Johan Hygum Dam

Ph.d., Kemiingeniør

20082019
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Research Output 2008 2019

2019

[58mCo]Co‐DOTA‐hEGF: A novel ligand for targeted Auger electron therapy of glioblastoma using convection‐enhanced delivery

Laursen, V., Baun, C., Aaberg Poulsen, C., Olsen, B. B., Dam, J. H., Jensen, A. & Thisgaard, H., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, S1, p. S511-S512

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Neoplasms
Somatostatin Receptors
68Ga-DOTATATE
64Cu-DOTATATE
HEPES

Multi-Curie Production of Gallium-68 on a Biomedical Cyclotron

Kumlin, J., Dam, J. H., Chua, C. J., Borjian, S., Kassaian, A., Hook, B., Zeisler, S., Schaffer, P. & Thisgaard, H., 1. Oct 2019, In : European Journal of Nuclear Medicine and Molecular Imaging. 46, Suppl. 1, p. S39 1 p., OP-086.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Preparation and evaluation of [F-18] AlF-NOTA-NOC for PET imaging of neuroendocrine tumors

Dam, J. H., Langkjær, N., Baun, C. & Olsen, B. B., May 2019, In : Journal of Labelled Compounds and Radiopharmaceuticals. 62, S1, p. S416-S417

Research output: Contribution to journalConference abstract in journalResearchpeer-review

10 Downloads (Pure)

Selection of an optimal macrocyclic chelator improves the imaging of prostate cancer using cobalt-labeled GRPR antagonist RM26

Mitran, B., Thisgaard, H., Rinne, S., Dam, J. H., Azami, F., Tolmachev, V., Orlova, A. & Rosenström, U., 19. Nov 2019, In : Scientific Reports. 9, 11 p., 17086.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Bombesin Receptors
Chelating Agents
Cobalt
Prostatic Neoplasms
Neoplasms
2018
33 Downloads (Pure)
Open Access
File
Cobalt
Neoplasms
Half-Life
Ligands
oleylamine

Selection of optimal macrocyclic chelator for high contrast PET imaging of gastrin releasing peptide receptor using cobalt-labeled bombesin antagonist RM26

Mitran, B., Thisgaard, H., Rinne, S. S., Rosenström, U., Azamy, F., Dam, J. H., Tolmachev, V. & Orlova, A., Oct 2018, In : European Journal of Nuclear Medicine and Molecular Imaging. 45, Suppl. 1, p. S672-S673 EP-0913.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

2017

[55Co]Co-DOTA-PSMA-617 for PET/CT Imaging of Prostate Cancer in Xenograft Mice

Dam, J. H., Olsen, B. B., Baun, C. & Thisgaard, H., 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, Suppl. 1, p. S640 1 p., P 458 .

Research output: Contribution to journalConference abstract in journalResearchpeer-review

[55Co]Co-DOTA-PSMA-617 for PET/CT Imaging of Prostate Cancer in Xenograft Mice

Dam, J. H., Olsen, B. B., Baun, C. & Thisgaard, H., 2017.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

[58mCo]Co-DOTA-PSMA-617: A novel radioligand for Auger electron therapy of prostate cancer

Thisgaard, H., Olsen, B. B., Baun, C. & Dam, J. H., 2017, In : Journal of Labelled Compounds and Radiopharmaceuticals. 60, Suppl. 1, p. S327 1 p., P 167.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

A PSMA Ligand Labeled with Cobalt-55 for PET Imaging of Prostate Cancer

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 2017, In : Molecular Imaging and Biology. 19, 6, p. 915–922

Research output: Contribution to journalJournal articleResearchpeer-review

Cobalt
Prostatic Neoplasms
Ligands
Heterografts
Neoplasms

Formulation and in vivo biodistribution of 57Co-porphyrin-labelled hydrophobic liquid nanoparticles

Hervella, P., Dam, J. H., Thisgaard, H., Baun, C., Olsen, B. B., Høilund-Carlsen, P. F. & Needham, D., 2017, In : European Journal of Nuclear Medicine and Molecular Imaging. 44, Suppl. 2, p. 307-308 OP-533.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

159 Downloads (Pure)

High contrast pet imaging of GRPR expression in prostate cancer using cobalt-labeled bombesin antagonist RM26

Mitran, B., Thisgaard, H., Rosenström, U., Dam, J. H., Larhed, M., Tolmachev, V. & Orlova, A., 2017, In : Contrast Media & Molecular Imaging (Print). 2017, 10 p., 6873684.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Bombesin Receptors
Cobalt
Prostatic Neoplasms
Radioactivity
Neoplasms
97 Downloads (Pure)

The use of radiocobalt as a label improves imaging of EGFR using DOTA-conjugated Affibody molecule

Garousi, J., Andersson, K. G., Dam, J. H., Olsen, B. B., Mitran, B., Orlova, A., Buijs, J., Ståhl, S., Löfblom, J., Thisgaard, H. & Tolmachev, V., 2017, In : Scientific Reports. 7, 10 p., 5961.

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File
Epidermal Growth Factor Receptor
Radioisotopes
Neoplasms
Cobalt Radioisotopes
Cobalt Isotopes
2016

[11C]NS14444, a new radiotracer for alpha-7 nACh receptors. Synthesis and preclinical evaluation

Någren, K., Dam, J. H., Baun, C., Andersen, T., Šačkus, A., Paliulis, O. & Peters, D., 2016, In : European Journal of Nuclear Medicine and Molecular Imaging. 43, Suppl. 1, p. 535 1 p., EP833.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

[11C]NS9531, [11C]NS9762 and [11C]NS6417, specific SERT tracers: pre-clinical evaluation in pigs and optimization of synthesis conditions using [11C]methyl triflate

Dam, J. H., Bender, D., Peters, D. & Någren, K., 2016, In : Nuclear Medicine and Biology. 43, 1, p. 42-51

Research output: Contribution to journalJournal articleResearchpeer-review

134 Downloads (Pure)

Highly Effective Auger-Electron Therapy in an Orthotopic Glioblastoma Xenograft Model using Convection-Enhanced Delivery

Thisgaard, H., Halle, B., Aaberg-Jessen, C., Olsen, B. B., Nautrup Therkelsen, A. S., Dam, J. H., Langkjær, N., Munthe, S., Någren, K., Høilund-Carlsen, P. F. & Kristensen, B. W., 2016, In : Theranostics. 6, 12, p. 2278-2291

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
File

In Vivo Evaluation of a Bombesin Analogue Labeled with Ga-68 and Co-55/57

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 2016, In : Molecular Imaging and Biology. 18, 3, p. 368-376

Research output: Contribution to journalJournal articleResearchpeer-review

2015

Estimation of Tumor Volumes by 11C-MeAIB and 18F-FDG PET in an Orthotopic Glioblastoma Rat Model

Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015, In : Journal of Nuclear Medicine. 56, 10, p. 1562-1568

Research output: Contribution to journalJournal articleResearchpeer-review

Fluorodeoxyglucose F18
Glioblastoma
Tumor Burden
Acids
Neoplasms

Estimation of tumour volumes by [11C]MeAIB and [18F]FDG PET in an orthotopic glioblastoma model

Aaberg-Jessen, C., Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 1 Supplement, p. 423-425 1 p., P173.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Estimation of tumour volumes by [11C]MeAIB and [18F]FDG PET in an orthotopic glioblastoma model

Aaberg-Jessen, C., Halle, B., Thisgaard, H., Hvidsten, S., Dam, J. H., Thykjær, A. S., Høilund-Carlsen, P. F., Schulz, M. K., Andersen, C. & Kristensen, B. W., 2015.

Research output: Contribution to conference without publisher/journalPosterResearchpeer-review

Relationship between somatostatin receptor expression, DNA damage and cell survival in cancer cells incubated with a cobalt-labeled octreotide analogue

Olsen, B. B., Dam, J. H., Müller, C., Mollenhauer, J., Høilund-Carlsen, P. F. & Thisgaard, H., 29. May 2015.

Research output: Contribution to conference without publisher/journalPosterResearch

Seeing the unseen-bioturbation in 4D: Tracing bioirrigation in marine sediment using positron emission tomography and computed tomography

Delefosse, M., Kristensen, E., Crunelle, D., Braad, P. E., Dam, J. H., Thisgaard, H., Thomassen, A. & Høilund-Carlsen, P. F., 4. Apr 2015, In : PLOS ONE. 10, 4, p. 1-17

Research output: Contribution to journalJournal articleResearchpeer-review

Open Access
Geologic Sediments
positron-emission tomography
Positron emission tomography
bioturbation
marine sediments

The use of radiocobalt as a label improves PET imaging of EGFR using DOTA-conjugated affibody molecules

Garousi, J., Anderson, K., Dam, J. H., Olsen, B. B., Orlova, A., Buijs, J., Ståhl, S., Thisgaard, H. & Tolmachew, V., 2015, In : European Journal of Nuclear Medicine and Molecular Imaging. 42, 1 Supplement, p. 244 1 p., OP582.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

77 Downloads (Pure)

Transition Metal Mediated Kumada Cross Coupling of [11C]CH3I and Aryl Grignard

Dam, J. H., 21. May 2015, In : Journal of Labelled Compounds and Radiopharmaceuticals. 58, S1

Research output: Contribution to journalConference abstract in journalResearchpeer-review

File
2014

Convection-enhanced delivery of the Auger-electron-emitter I-125-UdR: A highly efficient therapy in an Orthotopic Glioblastoma Xenograft Model

Halle, B., Thisgaard, H., Aaberg-Jessen, C., Olsen, B. B., Dam, J. H., Langkjaer, N., Munthe, S., Någren, K., Hoilund-Carlsen, P. F. & Kristensen, B. W., 2014, In : Neuro-Oncology. 16, p. 1

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Evaluation of Cobalt-Labeled Octreotide Analogs for Molecular Imaging and Auger Electron-Based Radionuclide Therapy

Thisgaard, H., Olsen, B. B., Dam, J. H., Bollen, P., Mollenhauer, J. & Høilund-Carlsen, P. F., 29. May 2014, In : Journal of Nuclear Medicine. 55, 8, p. 1311-1316

Research output: Contribution to journalJournal articleResearchpeer-review

Octreotide
Cobalt
Radioisotopes
Electrons
Therapeutic Uses
323 Downloads (Pure)

Good manufacturing practice production of the system A amino acid transport tracer [11C]MeAIB on a commercial synthesis module

Dam, J. H. & Någren, K., 2014, In : Journal of Labelled Compounds and Radiopharmaceuticals. 57, 1, p. 61-4

Research output: Contribution to journalJournal articleResearchpeer-review

File

In Vivo Evaluation of a Bombesin Analogue Labelled with 68Ga and 55/57Co

Dam, J. H., Olsen, B. B., Baun, C., Høilund-Carlsen, P. F. & Thisgaard, H., 18. Oct 2014, In : European Journal of Nuclear Medicine and Molecular Imaging. 41, 2. Supplement, p. S251 1 p., OP414.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

1071 Downloads (Pure)

Fully Automated Radiosynthesis and Formulation of [11C]MeAIB Applied for In Vivo Imaging of Glioblastoma

Dam, J. H., Halle, B., Thisgaard, H., Hvidsten, S., Kristensen, B. W. & Någren, K., 17. May 2013.

Research output: Contribution to conference without publisher/journalPosterResearch

Open Access
File
161 Downloads (Pure)

Fully Automated Radiosynthesis and Formulation of [11C]MeAIB Applied for In Vivo Imaging of Glioblastoma

Dam, J. H., Halle, B., Thisgaard, H., Hvidsten, S., Kristensen, B. W. & Någren, K., 2013, In : Journal of Labelled Compounds and Radiopharmaceuticals. 56, S1, p. S112 1 p.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Open Access
File
87 Downloads (Pure)

Preparation of the 11C-labelled SERT tracers NS9531, NS9762 and NS6417 on a GE FXc Pro module using [11C]methyl triflate

Någren, K., Dam, J. H., Bender, D. & Peters, D., 14. May 2013.

Research output: Contribution to conference without publisher/journalPosterResearch

File
108 Downloads (Pure)

Preparation of the C-11 labelled SERT tracers NS9531, NS9762 and NS6417 on a GE FX-C Pro module using C-11 methyl triflate.

Någren, K., Dam, J. H., Bender, D. & Peters, D., May 2013, In : Journal of Labelled Compounds and Radiopharmaceuticals. 56, S1, p. S102

Research output: Contribution to journalConference abstract in journalResearchpeer-review

File
2011

Radiosynthesis of 55Co- and 58mCo-labelled DOTATOC for positron emission tomography imaging and targeted radionuclide therapy

Thisgaard, H., Olesen, M. L. & Dam, J. H., 2011, In : Journal of Labelled Compounds and Radiopharmaceuticals. 54, 12, p. 758-762 5 p.

Research output: Contribution to journalJournal articleResearchpeer-review

2010

Amide Synthesis from Alcohols and Amines Catalyzed by Ruthenium N-Heterocyclic Carbene Complexes

Dam, J. H., Osztrovszky, G., Nordstrøm, L. U. & Madsen, R., 30. Apr 2010, In : Chemistry: A European Journal. 16, p. 6820-6827 8 p.

Research output: Contribution to journalJournal articleResearchpeer-review

Method for Preparation of Amides from Alcohols and Amines by Extrusion of Hydrogen

Dam, J. H., Nordstrøm, L. U., Vogt, H. & Madsen, R., 27. May 2010, IPC No. B01J31/32(2006.01), Patent No. 2010/058004A1, 23. Nov 2009

Research output: PatentResearch

PROCÉDÉ POUR LA PRÉPARATION D'AMIDES À PARTIR D'ALCOOLS ET D'AMINES PAR ÉLIMINATION D'HYDROGÈNE

Translated title of the contribution: METHOD FOR PREPARATION OF AMIDES FROM ALCOHOLS AND AMINES BY EXTRUSION OF HYDROGENNordstroem, L. U., Vogt, H., Madsen, R. & Dam, J. H., 27. May 2010, IPC No. C07C 231/ 10 A I, Patent No. WO2010058004, Priority date 27. Aug 2009, Priority No. DKPA200900967

Research output: PatentResearch

Ruthenium
Patents and inventions
Amides
Amines
Extrusion

Suppression of radiolysis on the FASTlab 18F-FDG synthesizer by the addition of ethanol.

Olesen, M. L., Salomonsen, H. H., Dam, J. H. & Någren, K. Å., 2010, In : European Journal of Nuclear Medicine and Molecular Imaging. 37, Suppl 2, p. S356-S356 1 p.

Research output: Contribution to journalConference articleResearchpeer-review

2009

Convergent Synthesis of Pancratistatin from Piperonal and Xylose

Dam, J. H. & Madsen, R., 2009, In : European Journal of Organic Chemistry. p. 4666-4673

Research output: Contribution to journalJournal articleResearchpeer-review

Organometallic Reactions: Development, Mechanistic Studies and Synthetic Applications

Dam, J. H., 2009, Technical University of Denmark, Denmark.

Research output: Book/anthology/thesis/reportPh.D. thesisResearch

2008

Combined Experimental and Theoretical Mechanistic Investigation of the Barbier Allylation in Aqueous Media

Dam, J. H., Fristrup, P. & Madsen, R., 2008, In : Journal of Organic Chemistry. 73, p. 3228-3235

Research output: Contribution to journalJournal articleResearchpeer-review