes
Tissue
Cell Cycle

Reprogramming the chromatin landscape: interplay of the estrogen and glucocorticoid receptors at the genomic level

Miranda, T. B., Voss, T. C., Sung, M-H., Baek, S., John, S., Hawkins, M., Grøntved, L., Schiltz, R. L. & Hager, G. L., 2013, In : Cancer Research. 73, 16, p. 5130-9

Research output: Contribution to journalJournal articleResearchpeer-review

Glucocorticoid Receptors
Cytoplasmic and Nuclear Receptors
2012

Impact of chromatin structure on PR signaling: transition from local to global analysis

Grøntved, L. & Hager, G. L., 2012, In : Molecular and Cellular Endocrinology. 357, 1-2, p. 30-36

Research output: Contribution to journalJournal articleResearchpeer-review

Progesterone Receptors
Chromatin
Steroid Receptors
Chromatin Assembly and Disassembly
Metagenomics

Rapid genome-scale mapping of chromatin accessibility in tissue

Grøntved, L., Bandle, R., John, S., Baek, S., Chung, H-J., Liu, Y., Aguilera, G., Oberholtzer, C., Hager, G. L. & Levens, D., 2012, In : Epigenetics & Chromatin. 5, 10, 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chromosome Mapping
Serratia marcescens nuclease
Deoxyribonuclease I
CpG Islands
Endonucleases

The Transcription Factor Encyclopedia

Yusuf, D., Butland, S. L., Swanson, M. I., Bolotin, E., Ticoll, A., Cheung, W. A., Zhang, X. Y., Dickman, C. T., Fulton, D. L., Lim, J. S., Schnabl, J. M., Ramos, O. H., Vasseur-Cognet, M., de Leeuw, C. N., Simpson, E. M., Ryffel, G. U., Lam, E. W-F., Kist, R., Wilson, M. S., Marco-Ferreres, R. & 94 others, Brosens, J. J., Beccari, L. L., Bovolenta, P., Benayoun, B. A., Monteiro, L. J., Schwenen, H. D., Grontved, L., Wederell, E., Mandrup, S., Veitia, R. A., Chakravarthy, H., Hoodless, P. A., Mancarelli, M., Torbett, B. E., Banham, A. H., Reddy, S. P., Cullum, R. L., Liedtke, M., Tschan, M. P., Vaz, M., Rizzino, A., Zannini, M., Frietze, S., Farnham, P. J., Eijkelenboom, A., Brown, P. J., Laperriere, D., Leprince, D., de Cristofaro, T., Prince, K. L., Putker, M., Del Peso, L., Camenisch, G., Wenger, R. H., Mikula, M., Rozendaal, M., Mader, S., Ostrowski, J., Rhodes, S. J., Van Rechem, C., Boulay, G., Olechnowicz, S. W., Breslin, M. B., Lan, M. S., Nanan, K. K., Wegner, M., Hou, J., Mullen, R. D., Colvin, S. C., Noy, P. J., Webb, C. F., Witek, M. E., Ferrell, S., Daniel, J. M., Park, J., Waldman, S. A., Peet, D. J., Taggart, M., Jayaraman, P-S., Karrich, J. J., Blom, B., Vesuna, F., O'Geen, H., Sun, Y., Gronostajski, R. M., Woodcroft, M. W., Hough, M. R., Chen, E., Europe-Finner, N., Karolczak-Bayatti, M., Bailey, J., Hankinson, O., Raman, V., Lebrun, D. P., Biswal, S., Harvey, C. J., Debruyne, J. P., Hogenesch, J. B., Hevner, R. F., Heligon, C., Luo, X. M., Blank, M. C., Millen, K. J., Sharlin, D. S., Forrest, D., Dahlman-Wright, K., Zhao, C., Mishima, Y., Sinha, S., Chakrabarti, R., Portales-Casamar, E., Sladek, F. M., Bradley, P. H. & Wasserman, W. W., 2012, In : Genome Biology (Online Edition). 13, 3, p. R24

Research output: Contribution to journalJournal articleResearchpeer-review

Encyclopedias
transcription factors
Information Storage and Retrieval
researchers
Research Personnel
2010

MED14 tethers mediator to the N-terminal domain of peroxisome proliferator-activated receptor gamma and is required for full transcriptional activity and adipogenesis

Grøntved, L., Madsen, M. S., Boergesen, M., Roeder, R. G. & Mandrup, S., 1. May 2010, In : Molecular and Cellular Biology. 30, 9, p. 2155-69 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Adipogenesis
PPAR gamma
Transcriptional Activation
TATA-Box Binding Protein
3T3-L1 Cells
2009

MED14 tethers the Mediator to the N-terminal domain of PPARg and is required for full transcriptional activity and adipogenesis

Grøntved, L., 2009.

Research output: Contribution to conference without publisher/journalPosterResearch

The PPAR{gamma}2 A/B-domain plays a gene-specific role in transactivation and cofactor recruitment

Bugge, A. S., Grøntved, L., Aagaard, M. M., Borup, R. & Mandrup, S., 1. Jun 2009, In : Molecular Endocrinology. 23, 6, p. 794-808 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
Transcriptional Activation
CREB-Binding Protein
Cyclic AMP Response Element-Binding Protein
Chromatin Immunoprecipitation
2008

Co-factors necessary for PPAR mediated transactivation of endogenous target genes

Grøntved, L., Nielsen, R., Stunnenberg, H. & Mandrup, S., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

Transcriptional Activation
PPAR alpha
Nucleotide Motifs
Cytoplasmic and Nuclear Receptors
Lipid Metabolism

Extensive mapping of PPAR binding to genomic DNA

Nielsen, R., Pedersen, T. Å., Trindade, L., van Driel, M., Grøntved, L., Brozek, J. J., Staels, B., Hum, D., Stunnenberg, H. & Mandrup, S., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

DNA
Hepatocellular Carcinoma
Adipogenesis
Immunoglobulin Class Switching
Cell Line

MED1 independent activation of endogenous target genes by PPARα

Grøntved, L., Bugge, A. K., Roeder, R. G. & Mandrup, S., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

PPAR alpha
PPAR gamma
Transcriptional Activation
Cytoplasmic and Nuclear Receptors

PPARγ2s A/B-domæne spiller en genspecifik rolle i transaktivering og co-faktor rekruttering

Bugge, A. S., Grøntved, L., M. Aagaard, M., Borup, R. & Mandrup, S., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

Adenoviridae
Fibroblasts
Natural Science Disciplines
Chromatin Immunoprecipitation
Transcriptional Activation

The adipogenic acetyltransferase Tip60 targets activation function 1 of peroxisome proliferator-activated receptor gamma

van Beekum, O., Brenkman, A. B., Grøntved, L., Hamers, N., van den Broek, N. J. F., Berger, R., Mandrup, S. & Kalkhoven, E., 2008, In : Endocrinology. 149, 4, p. 1840-1849 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
Adipocytes
Proteins
Adipogenesis
Chromatin Immunoprecipitation
2006

Molecular mechanisms of PPAR subtype specific transactivation of target genes as investigated by ChIP and adenoviral vectors

Nielsen, R., Grøntved, L., Bugge, A. K., Stunnenberg, H. & Mandrup, S., 2006.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

Peroxisome proliferator-activated receptor subtype- and cell-type-specific activation of genomic target genes upon adenoviral transgene delivery

Nielsen, R., Grøntved, L., Stunnenberg, H. G. & Mandrup, S., 2006, In : Molecular and Cellular Biology. 26, 15, p. 5698-5714 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

PPAR gamma
PPAR alpha
Chromatin Immunoprecipitation
Transcriptional Activation
Ligands

PPAR A/B domains in ligand-dependent and independent transactivation of genomic target genes.

Bugge, A. K., Grøntved, L., Nielsen, R., Larsen, M. M. K. & Mandrup, S., 2006.

Research output: Contribution to conference without publisher/journalPosterResearch

PPAR subtype and cell type specific activation of genomic target genes upon adenoviral transgene delivery

Nielsen, R., Grøntved, L., Stunnenberg, H. & Mandrup, S., 2006.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearch

2002

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents.

Helledie, T., Grøntved, L., Jensen, S. S., Kiilerich, P., Rietveld, L., Albrektsen, T., Boysen, M. S., Nøhr, J., Larsen, L. K., Fleckner, J., Stunnenberg, H. G., Kristiansen, K. & Mandrup, S., 2002, In : Journal of Biological Chemistry. 277, 30, p. 26821-30

Research output: Contribution to journalJournal articleResearchpeer-review

Diazepam Binding Inhibitor
Gene encoding
PPAR gamma
Response Elements
Rodentia