Kurt Højlund

Dr.Med, Chief Physician, PhD

  • J.B. Winsløws Vej 21, 3., Indgang 112

    5000 Odense C

    Denmark

19962019
If you made any changes in Pure these will be visible here soon.

Research Output 1996 2019

2019

Acute exercise increases plasma levels of muscle-derived microvesicles carrying fatty acid transport proteins

Nielsen, M. H., Sabaratnam, R., Pedersen, A. J. T., Højlund, K. & Handberg, A., 1. Oct 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4804-4814

Research output: Contribution to journalJournal articleResearchpeer-review

Fatty Acid Transport Proteins
Muscle
Skeletal Muscle
Exercise
Plasmas

DECODE EYE - Ocular and systemic complications in diabetic retinopathy

Grauslund, J., Suhr Thykjær, A., Stokholm, L., Højlund, K., Kawasaki, R., Møller, G., Kyvik, K. O., Dornonville de la Cour, M., Kessel, L. & Rubin, K. H., 2019.

Research output: Contribution to conference without publisher/journalPosterResearch

76 Downloads (Pure)

Differential methylation of the type 2 diabetes susceptibility locus KCNQ1 is associated with insulin sensitivity and is predicted by CpG site specific genetic variation

for the RISC consortium, Feb 2019, In : Diabetes Research and Clinical Practice. 148, p. 189-199

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Insulin Resistance
DNA Methylation
Single Nucleotide Polymorphism
Epigenomics

Exercise induction of key transcriptional regulators of metabolic adaptation in muscle is preserved in type 2 diabetes

Sabaratnam, R., Pedersen, A. J., Eskildsen, T. V., Kristensen, J. M., Wojtaszewski, J. F. P. & Højlund, K., 1. Oct 2019, In : The Journal of clinical endocrinology and metabolism. 104, 10, p. 4909-4920

Research output: Contribution to journalJournal articleResearchpeer-review

Medical problems
Type 2 Diabetes Mellitus
Muscle
Exercise
Muscles

Fatty Liver Among Adolescent Offspring of Women With Type 1 Diabetes (the EPICOM Study)

Knorr, S., Bytoft, B., Lohse, Z., Boisen, A. B., Clausen, T. D., Jensen, R. B., Damm, P., Beck-Nielsen, H., Holst, J. J., Hartmann, B., Møller, H. J., Højlund, K., Gravholt, C. H. & Jensen, D. M., Aug 2019, In : Diabetes Care. 42, 8, p. 1560-1568

Research output: Contribution to journalJournal articleResearchpeer-review

Fatty Liver
Mothers
Maternal Exposure
Insulin Resistance
Macrophage Activation
Nephrectomy
Kidney
Proteins
Aquaporin 2
Urine
89 Downloads (Pure)
Open Access
File
Stem cells
Mesenchymal Stromal Cells
Bone
Insulin
RNA Sequence Analysis
2018
147 Downloads (Pure)

Adrenal activity and metabolic risk during randomized escitalopram or placebo treatment in PCOS

Glintborg, D., Altinok, M. L., Ravn, P., Stage, K. B., Højlund, K. & Andersen, M., 1. Mar 2018, In : Endocrine Connections. 7, 3, p. 479-489

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Citalopram
Polycystic Ovary Syndrome
Placebos
Mental Health
Depression

Differential effects of age and sex on insulin sensitivity and body composition in adolescent offspring of women with type 1 diabetes: results from the EPICOM study

Lohse, Z., Knorr, S., Bytoft, B., Clausen, T. D., Jensen, R. B., Oturai, P., Beck-Nielsen, H., Gravholt, C. H., Damm, P., Højlund, K. & Jensen, D. M., Jan 2018, In : Diabetologia. 61, 1, p. 210–219

Research output: Contribution to journalJournal articleResearchpeer-review

Insulin Resistance
Insulin
Adipose Tissue
Exercise
Adiposity
Plasma (human)
Fourier Analysis
Mass spectrometry
Fourier transforms
Cholesterol

First Genome-Wide Association Study of Latent Autoimmune Diabetes in Adults Reveals Novel Insights Linking Immune and Metabolic Diabetes

Groop, L. C., Leslie, R. D., Grant, S. F. A. & Bone Mineral Density in Childhood Study, Nov 2018, In : Diabetes Care. 41, 11, p. 2396-2403

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Genome-Wide Association Study
Type 2 Diabetes Mellitus
Population Control
Latent Autoimmune Diabetes in Adults
Glycolysis
94 Downloads (Pure)

Intact regulation of muscle expression and circulating levels of myokines in response to exercise in patients with type 2 diabetes

Sabaratnam, R., Pedersen, A. J. T., Kristensen, J. M., Handberg, A., Wojtaszewski, J. F. P. & Højlund, K., 1. Jun 2018, In : Physiological Reports. 6, 12, 12 p., e13723.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Exercise
Muscles
Type 2 Diabetes Mellitus
Interleukin-15
Interleukin-6
72 Downloads (Pure)
Open Access
File
Type 2 Diabetes Mellitus
Cohort Studies
Insulin
Latent Autoimmune Diabetes in Adults
Endocrinology
25 Downloads (Pure)
Open Access
File
Resistance Training
Skeletal Muscle
Insulin Resistance
Adipose Tissue
Lipid Droplets
33 Downloads (Pure)

Proteomic study of skeletal muscle in obesity and type 2 diabetes: progress and potential

Kruse, R. & Højlund, K., 3. Oct 2018, In : Expert Review of Proteomics. 15, 10, p. 817-828

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
Medical problems
Type 2 Diabetes Mellitus
Muscle
Skeletal Muscle
Insulin
93 Downloads (Pure)

Renal function markers and insulin sensitivity after 3 years in a healthy cohort, the EGIR-RISC study

Siméon, S., Massy, Z., Højlund, K., Lalic, K., Porcellati, F., Dekker, J., Petrie, J., Currie, G. & Balkau, B., 31. May 2018, In : BMC Nephrology. 19, 12 p., 124.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Insulin Resistance
Kidney
Glomerular Filtration Rate
Albumins
Creatinine
105 Downloads (Pure)

Skeletal muscle O-GlcNAc transferase is important for muscle energy homeostasis and whole-body insulin sensitivity

Shi, H., Munk, A., Nielsen, T. S., Daughtry, M. R., Larsson, L., Li, S., Høyer, K. F., Geisler, H. W., Sulek, K., Kjøbsted, R., Fisher, T., Andersen, M. M., Shen, Z., Hansen, U. K., England, E. M., Cheng, Z., Højlund, K., Wojtaszewski, J. F. P., Yang, X., Hulver, M. W. & 3 others, Helm, R. F., Treebak, J. T. & Gerrard, D. E., 1. May 2018, In : Molecular Metabolism. 11, p. 160-177

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Insulin Resistance
Skeletal Muscle
Homeostasis
Interleukin-15
Muscles
69 Downloads (Pure)

The relationship between bone turnover and insulin sensitivity and secretion: Cross-sectional and prospective data from the RISC cohort study

Frost, M., Balkau, B., Hatunic, M., Konrad, T., Mingrone, G. & Højlund, K., 2018, In : Bone. 108, p. 98-105

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Glucose Tolerance Test
Insulin Resistance
Cohort Studies
Fasting
Glucose Clamp Technique
50 Downloads (Pure)

Transcriptional and epigenetic changes influencing skeletal muscle metabolism in women with polycystic ovary syndrome

Nilsson, E., Benrick, A., Kokosar, M., Krook, A., Lindgren, E., Källman, T., Martis, M. M., Højlund, K., Ling, C. & Stener-Victorin, E., 1. Dec 2018, In : The Journal of clinical endocrinology and metabolism. 103, 12, p. 4465–4477

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Polycystic Ovary Syndrome
Metabolism
Epigenomics
Muscle
Skeletal Muscle
2017

Abnormal levels of adipokines in adolescent offspring of women with type 1 diabetes – Results from the EPICOM study

Lohse, Z., Bytoft, B., Knorr, S., Clausen, T. D., Beck Jensen, R., Beck-Nielsen, H., Hermann, A. P., Oturai, P. S., Frystyk, J., Damm, P., Gravholt, C. H., Højlund, K. & Jensen, D. M., 2017, In : Metabolism. 72, p. 47-56

Research output: Contribution to journalJournal articleResearchpeer-review

Adiponectin
Leptin
Mothers
Adipose Tissue
Serum

Autonomic nervous system activation mediates the increase in whole-body glucose uptake in response to electroacupuncture

Benrick, A., Kokosar, M., Hu, M., Larsson, M., Maliqueo, M., Marcondes, R. R., Soligo, M., Protto, V., Jerlhag, E., Sazonova, A., Behre, C. J., Højlund, K., Thorén, P. & Stener-Victorin, E., 2017, In : F A S E B Journal. 31, 8, p. 3288-3297

Research output: Contribution to journalJournal articleResearchpeer-review

Electroacupuncture
Neurology
Chemical activation
Polycystic Ovary Syndrome
Glucose
90 Downloads (Pure)

Characterization of the CLASP2 Protein Interaction Network Identifies SOGA1 as a Microtubule-Associated Protein

Sørensen, R. K., Krantz, J., Barker, N., Coletta, R., Rafikov, R., Luo, M., Hoejlund, K., Mandarino, L. J. & Langlais, P. R., 2017, In : Molecular and Cellular Proteomics. 16, 10, p. 1718-1735

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Protein Interaction Maps
Microtubule-Associated Proteins
Glycogen Synthase
Actins
Proteins

Effects of insulin and exercise training on FGF21, its receptors and target genes in obesity and type 2 diabetes

Sørensen, R. K., Vienberg, S. G., Vind, B. F., Andersen, B. & Højlund, K., 2017, In : Diabetologia. 60, 10, p. 2042–2051

Research output: Contribution to journalJournal articleResearchpeer-review

Type 2 Diabetes Mellitus
Exercise
Insulin
White Adipose Tissue
Muscles

Intact initiation of autophagy and mitochondrial fission by acute exercise in skeletal muscle of patients with Type 2 diabetes

Kruse, R., Pedersen, A. J. T., Kristensen, J. M., Petersson, S. J., Wojtaszewski, J. & Højlund, K., 2017, In : Clinical Science. 131, 1, p. 37-47

Research output: Contribution to journalJournal articleResearchpeer-review

77 Downloads (Pure)
Open Access
File
Autoimmunity
Age of Onset
Fasting
Alanine Transaminase
Type 2 Diabetes Mellitus
137 Downloads (Pure)

Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels but Were Unaltered by Testosterone Therapy

Botha, J., Velling Magnussen, L., Nielsen, M. H., Nielsen, T. B., Højlund, K., Andersen, M. S. & Handberg, A., 2017, In : Journal of Diabetes Research. 2017, 9 p., 4257875.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Type 2 Diabetes Mellitus
Fats
Insulin Resistance
Liver
gamma-Glutamyltransferase

Mitochondrial phosphoproteomics of mammalian tissues

Kruse, R. & Højlund, K., 2017, In : Mitochondrion. 33, p. 45–57

Research output: Contribution to journalJournal articleResearchpeer-review

Adiponectin
Leptin
Type 2 Diabetes Mellitus
Fats
Placebos

Statement of Retraction. The SNARE Protein SNAP23 and the SNARE-Interacting Protein Munc18c in Human Skeletal Muscle Are Implicated in Insulin Resistance/Type 2 Diabetes. Diabetes 2010;59:1870-1878. DOI: 10.2337/db09-1503. PMID: 20460426

Boström, P., Andersson, L., Vind, B., Håversen, L., Rutberg, M., Wickström, Y., Larsson, E., Jansson, P-A., Svensson, M. K., Brånemark, R., Ling, C., Beck-Nielsen, H., Borén, J., Højlund, K. & Olofsson, S-O., 2017, In : Diabetes. 66, 5, p. 1426 1 p.

Research output: Contribution to journalComment/debateResearchpeer-review

Lipoprotein Lipase
Insulin Resistance
Mutation
Alleles
154 Downloads (Pure)

The Human Skeletal Muscle Proteome Project: a reappraisal of the current literature

Gonzalez-Freire, M., Semba, R. D., Ubaida-Mohien, C., Fabbri, E., Scalzo, P., Højlund, K., Dufresne, C., Lyashkov, A. & Ferrucci, L., 2017, In : Journal of Cachexia, Sarcopenia and Muscle. 8, 1, p. 5-18

Research output: Contribution to journalReviewResearchpeer-review

Open Access
File
Proteome
Sarcopenia
Skeletal Muscle
Muscle Proteins
Muscles
2016

Beta-cell function is associated with carotid intima-media thickness independently of insulin resistance in healthy individuals

Roussel, R., Natali, A., Balkau, B., Højlund, K., Sánchez, G., Nolan, J., Mari, A., Kozakova, M. & Bonnet, F., 2016, In : Journal of Hypertension. 34, 4, p. 685-691

Research output: Contribution to journalJournal articleResearchpeer-review

Insulin Resistance
Insulin
Gold
Prediabetic State
Glucose Clamp Technique
91 Downloads (Pure)

Changes in HbA1c and circulating and adipose tissue androgen levels in overweight-obese women with polycystic ovary syndrome in response to electroacupuncture

Stener-Victorin, E., Maliqueo, M., Soligo, M., Protto, V., Manni, L., Jerlhag, E., Kokosar, M., Sazonova, A., Behre, C. J., Lind, M., Ohlsson, C., Højlund, K. & Benrick, A., 2016, In : Obesity Science & Practice. 2, 4, p. 426-435

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Electroacupuncture
Polycystic Ovary Syndrome
Adipose Tissue
Nerve Growth Factor
Homeostasis
Type 2 Diabetes Mellitus
Insulin Resistance
Fats
Placebos
Glucose Clamp Technique

Follow-up duration influences the relative importance of OGTT and optimal timing of glucose measurements for predicting future type 2 diabetes

Nielsen, M. L., Pareek, M., Leósdóttir, M., Højlund, K., Eriksson, K-F., Nilsson, P. M. & Olsen, M. H., 2016, In : European Journal of Endocrinology. 174, 5, p. 591-600

Research output: Contribution to journalJournal articleResearchpeer-review

Glucose Tolerance Test
Type 2 Diabetes Mellitus
Fasting
Body Mass Index
Registries

Impaired Glucose Tolerance in Healthy Men Treated with St. John's Wort

Stage, T. B., Damkier, P., Christensen, M. M. H., Nielsen, L. B-K., Højlund, K. & Brøsen, K., 2016, In : Basic & Clinical Pharmacology & Toxicology. 118, 3, p. 219-224

Research output: Contribution to journalConference articleResearchpeer-review

Hypericum
Glucose Intolerance
Glucose
Insulin
Insulin Resistance
International Normalized Ratio
Phenprocoumon
Warfarin
Hypoglycemic Agents
Pharmaceutical Preparations

Intact Regulation of the AMPK Signaling Network in Response to Exercise and Insulin in Skeletal Muscle of Male Patients With Type 2 Diabetes: Illumination of AMPK Activation in Recovery From Exercise

Kjøbsted, R., Pedersen, A. J. T., Hingst, J. R., Sabaratnam, R., Birk, J. B., Kristensen, J. M., Højlund, K. & Wojtaszewski, J. F. P., 2016, In : Diabetes. 65, 5, p. 1219-1230

Research output: Contribution to journalJournal articleResearchpeer-review

AMP-Activated Protein Kinases
Lighting
Type 2 Diabetes Mellitus
Skeletal Muscle
Exercise

Metabolic Risk Profiles in Diabetes Stratified According to Age at Onset, Islet Autoimmunity and Fasting C-peptide

Wod, M., Yderstræde, K. B. & Højlund, K., 12. Jun 2016.

Research output: Contribution to conference without publisher/journalPosterResearch

Modification and Validation of the Triglyceride-to-HDL Cholesterol Ratio as a Surrogate of Insulin Sensitivity in White Juveniles and Adults without Diabetes Mellitus: The Single Point Insulin Sensitivity Estimator (SPISE)

Paulmichl, K., Hatunic, M., Højlund, K., Jotic, A., Krebs, M., Mitrakou, A., Porcellati, F., Tura, A., Bergsten, P., Forslund, A., Manell, H., Widhalm, K., Weghuber, D., Anderwald, C-H. & Beta-JUDO Investigators, 2016, In : Clinical Chemistry. 62, 9, p. 1211-1219

Research output: Contribution to journalJournal articleResearchpeer-review

Medical problems
HDL Cholesterol
Insulin Resistance
Diabetes Mellitus
Triglycerides
2015

A comparison of different glucometabolic markers for prediction of future type 2 diabetes in young and middle-aged subjects: a 20-year follow-up study

Nielsen, M. L., Pareek, M., Leosdottir, M., Hojlund, K., Nilsson, P. M. & Olsen, M. H., 2015, In : Diabetologia. 58, S1, p. S183 1 p., 364.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access

Differential effects of strength training and testosterone treatment on soluble CD36 in aging men: Possible relation to changes in body composition

Glintborg, D., Christensen, L. L., Kvorning, T., Larsen, R., Højlund, K., Brixen, K., Hougaard, D. M., Handberg, A. & Andersen, M., 2015, In : Scandinavian Journal of Clinical & Laboratory Investigation. 75, 8, p. 659-66

Research output: Contribution to journalJournal articleResearchpeer-review

Resistance Training
Placebos
Fats
Photon Absorptiometry

Dysregulation of muscle glycogen synthase in recovery from exercise in type 2 diabetes

Pedersen, A. J. T., Hingst, J. R., Friedrichsen, M., Kristensen, J. M., Højlund, K. & Wojtaszewski, J. F. P., Jul 2015, In : Diabetologia. 58, 7, p. 1569-1578

Research output: Contribution to journalJournal articleResearchpeer-review

Glycogen Synthase
Type 2 Diabetes Mellitus
Exercise
Muscles
Insulin

Endogenous glucose production increases in response to metformin treatment in the glycogen-depleted state in humans: a randomised trial

Christensen, M. M. H., Højlund, K., Hother-Nielsen, O., Stage, T. B., Damkier, P., Beck-Nielsen, H. & Brøsen, K., 14. Aug 2015, In : Diabetologia. 58, 1, p. 2494-2502

Research output: Contribution to journalJournal articleResearchpeer-review

Alleles
Hypoglycemia
Denmark
Glucagon
Lactic Acid

Glucose tolerance is associated with differential expression of microRNAs in skeletal muscle: results from studies of twins with and without type 2 diabetes

Bork-Jensen, J., Scheele, C., Christophersen, D. V., Nilsson, E., Friedrichsen, M., Fernandez-Twinn, D. S., Grunnet, L. G., Litman, T., Holmstrøm, K., Vind, B., Højlund, K., Beck-Nielsen, H., Wojtaszewski, J., Ozanne, S. E., Pedersen, B. K., Poulsen, P. & Vaag, A., Feb 2015, In : Diabetologia. 58, 2, p. 363-73 11 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Twin Studies
MicroRNAs
Type 2 Diabetes Mellitus
Skeletal Muscle
Insulin

Glutamic acid decarboxylase autoantibody-positivity post-partum is associated with impaired β-cell function in women with gestational diabetes mellitus

Lundberg, T. P., Højlund, K., Snogdal, L. S. & Jensen, D. M., 2015, In : Diabetic Medicine. 32, 2, p. 198-205

Research output: Contribution to journalJournal articleResearchpeer-review

Glutamate Decarboxylase
Gestational Diabetes
Insulin Resistance
Insulin
Glucose Tolerance Test

Hepatic Glucose Production Increases in Response to Metformin Treatment in the Glycogen-depleted State

Christensen, M. M. H., Højlund, K., Hother-Nielsen, O., Stage, T. B., Damkier, P., Beck-Nielsen, H. & Brøsen, K., 5. Jun 2015. 1 p.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Human muscle fiber type specific insulin signaling - Impact of obesity and type 2 diabetes

Albers, P. H., Pedersen, A. J. T., Birk, J. B., Kristensen, D. E., Vind, B. F., Baba, O., Nøhr, J., Højlund, K. & Wojtaszewski, J. F. P., 2015, In : Diabetes. 64, 2, p. 485-497

Research output: Contribution to journalJournal articleResearchpeer-review

Type 2 Diabetes Mellitus
Insulin
Muscles
Glycogen Synthase
Pyruvate Dehydrogenase (Lipoamide)

Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study

Vlachová, Z., Bytoft, B., Knorr, S., Clausen, T. D., Beck Jensen, R., Mathiesen, E. R., Højlund, K., Ovesen, P., Beck-Nielsen, H., Gravholt, C. H., Damm, P. & Jensen, D. M., Jul 2015, In : Diabetologia. 58, 7, p. 1454-1463

Research output: Contribution to journalJournal articleResearchpeer-review

Mothers
Prediabetic State
Insulin Resistance
Insulin
Glucose Intolerance

Intake of St John's wort improves the glucose tolerance in healthy subjects who ingest metformin compared with metformin alone

Stage, T. B., Pedersen, R. S., Damkier, P., Christensen, M. M. H., Feddersen, S., Larsen, J. T., Højlund, K. & Brøsen, K., Feb 2015, In : British Journal of Clinical Pharmacology. 79, 2, p. 298-306

Research output: Contribution to journalJournal articleResearchpeer-review

Pharmacokinetics
Confidence Intervals
Insulin
Herbal Medicine
Glucose Tolerance Test