Personal profile
Keywords
- Cell cycle
- DNA Replication
- DNA damage repair mechanisms
- DNA damage response
- Homologous Recombination
- BRCA1/BRCA2
- Metabolism
- Nucleotide Metabolism
- Redox signalling
- Chromatin regulation
- Cancer cells
- Quantitative Imaging
- Super-resolution microscopy
- Cell Biology
- Biochemistry
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Collaborations and top research areas from the last five years
Research output
- 34 Journal article
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PAF15–PCNA exhaustion governs the strand-specific control of DNA replication
Chhetri, G., Badugu, S. B., Petriman, N. A., Petersen, M. B., Güller, A. S., Fajri, N., Coulée, M., Pitchai, G. P., Novotný, J., Larsen, F. T., Møller, A. F., Ebbesen, M. F., Ravnsborg, T., Yadav, A. K., Balarasa, B., Lunding, A., Polasek-Sedlackova, H., Jensen, O. N., Ravnskjaer, K. & Brewer, J. R. & 4 others, , Mar 2026, In: Nature. 651, 8105, p. 521-532Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile11 Downloads (Pure) -
Metabolic control of replisome plasticity in genome surveillance
Petersen, M. B., Chhetri, G. & Somyajit, K., Oct 2025, In: Trends in Cell Biology. 35, 10, p. 880-892Research output: Contribution to journal › Journal article › Research › peer-review
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Homology-directed repair protects the replicating genome from metabolic assaults
Somyajit, K., Spies, J., Coscia, F., Kirik, U., Rask, M.-B., Lee, J.-H., Neelsen, K. J., Mund, A., Jensen, L. J., Paull, T. T., Mann, M. & Lukas, J., 22. Feb 2021, In: Developmental Cell. 56, 4, p. 461-477.e7Research output: Contribution to journal › Journal article › Research › peer-review
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Equilibrium between nascent and parental MCM proteins protects replicating genomes
Sedlackova, H., Rask, M.-B., Gupta, R., Choudhary, C., Somyajit, K. & Lukas, J., 21. Oct 2020, In: Nature. 587, p. 297–302Research output: Contribution to journal › Journal article › Research › peer-review
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Redox-sensitive alteration of replisome architecture safeguards genome integrity
Somyajit, K., Gupta, R., Sedlackova, H., Neelsen, K. J., Ochs, F., Rask, M.-B., Choudhary, C. & Lukas, J., 10. Nov 2017, In: Science. 358, 6364, p. 797-802Research output: Contribution to journal › Journal article › Research › peer-review
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Kræftens bekæmpelse - projektudgifter - Metabolic Regulation and Spatial Compartmentalization of BRCA1/2-RAD51 in Genome Protection: Unveiling BRCAness Beyond Genetics
Somyajit, K. (Project participant)
01/01/2026 → 31/12/2028
Project: Private Foundations
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EU - Horizon Europe - ERC Starting Grant - The molecular nexus coupling Cell Metabolism to Cell cycle and Genome Surveillance
Somyajit, K. (Project participant)
01/10/2023 → 30/09/2028
Project: EU
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Novo Nordisk Fonden - Bioscience and Basic Biomedicine - Decoding EZHIP: The Oncohistone Mimic Steering Chromatin Dynamics in Pediatric Ependymoma Brain Tumors
Somyajit, K. (PI)
01/01/2025 → 31/12/2027
Project: Private Foundations
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BørneCancerFonden - Epigenomic dysregulation and therapeutic targets in lethal ependymoma in children
Somyajit, K. (Project participant)
01/01/2025 → 31/12/2026
Project: Private Foundations
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Lundbeck Foundation Fellowship - Metabolic regulation of mammalian DNA replication
Somyajit, K. (Project participant)
01/08/2021 → 31/07/2026
Project: Research
Press/Media
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Dansk studie: Celler har en indbygget bremse for DNA-kopiering
04/03/2026
1 Media contribution
Press/Media: Press / Media
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Celler har en indbygget bremse for DNA-kopiering – og det kan få betydning for kræftbehandling
28/01/2026
1 Media contribution
Press/Media: Press / Media
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Fond uddeler 57 millioner kroner til hjerneforskere
22/01/2026
1 Media contribution
Press/Media: Press / Media