1994 …2022
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Personal profile


Personal Data: Born October 22, 1963; Married; Five children

University Address

Nucleic Acid Center
Department of Physics and Chemistry
University of Southern Denmark, Odense
Campusvej 55
DK-5230 Odense M, Denmark
Tel. +45 6550 2510
Fax. +45 6615 8780
E-mail: jwe@sdu.dk

Private Address: Frydenlundsvej 4, 5550 Langeskov, Denmark. Tel. +45 20846872

University Education:

Cand. scient.: Odense University (Chemistry/Biology; December 1988)
Ph.D.: Odense University (January 1992): "Synthesis of 2',3'-Dideoxynucleoside Analogues with Potential Activity against HIV"

Research Fellow: Department of Chemistry and Biochemistry, University of Colorado, USA (October 1990 - June 1991)

Assistant Professor: In organic chemistry at Department of Chemistry, Odense University (September 1991 - March 1994)

Associate Professor: In organic chemistry at Department of Chemistry, Odense University (April 1994 - September 1996)

Professor In bioorganic chemistry at Department of Chemistry, University of Copenhagen (October 1996 - July 2000)
In organic chemistry at Department of Chemistry, University of Southern Denmark, Odense (August 2000 -)

Present Research:
Bioorganic chemistry; nucleic acid biotechnology; Nanobioscience

Editorial Board Member:
Oligonucleotides (Mary Ann Liebert). Artificial DNA: PNA & XNA (Landes BioScience)

Author or co-author of >380 research papers in peer-reviewed scientific journals. H-Index = 55; Citations > 13.000 (SCI: Wengel J*; first publication in 1989)

Lectures and Seminars:
More than 120 invited lectures and seminars have been presented during the last 10 years in Denmark and abroad

IPR and Innovation:
Inventor or co-inventor on more than ten patents and patent applications. Co-inventor of the LNA (Locked Nucleic Acid) technology that forms the basis of the business activities of the companies Exiqon A/S (~60 employees) and Santaris Pharma A/S (~70 employees). Co-founder (2006) of RiboTask ApS.

Honors and Awards:
- Elected member of the Royal Danish Academy of Sciences and Letters;
- Elected member of the Danish Academy of Natural Sciences;
- Elected member of the Danish Academy of Technical Sciences;
- Natural Science Faculty Teaching Award, Odense University, 1995;
- Bjerrum-Brøndsted-Lang Lecturer, 1997;
- Parker-Davis Lecturer, Ohio State University, 2000;
- Biochemistry Teaching Award, University of Copenhagen, 2000;
- The Bjerrum Chemistry Award, 2001;
- The Lundbeck Foundation's Research Prize for Young Researchers, 2002;
- The Danish Academy of Natural Sciences Industry Award, 2002;
- The UCB Award for Excellence in Medicinal Chemistry 2004;
- Villum Kann Rasmussen Grant for Technical Research 2005;
- OBC Lecture Award Winner 2006;
- The Danish Association of Masters and PhD Research Award 2007;
- The Ib Henriksen Foundation Research Award 2008

Major Research Funding since 2001: 

ERC Advanced Grant
- EVOLNA – Evolution of LNA-based Aptamers (2011-2016; 2.5 mio. €).

International Funds – Partner in EU projects, local PI
- Pharmaco-Gene (LSHB-CT-2007-037283) - Design of Targeted Gene Pharmaceutics Using Self-assembling Functional Entities (2007-2010; 0.43 mio. € share of funding);
- RIGHT (LSHB-CT-2004-005276) - RNA Interference Technology as Human Therapeutic Tool (2005-2008; 0.74 mio. € share of funding);
- NAC-DRUG (MEST-CT-2004-504018) - Nucleic Acid Based Drug Design Training Center (2004-2008; 1.65 mio. €);

Public Danish Funds – Center Director and PI
- The Danish National Research Foundation: “Nucleic Acid Center” (2001-2011; 9.0 mio. €)

Private Danish Funds – PI 
- The Biomolecular Nanoscale Engineering Center (2012-2022; 60 mio. DKK) – A VKR Center of Excellence funded by the Villum Foundation

- VKR Fonden: “Electronic Properties of DNA-Based Molecules - Single Molecule Nanoscience” (2007-2010; 1.06 mio. €);
- Lundbeckfonden: “NanoCan Center - Nanomedicine research center for cancer stem cell targeting therapeutics” (2009-2014; 0.70 mio. € share of funding)

- Member of the board, Department of Chemistry, Odense University (1991-1992 and 1996)
- Member of the board, The Danish Chemical Society: Organic Chemistry Section (1997-2000); Chairman of the board (1999-2000)
- Chairman of the board, Chemical Laboratory II, Department of Chemistry, University of Copenhagen (1998-2000)
- Director of the Nucleic Acid Center funded by the Danish National Research Foundation (2001-)
- Chairman of the board, RiboTask ApS (2006-)
- Member of the Leadership Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark (2006-)
- Chairman of the research strategy board, Science Faculty, University of Southern Denmark (2011-)

Fingerprint Dive into the research topics where Jesper Wengel is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 15 Similar Profiles
Oligonucleotides Chemical Compounds
Nucleic Acids Chemical Compounds
Monomers Chemical Compounds
DNA Chemical Compounds
Nucleic acids Engineering & Materials Science
RNA Chemical Compounds
Nucleosides Chemical Compounds
Oligodeoxyribonucleotides Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

56 Downloads (Pure)

A self-assembled, modular nucleic acid-based nanoscaffold for multivalent theranostic medicine

Andersen, V. L., Vinther, M., Kumar, R., Ries, A., Wengel, J., Nielsen, J. S. & Kjems, J., 2019, In : Theranostics. 9, 9, p. 2662-2677

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Nucleic Acids
Precision Medicine
Confocal Microscopy
128 Downloads (Pure)

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28. Jan 2019, In : Journal of Controlled Release. 294, p. 247-258

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Hyaluronic Acid

Improved RE31 Analogues Containing Modified Nucleic Acid Monomers: Thermodynamic, Structural, and Biological Effects

Kotkowiak, W., Wengel, J., Scotton, C. J. & Pasternak, A., 14. Mar 2019, In : Journal of Medicinal Chemistry. 62, 5, p. 2499-2507

Research output: Contribution to journalJournal articleResearchpeer-review

Nucleic Acids
Nucleotide Aptamers
71 Downloads (Pure)

microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation

Moura, J., Sørensen, A., Leal, E. C., Svendsen, R., Carvalho, L., Willemoes, R. J., Jørgensen, P. T., Jenssen, H., Wengel, J., Dalgaard, L. T. & Carvalho, E., 9. Apr 2019, In : Scientific Reports. 9, 11 p., 5836.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Fibroblast Growth Factor 7
Wounds and Injuries
Diabetic Foot
17 Downloads (Pure)

Molecular determinants for agonist recognition and discrimination in P2X2 receptors

Gasparri, F., Wengel, J., Grutter, T. & Pless, S. A., 1. Jul 2019, In : Journal of General Physiology. 151, 7, p. 898-911 14 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Site-Directed Mutagenesis

Activities 2003 2019

Aarhus University - MSc exam

Jesper Wengel (Censor)
27. Jun 2019

Activity: ExaminationExternal examination

Research meeting at Karolinska Institute

Jesper Wengel (Participant)
20. May 2019

Activity: Other activitiesOther

1st DelNAM Summer School - In vivo gene delivery of nanomedicines

Jesper Wengel (Participant)
7. May 20199. May 2019

Activity: Attending an eventConference organisation or participation

1st DelNAM Workshop on Design and Synthesis of Nucleic Acids Mimics

Jesper Wengel (Organizer)
21. Mar 2019

Activity: Attending an eventOrganisation or participation in workshops, courses or seminars


Novel building blocks for therapeutic oligonucleotides

Jesper Wengel (Keynote speaker)
22. Nov 2018

Activity: Talks and presentationsConference presentations


Projects 2007 2022

Høj Teknologifonden - Novel Medicines microRNA

Wengel, J.


Project: Research

Novartis Pharma AG

Wengel, J.


Project: Research


Wengel, J.


Project: Research

Press / Media

RNA-lægemidler kan levere det næste kvantespring i biotekindustrien

Jesper Wengel


1 Media contribution

Press/Media: Press / Media

»Jeg fik nok, den dag min vægt nærmede sig 100 kg«

Jesper Wengel


1 Media contribution

Press/Media: Press / Media

Tiden i laboratoriet er det bedste

Jesper Wengel


1 item of Media coverage

Press/Media: Press / Media


Direktør Ib Henriksens Fond Forskerprisen 2008

Jesper Wengel (Recipient), 1. Dec 2008

Prize: Prizes, scholarships, distinctions

Dansk Magisterforenings forskningspris 2007

Jesper Wengel (Recipient), 27. Nov 2007

Prize: Prizes, scholarships, distinctions

OBC Lecture Award Winner 2006

Jesper Wengel (Recipient), 10. Sep 2006

Prize: Prizes, scholarships, distinctions

Villum Kann Rasmussen Fondens Årslegat 2005

Jesper Wengel (Recipient), 21. Jan 2005

Prize: Prizes, scholarships, distinctions

The UCB Award for Excellence in Medicinal Chemistry 2004

Jesper Wengel (Recipient), 15. Aug 2004

Prize: Prizes, scholarships, distinctions

Teaching & Supervision