1994 …2022
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Personal profile

Curriculum

Personal Data: Born October 22, 1963; Married; Five children

University Address

Nucleic Acid Center
Department of Physics and Chemistry
University of Southern Denmark, Odense
Campusvej 55
DK-5230 Odense M, Denmark
Tel. +45 6550 2510
Fax. +45 6615 8780
E-mail: jwe@sdu.dk

Private Address: Frydenlundsvej 4, 5550 Langeskov, Denmark. Tel. +45 20846872

University Education:

Cand. scient.: Odense University (Chemistry/Biology; December 1988)
Ph.D.: Odense University (January 1992): "Synthesis of 2',3'-Dideoxynucleoside Analogues with Potential Activity against HIV"

Research Fellow: Department of Chemistry and Biochemistry, University of Colorado, USA (October 1990 - June 1991)

Assistant Professor: In organic chemistry at Department of Chemistry, Odense University (September 1991 - March 1994)

Associate Professor: In organic chemistry at Department of Chemistry, Odense University (April 1994 - September 1996)

Professor In bioorganic chemistry at Department of Chemistry, University of Copenhagen (October 1996 - July 2000)
In organic chemistry at Department of Chemistry, University of Southern Denmark, Odense (August 2000 -)

Present Research:
Bioorganic chemistry; nucleic acid biotechnology; Nanobioscience

Editorial Board Member:
Oligonucleotides (Mary Ann Liebert). Artificial DNA: PNA & XNA (Landes BioScience)

Publications:
Author or co-author of >360 research papers in peer-reviewed scientific journals. H-Index = 53; Citations > 11.500 (SCI: Wengel J*; first publication in 1989)

Lectures and Seminars:
More than 120 invited lectures and seminars have been presented during the last 10 years in Denmark and abroad

IPR and Innovation:
Inventor or co-inventor on more than ten patents and patent applications. Co-inventor of the LNA (Locked Nucleic Acid) technology that forms the basis of the business activities of the companies Exiqon A/S (~60 employees) and Santaris Pharma A/S (~70 employees). Co-founder (2006) of RiboTask ApS.

Honors and Awards:
- Elected member of the Royal Danish Academy of Sciences and Letters;
- Elected member of the Danish Academy of Natural Sciences;
- Elected member of the Danish Academy of Technical Sciences;
- Natural Science Faculty Teaching Award, Odense University, 1995;
- Bjerrum-Brøndsted-Lang Lecturer, 1997;
- Parker-Davis Lecturer, Ohio State University, 2000;
- Biochemistry Teaching Award, University of Copenhagen, 2000;
- The Bjerrum Chemistry Award, 2001;
- The Lundbeck Foundation's Research Prize for Young Researchers, 2002;
- The Danish Academy of Natural Sciences Industry Award, 2002;
- The UCB Award for Excellence in Medicinal Chemistry 2004;
- Villum Kann Rasmussen Grant for Technical Research 2005;
- OBC Lecture Award Winner 2006;
- The Danish Association of Masters and PhD Research Award 2007;
- The Ib Henriksen Foundation Research Award 2008


Major Research Funding since 2001: 

ERC Advanced Grant
- EVOLNA – Evolution of LNA-based Aptamers (2011-2016; 2.5 mio. €).

International Funds – Partner in EU projects, local PI
- Pharmaco-Gene (LSHB-CT-2007-037283) - Design of Targeted Gene Pharmaceutics Using Self-assembling Functional Entities (2007-2010; 0.43 mio. € share of funding);
- RIGHT (LSHB-CT-2004-005276) - RNA Interference Technology as Human Therapeutic Tool (2005-2008; 0.74 mio. € share of funding);
- NAC-DRUG (MEST-CT-2004-504018) - Nucleic Acid Based Drug Design Training Center (2004-2008; 1.65 mio. €);

Public Danish Funds – Center Director and PI
- The Danish National Research Foundation: “Nucleic Acid Center” (2001-2011; 9.0 mio. €)

Private Danish Funds – PI 
- The Biomolecular Nanoscale Engineering Center (2012-2016; 30 mio. DKK) – A VKR Center of Excellence funded by the Villum Foundation

- VKR Fonden: “Electronic Properties of DNA-Based Molecules - Single Molecule Nanoscience” (2007-2010; 1.06 mio. €);
- Lundbeckfonden: “NanoCan Center - Nanomedicine research center for cancer stem cell targeting therapeutics” (2009-2014; 0.70 mio. € share of funding)

Administration:
- Member of the board, Department of Chemistry, Odense University (1991-1992 and 1996)
- Member of the board, The Danish Chemical Society: Organic Chemistry Section (1997-2000); Chairman of the board (1999-2000)
- Chairman of the board, Chemical Laboratory II, Department of Chemistry, University of Copenhagen (1998-2000)
- Director of the Nucleic Acid Center funded by the Danish National Research Foundation (2001-)
- Chairman of the board, RiboTask ApS (2006-)
- Member of the Leadership Group, Department of Physics, Chemistry and Pharmacy, University of Southern Denmark (2006-)
- Chairman of the research strategy board, Science Faculty, University of Southern Denmark (2011-)

Fingerprint Fingerprint is based on mining the text of the person's scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 15 Similar Profiles
Oligonucleotides Chemical Compounds
Nucleic Acids Chemical Compounds
Monomers Chemical Compounds
DNA Chemical Compounds
Nucleic acids Engineering & Materials Science
RNA Chemical Compounds
Nucleosides Chemical Compounds
Nucleotides Chemical Compounds

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output 1994 2019

Fibrin-hyaluronic acid hydrogel-based delivery of antisense oligonucleotides for ADAMTS5 inhibition in co-delivered and resident joint cells in osteoarthritis

Garcia, J. P., Stein, J., Cai, Y., Riemers, F., Wexselblatt, E., Wengel, J., Tryfonidou, M., Yayon, A., Howard, K. A. & Creemers, L. B., 28 Jan 2019, In : Journal of Controlled Release. 294, p. 247-258

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Hydrogel
Hyaluronic Acid
Chondrocytes
Joints
Disintegrins

Hydrogel-Assisted Antisense LNA Gapmer Delivery for In Situ Gene Silencing in Spinal Cord Injury

Moreno, P. M. D., Ferreira, A. R., Salvador, D., Rodrigues, M. T., Torrado, M., Carvalho, E. D., Tedebark, U., Sousa, M. M., Amaral, I. F., Wengel, J. & Pêgo, A. P., 2018, In : Molecular Therapy - Nucleic Acids. 11, p. 393-406

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Hydrogel
Spinal Ganglia
Nucleic Acids
Cell Survival
Down-Regulation

MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells

Ferino, A., Miglietta, G., Picco, R., Vogel, S., Wengel, J. & Xodo, L. E., 2018, In : RNA Biology. 15, 10, p. 1273-1285

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
MicroRNAs
Pancreatic Neoplasms
Cell-Penetrating Peptides
Nucleic Acids
Down-Regulation

Modification of oligodeoxynucleotides by on-column Suzuki cross-coupling reactions

Ejlersen, M., Lou, C., Sanghvi, Y. S., Tor, Y. & Wengel, J., 1 Jan 2018, In : Chemical Communications. 54, 57, p. 8003-8006

Research output: Contribution to journalLetterResearchpeer-review

Oligonucleotides
Oligodeoxyribonucleotides
Boronic Acids
Monomers
Acids

Novel conformationally constrained 2'-C-methylribonucleosides: synthesis and incorporation into oligonucleotides

Vejlegaard, K., Wegeberg, C., McKee, V. & Wengel, J., 2018, In : Organic & Biomolecular Chemistry. 16, 8, p. 1312-1321

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Oligonucleotides
Bearings (structural)
Derivatives
Ribonucleosides
Complementary RNA

Activities 2003 2018

Novel building blocks for therapeutic oligonucleotides

Jesper Wengel (Keynote speaker)
22 Nov 2018

Activity: Talks and presentationsConference presentations

Lipophilic LNA-based Antisense Oligonucleotides

Jesper Wengel (Speaker)
7 Nov 2018

Activity: Talks and presentationsConference presentations

4th BioNEC Mini-Symposium on Bio-molecular Synthesis and Nanotechnology

Jesper Wengel (Organizer)
6 Nov 2018

Activity: Attending an eventOrganisation or participation in workshops, courses or seminars

Novel DNA-mimicking monomers for gapmer antisense oligonucleotides

Jesper Wengel (Speaker)
29 Aug 2018

Activity: Talks and presentationsConference presentations

Aarhus University - Qualifying exam

Jesper Wengel (Censor)
27 Jul 2018

Activity: ExaminationExternal examination

Projects 2007 2022

Villumfondens postdoc stipendier Maj 2016

Wengel, J.

23/12/201523/12/2019

Project: ResearchDanish Private Sources

University of Minho - Bench fees - Daniela Eira Araújo

Wengel, J.

01/05/201831/10/2018

Project: ResearchForeign Sources

Villumfondens postdoc stipendier 2014-2015

Wengel, J.

11/05/201410/05/2018

Project: ResearchDanish Private Sources

Press / Media

»Jeg fik nok, den dag min vægt nærmede sig 100 kg«

Jesper Wengel

04/01/2018

1 media contribution

Press/Media: Press / Media

Tiden i laboratoriet er det bedste

Jesper Wengel

03/03/2017

1 item of media coverage

Press/Media: Press / Media

Fra laboratorieidé til milliardforretning

Jesper Wengel

27/11/2014

1 item of media coverage

Press/Media: Press / Media

Debat: I strid med sund fornuft

Jesper Wengel

20/06/2014

1 item of media coverage

Press/Media: Press / Media

Forrygende forvandling

Jesper Wengel

16/02/2014

1 item of media coverage

Press/Media: Press / Media

Prizes

Dansk Magisterforenings forskningspris 2007

Jesper Wengel (Recipient), 27 Nov 2007

Prize: Prizes, scholarships, distinctions

Direktør Ib Henriksens Fond Forskerprisen 2008

Jesper Wengel (Recipient), 1 Dec 2008

Prize: Prizes, scholarships, distinctions

OBC Lecture Award Winner 2006

Jesper Wengel (Recipient), 10 Sep 2006

Prize: Prizes, scholarships, distinctions

The UCB Award for Excellence in Medicinal Chemistry 2004

Jesper Wengel (Recipient), 15 Aug 2004

Prize: Prizes, scholarships, distinctions

Villum Kann Rasmussen Fondens Årslegat 2005

Jesper Wengel (Recipient), 21 Jan 2005

Prize: Prizes, scholarships, distinctions