Research output per year
Research output per year
Personal profile
Research areas
The impact of Noncoding RNAs (ncRNAs) such as microRNAs and, more recently, long ncRNAs (LncRNAs) onto eukaryotic gene regulation has just started to be understood. The research Group of Jan-Wilhelm Kornfeld lab would like to take part in this 'Noncoding RNA revolution' by identifying novel ncRNAs and elucidating their role in homeostatic circuits regulating energy homeostasis in health and disease. We apply state-of-the art techniques such as next-generation sequencing, the generation of transgenic mouse models and in vivo anti-ncRNA approaches to ultimately better understand the intricate biology of disease-associated ncRNAs. Our ultimatate goal is to define novel sequence-specific anti-ncRNAs therapeutics for anti-obesity intervention.
Research Interests
Noncoding RNAs, Energy Metabolism, Obesity, Type 2 Diabetes, Adipose tissue, Epigenetics
Education/Academic qualification
Independent Max Planck Group Leader, Max Planck Institute for Metabolism Research
2014 → 2017
Group Leader, Cologne Excellence Cluster on Cellular Stress Responses in Aging Diseases (CECAD)
2013 → 2017
Postdoctoral Fellow, University of Cologne
2008 → 2013
Cell Biology, Dr. rer. nat., Christian-Albrechts-University of Kiel
2006 → 2008
Tumor Biology, Dr. rer. nat, University Medical Center Hamburg-Eppendorf
2003 → 2006
Biochemistry, Diploma, Hannover Medical School
1997 → 2003
Keywords
- Bioinformatics
- Antisense and siRNA
- Obesity
- Fat cell development and function
- Cirrhosis
Fingerprint
Dive into the research topics where Jan-Wilhelm Kornfeld is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Researchers
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
-
2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction
Kaul, H., Isermann, L., Senft, K., Popovic, M., Georgomanolis, T., Baumann, L., Sivanesan, P., Pouikli, A., Nolte, H., Lucic, B., Hildebrandt, X., Seidel, K., Gnad, T., Gaedke, F., Göbel, U., Peters, F., Cherevatenko, M., Park, J. H., Schauss, A. & Peltzer, N. & 8 others, , Aug 2025, In: Nature Metabolism. 7, 8, p. 1593-1613Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile7 Downloads (Pure) -
Rapid downregulation of DICER is a hallmark of adipose tissue upon high-fat diet feeding
Madsen, S., Peluso, A. A., Yonamine, C. Y., Ingerslev, L. R., Dall, M., Petersen, P. S. S., Plucinska, K., Pradas-Juni, M., Moreno-Justicia, R., Gonzalez-Franquesa, A., Højlund, K., Kornfeld, J. W., Emanuelli, B., Vienberg, S. G. & Treebak, J. T., 1. Jan 2025, In: Molecular and Cellular Endocrinology. 595, 11 p., 112413.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Downloads (Pure) -
Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function
Khani, S., Topel, H., Kardinal, R., Tavanez, A. R., Josephrajan, A., Larsen, B. D. M., Gaudry, M. J., Leyendecker, P., Egedal, N. M., Güller, A. S., Stanic, N., Ruppert, P. M. M., Gaziano, I., Hansmeier, N. R., Schmidt, E., Klemm, P., Vagliano, L. M., Stahl, R., Duthie, F. & Krause, J. H. & 14 others, , Jun 2024, In: Nature Metabolism. 6, 6, p. 1053-1075Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile21 Downloads (Pure) -
Mouse vascularized adipose spheroids: an organotypic model for thermogenic adipocytes
Davidsen, L. I., Hagberg, C. E., Goitea, V., Lundby, S. M., Larsen, S., Ebbesen, M. F., Stanic, N., Topel Batarlar, H. & Kornfeld, J.-W., 25. Jun 2024, In: Frontiers in Endocrinology. 15, 18 p., 1396965.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile69 Downloads (Pure) -
Nanopore sequencing unveils the complexity of the cold-activated murine brown adipose tissue transcriptome
Engelhard, C. A., Khani, S., Derdak, S., Bilban, M. & Kornfeld, J. W., 18. Aug 2023, In: iScience. 26, 8, 24 p., 107190.Research output: Contribution to journal › Journal article › Research › peer-review
Open AccessFile73 Downloads (Pure)
Activities
-
Animal models and replacement strategies in obesity research
Kornfeld, J.-W. (Guest lecturer)
21. May 2025Activity: Talks and presentations › Talks and presentations in private or public companies
-
The role of Epigenetics in Diabetes and Nutrition: From Fundamental Insights to Therapeutic Innovations’
Kornfeld, J.-W. (Guest lecturer)
8. May 2025Activity: Talks and presentations › Guest lectures, external teaching and course activities at other universities
-
Pharmacological and nutritional activation of thermogenic adipose tissue
Kornfeld, J.-W. (Guest lecturer)
2. Apr 2025Activity: Talks and presentations › Conference presentations
-
Targeting thermogenic adipose tissue in cardiometabolic disease
Kornfeld, J.-W. (Guest lecturer)
20. Aug 2024Activity: Talks and presentations › Conference presentations
-
Noncoding RNAs in Cardiometabolic Disease
Kornfeld, J.-W. (Guest lecturer)
12. Jun 2024Activity: Talks and presentations › Conference presentations
-
Novo Nordisk Fonden - Bioscience and Basic Biomedicine -The role of paracrine miRNAs in metabolic dysfunction of the obese adipose tissue niche (PARAT)
Kornfeld, J.-W. (PI)
01/01/2024 → 31/12/2026
Project: Private Foundations
-
Syntara: Syntara - Project Pharmaxis in Australien 2025
Kornfeld, J.-W. (Project participant)
01/01/2025 → 31/12/2025
Project: Industry
-
Novo Nordisk Fonden - validatioNN: Translate your research to drug discovery
Kornfeld, J.-W. (Project participant)
01/02/2025 → 31/10/2025
Project: Private Foundations
-
Sygeforsikringen "Danmark" - Novel approaches to intergenerational epigenetic inheritance of Metabolic
Kornfeld, J.-W. (Project participant)
01/05/2021 → 30/04/2025
Project: Research
-
Novo Nordisk Fonden - Nutrient-chromatin crosstalk in adipose tissue health and metabolic disease (HISTONE HEALTH)
Kornfeld, J.-W. (PI)
01/01/2022 → 31/12/2024
Project: Research
Press/Media
-
Forskere fjernede aminosyrer fra forsøgsmusenes kost, og så tabte de sig
10/11/2025
1 Media contribution
Press/Media: Press / Media
-
Forskere fjernede aminosyrer fra forsøgsmusenes kost, og så tabte de sig
10/11/2025
1 Media contribution
Press/Media: Press / Media
-
Novo Nordisk Fonden uddeler 360 mio. kr. gennem sit Challenge Programme
21/08/2025
1 Media contribution
Press/Media: Press / Media
-
Sådan taber du dig ved at booste det gode fedt
26/07/2025
1 Media contribution
Press/Media: Press / Media
-
Sådan taber du dig ved at booste det gode fedt
08/05/2025
1 Media contribution
Press/Media: Press / Media
Teaching & Supervision
-
BMB508 - Advanced Molecular Biology
Kornfeld, J.-W. 01/01/2018 → …
Course: Teaching and supervision › Teaching
-
BMB822 - Modern Developments and Technologies in Molecular Cell Biology
Kornfeld, J.-W. & Meola, N. 01/01/2018 → …
Course: Teaching and supervision › Teaching
-
NAT501 - First year project - Responsible supervisor
Kornfeld, J.-W. & Kiefer, C. A. 01/01/2018 → …
Course: Teaching and supervision › Teaching
-
PhD Thesis Ana Rita Tavanez
Kornfeld, J.-W. 30/04/2022 → 01/05/2025
Course: Teaching and supervision › Supervision
-
PhD Thesis Rocio Valdebenito Malmros
Kornfeld, J.-W. 01/03/2021 → 29/02/2024
Course: Teaching and supervision › Supervision