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Research Output

2019

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

Berg, M., Polyzos, K. A., Agardh, H., Baumgartner, R., Forteza, M. J., Kareinen, I., Gisterå, A., Bottcher, G., Hurt-Camejo, E., Hansson, G. K. & Ketelhuth, D. F. J., 7. Oct 2019, In : Cardiovascular Research.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

Rad Pour, S., Morikawa, H., Kiani, N. A., Yang, M., Azimi, A., Shafi, G., Shang, M., Baumgartner, R., Ketelhuth, D. F. J., Kamleh, M. A., Wheelock, C. E., Lundqvist, A., Hansson, J. & Tegnér, J., 21. Aug 2019, In : Scientific Reports. 9, 1, 11 p., 12150.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

Centa, M., Jin, H., Hofste, L., Hellberg, S., Busch, A., Baumgartner, R., Verzaal, N. J., Lind Enoksson, S., Perisic Matic, L., Boddul, S. V., Atzler, D., Li, D. Y., Sun, C., Hansson, G. K., Ketelhuth, D. F. J., Hedin, U., Wermeling, F., Lutgens, E., Binder, C. J., Maegdesfessel, L. & 1 others, Malin, S. G., 21. May 2019, In : Circulation. 139, 21, p. 2466-2482

Research output: Contribution to journalJournal articleResearchpeer-review

Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

Tuñón, J., Badimón, L., Bochaton-Piallat, ML., Cariou, B., Daemen, MJ., Egido, J., Evans, PC., Hoefer, IE., Ketelhuth, DFJ., Lutgens, E., Matter, CM., Monaco, C. & Bäck, M., 2019, In : Cardiovascular Research. 115, p. 10-19

Research output: Contribution to journalJournal articleResearchpeer-review

Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C. & Evans, P. C., 15. Jul 2019, In : Cardiovascular Research. 115, 9, p. 1385-1392

Research output: Contribution to journalJournal articleResearchpeer-review

Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells

Grinnemo, K-H., Löfling, M., Nathanson, L., Baumgartner, R., Ketelhuth, D. F. J., Beljanski, V., Davies, L. C. & Österholm, C., 4. Dec 2019, In : Stem Cell Research & Therapy. 10, 15 p., 371.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Increased uptake of oxLDL does not exert lipotoxic effects in insulin-secreting cells

Ma, Z., Ketelhuth, D. F. J., Wirström, T., Ohki, T., Forteza, M. J., Wang, H., Grill, V., Wollheim, C. B. & Björklund, A., May 2019, In : Journal of Molecular Endocrinology. 62, 4, p. 159-168

Research output: Contribution to journalJournal articleResearchpeer-review

Proinflammatory Action of a New Electronegative Low-Density Lipoprotein Epitope

Faulin, T. D. E. S., Kazuma, S. M., Tripodi, G. L., Cavalcante, M. F., Wakasuqui, F., Oliveira, C. L. P., Degenhardt, M. F. D. S., Michaloski, J., Giordano, R. J., Ketelhuth, D. F. J. & Abdalla, D. S. P., 20. Aug 2019, In : Biomolecules. 9, 8, 17 p., 386.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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Quantification of Atherosclerosis in Mice

Centa, M., Ketelhuth, D. F. J., Malin, S. & Gisterå, A., 12. Jun 2019, In : Journal of visualized experiments : JoVE. 148, p. 9 e59828.

Research output: Contribution to journalJournal articleResearchpeer-review

The interplay between cytokines and the Kynurenine pathway in inflammation and atherosclerosis

Baumgartner, R., Forteza, M. J. & Ketelhuth, D. F. J., Oct 2019, In : Cytokine. 122, 9 p., 154148.

Research output: Contribution to journalJournal articleResearchpeer-review

2018

Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice

Forteza, M. J., Polyzos, K. A., Baumgartner, R., Suur, B. E., Mussbacher, M., Johansson, D. K., Hermansson, A., Hansson, G. K. & Ketelhuth, D. F. J., 7. May 2018, In : Frontiers in Immunology. 9, MAY, 10 p., 950.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Acute Loss of Apolipoprotein E Triggers an Autoimmune Response That Accelerates Atherosclerosis

Centa, M., Prokopec, K. E., Garimella, M. G., Habir, K., Hofste, L., Stark, J. M., Dahdah, A., Tibbitt, C. A., Polyzos, K. A., Gisterå, A., Johansson, D. K., Maeda, N. N., Hansson, G. K., Ketelhuth, D. F. J., Coquet, J. M., Binder, C. J., Karlsson, M. C. I. & Malin, S., Aug 2018, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 38, 8, p. e145-e158

Research output: Contribution to journalJournal articleResearchpeer-review

Apoptosis and Mobilization of Lymphocytes to Cardiac Tissue Is Associated with Myocardial Infarction in a Reperfused Porcine Model and Infarct Size in Post-PCI Patients

Forteza, M. J., Trapero, I., Hervas, A., de Dios, E., Ruiz-Sauri, A., Minana, G., Bonanad, C., Gómez, C., Oltra, R., Rios-Navarro, C., Ketelhuth, D. F. J., Nunez, J., Chorro, F. J. & Bodi, V., 1. Jan 2018, In : Oxidative Medicine and Cellular Longevity. 2018, 9 p., 1975167.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

ERV1/ChemR23 Signaling Protects Against Atherosclerosis by Modifying Oxidized Low-Density Lipoprotein Uptake and Phagocytosis in Macrophages

Laguna-Fernandez, A., Checa, A., Carracedo, M., Artiach, G., Petri, M. H., Baumgartner, R., Forteza, M. J., Jiang, X., Andonova, T., Walker, M. E., Dalli, J., Arnardottir, H., Gisterå, A., Thul, S., Wheelock, C. E., Paulsson-Berne, G., Ketelhuth, D. F. J., Hansson, G. K. & Bäck, M., 16. Oct 2018, In : Circulation. 138, 16, p. 1693-1705

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling

Lund, H., Pieber, M., Parsa, R., Grommisch, D., Ewing, E., Kular, L., Han, J., Zhu, K., Nijssen, J., Hedlund, E., Needhamsen, M., Ruhrmann, S., Guerreiro-Cacais, A. O., Berglund, R., Forteza, M. J., Ketelhuth, D. F. J., Butovsky, O., Jagodic, M., Zhang, X-M. & Harris, R. A., 1. May 2018, In : Nature Immunology. 19, 5, p. 435-441

Research output: Contribution to journalLetterResearchpeer-review

Interplay between hypercholesterolaemia and inflammation in atherosclerosis: Translating experimental targets into clinical practice

ESC Working Group on Atherosclerosis and Vascular Biology, Jun 2018, In : European Journal of Preventive Cardiology. 25, 9, p. 948-955

Research output: Contribution to journalJournal articleResearchpeer-review

Lipid-driven immunometabolic responses in atherosclerosis

Gisterå, A. & Ketelhuth, D. F. J., Oct 2018, In : Current Opinion in Lipidology. 29, 5, p. 375-380

Research output: Contribution to journalJournal articleResearchpeer-review

Low-Density Lipoprotein-Reactive T Cells Regulate Plasma Cholesterol Levels and Development of Atherosclerosis in Humanized Hypercholesterolemic Mice

Gisterå, A., Klement, M. L., Polyzos, K. A., Mailer, R. K. W., Duhlin, A., Karlsson, M. C. I., Ketelhuth, D. F. J. & Hansson, G. K., 27. Nov 2018, In : Circulation. 138, 22, p. 2513-2526

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Ruuth, M., Nguyen, S. D., Vihervaara, T., Hilvo, M., Laajala, T. D., Kondadi, P. K., Gisterå, A., Lähteenmäki, H., Kittilä, T., Huusko, J., Uusitupa, M., Schwab, U., Savolainen, M. J., Sinisalo, J., Lokki, M-L., Nieminen, M. S., Jula, A., Perola, M., Ylä-Herttula, S., Rudel, L. & 12 others, Öörni, A., Baumann, M., Baruch, A., Laaksonen, R., Ketelhuth, D. F. J., Aittokallio, T., Jauhiainen, M., Käkelä, R., Borén, J., Williams, K. J., Kovanen, P. T. & Öörni, K., 14. Jul 2018, In : European Heart Journal. 39, 27, p. 2562-2573

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
2017

Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population

Mailer, R. K. W., Gisterå, A., Polyzos, K. A., Ketelhuth, D. F. J. & Hansson, G. K., 15. Nov 2017, In : Scientific Reports. 7, 1, 15655.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access

Hypercholesterolemia Induces Differentiation of Regulatory T Cells in the Liver

Mailer, R. K. W., Gisterå, A., Polyzos, K. A., Ketelhuth, D. F. J. & Hansson, G. K., 26. May 2017, In : Circulation Research. 120, 11, p. 1740-1753

Research output: Contribution to journalJournal articleResearchpeer-review

Immune-mediated Mechanisms of Atheroslcerosis

Bäck, M., Ketelhuth, D., Malin, S., Olofsson, P. S., Paulsson-Berne, G., Yan, Z. Q. & Hansson, G. K., 2017, Encyclopedia of Cardiovascular: Research and Medicine. Sawyer, D. & Vasan, R. (eds.). 1. ed. Elsevier

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Microvesicles in vascular homeostasis and diseases

Ridger, V. C., Boulanger, C. M., Angelillo-Scherrer, A., Badimon, L., Blanc-Brude, O., Bochaton-Piallat, M-L., Boilard, E., Buzas, E. I., Caporali, A., Dignat-George, F., Evans, P. C., Lacroix, R., Lutgens, E., Ketelhuth, D. F. J., Nieuwland, R., Toti, F., Tuñon, J., Weber, C., Hoefer, I. E., Lip, G. Y. H. & 5 others, Werner, N., Shantsila, E., Ten Cate, H., Thomas, M. & Harrison, P., Jul 2017, In : Thrombosis and Haemostasis. 117, 7, p. 1296-1316

Research output: Contribution to journalReviewResearchpeer-review

The inflammatory cytokine interferon-gamma inhibits sortilin-1 expression in hepatocytes via the JAK/STAT pathway

Pirault, J., Polyzos, K. A., Petri, M. H., Ketelhuth, D. F. J., Bäck, M. & Hansson, G. K., Nov 2017, In : European Journal of Immunology. 47, 11, p. 1918-1924

Research output: Contribution to journalJournal articleResearchpeer-review

Vaccination against T-cell epitopes of native ApoB100 reduces vascular inflammation and disease in a humanized mouse model of atherosclerosis

Gisterå, A., Hermansson, A., Strodthoff, D., Klement, M. L., Hedin, U., Fredrikson, G. N., Nilsson, J., Hansson, G. K. & Ketelhuth, D. F. J., Apr 2017, In : Journal of Internal Medicine. 281, 4, p. 383-397

Research output: Contribution to journalJournal articleResearchpeer-review

2016

Adaptive Response of T and B Cells in Atherosclerosis

Ketelhuth, D. F. J. & Hansson, G. K., 19. Feb 2016, In : Circulation Research. 118, 4, p. 668-678

Research output: Contribution to journalReviewResearchpeer-review

Atherosclerosis Susceptibility in Mice Is Independent of the V1 Immunoglobulin Heavy Chain Gene

Centa, M., Gruber, S., Nilsson, D., Polyzos, K. A., Johansson, D. K., Hansson, G. K., Ketelhuth, D., Binder, C. J. & Malin, S., Jan 2016, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 36, 1, p. 25-36

Research output: Contribution to journalJournal articleResearchpeer-review

Neil3-dependent base excision repair regulates lipid metabolism and prevents atherosclerosis in Apoe-deficient mice

Skarpengland, T., Holm, S., Scheffler, K., Gregersen, I., Dahl, T. B., Suganthan, R., Segers, F. M., Østlie, I., Otten, J. J. T., Luna, L., Ketelhuth, D., Lundberg, A. M., Neurauter, C. G., Hildrestrand, G., Skjelland, M., Bjørndal, B., Svardal, A. M., Iversen, P. O., Hedin, U., Nygård, S. & 13 others, Olstad, O. K., Krohg-Sørensen, K., Slupphaug, G., Eide, L., Kuśnierczyk, A., Folkersen, L., Ueland, T., Berge, R. K., Hansson, G. K., Biessen, E. A. L., Halvorsen, B., Bjørås, M. & Aukrust, P., 22. Jun 2016, In : Scientific Reports. 6, 28337.

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Immunostaining of Lymphocytes in Mouse Atherosclerotic Plaque

Gisterå, A. & Ketelhuth, D. F. J., 2015, Methods in Mouse Atherosclerosis. Andrés, V. & Dorado, B. (eds.). New York: Humana Press, Vol. 1339. p. 149-159 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice

Polyzos, K. A., Ovchinnikova, O., Berg, M., Baumgartner, R., Agardh, H., Pirault, J., Gisterå, A., Assinger, A., Laguna-Fernandez, A., Bäck, M., Hansson, G. K. & Ketelhuth, D. F. J., 1. May 2015, In : Cardiovascular Research. 106, 2, p. 295-302

Research output: Contribution to journalJournal articleResearchpeer-review

Modulation of autoimmunity and atherosclerosis - common targets and promising translational approaches against disease

Ketelhuth, D. F. J. & Hansson, G. K., 24. Apr 2015, In : Circulation Journal. 79, 5, p. 924-933

Research output: Contribution to journalReviewResearchpeer-review

Open Access

Sterile inflammation in the spleen during atherosclerosis provides oxidation-specific epitopes that induce a protective B-cell response

Grasset, E. K., Duhlin, A., Agardh, H. E., Ovchinnikova, O., Hägglöf, T., Forsell, M. N., Paulsson-Berne, G., Hansson, G. K., Ketelhuth, D. F. J. & Karlsson, M. C. I., 21. Apr 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 16, p. E2030-E2038

Research output: Contribution to journalJournal articleResearchpeer-review

The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice

Ketelhuth, D. F. J., Hermansson, A., Hlawaty, H., Letourneur, D., Yan, Z. & Bäck, M., Sep 2015, In : Prostaglandins & Other Lipid Mediators. 121, Part A, p. 105-109

Research output: Contribution to journalJournal articleResearchpeer-review

The role of the kynurenine pathway of tryptophan metabolism in cardiovascular disease: An emerging field

Polyzos, K. A. & Ketelhuth, D. F. J., 2015, In : Hamostaseologie. 35, 2, p. 128-136

Research output: Contribution to journalReviewResearchpeer-review

Toll-Like Receptor 3 Influences Glucose Homeostasis and β-Cell Insulin Secretion

Strodthoff, D., Ma, Z., Wirström, T., Strawbridge, R. J., Ketelhuth, D. F. J., Engel, D., Clarke, R., Falkmer, S., Hamsten, A., Hansson, G. K., Björklund, A. & Lundberg, A. M., Oct 2015, In : Diabetes. 64, 10, p. 3425-3438

Research output: Contribution to journalJournal articleResearchpeer-review

2014

Apolipoprotein B100 danger-associated signal 1 (ApoBDS-1) triggers platelet activation and boosts platelet-leukocyte proinflammatory responses

Assinger, A., Wang, Y., Butler, L. M., Hansson, G. K., Yan, Z-Q., Söderberg-Nauclér, C. & Ketelhuth, D. F. J., Aug 2014, In : Thrombosis and Haemostasis. 112, 2, p. 332-341

Research output: Contribution to journalJournal articleResearchpeer-review

Lymphocytes In Atherosclerosis

Ketelhuth, D. & Hansson, G. K., 2014, Encyclopedia of Medical Immunology: Autoimmune Diseases. MacKay, I., R. Rose, N., Diamond, B. & Davidson, A. (eds.). Springer

Research output: Chapter in Book/Report/Conference proceedingEncyclopedia chapterResearchpeer-review

Mycobacterium bovis BCG killed by extended freeze-drying induces an immunoregulatory profile and protects against atherosclerosis

Ovchinnikova, O. A., Berge, N., Kang, C., Urien, C., Ketelhuth, D. F. J., Pottier, J., Drouet, L., Hansson, G. K., Marchal, G., Bäck, M., Schwartz-Cornil, I. & Lagranderie, M., Jan 2014, In : Journal of Internal Medicine. 275, 1, p. 49-58 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2013

Depletion of FOXP3+ regulatory T cells promotes hypercholesterolemia and atherosclerosis

Klingenberg, R., Gerdes, N., Badeau, R. M., Gisterå, A., Strodthoff, D., Ketelhuth, D. F. J., Lundberg, A. M., Rudling, M., Nilsson, S. K., Olivecrona, G., Zoller, S., Lohmann, C., Lüscher, T. F., Jauhiainen, M., Sparwasser, T. & Hansson, G. K., Mar 2013, In : Journal of Clinical Investigation. 123, 3, p. 1323-34 12 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice

Strodthoff, D., Lundberg, A. M., Agardh, H. E., Ketelhuth, D. F. J., Paulsson-Berne, G., Arner, P., Hansson, G. K. & Gerdes, N., Jun 2013, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 33, 6, p. 1189-96 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

T cell-based therapies for atherosclerosis

Ketelhuth, D. F. J., Gisterå, A., Johansson, D. K. & Hansson, G. K., 2013, In : Current Pharmaceutical Design. 19, 33, p. 5850-5858

Research output: Contribution to journalReviewResearchpeer-review

Toll-like receptor 3 and 4 signalling through the TRIF and TRAM adaptors in haematopoietic cells promotes atherosclerosis

Lundberg, A. M., Ketelhuth, D. F. J., Johansson, M. E., Gerdes, N., Liu, S., Yamamoto, M., Akira, S. & Hansson, G. K., 15. Jul 2013, In : Cardiovascular Research. 99, 2, p. 364-73 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Transforming growth factor-β signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway

Gisterå, A., Robertson, A-K. L., Andersson, J., Ketelhuth, D. F. J., Ovchinnikova, O., Nilsson, S. K., Lundberg, A. M., Li, M. O., Flavell, R. A. & Hansson, G. K., 31. Jul 2013, In : Science Translational Medicine. 5, 196, p. 196ra100

Research output: Contribution to journalJournal articleResearchpeer-review

Uptake of oxLDL and IL-10 production by macrophages requires PAFR and CD36 recruitment into the same lipid rafts

Rios, F. J. O., Ferracini, M., Pecenin, M., Koga, M. M., Wang, Y., Ketelhuth, D. F. J. & Jancar, S., 2013, In : PLOS ONE. 8, 10, p. e76893

Research output: Contribution to journalJournal articleResearchpeer-review

2012

Subcutaneous immunization with heat shock protein-65 reduces atherosclerosis in Apoe⁻/⁻ mice

Klingenberg, R., Ketelhuth, D. F. J., Strodthoff, D., Gregori, S. & Hansson, G. K., May 2012, In : Immunobiology. 217, 5, p. 540-7 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice

Zhang, L., Ovchinnikova, O., Jönsson, A., Lundberg, A. M., Berg, M., Hansson, G. K. & Ketelhuth, D. F. J., Aug 2012, In : European Heart Journal. 33, 16, p. 2025-34 10 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2011

Cellular immunity, low-density lipoprotein and atherosclerosis: break of tolerance in the artery wall

Ketelhuth, D. F. J. & Hansson, G. K., Nov 2011, In : Thrombosis and Haemostasis. 106, 5, p. 779-86 8 p.

Research output: Contribution to journalReviewResearchpeer-review

Identification of a danger-associated peptide from apolipoprotein B100 (ApoBDS-1) that triggers innate proatherogenic responses

Ketelhuth, D. F. J., Rios, F. J. O., Wang, Y., Liu, H., Johansson, M. E., Fredrikson, G. N., Hedin, U., Gidlund, M., Nilsson, J., Hansson, G. K. & Yan, Z-Q., 29. Nov 2011, In : Circulation. 124, 22, p. 2433-43, 1-7

Research output: Contribution to journalJournal articleResearchpeer-review

Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice

Hermansson, A., Johansson, D. K., Ketelhuth, D. F. J., Andersson, J., Zhou, X. & Hansson, G. K., 15. Mar 2011, In : Circulation. 123, 10, p. 1083-91 9 p.

Research output: Contribution to journalJournal articleResearchpeer-review