Kate Lykke Lambertsen

Ph.d., M.Sc.

  • J.B. Winsløws Vej 21, st.

    5000 Odense C

    Denmark

20002019
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Personal profile

Research areas

Research

In our laboratory we are studying cerebrovascular diseases of and trauma to the central nervous system, such as stroke and spinal cord injury (SCI) to try to understand the cellular and molecular mechanisms that contribute to secondary neuronal cell death. We have primarily one main research objective, which is to study the neuro-inflammatory response that occurs following stroke and SCI with the aim to contribute to the development of novel therapies for stroke and SCI patients.

To determine what role inflammation plays following experimental stroke we use transgenic mouse models and other molecular approaches to study the central but complex role of the pleiotrophic, microglial-derived cytokine tumor necrosis factor (TNF) for neuronal survival/death. We have shown that TNF is present in low concentrations in normal brain tissue and that production of TNF by activated microglia is observed already 4 - 6 h after ischemia, which is within the ”therapeutic window” (4 - 4.5 h) in both mouse models of ischemic stroke and in the clinical setting. In combination with this, we have shown using a bone marrow chimeric approach that constitutively and/or early induced, presumably, microglial-derived TNF has a neuroprotective effect in experimental stroke. Taken together, this focuses our attention in the direction of studying the role of microglia in modulating neuronal sensititivity to ischemia.

To determine what role(s) trauma-induced inflammation plays in mediating secondary neuronal injury and cell death following SCI, we use transgenic mouse models and other molecular biological approaches. We specifically use transgenic mice that are deficient in neuronal NF-kB, which is a transcription factor that plays a pivotal role in regulating inflammation, and possibly apoptotic cell death pathways. These studies are performed in close collaboration with the laboratory of associate professor John Bethea at the Miami Project to Cure Paralysis with the aim to identify the role of NF-kB activation in neurons and to test the neuroprotective potential in animal models of SCI.


Principal investigator


Kate Lykke Lambertsen graduated as a MSc from the University of Southern Denmark in 1999. She initiated her training in experimental neurobiology in the Department of Anatomy and Neurobiology, University of Southern Denmark, supervised by dr. Bente Finsen, when she was a master student. Following graduation in 1999 she became a PhD student in experimental neurobiology in the same department (maternity leave: December, 2001 – July, 2002). In 2004 she defended her PhD thesis entitled ”The patophysiological role of tumor necrosis factor and interferon gamma in focal cerebral ischemia in mice”. In 2005-2008 (maternity leave: March, 2005 – October, 2005) she did her first post doc funded by the Danish Medical Research Counsil at the Bente Finsen Laboratory, Medical Biotechnology Center, University of Southern Denmark. In 2008-09 she was a visiting scientist at the Miami Project to Cure Paralysis, in the laboratory headed by dr. John Bethea, funded by a grant from Carlsbergfondet. Upon her return to Odense, she was appointed an associate professor in Anatomy and Neurobiology at the Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark. Kate Lykke Lambertsen has been a board member of the Danish Society for Neuroscience since 2007. Current sources of funding include the Danish Medical Research Council, Lundbeck Foundation, Offerfonden and a number of other grants.


Staff:

  • PhD student Minna Christiansen Lund
  • PhD student Carina Jørgensen
  • Medical student Rikke Birk Hansen
  • Medical student Cathrine Laursen
  • Master student Maiken Nissen
  • Master student Ahmed Shaker Hisab Hisab
  • Master student Pernille Vinther Nielsen
  • ISA student Mette Bjørnholt-Hansen
  • ISA student Camilla Kusk Meller Jacobsen
  • Technician Ulla Damgaard Munk


Applied methodologies, techniques and facilities

* Experimental models of stroke and spinal cord injury.
* Behavioral assessment of functional outcome following injury.
* Transgenic mouse models.
* Molecular and cellular techniques: Quantitative real-time PCR, Elisa, Western blotting, in situ hybridization, immunohistochemistry, flow cytometry, fluorescence staining and double labelings, histochemistry, stereologi, volume estimations.

International collaborators:

Dr. Roberta Brambilla, The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine
Dr. Tomas Deierborg, University of Lund
Dr. Daniel Anthony, Department of Pharmacology, University of Oxford
Dr. Sofia Santos, Institute for Molecular and Cell Biology, University of Porto
Dr. Mathias Gelderblom, Department of Neurology, Hamburg University

National collaborators:

Dr. Kristian Strømgaard, Department of Medicinal Chemistry, University of Copenhagen
Dr. Anders Bach, Department of Medicinal Chemistry, University of Copenhagen
Dr. Karin Lykke-Hartmann, Department of Biomedicine, University of Aarhus
Dr. Lars Henrik Frich, Department of Orthopedics, Odense University Hospital
Dr. Petrine Wellendorf, Experimental Pharmacology, University of Copenhagen
Dr. Allan Stensballe, Department of Health Science and Technology, Aalborg University

 

Research information

PUBLICATIONS

Academic theses:

  1. Lambertsen KL (1999) The role of interferon-gamma (IFNγ) and tumor necrosis factor (TNF) in focal cerebral ischemia in mice. Master thesis, Faculty of Natural Sciences, University of Southern Denmark.
  2. Lambertsen KL (2004) The patophysiological role of tumor necrosis factor and interferon gamma in focal cerebral ischemia in mice. PhD thesis, Faculty of Health Sciences, University of Southern Denmark.


Peer-reviewed papers:

  1. Gregersen R, Lambertsen K, and Finsen B (2000) Microglia and macrophages are the major source of tumor necrosis factor (TNF) in permanent middle cerebral artery occlusion in mice. J Cereb Blood Flow Metab 20:53-65.
  2. Lambertsen KL, Gregersen R, Drøjdahl N, Owens T and Finsen B (2001) A specific and sensitive method for visualization of tumor necrosis factor in the murine central nervous system. Brain Res Brain Res Protocols 7:175-191.
  3. Lambertsen KL, Gregersen R, and Finsen B (2002) Microglial-macrophage synthesis of tumor necrosis factor after focal cerebral ischemia in mice is strain dependent. J Cereb Blood Flow Metab 22:785-797.
  4. Lambertsen KL, Gregersen R, Meldgaard M, Clausen BH, Heibøl EK, Ladeby R, Knudsen J, Frandsen A, Owens T, Finsen B (2004) A role for interferon-gamma in focal cerebral ischemia in mice. J Neuropathol Exp Neurol 63:942-955.
  5. Gramsbergen JB, Skjøth-Rasmussen J, Rasmussen C, Lambertsen KL (2004) On-line monitoring of striatum glucose and lactate in the endothelin-1 rat model of transient, focal cerebral ischemia using microdialysis and flow-injection analysis with biosensors. J Neurosci Methods 140:93-101.
  6. Lambertsen KL (2004) Tumor nekrose faktors og interferon-gammas patofysiologiske rolle ved fokal cerebral iskaemi i mus. Ugeskrift for Laeger 166:3011.
  7. Lambertsen KL, Meldgaard M, Ladeby R, Finsen B (2005) A quantitative study of microglial-macrophage synthesis of tumor necrosis factor during acute and late focal cerebral ischemia. J Cereb Blood Flow Metab 25:119-136.
  8. Clausen BH, Lambertsen KL, Meldgaard M, Finsen B (2005) A quantitative in situ hybridization and polymerase chain reaction study of microglial-macrophage expression of interleukin-1β mRNA following permanent middle cerebral artery occlusion in mice. Neuroscience 132:879-892.
  9. Wirenfeldt M, Babckock AA, Ladeby R, Lambertsen KL, Dagnaes-Hansen F, Leslie G, Owens T, Finsen B (2005) Microglial subpopulations in the acutely injured central nervous system. J Neurosci Res 82:507-512.
  10. Lyck L, Jelsing J, Jensen PS, Lambertsen KL, Pakkenberg B, Finsen B (2005) Immunohistochemical visualization of neurons and specific glial cells for stereological application in the porcine neocortex. J Neurosci Methods 152:229-242.
  11. Fenger C, Drøjdahl N, Wirenfeldt M, Sylvest L, Jørgensen OS, Meldgaard M, Lambertsen KL, Finsen B (2006) Tumor necrosis factor and its p55 and p75 receptors are not required for axonal lesion-induced microgliosis in mouse fascia dentata. Glia 54:591-605.
  12. Meldgaard M, Fenger C, Lambertsen KL, Pedersen MD, Finsen B. (2006) Validation of two reference genes for mRNA level studies of murine disease models in neurobiology. J Neurosci Methods 156:101-110.
  13. Clausen BH, Lambertsen KL, Finsen B (2006) Glyceraldehyde-3-phosphate dehydrogenase versus toluidine blue as a marker for infarct volume estimation following permanent occlusion of the middle cerebral artery in mice. Exp Brain Res 175:60-67.
  14. Lambertsen KL, Clausen BH, Fenger C, Wulf H, Owens T, Dagnæs-Hansen F, Meldgaard M, Finsen B (2007) Microglia and macrophages express TNF receptor p75 following middle cerebral artery occlusion in mice. Neuroscience 144:934-949.
  15. Degn M, Lambertsen KL, Petersen G, Meldgaard M, Artmann A, Clausen BH, Hansen SH, Finsen B, Hansen HS, Lund TM (2007) Changes in brain levels of N-acetylethanolamines and 2-arachidonoyl glycerol in focal cerebral ischemia in mice. J Neurochem 103:1907-1916.
  16. Clausen BH*, Lambertsen KL*, Babcock A, Holm TH, Dagnæs-Hansen F, Finsen B (2008) Interleukin-1β and tumor necrosis factor-α are expressed by different subsets of microglia and macrophages after ischemic stroke in mice. (*Delt førsteforfatterskab) J Neuroinflam 5:46. doi: 10.1186/1742-2094-5-46.
  17. Nielsen M, Lambertsen KL, Clausen BH, Meldgaard M, Diemer NH, Zimmer J, Finsen B (2009) Nuclear translocation of endonuclease G in degenerating neurons after permanent middle cerebral artery occlusion in mice. Exp Brain Res 194:17-27. doi: 10.1007/s00221-008-1665-5.
  18. Lambertsen KL, Clausen BH, Babcock AA, Gregersen R, Nielsen M, Wirenfeldt M, Haugaard LS, Færgemann NJ, Dagnaes-Hansen F, Bluethmann H, Meldgaard M, Deierborg T, Finsen B (2009) Microglia protect neurons against ischemia by synthesis of tumor necrosis factor. J Neurosci 29:1319-1330. doi: 10.1523/JNEUROSCI.5505-08.2009.
  19. Santos SD, Lambertsen KL, Clausen BH, Akinc A, Alvarez R, Finsen B, Saraiva MJ (2010) Cerebrospinal fluid transthyretin neuroprotection in a mouse model of brain ischemia. J Neurochem 115:1434-1444. doi: 10.1111/j.1471-4159.2010.07047.x.
  20. Lambertsen KL, Deierborg T, Gregersen R, Clausen BH, Wirenfeldt M, Nielsen HH, Dalmau I, Diemer NH, Dagnaes-Hansen F, Johansen FF, Keating A, Finsen B (2011) Differences in origin of reactive microglia in bone marrow chimeric mouse and rat after transient global ischemia. J Neuropathol Exp Neurol 70:481-494. doi: 10.1097/NEN.0b013e31821db3aa.
  21. Nielsen HH, Toft-Hansen H, Lambertsen KL, Owens T, Finsen B (2011) Promotion of oligodendrocyte formation by myelin reactive T-cells. Am J Pathol 179:2028-2041. doi: 10.1016/j.ajpath.2011.06.006.
  22. Bach A, Clausen BH, Vestergaard B, Chi CN, Round A, Sørensen PL, Nissen KB, Kastrup JS, Gajhede M, Jemth P, Kristensen AS, Lundström P, Lambertsen KL, Strømgaard K (2012) High-affinity, dimeric inhibitors of PSD-95 efficiently protect against ischemic brain damage. Proc Natl Acad Sci USA 109:3317-3322. doi: 10.1073/pnas.1113761109.
  23. Lambertsen KL, Biber K, Finsen B (2012) Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab 32:1677-1698. doi: 10.1038/jcbfm.2012.88.
  24. Lambertsen KL*, Gramsbergen JB*, Sivasaravanaparan M, Ditzel N, Sevelsted-Møller LM, Oliván-Viguera A, Rabjerg M, Wulff H, Köhler R (2012) Genetic KCa3.1-deficiency produces locomotor hyperactivity and alterations in cerebral monoamine levels. PLoSOne 7:e47744. doi: 10.1371/journal.pone.0047744.
  25. Brambilla R, Couch Y, Lambertsen KL (2013) The effect of stroke on immune function. Mol Cell Neurosci 53:26-33. doi: 10.1016/j.mcn.2012.08.011.
  26. Bracchi-Ricard V*, Lambertsen KL*, Ricard J, Nathanson L, Karmally S, Johnstone J, Ellman DG, Frydel B, McTigue D, Bethea JR (2013) Inhibition of astroglial NF-κB enhances oligodendrogenesis following spinal cord injury. (*Delt førsteforfatterskab) J Neuroinflamm 10:92. doi: 10.1186/1742-2094-10-92.
  27. Brambilla R, Morton P, Jopek, Ashbaugh J, Karmally S, Lambertsen KL, Bethea J (2013) Astrocytes play a key role in EAE pathophysiology by facilitating CNS immune cell infiltration, contributing to myelin damage and suppressing remyelination. Glia 62:452-467. doi: 10.1002/glia.22616.
  28. Lambertsen KL, Østergaard K, Clausen BH, Hansen S, Stenvang J, Thorsen SB, Meldgaard M, Kristensen BW, Hansen PB, Sørensen GL, Finsen B (2014) No effect of ablation of surfactant protein D in ischemic brain damage in mice. J Neuroinflam 11:123. doi: 10.1186/1742-2094-11-123.
  29. Novrup HG, Bracchi-Ricard V, Ellman DG, Ricard J, Jain A, Runko E, Lyck L, Yli-Karjanmaa M, Szymkowski DE, Pierce DD, Lambertsen KL*, Bethea JR* (2014) Central versus peripheral administration of XPro1595 is therapeutic following moderate spinal cord injury. (*Co-corresponding og delt seniorforfatterskab) J Neuroinflam 11:159. doi: 10.1186/s12974-014-0159-6.
  30. Clausen BH, Degn M, Martin NA, Couch Y, Karimi L, Ormhøj M, Schmidt M-LB, Gredal HB, Gardiner C, Sargent IIL, Szymkowski DE, Petit G, Deierborg T, Finsen B, Anthony DC, Lambertsen KL (2014) Peripherally administered anti-TNF therapy ameliorates functional outcomes after focal cerebral ischemia. J Neuroinflam 11:203. doi: 10.1186/s12974-014-0203-6.
  31. Babcock AA, Ilkjær L, Villadsen B, Clausen BH, Dissing-Olesen L, Bendixen ATM, Lyck L, Lambertsen KL, Finsen B (2015) Cytokine-producing microglia have an altered beta-amyloid load in aged APP/PS1 Tg mice. Brain Behav Immun 48:86-101. doi: 10.1016/j.bbi.2015.03.006.
  32. Secher N, Østergaard L, Iversen NK, Lambertsen KL, Clausen BH, Tønnesen E, Granfeldt (2015) Preserved cerebral microcirculation after cardiac arrest in a rat model. Microcirculation 22:464-74. doi: 10.1111/micc.12217.
  33. Grebing M, Nielsen HH, Fenger C, von Linstow C, Clausen BH, Jensen K, Söderman M, Lambertsen KL, Thomassen M, Kruse TA, Finsen B (2015) Myelin specific T cells induce interleukin-1beta expression in activated microglia in zones of axonal degeneration. Glia 64(3):407-24. doi: 10.1002/glia.22937.
  34. Inácio AR, Liu Y, Clausen BH, Svensson M, Kucharz K, Yang Y, Stankovich T, Khorooshi R, Lambertsen KL, Issazadeh-Navikas S, Deierborg T (2015) Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia. J Neuroinflam 12:211. doi: 10.1186/s12974-015-0427-0.
  35. Madsen PM, Clausen BH, Degn M, Thyssen S, Svensson M, Ditzel N, Finsen B, Deierborg T, Brambilla R, Lambertsen KL (2016) Genetic ablation of soluble TNF is associated with neuroprotection after focal cerebral ischemia. J Cereb Blood Flow Metab 36(9): 1553-1569. doi: 10.1177/0271678X15610339.
  36. Martin NA, Bonner H, Elkjær ML, D’Orsi B, Chen G, König HG, Svensson M, Deierborg T, Pfeiffer S, Prehn J, Lambertsen KL (2016) Deficiency of BID is partially neuroprotective in oxygen-glucose deprived organotypic hippocampal slice cultures, but not in a transient experimental stroke model. Front Cell Neurosci 10:14. doi: 10.3389/fncel.2016.00014.
  37. Clausen BH, Lambertsen KL, Dagnaes-Hansen F, Babcock AA, von Linstow C, Meldgaard M, Kristensen BW, Wieloch T, Deierborg T, Finsen B (2016) Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke. Acta Neuropathol 131(5):775-91. doi: 10.1007/s00401-016-1541-5.
  38. Bøttger P, Glerup S, Heuck A, Clausen BH, Gramsbergen JB, Lambertsen KL, Nissen P, Lykke-Hartmann K (2016) Obsessive-compulsive disorder-like and other co-morbid psychiatric manifestations couples to glutamate defects in a Na+/K+-ATPase FHM2 in vivo mutation mouse model. Sci Rep 6, 22047 doi:10.1038/srep22047.
  39. Schwengel K, Namsolleck P, Lucht K, Clausen BH, Lambertsen KL, Valero-Esquitino V, Thöne-Reineke C, Müller S, Widdop RE, Denton K, Horiuchi M, Iwai M, Boato F, Dahlöf B, Hallberg A, Unger T, Strekelings UM (2016) Angiotensin AT2-receptor stimulation improves survival and neurological outcome after experimental stroke in mice. J Mol Med (Berl) 94(8):957-66. doi: 10.1007/s00109-016-1406-3.
  40. Madsen PM, Mottie D, Karmally S, Szymkowski DE, Lambertsen KL, Bethea JR, Brambilla R (2016) Oligodendroglial TNFR2 mediates membrane TNF-dependent repair in neuroimmune disease by promoting oligodendrocyte differentiation and remyelination. J Neurosci 36(18):5128-5143. doi: 10.1523/JNEUROSCI.0211-16.2016.
  41. Clausen BH, Degn M, Sivasaravanaparan M, Fogtmann T, Andersen MG, Trojanowsky M, Gao H, Hvidsten S, Baun C, Deierborg T, Finsen B, Kristensen BW, Bak S, Meyer M, Lee J, Nedospasov SE, Brambilla R, Lambertsen KL (2016) Conditional deletion of myeloid increases neuronal sensitivity to focal cerebral ischemia. Sci Rep 6:29291; doi: 10.1038/srep29291.
  42. Nielsen MMB, Lambertsen KL, Clausen BH, Bhandari D, Spengler B, Janfeldt C, Hansen HS. Mass spectrometry imaging of biomarker lipids for phagocytosis and signaling during focal brain ischemia. Sci Rep 6, 39571; doi: 10.1038/srep39571.
  43. Ellman DG, Degn M*, Christiansen ML*, Clausen BH*, Novrup HG, Flæng SB, Jørgensen LH, Suntharalingam L, Brambilla R, Lambertsen KL (2016) Genetic ablation of soluble TNF does not affect lesion size and functional recovery after moderate spinal cord injury in mice. Mediators of Inflamm 2016:2684098. doi: 10.1155/2016/2684098.
  44. Gao H, Danzi M, Choi C, Taherian M, Hansen CD, Ellman D, Madsen PM, Lemmon V, Lambertsen KL, Brambilla R. Opposing functions of microglial and macrophagic TNFR2 in the pathogenesis of experimental autoimmune encephalomyelitis. Cell Reports 18(1):198-212. doi: 10.1016/j.celrep.2016.11.083.
  45. Gredal H, Thomsen BB, Boza-Serrano A, Garosi L, Rusbridge C, Anthony D, Møller A, Finsen B, Deierborg T, Lambertsen KL*, Berendt M*. IL-6 is increased in plasma and CSF of community-dwelling domestic dogs with acute ischaemic stroke. (*Delt seniorforfatterskab) Neuroreport 28(3):134-140. doi: 10.1097/WNR.0000000000000728.
  46. Thomsen BB, Gredal H, Wirenfeldt MW, Kristensen BW, Leifsson PS, Clausen BH, Larsen AE, Finsen B, Berendt M*, Lambertsen KL* (2017) Spontanous ischaemic stroke lesions in a dog brain resembles human ischaemic stroke (*Co-corresponding og delt seniorforfatterskab) Acta Vet Scand 59(1):7. doi: 10.1186/s13028-016-0275-7.
  47. Demuth H-U, Dijkhuizen RM, Gelderblom M, Michalski D, Orbe J, Otte WM, Petzold GC, Plesnila N, Reiser G, Reymann KG, Rueger MA, Sabel BA, Saur D, Savitz SI, Schilling S, Turner RJ, Vemuganti R, Vivien D, Yepes M, Zille M & Boltze J for the ISN&N meeting contributors (2017) Translational news: Recent progress in neurovascular and dementia research. Restor Neurol Neurosci 35(1):87-103. doi: 10.3233/RNN-160690 (Contributor)
  48. Clausen BH, Lundberg L, Yli-Karjanmaa, Martin NA, Svensson M, Alfsen MZ, Lyngsø K, Boza-Serrano A, Nielsen HH, Hansen PB, Finsen B, Deierborg T, Illés ZL*, Lambertsen KL* (2017) Fumarate decreases edema volume and improves functional outcome after experimental stroke. (*Co-corresponding og delt seniorforfatterskab) Exp Neurol, 295:144-154. doi: 10.1016/j.expneurol.2017.06.011.
  49. Grønhøj MH, Clausen BH, Fenger C, Lambertsen KL, Finsen B (2017) Beneficial potential of intravenously administered IL-6 in improving outcome after murine experimental stroke. Brain Behav Immun, pii: S0889-1591(17)30165-4. Doi: 10.1016/j.bbi.2017.05.019.
  50. Jensen P, Myhre CL, Lassen P, Khan AM, Lambertsen KL, Babcock AA, Finsen B, Larsen MR, Kempf SJ (2017) TNFα affects CREB-mediated neuroprotective signaling pathways of synaptic plasticity in neurons as revealed by proteomics and phospho-proteomics. Oncotarget, Jul 21. doi: 10.18632/oncotarget.19428
  51. Ellman DG, Novrup HG, Jørgensen LH, Lund MC, Yli-Karjanmaa M, Madsen PM, Vienhues JH, Dursun S, Bethea JR, Lykke-Hartmann K, Brambilla R, Lambertsen KL (2017) Neuronal ablation of IKK2 decreases IL-1β levels and lesion size and improves functional outcome after spinal cord injury in mice. JSM Neurosurgery and Spine 5(2):1090.
  52. Ellman DG, Isaksen TJ, Jørgensen LH, Wirenfeldt M, Lykke-Hartmann K, Lambertsen KL (2017) The loss-of-function disease-mutation G301R in the Na+/K+-ATPase α2 isoform decreases lesion volume and improves functional outcome 7 days after spinal cord injury in mice. BMC Neuroscience 18:66.
  53. Karabiyik C, Fernandes R, Figueiredo FR, Socodato R, Brakebusch C, Lykke Lambertsen K, Relvas JB, Santos SD (2017) Neuronal Rho GTPase Rac1 elimination confers neuroprotection in a mice model of permanent ischemic stroke. Brain Pathol, in press, doi:10.1111/bpa.12562
  54. Jensen PT, Lambertsen KL, Frich LH (2018) Assembly, maturation, and degradation of the supraspinatus enthesis. J Shoulder Elbow Surg 27:739-750. doi: 10.1016/j.jse.2017.10.030.
  55. Yang Y, Boza-Serrano A, Dunning CJR, Clausen BH, Lambertsen KL, Deierborg T (2018) Inflammation leads to distinct populations of extracellular vesicles from microglia. J Neuroinflam 15:168. doi: 10.1186/s12974-018-1204-7.
  56. Severino M, Sivasaravanaparan M, Olesen LØ, von Linstow CU, Metaxas A, Bouzinova E, Manzoor AK, Lambertsen KL, Babcock AA, Hasselstrøm J, Gramsbergen JB, Wiborg O, Finsen B (2018) No effect of chronic paroxetine treatment on established amyloid pathology in neocortex of an APP/PS1 transgenic model of Alzheimer's disease. Alzheimers Dement (N Y) 4:215-223. doi: 10.1016/j.trci.2018.04.005.
  57. Butt JH, Rostrup E, Hansen AS, Lambertsen KL, Kruuse C (2018) Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura. Brain Aug 22. doi: 10.1093/brain/awy228. [Epub ahead of print].
  58. Couch Y, Clausen BH, Ormhøj M, Andersen MG, Kring C, Møller-Nielsen M, Lambertsen KL (2018) Distal middle cerebral artery occlusion does not result in depression-like behaviours. F1000Research 7:1430. doi: 10.12688/f1000research.15769.1
  59. Lambertsen KL, Finsen B, Clausen BH (2019) Post-stroke inflammation – target or tool for therapy? Acta Neuropathol 137:693-714. doi: 10.1007/s00401-018-1930-z.
  60. Bach A, Clausen BH, Kristensen LK, Andersen MG, Ellman DG, Hansen PBL, Hasseldam H, Heitz M, Tuck E, Kopanitsa M, Grant S, Lykke-Hartmann K, Johansen FF, Lambertsen KL*, Stroemgaard K* (2019) Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 and MAGUK inhibitor. (*Delt seniorforfatterskab og co-corresponding authors). Neuropharmacology, May 15;150:100-111. doi: 10.1016/j.neuropharm.2019.02.035.
  61. Frich LH, Lambertsen KL, Hjarbaek J, Dahl JS, Larsen AH (2019) Musculoskeletal application and validation of speckle-tracking ultrasonography. BMS Musculoskeletal Disorders, May 4;20(1):192. doi: 10.1186/s12891-019-2562-8.
  62. Krawcyk RS, Vinther A, Petersen NC, Faber J, Iversen HK, Christensen T, Lambertsen KL, Rehman S, Klausen TW, Rostrup E, Kruuse C. Effect of Home-Based High-Intensity Interval Training in Patients with Lacunar Stroke: A Randomised Controlled Trial. Frontiers in Neurology, 10:664. doi: 10.3389/fneur.2019.00664
  63. Yli-Karjanmaa M*, Clausen BH*, Degn M, Novrup HG, Ellman DG, Jensen PT, Szymkowsky DE, Stensballe A, Meyer M, Brambilla R, Lambertsen KL (2019) Topical administration of the selective soluble TNF inhibitor XPro1595 reduces infarct volume after experimental focal cerebral ischemia. (*Delt førsteforfattere). Frontiers in Neuroscience, 13:781. doi: 10.3389/fnins.2019.00781.
  64. Larsen KS*, Yli-Karjanmaa M*, Fenger C, Kristensen LK, Martin NA, Jensen PT, Brenton A, Nathanson L, Nielsen PV, Lund MC, Carlsen SL, Gramsbergen JB, Szymkowski DE, Finsen B, Stubbe J, Frich LH, Stolph H, Brambilla R, Anthony DC, Meyer M, Lambertsen KL (2019) TNF deficiency causes alterations in the spatial organization of neurogenic zones and alters the number of microglia and neurons in the cerebral cortex (*Delt førsteforfattere) Brain Behav Immun, Sep 7. pii: S0889-1591(19)30576-8. doi: 10.1016/j.bbi.2019.08.195. [Epub ahead of print]
  65. Gredal H, Thomsen BB, Westrup U. Boza-Serrano A, Deierborg T, McEvoy F, Lambertsen KL, Berendt M (2019) Diagnosis and outcome in dogs with acute onset intracranial signs. J Small Animal Practice, accepted. DOI: 10.1111/jsap.13078

Book Chapters:

  1. Skjøth-Rasmussen J, Lambertsen K, Gramsbergen JB (2003) On-line glucose and lactate monitoring in rat striatum: Effect of malonate and correlation with histological damage. In: Monitoring Molecules in Neuroscience. Proceedings of the 10th International Conference on In Vivo Methods. Eds. J. Kehr, K. Fuxe, U. Ungerstedt, T.H. Svensson, Karolinska Institutet, Stockholm, pp. 265-267.
  2. Lambertsen KL, Deierborg T (2012) A detrimental role of MIF in ischemic brain damage. In: The MIF Handbook, World Scientific Publishing Co. Editor: Richard Bucala,Yale University, pp. 361-377. (ISBN: 978-981-4335-35-5).


Patents:

  1. Lambertsen KL, Novrup HG, Bethea J, Bracchi-Ricard V (equal contributors) (2014) Methods of treating spinal cord injury. Patent No: WO/2016/040581, PCT/US2015/049360.
  2. Lambertsen KL, Clausen BH, Finsen B, Nielsen HH, Finsen B (equal contributors) (2014) Fumaric acid derivatives for medical use. Patent No: WO2016074684 A1, PCT/DK2015/050344
  3. Lambertsen KL, Clausen BH, Meyer M (equal contributors) (2014) Tnf-alpha inhibitor for treating stroke. Patent No: WO2016078672 A1, PCT/DK2015/050358.
  4. Frich LH, Lambertsen KL, Dahl J, Hjarbaek J, Larsen AH (equal contributors) (2018) Ultrasound speckle tracking – Clinical ultility of speckle tracking, PCT/DK2018/050021.

 

Research areas

  • Health and Illness
  • Apoplexia, stroke, spinal cord injury, microglia

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Research Output 2000 2019

Diagnosis and outcome in dogs with acute onset intracranial signs

Gredal, H., Thomsen, B. B., Westrup, U., Boza-Serrano, A., Deierborg, T., McEvoy, F., Lambertsen, K. L. & Berendt, M., 6. Nov 2019, In : Journal of Small Animal Practice.

Research output: Contribution to journalJournal articleResearchpeer-review

18 Downloads (Pure)

Effect of Home-Based High-Intensity Interval Training in Patients with Lacunar Stroke: A Randomized Controlled Trial

Krawcyk, R. S., Vinther, A., Petersen, N. C., Faber, J., Iversen, H. K., Christensen, T., Lambertsen, K. L., Rehman, S., Klausen, T. W., Rostrup, E. & Kruuse, C., 28. Jun 2019, In : Frontiers in Neurology. 10, JUN, 15 p., 664.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Lacunar Stroke
Randomized Controlled Trials
Exercise
High-Intensity Interval Training
Cognition
52 Downloads (Pure)

Musculoskeletal application and validation of speckle-tracking ultrasonography

Frich, L. H., Lambertsen, K. L., Hjarbæk, J., Dahl, J. & Larsen, A. H., 4. May 2019, In : B M C Musculoskeletal Disorders. 20, 8 p., 192.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Ultrasonography
Muscles
Rotator Cuff
Isometric Contraction
Skeletal Muscle
65 Downloads (Pure)

Post-stroke inflammation – target or tool for therapy?

Lambertsen, K. L., Finsen, B. & Clausen, B. H., May 2019, In : Acta Neuropathologica. 137, 5, p. 693-714

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File

Selectivity, efficacy and toxicity studies of UCCB01-144, a dimeric neuroprotective PSD-95 inhibitor

Bach, A., Clausen, B. H., Kristensen, L. K., Andersen, M. G., Ellman, D. G., Hansen, P. B. L., Hasseldam, H., Heitz, M., Özcelik, D., Tuck, E. J., Kopanitsa, M. V., Grant, S. G. N., Lykke-Hartmann, K., Johansen, F. F., Lambertsen, K. L. & Strømgaard, K., 15. May 2019, In : Neuropharmacology. 150, p. 100-111

Research output: Contribution to journalJournal articleResearchpeer-review

N-Methyl-D-Aspartate Receptors
Arterial Pressure
Fluorescence Polarization
Middle Cerebral Artery Infarction
Rodentia

Activities 2001 2020

Neuroscience Day 2020 - Flowing Neuroscience, Aarhus University

Kate Lykke Lambertsen (Keynote speaker)
5. May 2020

Activity: Talks and presentationsGuest lectures, external teaching and course activities at other universities

The Brain Prize Meeting 2019: Silently losing the Brain – The enigma of small vessel disease

Kate Lykke Lambertsen (Organizer)
25. Nov 201927. Nov 2019

Activity: Attending an eventConference organisation or participation

Cells (Journal)

Kate Lykke Lambertsen (Editor)
1. Nov 201931. Aug 2020

Activity: Editorial work and peer reviewEditor of seriesResearch

The XIV European Meeting on Glial Cells in Health and Disease

Kate Lykke Lambertsen (Participant)
10. Jul 201913. Jul 2019

Activity: Attending an eventConference organisation or participation

Press / Media

Nyt om navne

Kate Lykke Lambertsen

21/04/2019

1 Media contribution

Press/Media: Press / Media

Kate er blevet professor i eksperimentel neurobiologi

Kate Lykke Lambertsen

19/04/2019

1 Media contribution

Press/Media: Press / Media

Professor i eksperimentel neurobiologi

Kate Lykke Lambertsen

09/04/2019

1 Media contribution

Press/Media: Press / Media

Professor i eksperimentel neurobiologi

Kate Lykke Lambertsen

09/04/2019

1 Media contribution

Press/Media: Press / Media

Harboøre-kvinde udnævnt til professor

Kate Lykke Lambertsen

09/04/2019

1 Media contribution

Press/Media: Press / Media

Prizes

Simon Fougner Hartmanns Familiefond

Kate Lykke Lambertsen (Recipient), 1. Jun 2016

Prize: Prizes, scholarships, distinctions

Savværksejer Jeppe Juhl og Hustru Ovita Juhls Mindelegat

Kate Lykke Lambertsen (Recipient), 2. Sep 2011

Prize: Prizes, scholarships, distinctions