20062020

Research output per year

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Personal profile

Research areas

My research focuses on how the cell’s architecture influences its metabolism and intracellular signaling and consequently its function. This has been accomplished by the use of experimental methods where the cell’s intracellular organization is maintained and by high-resolution imaging techniques as the electron microscope. Initially, my concern has been to elucidate the role and regulation of local storage of glycogen molecules (the principal storage form of glucose) in specific micro-domains within the cell. Using three different approaches, I and collaborators have shown that the link between glycogen depletion and impaired muscle function most likely originates from a connection between intramyofibrillar glycogen and SR calcium release. This was shown in mechanically skinned rat muscle fibers (Nielsen et al., 2009), isolated human SR vesicles (Ørtenblad et al.,2011), and intact mouse muscle fibers (Nielsen et al., 2014). Interestingly, we have also found that intramyofibrillar glycogen is preferentially depleted during prolonged exercise (Nielsen et al., 2011), which suggests that this could be the explanation for the glycogen-dependent component in the complexity of impaired muscle function during metabolic stress. In perspective, we have found that rodents and humans have almost the same amount of intramyofibrillar glycogen (Nielsen et al. 2014,2015), despite 4-fold differences in total glycogen, indicating a conserved role of intramyofibrillar glycogen across species. List of publications via Pubmed or Web of Science: "Nielsen J AND (Ortenblad N OR Schroder HD OR Vissing K) NOT (Nielsen JS OR Nielsen JH OR Nielsen JB OR Nielsen JL)".

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Research Output

Comment on: “changes in skeletal muscle glycogen content in professional soccer players before and after a match by a noninvasive musclesound® technology. a cross sectional pilot study nutrients 2020, 12(4), 971”

Ørtenblad, N., Nielsen, J., Gejl, K. D., Routledge, H. E., Morton, J. P., Close, G. L., Niemann, D. C., Bone, J. L. & Burke, L. M., 13. Jul 2020, In : Nutrients. 12, 7, 2 p., 2070.

Research output: Contribution to journalComment/debateResearchpeer-review

Open Access
File
1 Downloads (Pure)

Effects of Acute Exercise and Training on the Sarcoplasmic Reticulum Ca2+ Release and Uptake Rates in Highly Trained Endurance Athletes

Gejl, K. D., Andersson, E. P., Nielsen, J., Holmberg, H-C. & Ørtenblad, N., 7. Jul 2020, In : Frontiers in Physiology. 11, 11 p., 810.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
  • Heterogeneity in subcellular muscle glycogen utilisation during exercise impacts endurance capacity in man

    Jensen, R., Ørtenblad, N., Stausholm, M-L. H., Skjaerbaek, M. C., Larsen, D. N., Hansen, M., Holmberg, H-C., Plomgaard, P. & Nielsen, J., 20. Jul 2020, In : The Journal of Physiology.

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Inhibition of glycogenolysis prolongs action potential repriming period and impairs muscle function in rat skeletal muscle

    Jensen, R., Nielsen, J. & Ørtenblad, N., Feb 2020, In : The Journal of Physiology. 598, 4, p. 789-803

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Mitochondrial Structure and Function in the Metabolic Myopathy Accompanying Patients with Critical Limb Ischemia

    Groennebaek, T., Billeskov, T. B., Schytz, C. T., Jespersen, N. R., Bøtker, H. E., Olsen, R. K. J., Eldrup, N., Nielsen, J., Farup, J., De Paoli, F. V. & Vissing, K., 28. Feb 2020, In : Cells. 9, 3, 570.

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 11 Downloads (Pure)

    Activities

    Projektstyring, VIP

    Joachim Nielsen (Participant)

    22. Sep 2016

    Activity: Attending an eventOrganisation or participation in workshops, courses or seminars

    European Muscle Conference 2016

    Joachim Nielsen (Participant)

    2. Sep 2016

    Activity: Attending an eventConference organisation or participation

    European Journal of Applied Physiology (Journal)

    Joachim Nielsen (Peer reviewer)

    2016 → …

    Activity: Editorial work and peer reviewPeer review of manuscriptsResearch

    Assessment and evaluation of human muscle, nervous system and tendon-aponeurosis function in sports science, clinical science and aging

    Joachim Nielsen (Speaker)

    10. Mar 2015

    Activity: Talks and presentationsGuest lectures, external teaching and course activities at other universities

    Journal of Physiology and Biochemistry (Journal)

    Joachim Nielsen (Peer reviewer)

    2015 → …

    Activity: Editorial work and peer reviewPeer review of manuscriptsResearch

    Press / Media

    DR P4 Fyn: P4 morgen

    Joachim Nielsen

    01/11/2016

    1 Media contribution

    Press/Media: Press / Media

    Politiken: Derfor kan Thomas Delaney løbe solen sort

    Joachim Nielsen

    01/11/2016

    1 Media contribution

    Press/Media: Press / Media

    Forskere: Derfor kan Delaney løbe solen sort

    Joachim Nielsen

    01/11/2016

    1 item of Media coverage

    Press/Media: Press / Media

    SportsLab: Kan tre TV 2-mænd besejre én kvinde?

    Joachim Nielsen

    25/04/2016

    1 Media contribution

    Press/Media: Press / Media

    Prizes

    Young Investigator Award - Congress of the European College of Sport Science

    Nielsen, Joachim (Recipient), 27. Jun 2009

    Prize: Prizes, scholarships, distinctions

    Teaching & Supervision

    Sommerskole

    Alice Kongsted, Joachim Nielsen & Henriette Bondo Andersen

    01/08/201727/09/2019

    Course: Teaching