• J.B. Winsløws Vej 9 B, st. tv.

    5000 Odense C

    Denmark

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Personal profile

Research areas

Genetic epidemiology, epigenetics, pigment genetics and aging research.

Curriculum

Education

  • Ph.d. University of Copenhagen, 2008.
  • Master of Science, University of Southern Denmark, 2002.

Academic carreer

  • Post.doc. at the Department of Epidemiology, University of Southern Denmark, 2009 -
  • Forensic geneticist at the Department of Forensic Medicine, University of Copenhagen, 2008 - 2009.
  • PhD-student at the Department of Forensic Medicine, University of Copenhagen, Københavs Universistet, 2004 - 2008.
  • Forensic geneticist at the Department of Forensic Medicine, University of Copenhagen, 2003 - 2004.
  • Research assistant at the Department of Forensic Medicine, University of Copenhagen, 2002 - 2003.

Internationale experience

  • PhD student at MRC Human Genetics Unit, Edinburgh 2006-2007.
  • EU program - High Throughput Analysis of Single Nucleotide Polymorphisms (SNPs) for the forensic IDentification of Persons. http://www.snpforid.org 2003-2006.
  • Erasmus exchange at Universitat de Barcelona 2000.

Peer reviewed
Mengel-From J, Borsting C, Sanchez JJ, Eiberg H, Morling N. Determination of cis/trans phase of variations in the MC1R gene with allele-specific PCR and single base extension. Electrophoresis. 2008 Dec; 29(23):4780-7.

Eiberg H, Troelsen J, Nielsen M, Mikkelsen A, Mengel-From J, Kjaer K, Hansen L. Blue eye color in humans may be caused by a perfectly associated founder mutation in a regulatory element located within the HERC2 gene inhibiting OCA2 expression. Human Genetics. 2008, 123(2):177-187.

Mengel-Jorgensen,J., Jensen,S.S., Rasmussen,A., Poehlsgaard,J., Iversen,J.J.L. & Kirpekar,F. Modifications in Thermus thermophilus 23 S ribosomal RNA are centered in regions of RNA-RNA contact. Journal of biological chemistry. (2006). 281: (31), 22108-22117.

Mengel-Jorgensen J, Sanchez JJ, Borsting C, Kirpekar F & Morling N. Typing of multiple SNPs using ribonuclease cleavage of DNA/RNA chimeric single base extension primers and detection by MALDI-TOF mass spectrometry. Analytical chemistry. (2005). 77: (16), 5229-5235.

Mengel-Jorgensen J, Sanchez JJ, Borsting C, Kirpekar F & Morling N. MALDI-TOF mass spectrometric detection of multiplex single base extended primers. A study of 17 y-chromosome single-nucleotide polymorphisms. Analytical chemistry. (2004). 76: (20), 6039-6045.

Madsen CT, Mengel-Jorgensen J, Kirpekar F, Douthwaite S. Identifying the methyltransferases for m(5)U747 and m(5)U1939 in 23S rRNA using MALDI mass spectrometry. Nucleic Acids Res. 2003, 31, 4738-46.

Mengel-Jorgensen J and Kirpekar F. Detection of pseudouridines and other modifications in tRNA cyanoethylation and MALDI mass spectrometry. Nucleic Acids Res. 2002, 30: e135. 

Other scientific contributions 

Wächter A, Mengel-From J, Borsting C, Morling N. A 50 SNP-multiplex mass spectrometry assay for human identification. Forensic Science International: Genetic Supplement Series. 2008, 1:487-9.

Mengel-Jorgensen J, Wächter A, Børsting C, Sanchez JJ, Morling N PCR and SBE multiplexes for determination of SNPs associated with hair and eye colours in humans. DNA in forensic, Innsbruck, Austria, September 2006.

Mengel-Jorgensen J, Borsting C, Sanchez JJ, Morling N. Gene variations associated with hair and eye colours in humans 13th European Society for Pigment Cell Research, Barcelona, Spain. Pigment Cell research 2006, 19, 5, 520.

Mengel-From,J., Eiberg,H., Borsting,C. & Morling,N. Genetic screening of 15 SNPs in the MC1R gene in relation to hair colour in Danes. Elsevier (2006).55-57. Progress in Forensic Genetics 11.

Mengel-From,J., Sanchez Sanchez,J.J., Borsting,C., Kirpekar,F. & Morling,N. Multiplex Y chromosome SNP genotyping using MALDI-TOF mass spectrometry. Elsevier (2004).15-17. Progress in Forensic Genetics 10.

Sanchez,J.J., Borsting,C., Hernandez,A., Mengel-From,J. & Morling,N. Y chromosome SNP haplogroups in Danes, Greenlanders and Somalis. Elsevier (2004).347-349. Progress in Forensic Genetics 10.

Phillips C., Lareu M., Brion M., Sobrino B., Carracedo A., Boersting C., Kirpekar F., Mengel-Joergensen J., Sanchez J.J., Morling N., Syndercombe Court D., Balogh K., Bogus M., Bender K., SchneiderP.M. Selecting Single Nucleotide Polymorphisms for Forensic Applications Elsevier International Congress Series 1261 (2004) Progress in Forensic Genetics 10.

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Research Output

Age‐dependent DNA methylation patterns on the Y chromosome in elderly males

Lund, J. B., Li, S., Christensen, K., Mengel-From, J., Thinggaard, M. S., Marioni, R. E., Starr, J., Pattie, A., Deary, I. J., Baumbach, J. & Tan, Q., Feb 2020, In : Aging Cell. 19, 2, 8 p., e12907.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
  • 106 Downloads (Pure)
  • DNA methylation QTL analysis identifies new regulators of human longevity

    Szymczak, S., Dose, J., Torres, G. G., Heinsen, F-A., Venkatesh, G., Datlinger, P., Nygaard, M., Mengel-From, J., Flachsbart, F., Klapper, W., Christensen, K., Lieb, W., Schreiber, S., Häsler, R., Bock, C., Franke, A. & Nebel, A., 8. May 2020, In : Human Molecular Genetics. 29, 7, p. 1154-1167

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 18 Downloads (Pure)

    Exploratory analysis of age and sex dependent DNA methylation patterns on the X-chromosome in whole blood samples

    Li, S., Lund, J., Christensen, K., Baumbach, J., Mengel-Jørgensen, J., Kruse, T. A., Li, W., Mohammadnejad, A., Pattie, A., Marioni, R. E., Deary, I. J. & Tan, Q., 28. Apr 2020, In : Genome Medicine. 12, 39, 13 p., 39 .

    Research output: Contribution to journalJournal articleResearchpeer-review

    Open Access
    File
  • 30 Downloads (Pure)

    Activities

    • 5 Conference organisation or participation
    • 5 Conference presentations
    • 5 Talks and presentations in private or public companies
    • 1 Peer review of manuscripts

    P L o S One (Journal)

    Jonas Mengel-From (Peer reviewer), & Floor Dijkstra Zegers (Peer reviewer)

    Aug 2020

    Activity: Editorial work and peer reviewPeer review of manuscriptsResearch

    Molecular biomarkers of aging - experiences from the Danish Twin Register and Aging Biobank

    Jonas Mengel-From (Keynote speaker)

    8. Jul 2019

    Activity: Talks and presentationsTalks and presentations in private or public companies

    49th Annual Meeting of the Behavior Genetics Association

    Jonas Mengel-From (Participant)

    26. Jun 201929. Jun 2019

    Activity: Attending an eventConference organisation or participation

    Implementation of Digital Data Collection for Cognitive Performance in the Long Life Family Study

    Jonas Mengel-Jørgensen (Speaker)

    Nov 2018

    Activity: Talks and presentationsConference presentations

    Projects

    Press / Media

    New hair colour genes identified

    Jonas Mengel-Jørgensen

    16/04/2018

    1 Media contribution

    Press/Media: Press / Media

    Shot of Klotho Boosts Memory In Aging and Diseased Mice

    Jonas Mengel-Jørgensen

    15/08/2017

    1 Media contribution

    Press/Media: Press / Media

    VIDENSKAB: Broccoli kan indeholde ' ungdomseliksir'

    Jonas Mengel-Jørgensen

    19/02/2017

    1 item of Media coverage

    Press/Media: Press / Media

    Broccolieliksir gør gamle mus unge igen

    Jonas Mengel-Jørgensen

    13/02/2017

    1 item of Media coverage

    Press/Media: Press / Media