Lars Folke Olsen

cand.scient.

  • Campusvej 55

    5230 Odense M

    Denmark

1977 …2019
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Research Output 1977 2019

2019

Coupled response of membrane hydration with oscillating metabolism in live cells: An alternative way to modulate structural aspects of biological membranes?

Bagatolli, L. A., Stock, R. P. & Olsen, L. F., 1. Nov 2019, In : Biomolecules. 9, 11, 687.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Biological membranes
Metabolism
Hydration
Membranes
Water

Delivery of proteins encapsulated in chitosan-tripolyphosphate nanoparticles to human skin melanoma cells

Stie, M. B., Thoke, H. S., Issinger, O-G., Hochscherf, J., Guerra, B. & Olsen, L. F., Feb 2019, In : Colloids and Surfaces B: Biointerfaces. 174, p. 216-223

Research output: Contribution to journalJournal articleResearchpeer-review

Chitosan
Bovine Serum Albumin
Melanoma
delivery
Skin
2018
99 Downloads (Pure)

Effect of macromolecular crowding on the kinetics of glycolytic enzymes and the behaviour of glycolysis in yeast

Thoke, H. S., Bagatolli, L. A. & Olsen, L. F., 1. Oct 2018, In : Integrative Biology. 10, 10, p. 587-597

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
34 Downloads (Pure)

Is a constant low-entropy process at the root of glycolytic oscillations?

Thoke, H. S., Olsen, L. F., Duelund, L., Stock, R. P., Heimburg, T. & Bagatolli, L., Sep 2018, In : Journal of Biological Physics. 44, 3, p. 419-431

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Entropy
entropy
oscillations
thermodynamics
metabolites
2017
116 Downloads (Pure)

The dynamics of intracellular water constrains glycolytic oscillations in Saccharomyces cerevisiae

Thoke, H. S., Thorsteinsson, S., Stock, R. P., Bagatolli, L. & Olsen, L. F., 2017, In : Scientific Reports. 7, 12 p., 16250.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2016
96 Downloads (Pure)

Calibrated kallikrein generation in human plasma

Biltoft, D., Sidelmann, J. J., Olsen, L. F., Palarasah, Y. & Gram, J., 29. Jun 2016, In : Clinical Biochemistry. 49, 15, p. 1188-1194

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Plasma (human)
Kallikreins
Factor XII
Prekallikrein
Tissue Kallikreins

Polymeric pH nanosensor with extended measurement range bearing octaarginine as cell penetrating peptide

Ke, P., Sun, H., Liu, M., Su, Z., Hu, K., Zhua, H., Guo, H., Sun, H., Andresen, L. T. & Olsen, L. F., Jan 2016, In : IET Nanobiotechnology. 10, 1, p. 8-12

Research output: Contribution to journalJournal articleResearchpeer-review

Selection of Aptamers for Metabolic Sensing and Construction of Optical Nanosensors

Long, Y., Pfeiffer, F., Mayer, G., Schrøder, T. D., Özalp, V. C. & Olsen, L. F., 2016, Nucleic Acid Aptamers : Selection, Characterization, and Application. Mayer, G. (ed.). Humana Press, Vol. Part I. p. 3-19 (Methods in Molecular Biology, Vol. 1380).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Coloring Agents
Ions
fructose-1,6-diphosphate
2015
386 Downloads (Pure)

Tight Coupling of Metabolic Oscillations and Intracellular Water Dynamics in Saccharomyces cerevisiae

Thoke, H. S., Tobiesen, A., Brewer, J. R., Hansen, P. L., Stock, R., Olsen, L. F. & Bagatolli, L., 23. Feb 2015, In : PLOS ONE. 10, 2, 16 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
2014

Experimental and model study of the formation of chitosan-tripolyphosphate-siRNA nanoparticles

Schrøder, T. D., Olsen, L. F. & Long, Y., 19. Jul 2014, In : Colloid and Polymer Science. 292, 11, p. 2869-2880 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Chitosan
RNA
Small Interfering RNA
Nanoparticles
nanoparticles
2013

A combination of dynamic light scattering and polarized resonance Raman scattering applied in the study of Arenicola Marina extracellular hemoglobin

Jernshøj, K. D., Hassing, S. & Olsen, L. F., 2013, In : Journal of Chemical Physics. 139, p. 065104-1-065104-10

Research output: Contribution to journalJournal articleResearchpeer-review

An experimental study of the regulation of glycolytic oscillations in yeast

Schrøder, T. D., Özalp, V. C., Lunding, A., Jernshøj, K. D. & Olsen, L. F., Dec 2013, In : FEBS Journal. 280, 23, p. 6033-6044

Research output: Contribution to journalJournal articleResearchpeer-review

Gene Deletion
Hexokinase
Glycolysis
Adenosine Triphosphatases
Protein Isoforms

Nanoparticle embedded enzymes for improved lateral flow sensors

Özalp, V. C., Zeydanlı, U. S., Lunding, A., Kavruk, M., Öz, M. T., Eyidoğan, F., Olsen, L. F. & Öktem, H. A., 2013, In : Analyst. 138, p. 4255-4359 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

The Yin and Yang of redox regulation

Olsen, L. F., Issinger, O-G. & Guerra, B., 2013, In : Redox Report (Online). 18, p. 245-252

Research output: Contribution to journalReviewResearchpeer-review

2012

Measurements of intracellular ATP provide new insight into the regulation of glycolysis in the yeast Saccharomyces cerevisiae

Ytting, C. K., Fuglsang, A. T., Hiltunen, J. K., Kastaniotis, A. J., Özalp, V. C., Nielsen, L. J. & Olsen, L. F., 2012, In : Integrative Biology. 4, 1, p. 99-107

Research output: Contribution to journalJournal articleResearchpeer-review

Oscillations in glycolysis in Saccharomyces cerevisiae: The role of autocatalysis and intracellular ATPase activity

Kloster, A. & Olsen, L. F., 8. May 2012, In : Biophysical Chemistry. 165-ø166, p. 39-47

Research output: Contribution to journalJournal articleResearchpeer-review

Protein ordering of extracellular Giant Hemoglobin studied by Polarized Resonance Raman Scattering and Dynamic Light Scattering

Jernshøj, K. D., Hassing, S. & Olsen, L. F., 2012.

Research output: Contribution to conference without publisher/journalConference abstract for conferenceResearchpeer-review

Sphingomyelinase D activity in model membranes: structural effects of in situ generation of ceramide-1-phosphate

Stock, R., Brewer, J. R., Wagner, K., Ramos-Cerrillo, B., Duelund, L., Jernshøj, K. D., Olsen, L. F. & Bagatolli, L., 25. Apr 2012, In : PLOS ONE. 7, 4, p. 1-15 (e-36003) 15 p.

Research output: Contribution to journalJournal articleResearchpeer-review

ceramides
sphingomyelins
Sphingomyelins
phosphates
Membranes
2011

Extracellular ATP induces spikes in cytosolic free Ca2+ but not in NADH oxidase activity in neutrophils

Brasen, J. C., Olsen, L. F. & Hallett, M. B., 2011, In : B B A - Molecular Cell Research. 1813, 8, p. 1446-1452

Research output: Contribution to journalJournal articleResearchpeer-review

2010

An Aptamer-Based Nanobiosensor for Real-Time Measurements of ATP Dynamics

Özalp, C., Nielsen, L. J. & Olsen, L. F., 2010, In : ChemBioChem. 11, p. 2538-2541 4 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Aptamers Embedded in Polyacrylamide Nanoparticles: A Tool for in Vivo Metabolite Sensing

Nielsen, L. J., Olsen, L. F. & Özalp, C., 2010, In : A C S Nano. 4, 8, p. 4361-4370 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Cell surface topology creates high Ca2+ signalling microdomains

Brasen, J. C., Olsen, L. F. & Hallett, M. B., 1. Apr 2010, In : Cell Calcium. 47, 4, p. 339-49 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Membranes
Cell Size
Cell Membrane
Enzymes

Langt fra ligevægt

Brasen, J. C. & Olsen, L. F., 1. May 2010, In : Aktuel Naturvidenskab. 2, p. 31-34 4 p.

Research output: Contribution to journalJournal articleCommunication

On the mechanism of oscillations in neutrophils

Brasen, J. C., Barington, T. & Olsen, L. F., 1. May 2010, In : Biophysical Chemistry. 148, 1-3, p. 82-92 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

1-Butanol
Neutrophils
Cytochalasin B
1-Phosphatidylinositol 4-Kinase
NAD

Time-resolved Measurements of Intracellular ATP in the Yeast Saccharomyces Cerevisiae using a New Type of Nanobiosensor

Özalp, C., Pedersen, T. R., Nielsen, L. J. & Olsen, L. F., 26. Nov 2010, In : Journal of Biological Chemistry. 285, 48, p. 37579-37588 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2009

Clinical consequences of hospital variation in use of oral anticoagulant therapy after first-time admission for atrial fibrillation

Hansen, M. L., Gadsbøll, N., Rasmussen, S., Gislason, G. H., Folke, F., Andersen, S. S., Schramm, T. K., Sørensen, R., Andersen, S. S., Abildstrøm, S. Z., Madsen, M., Poulsen, H. E., Køber, L. & Andersen, S. S., 1. Mar 2009, In : Journal of Internal Medicine. 265, 3, p. 335-44 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Prescriptions
Low-Volume Hospitals
High-Volume Hospitals
Community Hospital
Denmark

Regulation of Glycolytic Oscillations by Mitochondrial and Plasma Membrane H+-ATPases

Olsen, L. F., Andersen, A. Z., Lunding, A., Brasen, J. C. & Poulsen, A. K., 6. May 2009, In : Biophysical Journal. 96, 9, p. 3850-3861

Research output: Contribution to journalJournal articleResearchpeer-review

Risk of myocardial infarction and death associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs) among healthy individuals: a nationwide cohort study

Fosbøl, E. L., Gislason, G. H., Jacobsen, S., Folke, F., Hansen, M. L., Schramm, T. K., Sørensen, R., Rasmussen, J. N., Andersen, S. S., Abildstrøm, S., Traerup, J., Poulsen, H. E., Rasmussen, S., Køber, L. & Torp-Pedersen, C., 2009, In : Clinical Pharmacology and Therapeutics. 85, 2, p. 190-197

Research output: Contribution to journalJournal articleResearchpeer-review

Cohort Studies
Diclofenac
Celecoxib
Pharmaceutical Preparations
Naproxen

The interplay between glycolysis and the calcium signal and membrane potential of human neutrophils stimulated with FMLP

Brasen, J. C. & Olsen, L. F., 2009. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearch

The Metabolic pH Response in Lactococcus lactis: An Integrative Experimental and Modelling Approach

Andersen, A. Z., Carvalho, A. L., Neves, A. R., Santos, H., Kummer, U. & Olsen, L. F., 1. Feb 2009, In : Computational Biology and Chemistry. 33, 1, p. 71-83 13 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2008

Mute single cells start to sing when in a choir

Poulsen, A. K., Andersen, A. Z., Brasen, J. C. & Olsen, L. F., 2008. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearch

Optical nanosensors for monitoring metabolite dynamics in living cells

Poulsen, A. K., Brasen, J. C. & Olsen, L. F., 2008. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearch

Optical nanosensors for monitoring metabolite dynamics in living cells

Poulsen, A. K., Brasen, J. C. & Olsen, L. F., 2008, 12th ECSBM Book of Abstracts. 1 ed. ECSBM, Vol. 12. p. 239 1 p.

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearch

Probing Glycolytic and Membrane Potential Oscillations in Saccharomyces cerevisiae

Poulsen, A. K., Andersen, A. Z., Brasen, J. C., Scharff-Poulsen, A. M. & Olsen, L. F., 2008, In : Biochemistry. 47, 8, p. 7477–7484 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Singing in concert: Coupling of glycolytic oscillations with oscillations in mitochondrial membrane potential in Sachharomyces cerevisiae

Olsen, L. F., Poulsen, A., Brasen, J. C. & Andersen, A. Z., 2008. 2 p.

Research output: Contribution to conference without publisher/journalPosterResearch

Synchronisation of glycolytic oscillations in a suspension of human neutrophils

Brasen, J. C., Poulsen, A. K. & Olsen, L. F., 2008.

Research output: Contribution to conference without publisher/journalPosterResearch

glycolysis
neutrophils
synchronism
inorganic peroxides
oscillations
2007

Dynamic instabilities within living neutrophils

Petty, H. R., Romero, R., Olsen, L. F. & Kummer, U., 2007, Introduction to Systems Biology. Choi, S. (ed.). Totowa, New Jersey: AAAI Press, p. 319-335 17 p.

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearch

Horseradish peroxidase embedded in polyacrylamide nanoparticles enables optical detection of reactive oxygen species

Poulsen, A. K., Scharff-Poulsen, A. M. & Olsen, L. F., 1. Jul 2007, In : Analytical Biochemistry. 366, 1, p. 29-36 7 p.

Research output: Contribution to journalJournal articleResearchpeer-review

On-line measurements of oscillating mitochondrial membrane potential in glucose-fermenting Saccharomyces cerevisiae

Andersen, A. Z., Poulsen, A. K., Brasen, J. C. & Olsen, L. F., 2007, In : Yeast. 24, 9, p. 731-739 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Single cell studies and simulation of cell-cell interactions using oscillating glycolysis in yeast cells

Poulsen, A. K., Pedersen, M. Ø. & Olsen, L. F., 2007, In : Biophysical Chemistry. 125, 2-3, p. 275-280 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Sugar metabolism of Lactococcus lactis during short term acid stress: Experimental and theoretical studies

Andersen, A. Z., Carvalhos, A. L., Neves, A. R., Santos, H. & Olsen, L. F., 2007.

Research output: Contribution to conference without publisher/journalPosterResearch

Synchronisation of glycolytic oscillations in a suspension of human neutrophils

Brasen, J. C., Poulsen, A. K. & Olsen, L. F., 2007. 3 p.

Research output: Contribution to conference without publisher/journalPaperResearch

2006

Optical nano-sensor for detection of reactive oxygen species

Poulsen, A. K. & Olsen, L. F., 2006, IPC No. 60/829, Patent No. 154, 12. Oct 2006

Research output: PatentResearch

2005

A mathematical model of the synchronization of NAD(P)H oscillations between tumour cells and neutrophils

Hansen, T. A., Brasen, J. C. & Olsen, L. F., 2005, Proceedings of the Conference on Modelling and Simulation in Biology, Medicine and Biomedical Engineering. Fritzson, P. (ed.). Linköping University Electronic Press, p. 97-104

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

No music without melody: How to understand biochemical systems by understanding their dynamics

Kummer, U. & Olsen, L. F., 2005, In : Topics in Current Genetics. 13, p. 81-93

Research output: Contribution to journalJournal articleResearchpeer-review

2004

Human myeloperoxidase catalyzes an oscillating peroxidase-oxidase reaction.

Brasen, J. C., Lunding, A. & Olsen, L. F., 2004, In : Archives of Biochemistry and Biophysics. 431, p. 55-62

Research output: Contribution to journalJournal articleResearchpeer-review

On the encoding and decoding of calcium signals in hepatocytes

Larsen, A. Z., Olsen, L. F. & Kummer, U., 2004, In : Biophysical Chemistry. 107, p. 83-99 17 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Prediction analysis for measles epidemics.

Sumi, A., Ohtomo, N., Tanaka, Y., Sawmura, S., Olsen, L. F. & Kobayashi, N., 2004, In : Japanese Journal of Applied Physics. 42, p. 7611-7620

Research output: Contribution to journalJournal articleResearchpeer-review

Sustained glycolytic oscillations - No need for cyanide, FEMS

Poulsen, A. K., Lauritsen, F. R. & Olsen, L. F., 2004, In : FEMS Microbiology Letters. 236, p. 261-266

Research output: Contribution to journalJournal articleResearchpeer-review