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Personal profile

Research interests

Cardiovascular immunology and metabolism

Cardiovascular diseases (CVDs) are the leading cause of mortality and disability worldwide, imposing a significant burden on society. Coronary heart disease and cerebrovascular disease, the two most common forms of cardiovascular disease, are caused by acute complications of atherosclerosis. CVD kills over 17 million individuals every year, which accounts for one third of all global deaths.

Although population-wide management of traditional risk factors for CVDs (e.g. hyperlipidemia, high-blood pressure, glycaemia) has reduced the incidence of cardiovascular events in developed countries, substantial residual risk remains. Thus, translational therapeutic strategies targeting novel molecular pathways regulating atherosclerosis are needed.

Atherosclerosis is a chronic inflammatory disease initiated by retention and accumulation of lipids in the artery wall, especially low-density lipoprotein (LDL), leading to maladaptive responses of innate and adaptive immune cells. Notably, metabolism and activation are fully integrated in immune cells, and systemic or microenvironmental changes in metabolism have been shown to modulate their responses.

In pioneer work, we have identified several targets to modulate the unwanted immune responses in the artery wall, including components of LDL that can trigger innate and adaptive immune cells, and metabolites of the essential amino acid tryptophan, via the Kynurenine pathway. Our research indicates that metabolites are not just ‘fuels’ in their metabolic pathways, but that they can also act as signalling molecules in immune cells and influence atherosclerosis. By increasing the understanding of the immunometabolic reactions controlling immune responses in atherogenesis, our research will lead to the development of new drugs to treat and prevent atherosclerotic CVDs.

External positions

Senior Research fellow, Karolinska Institute

2014 → …

Research areas

  • Atheroscleroris
  • Immunesystem
  • Metabolism

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Research Output

3-Hydroxyanthralinic acid Metabolism Controls the Hepatic Srebp/Lipoprotein axis, Inhibits Inflammasome Activation in Macrophages, and Decreases Atherosclerosis in LDLR-/- Mice

Berg, M., Polyzos, K. A., Agardh, H., Baumgartner, R., Forteza, M. J., Kareinen, I., Gisterå, A., Bottcher, G., Hurt-Camejo, E., Hansson, G. K. & Ketelhuth, D. F. J., 7. Oct 2019, In : Cardiovascular Research.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
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    Exhaustion of CD4+ T-cells mediated by the Kynurenine Pathway in Melanoma

    Rad Pour, S., Morikawa, H., Kiani, N. A., Yang, M., Azimi, A., Shafi, G., Shang, M., Baumgartner, R., Ketelhuth, D. F. J., Kamleh, M. A., Wheelock, C. E., Lundqvist, A., Hansson, J. & Tegnér, J., 21. Aug 2019, In : Scientific Reports. 9, 1, 11 p., 12150.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
  • Germinal Center-Derived Antibodies Promote Atherosclerosis Plaque Size and Stability

    Centa, M., Jin, H., Hofste, L., Hellberg, S., Busch, A., Baumgartner, R., Verzaal, N. J., Lind Enoksson, S., Perisic Matic, L., Boddul, S. V., Atzler, D., Li, D. Y., Sun, C., Hansson, G. K., Ketelhuth, D. F. J., Hedin, U., Wermeling, F., Lutgens, E., Binder, C. J., Maegdesfessel, L. & 1 others, Malin, S. G., 21. May 2019, In : Circulation. 139, 21, p. 2466-2482

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Identifying the anti-inflammatory response to lipid lowering therapy: a position paper from the working group on atherosclerosis and vascular biology of the European Society of Cardiology

    Tuñón, J., Badimón, L., Bochaton-Piallat, ML., Cariou, B., Daemen, MJ., Egido, J., Evans, PC., Hoefer, IE., Ketelhuth, DFJ., Lutgens, E., Matter, CM., Monaco, C. & Bäck, M., 2019, In : Cardiovascular Research. 115, p. 10-19

    Research output: Contribution to journalJournal articleResearchpeer-review

    Immunometabolism and atherosclerosis: perspectives and clinical significance: a position paper from the Working Group on Atherosclerosis and Vascular Biology of the European Society of Cardiology

    Ketelhuth, D. F. J., Lutgens, E., Bäck, M., Binder, C. J., Van den Bossche, J., Daniel, C., Dumitriu, I. E., Hoefer, I., Libby, P., O'Neill, L., Weber, C. & Evans, P. C., 15. Jul 2019, In : Cardiovascular Research. 115, 9, p. 1385-1392

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Activities

    • 21 Conference presentations

    Fokus kranskärl

    Daniel Ketelhuth (Speaker)
    14. Jan 2019

    Activity: Talks and presentationsConference presentations

    Karolinska Institute-Shandong joint symposium

    Daniel Ketelhuth (Speaker)
    18. Oct 2018

    Activity: Talks and presentationsConference presentations

    INTRICARE EU Horizon 2020 Marie Curie ITN course

    Daniel Ketelhuth (Speaker)
    25. Sep 2018

    Activity: Talks and presentationsConference presentations

    24th Annual Scientific Research Meeting KI-Mayo Clinic

    Daniel Ketelhuth (Speaker)
    10. Sep 2018

    Activity: Talks and presentationsConference presentations

    4th University of Sao Paulo-Karolisnka Institute Scientific Research Meeting

    Daniel Ketelhuth (Speaker)
    23. Aug 2018

    Activity: Talks and presentationsConference presentations